Motif ID: NR6A1.p2

Z-value: 1.091


Transcription factors associated with NR6A1.p2:

Gene SymbolEntrez IDGene Name
NR6A1 2649 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR6A1chr9_-_127533397-0.273.0e-01Click!


Activity profile for motif NR6A1.p2.

activity profile for motif NR6A1.p2


Sorted Z-values histogram for motif NR6A1.p2

Sorted Z-values for motif NR6A1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_224903324 4.487 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr19_-_6720585 2.301 NM_000064
C3
complement component 3
chr17_-_48264039 2.284 COL1A1
collagen, type I, alpha 1
chr15_+_101420004 2.027 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr7_+_100199881 1.875 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr1_+_19923457 1.727 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr15_+_101420032 1.398 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr16_+_56642477 1.299 NM_005953
MT2A
metallothionein 2A
chr12_+_7169192 1.051


chr2_-_162930629 1.040 DPP4
dipeptidyl-peptidase 4
chr9_+_124043719 0.912 GSN
gelsolin
chr2_-_162930500 0.837 DPP4
dipeptidyl-peptidase 4
chr7_-_150038689 0.784 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr10_+_123754141 0.700 TACC2
transforming, acidic coiled-coil containing protein 2
chr17_-_27402626 0.602 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr2_-_162930544 0.581 DPP4
dipeptidyl-peptidase 4
chr3_+_133464883 0.525 NM_001063
TF
transferrin
chr3_+_46619075 0.424 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr1_-_153538305 0.420 NM_005978
S100A2
S100 calcium binding protein A2
chr19_-_15083729 0.407 NM_005071
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr12_-_7261788 0.395 NM_016546
C1RL
complement component 1, r subcomponent-like
chr12_+_100897137 0.364 NM_001206992
NM_001206993
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr3_+_133465204 0.349 TF
transferrin
chr9_-_38069082 0.337 SHB
Src homology 2 domain containing adaptor protein B
chr9_-_38069207 0.328 NM_003028
SHB
Src homology 2 domain containing adaptor protein B
chr6_-_133035180 0.314 NM_004666
VNN1
vanin 1
chr6_+_129204285 0.313 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr8_-_145018057 0.303 NM_201382
PLEC
plectin
chr2_+_18059923 0.288 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr3_-_52312257 0.283 WDR82
WD repeat domain 82
chr1_+_225997742 0.275 NM_001136018
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr10_-_126107493 0.264 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr19_-_43709692 0.257 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr2_-_162929928 0.252 DPP4
dipeptidyl-peptidase 4
chr1_+_225997804 0.250 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr3_+_133465098 0.249 TF
transferrin
chr17_+_75446735 0.241 SEPT9
septin 9
chr9_+_139981338 0.203 MAN1B1
mannosidase, alpha, class 1B, member 1
chr10_+_89419352 0.188 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr12_-_6484389 0.174 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr2_-_31361591 0.171 NM_001253826
NM_024572
GALNT14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)

chr20_-_3149070 0.149 NM_014731
ProSAPiP1
ProSAPiP1 protein
chrX_-_21776158 0.149 NM_014332
SMPX
small muscle protein, X-linked
chr1_+_145209067 0.148 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr5_+_140749830 0.140 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr7_+_73868236 0.140 GTF2IRD1
GTF2I repeat domain containing 1
chr10_-_126107454 0.131 OAT
ornithine aminotransferase
chr1_+_26503973 0.131 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr18_+_33767420 0.116 NM_017947
MOCOS
molybdenum cofactor sulfurase
chr9_-_21217303 0.111 NM_002173
IFNA16
interferon, alpha 16
chr11_+_36317724 0.089 NM_001160167
PRR5L
proline rich 5 like
chr1_-_147624436 0.087 NM_183372
NBPF11
neuroblastoma breakpoint family, member 11
chr6_-_43484503 0.087 YIPF3
Yip1 domain family, member 3
chr17_+_75446612 0.086 NM_001113496
SEPT9
septin 9
chr9_+_35792405 0.083 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr7_+_73868111 0.076 NM_001199207
NM_005685
NM_016328
GTF2IRD1


GTF2I repeat domain containing 1


chr17_-_29624249 0.075 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chrX_+_48620153 0.074 NM_001080489
GLOD5
glyoxalase domain containing 5
chr7_-_97601564 0.069 MGC72080
MGC72080 pseudogene
chr19_+_496453 0.066 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr19_+_10197023 0.064 C19orf66
chromosome 19 open reading frame 66
chr6_-_43484701 0.051 NM_015388
YIPF3
Yip1 domain family, member 3
chr1_+_212738675 0.050 NM_001030287
ATF3
activating transcription factor 3
chr3_-_38178463 0.050 ACAA1
acetyl-CoA acyltransferase 1
chr12_-_110252600 0.048 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr16_+_31366529 0.046 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr12_-_10562142 0.044 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 readthrough
killer cell lectin-like receptor subfamily C, member 4
chr14_+_93118793 0.043 RIN3
Ras and Rab interactor 3
chr1_-_20834609 0.043 NM_024544
MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr3_+_46411632 0.040 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr16_+_1386197 0.040 NM_001199096
BAIAP3
BAI1-associated protein 3
chr10_+_51837885 0.038 NM_018232
FAM21B
family with sequence similarity 21, member B
chr12_+_109273856 0.035 NM_001917
DAO
D-amino-acid oxidase
chr19_-_5846465 0.034 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr3_-_128294928 0.033 NM_007354
C3orf27
chromosome 3 open reading frame 27
chrX_-_104465349 0.033 NM_031274
TEX13A
testis expressed 13A
chr19_+_10196972 0.030 C19orf66
chromosome 19 open reading frame 66
chr10_+_47894022 0.029 NM_018232
FAM21B
family with sequence similarity 21, member B
chr2_-_211090146 0.028 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr10_+_106013951 0.027 NM_001191003
GSTO1
glutathione S-transferase omega 1
chr22_+_32010152 0.024 SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr10_+_106014467 0.019 NM_001191002
NM_004832
GSTO1

glutathione S-transferase omega 1

chr1_+_78511588 0.018 NM_017655
GIPC2
GIPC PDZ domain containing family, member 2
chr12_+_2921786 0.017 NM_018463
ITFG2
integrin alpha FG-GAP repeat containing 2
chr12_+_108956293 0.014 NM_014301
NM_213595
ISCU

iron-sulfur cluster scaffold homolog (E. coli)

chr9_-_21228132 0.012 NM_021268
IFNA17
interferon, alpha 17
chr8_-_53626991 0.012 NM_001083617
NM_014781
RB1CC1

RB1-inducible coiled-coil 1

chr4_-_48014960 0.011 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr7_-_126883568 0.009 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr4_+_41614725 0.009 LIMCH1
LIM and calponin homology domains 1
chr7_-_137531585 0.009 NM_004717
DGKI
diacylglycerol kinase, iota
chr17_-_9929567 0.008 NM_001130831
GAS7
growth arrest-specific 7
chrY_-_1460901 0.008 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr12_-_58135853 0.007 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr5_-_41213513 0.007 NM_000065
C6
complement component 6
chr14_-_47120940 0.007 NM_080746
RPL10L
ribosomal protein L10-like
chr7_-_2883649 0.005 NM_007353
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr1_-_20834516 0.004 MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr1_-_40236926 0.004 NM_022120
OXCT2
3-oxoacid CoA transferase 2
chr12_+_116997185 0.002 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chrX_+_47229981 0.001 NM_003446
ZNF157
zinc finger protein 157

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
263.62 1.81e-03 GO:0010953 regulation of protein maturation by peptide bond cleavage
263.62 1.81e-03 GO:0070613 regulation of protein processing
225.98 2.49e-03 GO:0060324 face development
186.12 3.72e-03 GO:0060322 head development
32.17 5.59e-03 GO:0030155 regulation of cell adhesion
95.94 1.44e-02 GO:0022407 regulation of cell-cell adhesion
67.40 2.93e-02 GO:0007162 negative regulation of cell adhesion
57.62 4.02e-02 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
56.59 4.17e-02 GO:0002706 regulation of lymphocyte mediated immunity
56.59 4.17e-02 GO:0002819 regulation of adaptive immune response

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.63 5.77e-03 GO:0005615 extracellular space
5.67 7.78e-03 GO:0005576 extracellular region
16.15 1.02e-02 GO:0031012 extracellular matrix
7.68 1.40e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
33.29 9.31e-04 GO:0061134 peptidase regulator activity
90.47 2.99e-03 GO:0005518 collagen binding
32.39 2.35e-02 GO:0008201 heparin binding
28.11 3.11e-02 GO:0004866 endopeptidase inhibitor activity
27.62 3.22e-02 GO:0030414 peptidase inhibitor activity
26.92 3.39e-02 GO:0061135 endopeptidase regulator activity
24.83 3.98e-02 GO:0005539 glycosaminoglycan binding
23.04 4.62e-02 GO:0001871 pattern binding
23.04 4.62e-02 GO:0030247 polysaccharide binding