• All motifs sorted by activity significance
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• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: TBX4,5.p2

Z-value: 2.953

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_4675175	5.515	NM_003963	TM4SF5	transmembrane 4 L six family member 5
chr14_+_95078713	4.471	NM_001085	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr3_+_186330859	4.056		AHSG	alpha-2-HS-glycoprotein
chr6_+_31623668	3.730	NM_019101	APOM	apolipoprotein M
chrY_+_15016698	3.534	NM_004660	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr10_+_114135013	3.348	NM_203380	ACSL5	acyl-CoA synthetase long-chain family member 5
chr12_+_7169192	3.251
chr3_+_186330844	2.989	NM_001622	AHSG	alpha-2-HS-glycoprotein
chr3_+_186330711	2.796		AHSG	alpha-2-HS-glycoprotein
chr14_-_54421269	2.721	NM_130851	BMP4	bone morphogenetic protein 4
chr6_-_11232901	2.669	NM_006403 NM_182966	NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr17_-_7017558	2.633	NM_080914	ASGR2	asialoglycoprotein receptor 2
chrY_+_15016018	2.612	NM_001122665	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr16_-_52581713	2.606	NM_001146188	TOX3	TOX high mobility group box family member 3
chr6_+_31623688	2.569		APOM	apolipoprotein M
chr9_-_123837410	2.495		C5	complement component 5
chr12_+_66218879	2.442		HMGA2	high mobility group AT-hook 2
chr1_-_173174611	2.257		TNFSF4	tumor necrosis factor (ligand) superfamily, member 4
chr3_+_133465098	2.243		TF	transferrin
chr3_-_49726081	2.200	NM_020998	MST1	macrophage stimulating 1 (hepatocyte growth factor-like)
chr11_-_2159472	2.195		IGF2	insulin-like growth factor 2 (somatomedin A)
chr1_-_161193190	2.176		APOA2	apolipoprotein A-II
chr6_+_132129195	2.130		ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1
chr3_-_120400957	2.080		HGD	homogentisate 1,2-dioxygenase
chr12_+_69742130	2.061	NM_000239	LYZ	lysozyme
chr12_-_26985922	2.016	NM_002223	ITPR2	inositol 1,4,5-trisphosphate receptor, type 2
chr16_+_3115638	2.007	NM_001012634	IL32	interleukin 32
chr6_+_31949800	1.976	NM_001242823 NM_001252204 NM_007293 NM_001002029	LOC100293534 C4A C4B	complement C4-B-like complement component 4A (Rodgers blood group) complement component 4B (Chido blood group)
chr22_+_23229959	1.970	NM_001178126	IGLL5 IGLC1	immunoglobulin lambda-like polypeptide 5 immunoglobulin lambda constant 1 (Mcg marker)
chrX_+_46940235	1.922		RGN	regucalcin (senescence marker protein-30)
chr6_+_31982538	1.901	NM_001242823 NM_001252204 NM_007293 NM_001002029	LOC100293534 C4A C4B	complement C4-B-like complement component 4A (Rodgers blood group) complement component 4B (Chido blood group)
chr12_+_69742140	1.897		LYZ	lysozyme
chr7_+_94285620	1.808	NM_001040152 NM_001184961 NM_001184962 NM_015068	PEG10	paternally expressed 10
chr22_+_38201113	1.794	NM_005318	H1F0	H1 histone family, member 0
chr3_+_133464883	1.786	NM_001063	TF	transferrin
chr16_+_3115641	1.774	NM_001012632 NM_001012636	IL32	interleukin 32
chrX_-_130423387	1.764	NM_001170961 NM_001170962 NM_001555 NM_205833	IGSF1	immunoglobulin superfamily, member 1
chr7_+_94285736	1.752		PEG10	paternally expressed 10
chr2_-_61697899	1.744		USP34	ubiquitin specific peptidase 34
chr6_+_26368405	1.716	NM_001197246	BTN3A2	butyrophilin, subfamily 3, member A2
chr7_+_94285676	1.702	NM_001172437 NM_001172438	PEG10	paternally expressed 10
chr7_+_29234111	1.697	NM_004067	CHN2	chimerin (chimaerin) 2
chr21_+_38445562	1.695	NM_001001894	TTC3	tetratricopeptide repeat domain 3
chr16_+_3115312	1.682	NM_001012631 NM_001012633 NM_001012718 NM_004221	IL32	interleukin 32
chrX_-_130423199	1.651		IGSF1	immunoglobulin superfamily, member 1
chr3_+_133465204	1.648		TF	transferrin
chr9_-_132805456	1.626	NM_015033	FNBP1	formin binding protein 1
chr9_-_132805256	1.625		FNBP1	formin binding protein 1
chr11_+_73358593	1.622	NM_001130034 NM_001130035	PLEKHB1	pleckstrin homology domain containing, family B (evectins) member 1
chr10_+_114135965	1.599		ACSL5	acyl-CoA synthetase long-chain family member 5
chr2_+_219283809	1.576	NM_007127	VIL1	villin 1
chr2_-_188419049	1.544		TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr17_-_74533623	1.534	NM_134268	CYGB	cytoglobin
chr1_+_155100304	1.530	NM_004428 NM_182685	EFNA1	ephrin-A1
chr7_-_103629962	1.529	NM_005045 NM_173054	RELN	reelin
chr11_+_7535000	1.511	NM_003621	PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_-_173886464	1.506	NM_000488	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1
chr16_+_3115639	1.503		IL32	interleukin 32
chr3_+_167453431	1.501	NM_001122752 NM_005025	SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr19_-_39108534	1.483	NM_001042600 NM_007181	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1
chr17_+_34431219	1.483	NM_002984	CCL4	chemokine (C-C motif) ligand 4
chr6_+_28092386	1.482	NM_025231	ZSCAN16	zinc finger and SCAN domain containing 16
chr20_+_8112762	1.481	NM_015192 NM_182734	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)
chr14_-_107013474	1.449		IGHA1 IGHG1	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_82068830	1.443	NM_002153	HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2
chr17_+_34538464	1.434	NM_207007 NM_001001435	CCL4L2 CCL4L1	chemokine (C-C motif) ligand 4-like 2 chemokine (C-C motif) ligand 4-like 1
chr11_-_694842	1.424		DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)
chr11_-_695069	1.423		DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)
chr20_-_22565050	1.416	NM_021784	FOXA2	forkhead box A2
chr1_-_85930610	1.405		DDAH1	dimethylarginine dimethylaminohydrolase 1
chr10_+_114135937	1.398	NM_016234	ACSL5	acyl-CoA synthetase long-chain family member 5
chr2_+_177053306	1.396	NM_024501	HOXD1	homeobox D1
chr2_+_170590241	1.366	NM_144711	KLHL23	kelch-like 23 (Drosophila)
chr11_-_75236418	1.358	NM_030792	GDPD5	glycerophosphodiester phosphodiesterase domain containing 5
chr2_-_216946463	1.350	NM_018441	PECR	peroxisomal trans-2-enoyl-CoA reductase
chr6_+_132129154	1.349	NM_006208	ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1
chr6_-_11232883	1.341		NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr16_+_3115611	1.328	NM_001012635	IL32	interleukin 32
chr4_-_155511838	1.319	NM_000508 NM_021871	FGA	fibrinogen alpha chain
chrY_+_15016775	1.313		DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr10_+_31608097	1.302	NM_001174093 NM_001174095 NM_001174096 NM_030751	ZEB1	zinc finger E-box binding homeobox 1
chr3_-_182880463	1.291	NM_014398	LAMP3	lysosomal-associated membrane protein 3
chr11_+_60223281	1.282	NM_021950 NM_152866	MS4A1	membrane-spanning 4-domains, subfamily A, member 1
chrY_-_2368963	1.273	NM_145177 NM_001171136 NM_004729	DHRSX ZBED1	dehydrogenase/reductase (SDR family) X-linked zinc finger, BED-type containing 1
chr17_-_47439326	1.272	NM_001145365 NM_014897	ZNF652	zinc finger protein 652
chr7_-_94285372	1.267		SGCE	sarcoglycan, epsilon
chr7_-_94285426	1.250		SGCE	sarcoglycan, epsilon
chr10_+_124768401	1.236	NM_001609	ACADSB	acyl-CoA dehydrogenase, short/branched chain
chr17_-_79008372	1.234		FLJ90757	uncharacterized LOC440465
chr10_-_95360959	1.228	NM_006744	RBP4	retinol binding protein 4, plasma
chr1_-_23885916	1.226		ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr11_-_695010	1.212		DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)
chr22_-_37545944	1.198	NM_000878	IL2RB	interleukin 2 receptor, beta
chr7_-_994259	1.198	NM_006869	ADAP1	ArfGAP with dual PH domains 1
chr2_-_89165652	1.189
chr6_+_31543340	1.181	NM_000594	TNF	tumor necrosis factor
chr7_-_94285477	1.179	NM_001099400 NM_001099401 NM_003919	SGCE	sarcoglycan, epsilon
chr11_-_115375065	1.171	NM_001098517 NM_014333	CADM1	cell adhesion molecule 1
chr11_-_2170792	1.160	NM_001007139	IGF2	insulin-like growth factor 2 (somatomedin A)
chr4_-_186733372	1.146	NM_003603 NM_001145670	SORBS2	sorbin and SH3 domain containing 2
chr2_+_128176019	1.138		PROC	protein C (inactivator of coagulation factors Va and VIIIa)
chr16_+_57406398	1.129	NM_002996	CX3CL1	chemokine (C-X3-C motif) ligand 1
chr19_+_49838700	1.128		CD37	CD37 molecule
chr7_-_994008	1.115		ADAP1	ArfGAP with dual PH domains 1
chr19_+_49838673	1.100	NM_001040031 NM_001774	CD37	CD37 molecule
chr11_-_63381485	1.086		PLA2G16	phospholipase A2, group XVI
chr18_-_47339854	1.083		ACAA2	acetyl-CoA acyltransferase 2
chr12_-_117537090	1.080	NM_001168325 NM_017899	TESC	tescalcin
chr19_+_49838734	1.078		CD37	CD37 molecule
chr20_-_22564893	1.077		FOXA2	forkhead box A2
chrX_+_70443055	1.077	NM_000166	GJB1	gap junction protein, beta 1, 32kDa
chr19_-_9731883	1.049	NM_152289	ZNF561	zinc finger protein 561
chr1_+_17846818	1.033		ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like
chrX_-_2418963	1.028	NM_145177 NM_001171136 NM_004729	DHRSX ZBED1	dehydrogenase/reductase (SDR family) X-linked zinc finger, BED-type containing 1
chr18_+_32556891	1.027	NM_001143826	MAPRE2	microtubule-associated protein, RP/EB family, member 2
chr17_+_67410825	1.026	NM_002758	MAP2K6	mitogen-activated protein kinase kinase 6
chr7_-_22396511	1.024	NM_012294	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5
chr6_-_31619481	1.024
chr16_+_82068910	1.013		HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2
chr11_+_61447816	1.005	NM_006133	DAGLA	diacylglycerol lipase, alpha
chr19_-_51869632	1.002	NM_001985	ETFB	electron-transfer-flavoprotein, beta polypeptide
chr2_+_62932786	1.001	NM_001142616 NM_015252	EHBP1	EH domain binding protein 1
chr1_+_150954498	1.000	NM_003568	ANXA9	annexin A9
chr1_-_173886401	1.000		SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1
chr11_-_63381840	1.000		PLA2G16	phospholipase A2, group XVI
chr6_-_31620142	0.999	NM_001098534	BAG6	BCL2-associated athanogene 6
chr2_-_61697846	0.989	NM_014709	USP34	ubiquitin specific peptidase 34
chr19_+_49838646	0.979		CD37	CD37 molecule
chr14_+_74003817	0.975	NM_001037161	ACOT1	acyl-CoA thioesterase 1
chr7_-_77045706	0.968	NM_017439	PION	pigeon homolog (Drosophila)
chr20_-_4804067	0.955	NM_014737	RASSF2	Ras association (RalGDS/AF-6) domain family member 2
chr8_-_124408665	0.952		ATAD2	ATPase family, AAA domain containing 2
chr14_-_107113943	0.950		IGHA1 IGHG1	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_+_50304989	0.948	NM_001005914 NM_004636	SEMA3B	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr1_-_27240430	0.940	NM_021969	NR0B2	nuclear receptor subfamily 0, group B, member 2
chr8_+_21912327	0.940	NM_001114136 NM_001114139	EPB49	erythrocyte membrane protein band 4.9 (dematin)
chr5_-_42811959	0.936	NM_001085486 NM_001093726 NM_005410	SEPP1	selenoprotein P, plasma, 1
chr10_+_124768498	0.931		ACADSB	acyl-CoA dehydrogenase, short/branched chain
chr10_-_97416367	0.930		ALDH18A1	aldehyde dehydrogenase 18 family, member A1
chr13_+_113760101	0.925	NM_000131 NM_019616	F7	coagulation factor VII (serum prothrombin conversion accelerator)
chr14_+_101193313	0.915		DLK1	delta-like 1 homolog (Drosophila)
chr14_-_106774311	0.911		IGHA1	immunoglobulin heavy constant alpha 1
chr2_-_188419185	0.908	NM_001032281 NM_006287	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr7_+_26331493	0.907	NM_001199835 NM_013322	SNX10	sorting nexin 10
chr11_+_61522860	0.903	NM_013279	C11orf9	chromosome 11 open reading frame 9
chr15_+_81071708	0.897	NM_018689	KIAA1199	KIAA1199
chr16_-_55867016	0.893	NM_001025194 NM_001025195 NM_001266	CES1	carboxylesterase 1
chr2_+_69969250	0.892		ANXA4	annexin A4
chrX_+_114795176	0.889	NM_005032	PLS3	plastin 3
chr22_-_50893728	0.883		SBF1	SET binding factor 1
chr17_+_80190107	0.881	NM_001042423	SLC16A3	solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr13_+_31287614	0.881	NM_001204406	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chrX_+_95939851	0.876		DIAPH2	diaphanous homolog 2 (Drosophila)
chr8_-_80993009	0.867	NM_001025252	TPD52	tumor protein D52
chr8_+_56015013	0.863	NM_052898	XKR4	XK, Kell blood group complex subunit-related family, member 4
chr11_+_22696318	0.861	NM_005256	GAS2	growth arrest-specific 2
chr12_+_51318743	0.841		METTL7A	methyltransferase like 7A
chr16_+_58059469	0.838		MMP15	matrix metallopeptidase 15 (membrane-inserted)
chr1_+_151584514	0.832	NM_030918	SNX27	sorting nexin family member 27
chr2_+_30369868	0.828		YPEL5	yippee-like 5 (Drosophila)
chr5_-_95158365	0.818		GLRX	glutaredoxin (thioltransferase)
chr5_-_78282356	0.815	NM_000046	ARSB	arylsulfatase B
chr6_-_16761600	0.815	NM_000332 NM_001128164	ATXN1	ataxin 1
chr7_-_111846384	0.808	NM_014705	DOCK4	dedicator of cytokinesis 4
chr2_+_69969105	0.808	NM_001153	ANXA4	annexin A4
chr16_+_12058963	0.804	NM_001192	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr9_-_75567915	0.801		ALDH1A1	aldehyde dehydrogenase 1 family, member A1
chr2_+_71295685	0.797		NAGK	N-acetylglucosamine kinase
chr22_+_24823529	0.795	NM_000675	ADORA2A	adenosine A2a receptor
chr10_+_31607419	0.793		ZEB1	zinc finger E-box binding homeobox 1
chr19_-_51869579	0.793		ETFB	electron-transfer-flavoprotein, beta polypeptide
chr4_-_44728518	0.793	NM_138335	GNPDA2	glucosamine-6-phosphate deaminase 2
chr12_-_56211503	0.791		SARNP	SAP domain containing ribonucleoprotein
chr5_-_172755418	0.780		STC2	stanniocalcin 2
chr2_+_30369749	0.778	NM_001127399 NM_001127400 NM_001127401 NM_016061	YPEL5	yippee-like 5 (Drosophila)
chr5_-_95158465	0.777	NM_001118890 NM_001243658 NM_001243659 NM_002064	GLRX	glutaredoxin (thioltransferase)
chr3_+_39851028	0.776	NM_015460	MYRIP	myosin VIIA and Rab interacting protein
chr2_+_30369800	0.772		YPEL5	yippee-like 5 (Drosophila)
chr10_-_97416564	0.772	NM_001017423 NM_002860	ALDH18A1	aldehyde dehydrogenase 18 family, member A1
chr2_-_152955810	0.769		CACNB4	calcium channel, voltage-dependent, beta 4 subunit
chr14_+_24605366	0.761	NM_006263 NM_176783	PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr5_-_108745569	0.753	NM_014819	PJA2	praja ring finger 2
chr2_+_109065665	0.751		GCC2	GRIP and coiled-coil domain containing 2
chr10_+_97515408	0.743	NM_001164178 NM_001164181 NM_001164179 NM_001164182 NM_001164183 NM_001776	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1
chr17_-_42580927	0.741	NM_001002909	GPATCH8	G patch domain containing 8
chr1_+_16090993	0.738	NM_001024215	FBLIM1	filamin binding LIM protein 1
chr19_-_23578226	0.738	NM_003430	ZNF91	zinc finger protein 91
chr20_-_3149070	0.732	NM_014731	ProSAPiP1	ProSAPiP1 protein
chr5_-_130970907	0.726	NM_001164386 NM_001164387 NM_001164388 NM_001164389 NM_001164390 NM_016340	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6
chrX_-_70331297	0.726	NM_000206	IL2RG	interleukin 2 receptor, gamma
chr14_+_24605393	0.722		PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr3_+_52828783	0.721	NM_002217	ITIH3	inter-alpha-trypsin inhibitor heavy chain 3
chr9_-_130742803	0.720	NM_001035254	FAM102A	family with sequence similarity 102, member A
chrX_-_48693934	0.717	NM_013271	PCSK1N	proprotein convertase subtilisin/kexin type 1 inhibitor
chr6_+_31913763	0.715		CFB	complement factor B
chr9_-_75568232	0.712	NM_000689	ALDH1A1	aldehyde dehydrogenase 1 family, member A1
chr17_-_42580745	0.711		GPATCH8	G patch domain containing 8
chr2_+_242127923	0.707	NM_001001666 NM_001001891	ANO7	anoctamin 7
chr6_+_34759816	0.705		UHRF1BP1	UHRF1 binding protein 1
chr19_+_10381763	0.700		ICAM1	intercellular adhesion molecule 1

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
2.86	2.73e-05	GO:0048583	regulation of response to stimulus
3.53	7.52e-04	GO:0009611	response to wounding
1.66	1.61e-03	GO:0050896	response to stimulus
20.09	3.32e-03	GO:0050707	regulation of cytokine secretion
13.19	4.32e-03	GO:0050708	regulation of protein secretion
5.75	6.35e-03	GO:0006954	inflammatory response
3.51	6.87e-03	GO:0006955	immune response
15.98	1.06e-02	GO:0002700	regulation of production of molecular mediator of immune response
24.45	1.44e-02	GO:0002637	regulation of immunoglobulin production
14.96	1.47e-02	GO:0050714	positive regulation of protein secretion
46.86	2.17e-02	GO:0051023	regulation of immunoglobulin secretion
9.93	2.24e-02	GO:0051222	positive regulation of protein transport
38.34	4.22e-02	GO:0050710	negative regulation of cytokine secretion
18.75	4.30e-02	GO:0006958	complement activation, classical pathway
3.80	4.84e-02	GO:0080134	regulation of response to stress
11.72	4.87e-02	GO:0072376	protein activation cascade

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
4.66	6.71e-08	GO:0005615	extracellular space
3.07	3.27e-07	GO:0005576	extracellular region
3.70	4.58e-06	GO:0044421	extracellular region part

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
11.20	1.10e-05	GO:0004866	endopeptidase inhibitor activity
11.01	1.28e-05	GO:0030414	peptidase inhibitor activity
10.73	1.60e-05	GO:0061135	endopeptidase regulator activity
6.97	4.97e-05	GO:0004857	enzyme inhibitor activity
8.86	8.29e-05	GO:0061134	peptidase regulator activity
3.47	3.13e-04	GO:0030234	enzyme regulator activity
6.74	2.68e-03	GO:0005125	cytokine activity
12.79	3.07e-02	GO:0008009	chemokine activity
11.48	4.66e-02	GO:0042379	chemokine receptor binding