Motif ID: ZEB1.p2

Z-value: 4.253


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZEB1chr10_+_31610063-0.829.7e-05Click!


Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_38755422 10.527 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755238 9.980 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755097 9.796 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr7_+_26331493 7.878 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr4_+_75310852 7.654 NM_001657
AREG
amphiregulin
chr2_+_47596286 6.621 NM_002354
EPCAM
epithelial cell adhesion molecule
chr4_+_75480628 6.606 NM_001657
AREG
amphiregulin
chr18_+_29078026 6.598 NM_001943
DSG2
desmoglein 2
chr2_+_47596447 6.375 EPCAM
epithelial cell adhesion molecule
chr1_+_1981902 6.279 NM_002744
PRKCZ
protein kinase C, zeta
chr6_+_7541837 6.233 DSP
desmoplakin
chr6_+_7541863 6.087 NM_001008844
NM_004415
DSP

desmoplakin

chr6_+_7541892 5.984 DSP
desmoplakin
chr7_+_26331611 5.878 SNX10
sorting nexin 10
chr20_-_6103562 5.842 FERMT1
fermitin family member 1
chr16_+_68771192 5.255 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr21_-_43187197 5.027 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr1_+_60280462 4.857 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr2_-_166650770 4.798 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr19_+_35739519 4.771 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr8_+_95653272 4.484 ESRP1
epithelial splicing regulatory protein 1
chr19_+_35739778 4.293 LSR
lipolysis stimulated lipoprotein receptor
chr16_+_68679229 4.246 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr14_-_67878859 4.245 PLEK2
pleckstrin 2
chr14_-_67878770 4.187 NM_016445
PLEK2
pleckstrin 2
chr2_-_20424627 4.081 NM_002997
SDC1
syndecan 1
chr21_-_43187265 4.069 RIPK4
receptor-interacting serine-threonine kinase 4
chr2_+_17721806 4.002 NM_003385
VSNL1
visinin-like 1
chr11_+_121322848 3.864 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr17_-_39942937 3.841 NM_002230
NM_021991
JUP

junction plakoglobin

chr19_+_35739282 3.713 LSR
lipolysis stimulated lipoprotein receptor
chr16_+_68771214 3.671 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr14_-_61747956 3.524 TMEM30B
transmembrane protein 30B
chr2_+_17721983 3.424 VSNL1
visinin-like 1
chr19_+_35739838 3.351 LSR
lipolysis stimulated lipoprotein receptor
chr8_+_86376130 3.312 NM_000067
CA2
carbonic anhydrase II
chr1_-_209979388 3.268 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr4_+_4388804 3.180 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr11_+_32851469 3.136 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chrX_+_131157635 3.134 NM_001042452
MST4
serine/threonine protein kinase MST4
chr5_+_76114832 3.089 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr3_-_45187861 2.979 CDCP1
CUB domain containing protein 1
chr6_-_10419786 2.951 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr20_+_61448391 2.855 NM_001853
COL9A3
collagen, type IX, alpha 3
chr3_-_45187897 2.777 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr5_+_167718485 2.768 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr20_-_10654139 2.731 JAG1
jagged 1
chr3_-_45187843 2.723 CDCP1
CUB domain containing protein 1
chr17_+_73717515 2.706 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr12_-_52914080 2.661 NM_000424
KRT5
keratin 5
chr11_+_722282 2.648 EPS8L2
EPS8-like 2
chr4_+_4388717 2.599 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr19_-_51487070 2.579 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr4_-_36245893 2.540 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_-_68269948 2.535 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr2_-_20425166 2.444 NM_001006946
SDC1
syndecan 1
chr17_+_73717556 2.431 ITGB4
integrin, beta 4
chr5_+_76114881 2.406 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr16_-_11680756 2.404 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr20_+_25228698 2.369 NM_002862
PYGB
phosphorylase, glycogen; brain
chr17_+_73521744 2.360 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr14_-_61748510 2.346 NM_001017970
TMEM30B
transmembrane protein 30B
chrX_+_152908819 2.341 DUSP9
dual specificity phosphatase 9
chr2_-_216878314 2.324 NM_018000
MREG
melanoregulin
chr20_-_10654429 2.236 NM_000214
JAG1
jagged 1
chr7_-_22396511 2.210 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr17_+_73717596 2.198 ITGB4
integrin, beta 4
chr1_+_183155393 2.153 LAMC2
laminin, gamma 2
chr6_+_36098261 2.046 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr4_+_89300110 1.999 HERC6
hect domain and RLD 6
chr17_-_80041166 1.966 FASN
fatty acid synthase
chr11_-_71159371 1.966 DHCR7
7-dehydrocholesterol reductase
chr17_-_80042414 1.946 FASN
fatty acid synthase
chr10_+_124134093 1.931 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr11_+_69924407 1.922 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr3_+_186330844 1.908 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr2_+_163200582 1.863 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr6_-_47277354 1.850 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr6_-_47277246 1.829 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr7_+_55086922 1.809 EGFR
epidermal growth factor receptor
chr3_+_186330711 1.799 AHSG
alpha-2-HS-glycoprotein
chrX_+_105969875 1.793 NM_194463
RNF128
ring finger protein 128
chrX_-_133119475 1.789 GPC3
glypican 3
chr4_+_89299980 1.787 HERC6
hect domain and RLD 6
chr1_+_154377668 1.774 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr1_-_11714738 1.767 NM_012168
FBXO2
F-box protein 2
chr7_+_115850546 1.763 NM_015641
TES
testis derived transcript (3 LIM domains)
chr3_+_186330859 1.755 AHSG
alpha-2-HS-glycoprotein
chr3_-_189838673 1.725 LEPREL1
leprecan-like 1
chr6_-_47277511 1.718 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr6_-_47277646 1.703 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr20_+_44035203 1.696 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr12_+_56473944 1.690 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr17_-_39684499 1.689 KRT19
keratin 19
chr1_+_46646199 1.674 TSPAN1
tetraspanin 1
chr11_-_115375065 1.660 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr18_+_61144143 1.657 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr2_+_163200623 1.623 GCA
grancalcin, EF-hand calcium binding protein
chr8_-_110657025 1.621 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr20_+_43991739 1.604 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 readthrough
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr12_+_56473808 1.596 NM_001982
NM_001005915
ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

chrX_+_152954965 1.584 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr20_+_61273786 1.562 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr16_+_68679198 1.561 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr8_+_95653399 1.559 ESRP1
epithelial splicing regulatory protein 1
chr4_+_79472741 1.552 NM_005139
ANXA3
annexin A3
chr17_+_40811261 1.548 NM_016437
TUBG2
tubulin, gamma 2
chr8_+_95653340 1.545 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr18_-_21166440 1.530 NM_000271
NPC1
Niemann-Pick disease, type C1
chr17_+_2680349 1.527 RAP1GAP2
RAP1 GTPase activating protein 2
chr12_-_28122884 1.482 NM_198964
NM_198966
PTHLH

parathyroid hormone-like hormone

chr4_+_85504056 1.476 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr1_+_183155361 1.472 LAMC2
laminin, gamma 2
chr1_+_183155173 1.457 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr16_-_4987056 1.445 NM_002705
PPL
periplakin
chr2_-_165477986 1.432 GRB14
growth factor receptor-bound protein 14
chr19_+_35607218 1.428 FXYD3
FXYD domain containing ion transport regulator 3
chr9_-_100954883 1.426 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr12_-_52886971 1.421 NM_005554
KRT6A
keratin 6A
chr12_+_57984992 1.421 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr1_+_35247838 1.411 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr20_+_61273823 1.403 SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr12_+_57984914 1.400 NM_001146258
NM_001146259
NM_001146260
NM_024779
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr18_-_21166378 1.372 NPC1
Niemann-Pick disease, type C1
chr2_-_165477818 1.368 GRB14
growth factor receptor-bound protein 14
chr11_-_71159442 1.358 NM_001163817
NM_001360
DHCR7

7-dehydrocholesterol reductase

chr5_-_74162614 1.357 NM_015566
FAM169A
family with sequence similarity 169, member A
chr12_-_110939877 1.356 NM_016226
NM_057180
VPS29

vacuolar protein sorting 29 homolog (S. cerevisiae)

chr1_-_59042827 1.308 TACSTD2
tumor-associated calcium signal transducer 2
chr5_+_218355 1.304 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr10_+_38645293 1.288 HSD17B7P2
hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2
chr2_-_122042767 1.286 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr4_+_89299874 1.281 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr20_+_44034632 1.275 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr19_+_7702010 1.269 STXBP2
syntaxin binding protein 2
chr1_-_160990862 1.258 F11R
F11 receptor
chr2_-_224903933 1.253 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr19_-_51522953 1.245 NM_145888
KLK10
kallikrein-related peptidase 10
chr8_-_145638929 1.243 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr2_+_216176808 1.243 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr4_+_128703402 1.232 NM_014278
HSPA4L
heat shock 70kDa protein 4-like
chr4_-_151936377 1.227 NM_001199282
LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr17_-_80056033 1.221 FASN
fatty acid synthase
chr12_-_85306579 1.219 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr1_-_27240430 1.214 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr1_-_95007139 1.210 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr6_+_30294224 1.202


chr1_+_162760491 1.199 NM_016371
HSD17B7
hydroxysteroid (17-beta) dehydrogenase 7
chr14_+_65171149 1.199 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr12_-_85306569 1.196 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr14_+_31343642 1.188 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr15_+_40545348 1.186 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_-_27816542 1.164 WASF2
WAS protein family, member 2
chr1_-_6662681 1.162 KLHL21
kelch-like 21 (Drosophila)
chr16_-_52581713 1.159 NM_001146188
TOX3
TOX high mobility group box family member 3
chr7_+_94536926 1.157 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr12_-_33049664 1.157 NM_001005242
NM_004572
PKP2

plakophilin 2

chr8_-_81083660 1.144 NM_001025253
NM_005079
TPD52

tumor protein D52

chr2_-_235405692 1.143 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr20_-_60942300 1.134 NM_005560
LAMA5
laminin, alpha 5
chr16_-_52580805 1.132 NM_001080430
TOX3
TOX high mobility group box family member 3
chr8_-_28243941 1.130 NM_018660
ZNF395
zinc finger protein 395
chr4_-_151936648 1.124 NM_006726
LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr17_+_79935493 1.122 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr17_+_79935410 1.121 NM_001251888
NM_024083
ASPSCR1

alveolar soft part sarcoma chromosome region, candidate 1

chr12_-_63328857 1.120 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr4_-_57301643 1.116 NM_002703
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr3_+_167453431 1.098 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr11_+_68079999 1.094 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr20_+_361272 1.092 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr2_+_64681270 1.090 NM_014181
LGALSL
lectin, galactoside-binding-like
chr19_+_7701976 1.089 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr17_+_65373923 1.083 NM_012417
NM_181671
PITPNC1

phosphatidylinositol transfer protein, cytoplasmic 1

chr3_-_189838907 1.074 NM_018192
LEPREL1
leprecan-like 1
chr7_+_16793320 1.067 NM_014399
TSPAN13
tetraspanin 13
chr1_+_26872306 1.059 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_59043165 1.058 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr18_+_55816546 1.056 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr19_-_51523272 1.031 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr5_-_1524022 1.028 NM_024830
LPCAT1
lysophosphatidylcholine acyltransferase 1
chr2_+_118846029 1.027 NM_016133
INSIG2
insulin induced gene 2
chr16_+_1728283 1.026 HN1L
hematological and neurological expressed 1-like
chr1_+_2005424 1.025 NM_001242874
PRKCZ
protein kinase C, zeta
chr5_+_52284903 1.018 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr3_-_8693723 1.010 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr1_-_161008710 1.007 TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr12_-_6484904 1.000 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chrX_+_131157231 0.997 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr7_+_17338182 0.992 NM_001621
AHR
aryl hydrocarbon receptor
chr18_-_48724031 0.991 NM_016626
MEX3C
mex-3 homolog C (C. elegans)
chr5_+_218428 0.986 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr1_-_197744529 0.978 NM_001195215
NM_001195216
NM_144977
DENND1B


DENN/MADD domain containing 1B


chr1_+_26872342 0.977 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_161008733 0.977 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr18_+_47088400 0.961 NM_006033
LIPG
lipase, endothelial
chr18_+_55862577 0.958 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_+_65171243 0.955 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_+_706103 0.952 NM_022772
EPS8L2
EPS8-like 2
chr10_-_118764559 0.948 KIAA1598
KIAA1598
chr4_-_16085666 0.946 PROM1
prominin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.79 3.20e-05 GO:0008544 epidermis development
2.38 4.45e-04 GO:0048513 organ development
1.97 5.59e-04 GO:0048856 anatomical structure development
3.86 6.51e-04 GO:0009887 organ morphogenesis
2.00 1.35e-03 GO:0048731 system development
3.18 1.67e-03 GO:0009888 tissue development
4.51 4.58e-03 GO:0060429 epithelium development
1.80 9.95e-03 GO:0007275 multicellular organismal development
1.74 1.21e-02 GO:0032502 developmental process
13.32 2.52e-02 GO:0031100 organ regeneration

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.94 1.11e-05 GO:0005886 plasma membrane
2.32 1.47e-05 GO:0044459 plasma membrane part
1.91 1.90e-05 GO:0071944 cell periphery
1.55 3.76e-05 GO:0016020 membrane
28.11 1.03e-04 GO:0030057 desmosome
6.37 5.84e-04 GO:0005911 cell-cell junction
1.57 1.47e-03 GO:0044425 membrane part
4.94 5.41e-03 GO:0016323 basolateral plasma membrane
5.51 1.58e-02 GO:0070161 anchoring junction
3.14 2.31e-02 GO:0030054 cell junction
1.32 2.33e-02 GO:0005737 cytoplasm

Nothing significant found in function category.