Motif ID: AAGGUGC

Z-value: 0.270


Mature miRNA associated with seed AAGGUGC:

NamemiRBase Accession
hsa-miR-18a-5p MIMAT0000072
hsa-miR-18b-5p MIMAT0001412
hsa-miR-4735-3p MIMAT0019861



Activity profile for motif AAGGUGC.

activity profile for motif AAGGUGC


Sorted Z-values histogram for motif AAGGUGC

Sorted Z-values for motif AAGGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAGGUGC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_132272504 0.795 ENST00000367976.3
CTGF
connective tissue growth factor
chr4_+_55524085 0.549 ENST00000412167.2
ENST00000288135.5
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr6_+_112408768 0.437 ENST00000368656.2
ENST00000604268.1
FAM229B

family with sequence similarity 229, member B

chr12_+_104458235 0.406 ENST00000229330.4
HCFC2
host cell factor C2
chr9_-_35563896 0.355 ENST00000399742.2
FAM166B
family with sequence similarity 166, member B
chr6_+_39760783 0.317 ENST00000398904.2
ENST00000538976.1
DAAM2

dishevelled associated activator of morphogenesis 2

chr15_-_61521495 0.299 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr3_-_114790179 0.291 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr12_+_12764773 0.276 ENST00000228865.2
CREBL2
cAMP responsive element binding protein-like 2
chr11_-_108464321 0.235 ENST00000265843.4
EXPH5
exophilin 5
chr9_-_74383799 0.234 ENST00000377044.4
TMEM2
transmembrane protein 2
chr3_-_123603137 0.231 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
MYLK



myosin light chain kinase



chr16_+_69599861 0.194 ENST00000354436.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr13_-_77601282 0.158 ENST00000355619.5
FBXL3
F-box and leucine-rich repeat protein 3
chr11_+_108093839 0.154 ENST00000452508.2
ATM
ataxia telangiectasia mutated
chr5_+_56111361 0.141 ENST00000399503.3
MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chrX_+_150565653 0.139 ENST00000330374.6
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr1_+_87794150 0.138 ENST00000370544.5
LMO4
LIM domain only 4
chr2_+_12857015 0.134 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr12_+_69864129 0.132 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
FRS2









fibroblast growth factor receptor substrate 2









chr2_+_24714729 0.132 ENST00000406961.1
ENST00000405141.1
NCOA1

nuclear receptor coactivator 1

chr10_+_133918175 0.130 ENST00000298622.4
JAKMIP3
Janus kinase and microtubule interacting protein 3
chr6_-_107436473 0.128 ENST00000369042.1
BEND3
BEN domain containing 3
chr17_-_27621125 0.128 ENST00000579665.1
ENST00000225388.4
NUFIP2

nuclear fragile X mental retardation protein interacting protein 2

chr5_-_73937244 0.127 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
ENC1


ectodermal-neural cortex 1 (with BTB domain)


chr11_-_130184555 0.121 ENST00000525842.1
ZBTB44
zinc finger and BTB domain containing 44
chr18_-_45456930 0.120 ENST00000262160.6
ENST00000587269.1
SMAD2

SMAD family member 2

chr5_-_180288248 0.116 ENST00000512132.1
ENST00000506439.1
ENST00000502412.1
ENST00000359141.6
ZFP62



ZFP62 zinc finger protein



chr1_+_38259540 0.112 ENST00000397631.3
MANEAL
mannosidase, endo-alpha-like
chr3_+_187930719 0.109 ENST00000312675.4
LPP
LIM domain containing preferred translocation partner in lipoma
chr9_+_96338860 0.108 ENST00000375376.4
PHF2
PHD finger protein 2
chr11_-_72853091 0.103 ENST00000311172.7
ENST00000409314.1
FCHSD2

FCH and double SH3 domains 2

chr6_+_122720681 0.101 ENST00000368455.4
ENST00000452194.1
HSF2

heat shock transcription factor 2

chr15_+_76629064 0.099 ENST00000290759.4
ISL2
ISL LIM homeobox 2
chr17_+_68165657 0.095 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr7_+_90225796 0.092 ENST00000380050.3
CDK14
cyclin-dependent kinase 14
chr17_+_40834580 0.090 ENST00000264638.4
CNTNAP1
contactin associated protein 1
chr16_+_71879861 0.090 ENST00000568581.1
ENST00000427980.2
IST1
ATXN1L
increased sodium tolerance 1 homolog (yeast)
ataxin 1-like
chr16_+_28996114 0.089 ENST00000395461.3
LAT
linker for activation of T cells
chr3_+_105085734 0.085 ENST00000306107.5
ALCAM
activated leukocyte cell adhesion molecule
chr10_+_111767720 0.083 ENST00000356080.4
ENST00000277900.8
ADD3

adducin 3 (gamma)

chr12_-_56652111 0.081 ENST00000267116.7
ANKRD52
ankyrin repeat domain 52
chr20_+_49348081 0.078 ENST00000371610.2
PARD6B
par-6 family cell polarity regulator beta
chrX_-_24045303 0.078 ENST00000328046.8
KLHL15
kelch-like family member 15
chr12_+_54943134 0.074 ENST00000243052.3
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr1_+_162467595 0.073 ENST00000538489.1
ENST00000489294.1
UHMK1

U2AF homology motif (UHM) kinase 1

chr7_+_66386204 0.072 ENST00000341567.4
ENST00000607045.1
TMEM248

transmembrane protein 248

chr12_+_11802753 0.072 ENST00000396373.4
ETV6
ets variant 6
chr2_+_36582857 0.070 ENST00000280527.2
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr9_+_108424738 0.068 ENST00000334077.3
TAL2
T-cell acute lymphocytic leukemia 2
chr16_-_57219966 0.067 ENST00000565760.1
ENST00000309137.8
ENST00000570184.1
ENST00000562324.1
FAM192A



family with sequence similarity 192, member A



chr22_+_40573921 0.065 ENST00000454349.2
ENST00000335727.9
TNRC6B

trinucleotide repeat containing 6B

chr2_-_26101374 0.065 ENST00000435504.4
ASXL2
additional sex combs like 2 (Drosophila)
chr4_-_125633876 0.064 ENST00000504087.1
ENST00000515641.1
ANKRD50

ankyrin repeat domain 50

chr1_+_26737253 0.063 ENST00000326279.6
LIN28A
lin-28 homolog A (C. elegans)
chr17_-_7382834 0.063 ENST00000380599.4
ZBTB4
zinc finger and BTB domain containing 4
chr16_+_77822427 0.062 ENST00000302536.2
VAT1L
vesicle amine transport 1-like
chr20_+_60697480 0.061 ENST00000370915.1
ENST00000253001.4
ENST00000400318.2
ENST00000279068.6
ENST00000279069.7
LSM14B




LSM14B, SCD6 homolog B (S. cerevisiae)




chr7_-_100287071 0.061 ENST00000275732.5
GIGYF1
GRB10 interacting GYF protein 1
chr21_-_40685477 0.060 ENST00000342449.3
BRWD1
bromodomain and WD repeat domain containing 1
chr18_-_29522989 0.058 ENST00000582539.1
ENST00000283351.4
ENST00000582513.1
TRAPPC8


trafficking protein particle complex 8


chr6_-_86352642 0.057 ENST00000355238.6
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr1_-_204329013 0.057 ENST00000272203.3
ENST00000414478.1
PLEKHA6

pleckstrin homology domain containing, family A member 6

chr1_-_51425902 0.056 ENST00000396153.2
FAF1
Fas (TNFRSF6) associated factor 1
chr4_+_6784401 0.056 ENST00000425103.1
ENST00000307659.5
KIAA0232

KIAA0232

chr20_+_30865429 0.049 ENST00000375712.3
KIF3B
kinesin family member 3B
chr2_+_46926048 0.049 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chr1_-_55680762 0.048 ENST00000407756.1
ENST00000294383.6
USP24

ubiquitin specific peptidase 24

chr8_+_28747884 0.044 ENST00000287701.10
ENST00000444075.1
ENST00000403668.2
ENST00000519662.1
ENST00000558662.1
ENST00000523613.1
ENST00000560599.1
ENST00000397358.3
HMBOX1







homeobox containing 1







chr17_+_27717415 0.044 ENST00000583121.1
ENST00000261716.3
TAOK1

TAO kinase 1

chr1_-_70820357 0.042 ENST00000370944.4
ENST00000262346.6
ANKRD13C

ankyrin repeat domain 13C

chr11_+_109964087 0.041 ENST00000278590.3
ZC3H12C
zinc finger CCCH-type containing 12C
chr5_+_122424816 0.041 ENST00000407847.4
PRDM6
PR domain containing 6
chr6_-_37665751 0.040 ENST00000297153.7
ENST00000434837.3
MDGA1

MAM domain containing glycosylphosphatidylinositol anchor 1

chr5_-_139422654 0.040 ENST00000289409.4
ENST00000358522.3
ENST00000378238.4
ENST00000289422.7
ENST00000361474.1
ENST00000545385.1
ENST00000394770.1
ENST00000541337.1
NRG2







neuregulin 2







chr6_+_134274322 0.038 ENST00000367871.1
ENST00000237264.4
TBPL1

TBP-like 1

chr15_+_73344791 0.037 ENST00000261908.6
NEO1
neogenin 1
chr11_-_79151695 0.034 ENST00000278550.7
TENM4
teneurin transmembrane protein 4
chr4_+_154125565 0.033 ENST00000338700.5
TRIM2
tripartite motif containing 2
chr21_-_18985158 0.031 ENST00000339775.6
BTG3
BTG family, member 3
chr12_+_94542459 0.030 ENST00000258526.4
PLXNC1
plexin C1
chr1_-_110052302 0.029 ENST00000369864.4
ENST00000369862.1
AMIGO1

adhesion molecule with Ig-like domain 1

chr9_+_125703282 0.028 ENST00000373647.4
ENST00000402311.1
RABGAP1

RAB GTPase activating protein 1

chr2_-_206950781 0.028 ENST00000403263.1
INO80D
INO80 complex subunit D
chr2_+_166326157 0.027 ENST00000421875.1
ENST00000314499.7
ENST00000409664.1
CSRNP3


cysteine-serine-rich nuclear protein 3


chr1_+_42846443 0.027 ENST00000410070.2
ENST00000431473.3
RIMKLA

ribosomal modification protein rimK-like family member A

chr10_+_102295616 0.026 ENST00000299163.6
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr20_+_43104508 0.026 ENST00000262605.4
ENST00000372904.3
TTPAL

tocopherol (alpha) transfer protein-like

chr21_-_36260980 0.025 ENST00000344691.4
ENST00000358356.5
RUNX1

runt-related transcription factor 1

chr16_-_17564738 0.025 ENST00000261381.6
XYLT1
xylosyltransferase I
chr1_-_228135599 0.024 ENST00000272164.5
WNT9A
wingless-type MMTV integration site family, member 9A
chr9_+_91003271 0.024 ENST00000375859.3
ENST00000541629.1
SPIN1

spindlin 1

chr3_+_152017181 0.022 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
MBNL1



muscleblind-like splicing regulator 1



chr6_+_138188551 0.022 ENST00000237289.4
ENST00000433680.1
TNFAIP3

tumor necrosis factor, alpha-induced protein 3

chr1_+_167190066 0.022 ENST00000367866.2
ENST00000429375.2
ENST00000452019.1
ENST00000420254.3
ENST00000541643.3
POU2F1




POU class 2 homeobox 1




chr3_-_169899504 0.021 ENST00000474275.1
ENST00000484931.1
ENST00000494943.1
ENST00000497658.1
ENST00000465896.1
ENST00000475729.1
ENST00000495893.2
ENST00000481639.1
ENST00000467570.1
ENST00000466189.1
PHC3









polyhomeotic homolog 3 (Drosophila)









chrX_-_19905703 0.021 ENST00000397821.3
SH3KBP1
SH3-domain kinase binding protein 1
chr2_-_201828356 0.020 ENST00000234296.2
ORC2
origin recognition complex, subunit 2
chr3_+_37903432 0.020 ENST00000443503.2
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr4_+_79697495 0.019 ENST00000502871.1
ENST00000335016.5
BMP2K

BMP2 inducible kinase

chr7_-_121036337 0.019 ENST00000426156.1
ENST00000359943.3
ENST00000412653.1
FAM3C


family with sequence similarity 3, member C


chr1_-_57889687 0.018 ENST00000371236.2
ENST00000371230.1
DAB1

Dab, reelin signal transducer, homolog 1 (Drosophila)

chr12_-_56583332 0.018 ENST00000347471.4
ENST00000267064.4
ENST00000394023.3
SMARCC2


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2


chr4_-_42659102 0.018 ENST00000264449.10
ENST00000510289.1
ENST00000381668.5
ATP8A1


ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1


chr3_-_33481835 0.016 ENST00000283629.3
UBP1
upstream binding protein 1 (LBP-1a)
chr20_+_277737 0.016 ENST00000382352.3
ZCCHC3
zinc finger, CCHC domain containing 3
chr4_-_185395672 0.015 ENST00000393593.3
IRF2
interferon regulatory factor 2
chr10_+_72575643 0.015 ENST00000373202.3
SGPL1
sphingosine-1-phosphate lyase 1
chr3_+_107241783 0.015 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
BBX



bobby sox homolog (Drosophila)



chr1_+_62208091 0.014 ENST00000316485.6
ENST00000371158.2
INADL

InaD-like (Drosophila)

chr12_+_5019061 0.014 ENST00000382545.3
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chr5_+_78532003 0.012 ENST00000396137.4
JMY
junction mediating and regulatory protein, p53 cofactor
chr3_+_43328004 0.011 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNRK



SNF related kinase



chr1_-_109506036 0.010 ENST00000369976.1
ENST00000356970.2
ENST00000369971.2
ENST00000415331.1
ENST00000357393.4
CLCC1



AKNAD1
chloride channel CLIC-like 1



AKNA domain containing 1
chr10_-_119806085 0.009 ENST00000355624.3
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr1_+_22379120 0.008 ENST00000400259.1
ENST00000344548.3
CDC42

cell division cycle 42

chr5_+_96271141 0.006 ENST00000231368.5
LNPEP
leucyl/cystinyl aminopeptidase
chr7_-_44924939 0.006 ENST00000395699.2
PURB
purine-rich element binding protein B
chr5_+_125935960 0.005 ENST00000297540.4
PHAX
phosphorylated adaptor for RNA export
chr3_+_141205852 0.004 ENST00000286364.3
ENST00000452898.1
RASA2

RAS p21 protein activator 2

chr10_-_81205373 0.003 ENST00000372336.3
ZCCHC24
zinc finger, CCHC domain containing 24
chr9_-_127952032 0.003 ENST00000456642.1
ENST00000373546.3
ENST00000373547.4
PPP6C


protein phosphatase 6, catalytic subunit


chr1_+_100435315 0.003 ENST00000370155.3
ENST00000465289.1
SLC35A3

solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3

chrX_+_108780062 0.002 ENST00000372106.1
NXT2
nuclear transport factor 2-like export factor 2
chr5_+_102594403 0.001 ENST00000319933.2
C5orf30
chromosome 5 open reading frame 30
chr22_-_44258360 0.001 ENST00000330884.4
ENST00000249130.5
SULT4A1

sulfotransferase family 4A, member 1

chr3_+_42695176 0.001 ENST00000232974.6
ENST00000457842.3
ZBTB47

zinc finger and BTB domain containing 47


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0034059 response to anoxia(GO:0034059)
0.2 0.5 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.1 0.2 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 0.1 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.1 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.1 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.0 0.1 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.1 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.3 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.0 GO:0032289 central nervous system myelin formation(GO:0032289)
0.0 0.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0 0.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.6 GO:0042629 mast cell granule(GO:0042629)
0.0 0.0 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.1 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.2 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway