• All motifs sorted by activity significance
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• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: NFE2L2.p2

Z-value: 2.015

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr22_+_23010757	8.990
chrX_-_154563735	5.274	NM_001289	CLIC2	chloride intracellular channel 2
chr22_+_22569155	5.209
chr22_+_23040394	4.274		IGL@	immunoglobulin lambda locus
chrX_-_100641143	4.102	NM_000061	BTK	Bruton agammaglobulinemia tyrosine kinase
chr22_+_22735134	3.992		CYAT1	immunoglobulin lambda light chain-like
chr22_+_22723972	3.675
chr19_-_7764283	3.126	NM_001207019	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)
chr22_+_23229959	3.121	NM_001178126	IGLL5 IGLC1	immunoglobulin lambda-like polypeptide 5 immunoglobulin lambda constant 1 (Mcg marker)
chr22_+_22735207	3.090		IGLJ3	immunoglobulin lambda joining 3
chr22_+_22758538	3.082
chr22_+_22712091	3.079		IGLV1-44 IGL@	immunoglobulin lambda variable 1-44 immunoglobulin lambda locus
chr22_+_23165273	3.045
chr9_-_123688352	3.015		TRAF1	TNF receptor-associated factor 1
chr17_+_30771520	2.967		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr11_+_67351276	2.645		GSTP1	glutathione S-transferase pi 1
chr11_+_67351065	2.617	NM_000852	GSTP1	glutathione S-transferase pi 1
chrX_+_12993224	2.417	NM_021109	TMSB4X	thymosin beta 4, X-linked
chr22_+_22786283	2.415
chr13_-_99959649	2.332	NM_004951	GPR183	G protein-coupled receptor 183
chr17_-_38721701	2.180	NM_001838	CCR7	chemokine (C-C motif) receptor 7
chr17_+_30771494	2.097	NM_002815	PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr7_-_134854225	2.021	NM_001243753 NM_001243755	C7orf49	chromosome 7 open reading frame 49
chr14_-_106733392	2.001		IGHG1 IGHG3	immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker)
chr12_-_15114495	1.988	NM_001175	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr17_+_30771522	1.977		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771532	1.959		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_-_28618836	1.953		BLMH	bleomycin hydrolase
chr17_+_30771485	1.941		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_+_84569427	1.915		CYB5R4	cytochrome b5 reductase 4
chr22_+_22676814	1.901
chr14_-_106967528	1.868		IGHA1 IGHA2 IGHG1 IGHM	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant alpha 2 (A2m marker) immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant mu
chr6_-_24877453	1.860	NM_015864	FAM65B	family with sequence similarity 65, member B
chr6_+_84569394	1.843		CYB5R4	cytochrome b5 reductase 4
chr12_-_8765438	1.819	NM_020661	AICDA	activation-induced cytidine deaminase
chr14_-_106539099	1.713		IGHA1 IGHG1 IGHG3	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker)
chr11_+_10476665	1.696	NM_001025389	AMPD3	adenosine monophosphate deaminase 3
chr14_-_106641585	1.685		IGHV4-31 IGHA1 IGHA2 IGHG1	immunoglobulin heavy variable 4-31 immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant alpha 2 (A2m marker) immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_-_29641087	1.683		EVI2B	ecotropic viral integration site 2B
chr22_+_23222897	1.676		CYAT1	immunoglobulin lambda light chain-like
chr11_+_118958696	1.659	NM_001024382	HMBS	hydroxymethylbilane synthase
chrX_-_109683457	1.645	NM_001171689	AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_-_158656487	1.595	NM_003126	SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr6_+_84569364	1.500	NM_016230	CYB5R4	cytochrome b5 reductase 4
chr10_-_6019880	1.488	NM_001243539	IL15RA	interleukin 15 receptor, alpha
chr3_-_98241357	1.488		CLDND1	claudin domain containing 1
chr1_-_225616556	1.480	NM_194442	LBR	lamin B receptor
chr12_-_102591547	1.479	NM_002674	PMCH	pro-melanin-concentrating hormone
chr6_+_44195008	1.469		SLC29A1	solute carrier family 29 (nucleoside transporters), member 1
chr3_-_58200397	1.444	NM_004944	DNASE1L3	deoxyribonuclease I-like 3
chr16_+_27438578	1.438	NM_021798	IL21R	interleukin 21 receptor
chr22_+_23154240	1.427
chr22_+_23134980	1.408
chr17_-_73150769	1.363	NM_001002032 NM_001002033 NM_016185	HN1	hematological and neurological expressed 1
chr15_+_89182038	1.357	NM_002201	ISG20	interferon stimulated exonuclease gene 20kDa
chr12_-_71182699	1.333	NM_001207015	PTPRR	protein tyrosine phosphatase, receptor type, R
chr1_+_154966061	1.308	NM_018655	LENEP	lens epithelial protein
chr9_+_130922471	1.306	NM_024112	C9orf16	chromosome 9 open reading frame 16
chr17_-_28619183	1.296	NM_000386	BLMH	bleomycin hydrolase
chr14_-_107170400	1.284		IGHV4-31 IGHV1-69 IGHA1 IGHG1 IGHG3 IGHM	immunoglobulin heavy variable 4-31 immunoglobulin heavy variable 1-69 immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker) immunoglobulin heavy constant mu
chr14_-_106926393	1.280		IGHA1 IGHG1	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_+_119738542	1.269	NM_001137554	MCTS1	malignant T cell amplified sequence 1
chr7_+_150688143	1.252	NM_000603	NOS3	nitric oxide synthase 3 (endothelial cell)
chr22_+_22764094	1.237
chr10_-_6019454	1.233	NM_002189 NM_172200	IL15RA	interleukin 15 receptor, alpha
chr8_-_42623928	1.230	NM_001199279 NM_004198	CHRNA6	cholinergic receptor, nicotinic, alpha 6
chr7_+_150434435	1.204	NM_018384	GIMAP5	GTPase, IMAP family member 5
chr6_+_33043702	1.173	NM_002121	HLA-DPB1	major histocompatibility complex, class II, DP beta 1
chr6_-_35696359	1.146	NM_001145775	FKBP5	FK506 binding protein 5
chr4_-_40517913	1.142	NM_019027	RBM47	RNA binding motif protein 47
chrX_-_119445306	1.126	NM_001104544 NM_001104545 NM_017938	FAM70A	family with sequence similarity 70, member A
chr19_-_56348127	1.125	NM_145007	NLRP11	NLR family, pyrin domain containing 11
chr7_+_130794854	1.119	NM_001145354	MKLN1	muskelin 1, intracellular mediator containing kelch motifs
chr21_+_33031932	1.112	NM_000454	SOD1	superoxide dismutase 1, soluble
chr6_+_36410800	1.112		KCTD20	potassium channel tetramerisation domain containing 20
chr14_-_107122358	1.109
chr6_+_36410543	1.089	NM_173562	KCTD20	potassium channel tetramerisation domain containing 20
chr6_-_84140758	1.079		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr6_-_84140744	1.077		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr1_+_12123433	1.036	NM_001243	TNFRSF8	tumor necrosis factor receptor superfamily, member 8
chr3_+_48507209	1.030	NM_016381 NM_033629	TREX1	three prime repair exonuclease 1
chr16_+_30077120	1.024		ALDOA	aldolase A, fructose-bisphosphate
chr6_-_35888816	1.018		SRPK1	SRSF protein kinase 1
chr15_+_44829373	1.017		EIF3J	eukaryotic translation initiation factor 3, subunit J
chr6_-_154677868	1.014	NM_001130700 NM_015553	IPCEF1	interaction protein for cytohesin exchange factors 1
chr8_-_30585220	0.987		GSR	glutathione reductase
chr15_-_83240499	0.980	NM_001079533 NM_001079534 NM_001079535	CPEB1	cytoplasmic polyadenylation element binding protein 1
chr21_-_46237882	0.977		SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr17_-_29641094	0.955	NM_006495	EVI2B	ecotropic viral integration site 2B
chr13_-_41593405	0.939		ELF1	E74-like factor 1 (ets domain transcription factor)
chr2_-_142889269	0.934	NM_018557	LRP1B	low density lipoprotein receptor-related protein 1B
chr16_+_30077146	0.930		ALDOA	aldolase A, fructose-bisphosphate
chr15_+_44829332	0.929		EIF3J	eukaryotic translation initiation factor 3, subunit J
chr16_-_1429612	0.915	NM_001193389 NM_023076	UNKL	unkempt homolog (Drosophila)-like
chr3_-_98241748	0.909		CLDND1	claudin domain containing 1
chrX_-_110513750	0.908	NM_014289	CAPN6	calpain 6
chr19_-_6670598	0.891	NM_003807 NM_172014	TNFSF14	tumor necrosis factor (ligand) superfamily, member 14
chr15_+_44829265	0.883	NM_003758	EIF3J	eukaryotic translation initiation factor 3, subunit J
chr17_-_29641068	0.878		EVI2B	ecotropic viral integration site 2B
chr14_-_106774311	0.873		IGHA1	immunoglobulin heavy constant alpha 1
chr6_+_106546736	0.863	NM_182907	PRDM1	PR domain containing 1, with ZNF domain
chr19_-_6670078	0.854		TNFSF14	tumor necrosis factor (ligand) superfamily, member 14
chr16_+_30076993	0.847	NM_001243177 NM_184041	ALDOA	aldolase A, fructose-bisphosphate
chr6_+_150070844	0.846		PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr22_-_19466725	0.844	NM_001035247 NM_005659	UFD1L	ubiquitin fusion degradation 1 like (yeast)
chr2_+_231921625	0.843		PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr10_-_76868853	0.843	NM_001007271 NM_001007272 NM_001007273	DUSP13	dual specificity phosphatase 13
chr3_+_48507621	0.832		TREX1	three prime repair exonuclease 1
chr11_-_3862183	0.824	NM_001665	RHOG	ras homolog gene family, member G (rho G)
chr6_+_150070818	0.809	NM_001252049 NM_001252050 NM_001252051 NM_001252052 NM_001252053 NM_005389	PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr22_-_19466621	0.805		UFD1L	ubiquitin fusion degradation 1 like (yeast)
chr6_+_32121228	0.802	NM_138717	PPT2	palmitoyl-protein thioesterase 2
chr19_-_2038937	0.801		MKNK2	MAP kinase interacting serine/threonine kinase 2
chr22_+_22735202	0.801
chr5_-_176936857	0.801	NM_024872	DOK3	docking protein 3
chr7_+_107204402	0.795	NM_181581	DUS4L	dihydrouridine synthase 4-like (S. cerevisiae)
chr6_-_35888889	0.793		SRPK1	SRSF protein kinase 1
chr19_-_6591012	0.792		CD70	CD70 molecule
chr22_+_23063107	0.788		IGLJ3	immunoglobulin lambda joining 3
chrX_-_119445279	0.783		FAM70A	family with sequence similarity 70, member A
chr7_+_139528951	0.781	NM_001061 NM_001166253 NM_030984	TBXAS1	thromboxane A synthase 1 (platelet)
chr11_-_3862137	0.780		RHOG	ras homolog gene family, member G (rho G)
chr6_-_35888937	0.771	NM_003137	SRPK1	SRSF protein kinase 1
chr1_-_150208441	0.770		ANP32E	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_-_246580710	0.761	NM_022743	SMYD3	SET and MYND domain containing 3
chrX_-_64754594	0.754		LAS1L	LAS1-like (S. cerevisiae)
chr10_+_85899184	0.750	NM_014394	GHITM	growth hormone inducible transmembrane protein
chr17_+_43299277	0.749	NM_005892	FMNL1	formin-like 1
chr6_+_44214853	0.739		HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1
chr12_-_57030083	0.733	NM_013449	BAZ2A	bromodomain adjacent to zinc finger domain, 2A
chr10_+_121411086	0.730		BAG3	BCL2-associated athanogene 3
chrX_-_53350521	0.728	NM_001111125	IQSEC2	IQ motif and Sec7 domain 2
chr6_+_150070856	0.725		PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr12_+_64845839	0.724	NM_013254	TBK1	TANK-binding kinase 1
chr15_+_81517639	0.723	NM_172217	IL16	interleukin 16
chr2_-_233641225	0.722	NM_001172416 NM_001172417 NM_002242	KCNJ13	potassium inwardly-rectifying channel, subfamily J, member 13
chr7_+_148395886	0.716	NM_003592	CUL1	cullin 1
chr11_+_10477480	0.704	NM_001025390	AMPD3	adenosine monophosphate deaminase 3
chr1_+_233749749	0.701	NM_002245	KCNK1	potassium channel, subfamily K, member 1
chr1_-_109969044	0.701		PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr7_+_148396016	0.698		CUL1	cullin 1
chr8_-_59571920	0.696	NM_001144772	NSMAF	neutral sphingomyelinase (N-SMase) activation associated factor
chr15_+_40733302	0.695	NM_014952	BAHD1	bromo adjacent homology domain containing 1
chr10_-_99052429	0.691	NM_001204300 NM_032900	ARHGAP19	Rho GTPase activating protein 19
chr6_+_44214786	0.689	NM_007355	HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1
chr8_-_59572403	0.687	NM_003580	NSMAF	neutral sphingomyelinase (N-SMase) activation associated factor
chr1_-_150208462	0.681	NM_001136478 NM_030920	ANP32E	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_-_109969058	0.676	NM_001199772 NM_002790 NM_001199773 NM_001199774	PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr17_+_73598139	0.676		MYO15B	myosin XVB pseudogene
chr22_+_23029175	0.673		IGLV3-25	immunoglobulin lambda variable 3-25
chr2_-_220173693	0.667	NM_001199764	PTPRN	protein tyrosine phosphatase, receptor type, N
chrX_-_72434623	0.660		NAP1L2	nucleosome assembly protein 1-like 2
chr17_-_45899133	0.654	NM_145798	OSBPL7	oxysterol binding protein-like 7
chr11_-_14541867	0.642		PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1
chrX_-_64754637	0.636	NM_001170649 NM_001170650 NM_031206	LAS1L	LAS1-like (S. cerevisiae)
chr22_-_39268214	0.636		CBX6	chromobox homolog 6
chr11_-_47447457	0.635		PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr4_-_76944585	0.627	NM_001565	CXCL10	chemokine (C-X-C motif) ligand 10
chr21_-_33651324	0.617	NM_018944	MIS18A	MIS18 kinetochore protein homolog A (S. pombe)
chr14_+_103800678	0.614		EIF5	eukaryotic translation initiation factor 5
chr1_+_14075861	0.614	NM_001007257	PRDM2	PR domain containing 2, with ZNF domain
chr6_+_34206567	0.613	NM_145905	HMGA1	high mobility group AT-hook 1
chr12_-_76478737	0.607	NM_004537 NM_139207	NAP1L1	nucleosome assembly protein 1-like 1
chr16_+_90168671	0.607		FAM157C	family with sequence similarity 157, member C
chr7_+_148395995	0.605		CUL1	cullin 1
chr7_+_150434679	0.598		GIMAP5	GTPase, IMAP family member 5
chr2_-_89292396	0.595		IGKC	immunoglobulin kappa constant
chr1_-_109968951	0.594		PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5
chr18_-_267987	0.592	NM_005131	THOC1	THO complex 1
chr3_+_133118789	0.587	NM_003571	BFSP2	beaded filament structural protein 2, phakinin
chr3_+_132373289	0.586	NM_198329	UBA5	ubiquitin-like modifier activating enzyme 5
chr12_+_56137063	0.580	NM_005811	GDF11	growth differentiation factor 11
chr8_-_59572385	0.575		NSMAF	neutral sphingomyelinase (N-SMase) activation associated factor
chr3_+_184038050	0.568	NM_004953	EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chr16_-_67517715	0.567	NM_001138	AGRP	agouti related protein homolog (mouse)
chrX_-_129244422	0.566		ELF4	E74-like factor 4 (ets domain transcription factor)
chr1_-_150208134	0.562		ANP32E	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr17_-_45899118	0.561		OSBPL7	oxysterol binding protein-like 7
chr3_+_141043054	0.557	NM_001080412	ZBTB38	zinc finger and BTB domain containing 38
chr18_+_158480	0.554	NM_001037334 NM_005151	USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr2_-_214016332	0.551	NM_001079526	IKZF2	IKAROS family zinc finger 2 (Helios)
chr17_-_65362635	0.547		PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr10_+_115312777	0.544	NM_004132	HABP2	hyaluronan binding protein 2
chr10_+_131934674	0.544		GLRX3	glutaredoxin 3
chrX_-_72434656	0.536		NAP1L2	nucleosome assembly protein 1-like 2
chr7_+_112063131	0.536	NM_001007245 NM_001197080	IFRD1	interferon-related developmental regulator 1
chr3_-_98241722	0.536		CLDND1	claudin domain containing 1
chr10_-_94333721	0.531		IDE	insulin-degrading enzyme
chr5_+_179125362	0.530		CANX	calnexin
chr6_-_84140651	0.530		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_+_18699494	0.529	NM_001100418 NM_001100419	C19orf60	chromosome 19 open reading frame 60
chr2_+_231921608	0.528		PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr3_+_184038445	0.527		EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chr1_+_114493766	0.525	NM_198269	HIPK1	homeodomain interacting protein kinase 1
chr17_+_45286427	0.522	NM_001002841	MYL4	myosin, light chain 4, alkali; atrial, embryonic
chr14_-_23284565	0.520		SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_+_14075931	0.517		PRDM2	PR domain containing 2, with ZNF domain
chr6_-_33548017	0.515	NM_001188	BAK1	BCL2-antagonist/killer 1
chr12_+_50794591	0.513	NM_001170803 NM_001170804 NM_001170808 NM_052879 NM_199188 NM_199190	LARP4	La ribonucleoprotein domain family, member 4
chr11_-_14541886	0.512	NM_001143937 NM_002786	PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
3.38	4.56e-03	GO:0002376	immune system process
4.09	1.18e-02	GO:0006955	immune response
145.40	2.88e-02	GO:0051772	regulation of nitric-oxide synthase 2 biosynthetic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
32.73	1.96e-06	GO:0003823	antigen binding
109.05	1.04e-02	GO:0008296	3'-5'-exodeoxyribonuclease activity
21.12	3.14e-02	GO:0004536	deoxyribonuclease activity