Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 2.741


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF7L2chr10_+_1147099630.887.7e-06Click!
LEF1chr4_-_109087876-0.792.7e-04Click!
TCF7L1chr2_+_853603730.504.8e-02Click!
TCF7chr5_+_133451297-0.273.1e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_54074037 6.489 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr10_+_7745341 5.923 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745354 5.399 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745325 5.248 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_-_128841432 4.878 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr11_+_69455837 4.580 NM_053056
CCND1
cyclin D1
chr14_-_65409445 4.556 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr4_+_39063851 4.292 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr11_+_69455938 4.261 CCND1
cyclin D1
chr10_+_7745229 4.164 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr18_-_25757351 4.035 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr4_-_186877413 3.963 SORBS2
sorbin and SH3 domain containing 2
chr5_-_16936371 3.818 NM_012334
MYO10
myosin X
chr1_-_225840660 3.818 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr10_+_7745284 3.803 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chrX_-_105282714 3.639 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr7_-_107643330 3.591 NM_002291
LAMB1
laminin, beta 1
chr12_-_122296619 3.259 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr5_-_16738346 3.192 MYO10
myosin X
chr4_-_157892545 3.186 NM_016205
PDGFC
platelet derived growth factor C
chr2_+_228678556 3.062 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr3_-_149375584 3.042 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr1_+_93913566 2.976 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr3_-_134093235 2.965 NM_016201
AMOTL2
angiomotin like 2
chr10_-_5045967 2.738 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr11_+_69455978 2.702 CCND1
cyclin D1
chr11_+_46740769 2.695 F2
coagulation factor II (thrombin)
chr11_+_46740736 2.611 NM_000506
F2
coagulation factor II (thrombin)
chr4_-_157892054 2.599 PDGFC
platelet derived growth factor C
chr5_+_34684611 2.596 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr17_-_39093671 2.572 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr18_+_3449972 2.532 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr3_-_148939784 2.450 NM_000096
CP
ceruloplasmin (ferroxidase)
chr19_-_18717467 2.393 CRLF1
cytokine receptor-like factor 1
chr5_-_39394423 2.360 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr18_+_55888799 2.352 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr19_-_18717631 2.343 NM_004750
CRLF1
cytokine receptor-like factor 1
chr11_+_101983170 2.313 NM_001195045
YAP1
Yes-associated protein 1
chr13_+_111137249 2.304 COL4A2
collagen, type IV, alpha 2
chr3_-_79817058 2.284 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr18_+_55888838 2.263 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr8_-_17579729 2.230 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr2_+_102314162 2.220 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr10_-_118765087 2.168 NM_001127211
NM_018330
KIAA1598

KIAA1598

chr11_+_129940462 2.166 NM_001243299
APLP2
amyloid beta (A4) precursor-like protein 2
chr1_-_95392501 2.145 NM_001839
CNN3
calponin 3, acidic
chr7_+_94292737 2.144 PEG10
paternally expressed 10
chr5_+_102201526 2.088 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr12_+_19282402 2.069 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr20_-_43977023 2.056 NM_002999
SDC4
syndecan 4
chr6_-_11232900 2.047 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr17_+_72428228 2.001 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr19_-_6720585 1.992 NM_000064
C3
complement component 3
chr19_-_18717577 1.894 CRLF1
cytokine receptor-like factor 1
chr7_-_134143864 1.887 NM_001628
AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr11_+_69455884 1.876 CCND1
cyclin D1
chrX_+_54835492 1.855 NM_201222
MAGED2
melanoma antigen family D, 2
chr13_+_111134933 1.852 COL4A2
collagen, type IV, alpha 2
chr6_+_123109970 1.749 NM_006714
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr3_-_123339178 1.718 MYLK
myosin light chain kinase
chr10_+_114709963 1.693 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr8_-_17580024 1.689 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr10_-_52645384 1.680 A1CF
APOBEC1 complementation factor
chr18_-_25756946 1.674 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chrX_+_46937744 1.634 NM_004683
NM_152869
RGN

regucalcin (senescence marker protein-30)

chr5_+_66124603 1.633 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr6_+_167704802 1.593 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr1_-_43424324 1.586 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr16_+_72088507 1.574 NM_001126102
NM_005143
HP

haptoglobin

chr17_-_56494889 1.560 RNF43
ring finger protein 43
chr7_+_94292816 1.546 PEG10
paternally expressed 10
chr3_+_186330711 1.535 AHSG
alpha-2-HS-glycoprotein
chr1_+_100111430 1.505 NM_017734
PALMD
palmdelphin
chr17_-_56494930 1.487 NM_017763
RNF43
ring finger protein 43
chr16_-_28620648 1.471 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr6_-_11232883 1.470 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr3_+_186330844 1.458 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr10_-_116392099 1.448 ABLIM1
actin binding LIM protein 1
chr1_-_173886464 1.445 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr22_+_38599026 1.405 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr18_+_55888750 1.404 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_-_94854910 1.400 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_-_30024594 1.394 NM_003174
SVIL
supervillin
chr16_-_12897693 1.382 NM_001099455
NM_018340
CPPED1

calcineurin-like phosphoesterase domain containing 1

chr12_-_15942116 1.382 EPS8
epidermal growth factor receptor pathway substrate 8
chr4_-_139163222 1.378 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr14_-_105444693 1.372 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr10_-_99446899 1.364 NM_021732
AVPI1
arginine vasopressin-induced 1
chrX_-_128657453 1.363 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr3_-_123339423 1.361 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr6_+_143929316 1.352 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr20_+_11898536 1.352 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr7_-_139876718 1.350 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr22_-_36236421 1.342 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr6_-_2840683 1.339 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr5_-_39424930 1.326 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr6_-_11232901 1.307 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr10_-_88717319 1.295 NM_024756
MMRN2
multimerin 2
chr1_+_82266081 1.274 NM_012302
LPHN2
latrophilin 2
chr1_-_151966303 1.274 S100A10
S100 calcium binding protein A10
chr13_+_111138079 1.262 COL4A2
collagen, type IV, alpha 2
chr5_+_131593388 1.255 PDLIM4
PDZ and LIM domain 4
chr9_-_99145876 1.253 SLC35D2
solute carrier family 35, member D2
chr9_-_14398981 1.246 NM_001190738
NFIB
nuclear factor I/B
chr2_+_219646704 1.244 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr11_+_129979330 1.211 APLP2
amyloid beta (A4) precursor-like protein 2
chr6_+_121756744 1.205 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr7_-_30066124 1.202 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr2_-_39664129 1.192 NM_003618
MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr9_-_99145991 1.187 NM_007001
SLC35D2
solute carrier family 35, member D2
chr15_-_90347534 1.170 ANPEP
alanyl (membrane) aminopeptidase
chr10_-_116444374 1.169 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr2_+_47596447 1.168 EPCAM
epithelial cell adhesion molecule
chr10_-_32345293 1.162 KIF5B
kinesin family member 5B
chr1_-_43424536 1.154 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr17_-_39092714 1.153 KRT23
keratin 23 (histone deacetylase inducible)
chr2_+_47596286 1.137 NM_002354
EPCAM
epithelial cell adhesion molecule
chr10_-_52645430 1.128 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr14_-_74485813 1.125 NM_001249
ENTPD5
ectonucleoside triphosphate diphosphohydrolase 5
chr1_-_151966276 1.119 S100A10
S100 calcium binding protein A10
chr8_-_11725628 1.118 NM_001908
NM_147780
NM_147781
NM_147782
NM_147783
CTSB




cathepsin B




chrX_+_102632108 1.106 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr6_+_123110345 1.096 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr7_+_29234111 1.073 NM_004067
CHN2
chimerin (chimaerin) 2
chr6_-_47253962 1.070 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr12_+_78225068 1.065 NM_014903
NAV3
neuron navigator 3
chr6_-_134639195 1.051 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr18_+_3447607 1.047 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr10_-_32345337 1.041 NM_004521
KIF5B
kinesin family member 5B
chr5_-_39425297 1.023 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr9_+_71819926 1.016 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr5_+_34656482 0.997 RAI14
retinoic acid induced 14
chr10_+_102732285 0.989 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr1_-_173886401 0.987 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr3_+_159557649 0.987 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr3_+_52813936 0.975 NM_001166435
NM_001166436
ITIH1

inter-alpha-trypsin inhibitor heavy chain 1

chr4_-_41216455 0.963 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr17_-_63822660 0.963 NM_001037325
CEP112
centrosomal protein 112kDa
chr7_+_137761177 0.929 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr2_-_165478357 0.921 NM_004490
GRB14
growth factor receptor-bound protein 14
chrX_+_135229536 0.920 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr2_+_219283809 0.909 NM_007127
VIL1
villin 1
chr16_-_87525317 0.902 NM_015144
ZCCHC14
zinc finger, CCHC domain containing 14
chr6_-_11382501 0.895 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr17_-_62658175 0.894 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr5_+_36606667 0.892 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr21_+_35190586 0.884 ITSN1
intersectin 1 (SH3 domain protein)
chr12_-_6451156 0.883 NM_001065
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr5_+_109025135 0.882 NM_002372
MAN2A1
mannosidase, alpha, class 2A, member 1
chr3_+_159557745 0.875 SCHIP1
schwannomin interacting protein 1
chr7_-_134143804 0.860 AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr14_+_85996454 0.858 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr11_+_86511490 0.857 NM_007173
PRSS23
protease, serine, 23
chr12_-_122326516 0.856 NM_001171993
HPD
4-hydroxyphenylpyruvate dioxygenase
chr4_+_146402704 0.850 NM_005900
SMAD1
SMAD family member 1
chr15_+_25068793 0.849 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr10_+_71561643 0.849 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr14_+_105941061 0.849 NM_001312
CRIP2
cysteine-rich protein 2
chr3_-_120400957 0.847 HGD
homogentisate 1,2-dioxygenase
chr1_-_16482426 0.840 NM_004431
EPHA2
EPH receptor A2
chr1_-_115053677 0.839 TRIM33
tripartite motif containing 33
chr5_+_96211643 0.839 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr4_-_70626429 0.836 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr8_+_32579350 0.830 NM_001159996
NRG1
neuregulin 1
chr12_+_53491417 0.828 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr10_-_32345123 0.826 KIF5B
kinesin family member 5B
chr9_+_123963728 0.820 GSN
gelsolin
chr11_+_44117098 0.816 NM_001178083
NM_207122
EXT2

exostosin 2

chr22_+_39052671 0.806 CBY1
chibby homolog 1 (Drosophila)
chr5_-_73937248 0.801 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr6_-_32145841 0.800 NM_032741
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr5_+_131593377 0.799 PDLIM4
PDZ and LIM domain 4
chr3_+_186330859 0.798 AHSG
alpha-2-HS-glycoprotein
chr16_+_72097124 0.797 NM_020995
HPR
haptoglobin-related protein
chr10_-_126107493 0.787 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr9_+_116207010 0.782 NM_144488
RGS3
regulator of G-protein signaling 3
chr1_+_2036154 0.775 NM_001033582
PRKCZ
protein kinase C, zeta
chr11_-_72385411 0.775 NM_002599
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chrX_-_106362018 0.770 RBM41
RNA binding motif protein 41
chr2_+_9346909 0.764 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr13_+_102104941 0.759 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr19_+_18496966 0.752 NM_004864
GDF15
growth differentiation factor 15
chr1_+_19972259 0.749 NM_001204086
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr12_-_28124915 0.748 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr2_+_11680079 0.735 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr1_+_19971865 0.733 NM_001204085
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr5_+_131593331 0.732 NM_001131027
NM_003687
PDLIM4

PDZ and LIM domain 4

chr10_+_5005453 0.731 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr8_-_125579395 0.731 MTSS1
metastasis suppressor 1
chr10_+_71561687 0.725 COL13A1
collagen, type XIII, alpha 1
chr1_-_110306525 0.724 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr16_+_57702156 0.715 NM_170776
GPR97
G protein-coupled receptor 97
chr10_+_73723992 0.714 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr3_-_114478117 0.713 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr5_+_36606456 0.711 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr1_-_95392449 0.711 CNN3
calponin 3, acidic
chr16_+_30210548 0.711 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr12_+_112204711 0.703 ALDH2
aldehyde dehydrogenase 2 family (mitochondrial)
chr8_+_40010986 0.699 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr20_+_18269120 0.698 NM_001083330
NM_003434
ZNF133

zinc finger protein 133


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
12.46 4.49e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
16.17 7.32e-03 GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
8.86 7.49e-03 GO:0030162 regulation of proteolysis
6.96 1.04e-02 GO:0052548 regulation of endopeptidase activity
6.67 1.42e-02 GO:0052547 regulation of peptidase activity
4.09 1.87e-02 GO:0048585 negative regulation of response to stimulus
12.42 2.70e-02 GO:0010951 negative regulation of endopeptidase activity

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.56 4.91e-04 GO:0005615 extracellular space
3.00 2.66e-03 GO:0044421 extracellular region part
7.38 5.22e-03 GO:0005912 adherens junction
6.63 1.03e-02 GO:0070161 anchoring junction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
9.85 1.62e-04 GO:0004866 endopeptidase inhibitor activity
9.68 1.85e-04 GO:0030414 peptidase inhibitor activity
9.43 2.25e-04 GO:0061135 endopeptidase regulator activity
13.46 5.88e-04 GO:0004867 serine-type endopeptidase inhibitor activity
7.79 9.47e-04 GO:0061134 peptidase regulator activity
5.65 3.38e-03 GO:0004857 enzyme inhibitor activity
41.71 4.74e-03 GO:0045295 gamma-catenin binding
2.86 2.33e-02 GO:0030234 enzyme regulator activity
69.51 3.48e-02 GO:0070053 thrombospondin receptor activity
3.46 3.63e-02 GO:0008092 cytoskeletal protein binding