Motif ID: AIRE

Z-value: 0.589


Transcription factors associated with AIRE:

Gene SymbolEntrez IDGene Name
AIRE ENSG00000160224.12 AIRE

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
AIREhg19_v2_chr21_+_45705752_457057670.414.9e-02Click!


Activity profile for motif AIRE.

activity profile for motif AIRE


Sorted Z-values histogram for motif AIRE

Sorted Z-values for motif AIRE



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_57524061 1.950 ENST00000508121.1
HOPX
HOP homeobox
chr12_-_25101920 1.339 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr8_+_54764346 1.156 ENST00000297313.3
ENST00000344277.6
RGS20

regulator of G-protein signaling 20

chr21_-_44495919 0.914 ENST00000398158.1
CBS
cystathionine-beta-synthase
chr12_+_75874984 0.872 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr14_-_55658323 0.809 ENST00000554067.1
ENST00000247191.2
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr14_-_55658252 0.808 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr21_-_44495964 0.803 ENST00000398168.1
ENST00000398165.3
CBS

cystathionine-beta-synthase

chr21_+_30502806 0.793 ENST00000399928.1
ENST00000399926.1
MAP3K7CL

MAP3K7 C-terminal like

chr20_+_44637526 0.788 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr12_+_75874580 0.773 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr1_+_165864821 0.771 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr21_+_39644214 0.770 ENST00000438657.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr16_+_11439286 0.759 ENST00000312499.5
ENST00000576027.1
RMI2

RecQ mediated genome instability 2

chr21_+_39644305 0.751 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr21_+_39644172 0.725 ENST00000398932.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_+_35211511 0.719 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr21_+_39644395 0.714 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr4_-_104119528 0.713 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE


centromere protein E, 312kDa


chr17_+_7210294 0.699 ENST00000336452.7
EIF5A
eukaryotic translation initiation factor 5A
chr12_+_75874460 0.613 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr9_-_70178815 0.564 ENST00000377420.1
FOXD4L5
forkhead box D4-like 5
chr6_-_39290744 0.556 ENST00000507712.1
KCNK16
potassium channel, subfamily K, member 16
chr12_-_11139511 0.549 ENST00000506868.1
TAS2R50
taste receptor, type 2, member 50
chr9_+_42717234 0.545 ENST00000377590.1
FOXD4L2
forkhead box D4-like 2
chr1_-_161208013 0.518 ENST00000515452.1
ENST00000367983.4
NR1I3

nuclear receptor subfamily 1, group I, member 3

chr9_-_70429731 0.512 ENST00000377413.1
FOXD4L4
forkhead box D4-like 4
chr16_+_32077386 0.505 ENST00000354689.6
IGHV3OR16-9
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr5_-_77844974 0.474 ENST00000515007.2
LHFPL2
lipoma HMGIC fusion partner-like 2
chr9_-_113761720 0.456 ENST00000541779.1
ENST00000374430.2
LPAR1

lysophosphatidic acid receptor 1

chr8_-_7309887 0.446 ENST00000458665.1
ENST00000528168.1
SPAG11B

sperm associated antigen 11B

chr15_-_99789736 0.435 ENST00000560235.1
ENST00000394132.2
ENST00000560860.1
ENST00000558078.1
ENST00000394136.1
ENST00000262074.4
ENST00000558613.1
ENST00000394130.1
ENST00000560772.1
TTC23








tetratricopeptide repeat domain 23








chr19_+_45418067 0.429 ENST00000589078.1
ENST00000586638.1
APOC1

apolipoprotein C-I

chrX_-_49041242 0.423 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3



prickle homolog 3 (Drosophila)



chr2_-_225811747 0.416 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr3_-_121468513 0.403 ENST00000494517.1
ENST00000393667.3
GOLGB1

golgin B1

chr4_-_120222076 0.401 ENST00000504110.1
C4orf3
chromosome 4 open reading frame 3
chr16_+_446713 0.396 ENST00000397722.1
ENST00000454619.1
NME4

NME/NM23 nucleoside diphosphate kinase 4

chr3_-_121468602 0.394 ENST00000340645.5
GOLGB1
golgin B1
chr8_+_7716700 0.389 ENST00000454911.2
ENST00000326625.5
SPAG11A

sperm associated antigen 11A

chr10_-_75682535 0.384 ENST00000409178.1
C10orf55
chromosome 10 open reading frame 55
chr19_+_45417812 0.380 ENST00000592535.1
APOC1
apolipoprotein C-I
chr17_-_39150385 0.379 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr19_-_48753064 0.360 ENST00000520153.1
ENST00000357778.5
ENST00000520015.1
CARD8


caspase recruitment domain family, member 8


chr22_+_36649056 0.354 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1



apolipoprotein L, 1



chr2_-_136633940 0.354 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr12_+_10658489 0.343 ENST00000538173.1
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr19_+_45417921 0.340 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1


apolipoprotein C-I


chr14_-_106668095 0.336 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr20_-_43150601 0.335 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
SERINC3


serine incorporator 3


chr20_+_44036900 0.333 ENST00000443296.1
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr8_+_128748308 0.331 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr14_-_107283278 0.328 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chrM_-_14670 0.324 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr7_-_36764142 0.324 ENST00000258749.5
ENST00000535891.1
AOAH

acyloxyacyl hydrolase (neutrophil)

chr10_-_101841588 0.322 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr2_-_208994548 0.309 ENST00000282141.3
CRYGC
crystallin, gamma C
chr1_-_161207986 0.308 ENST00000506209.1
ENST00000367980.2
NR1I3

nuclear receptor subfamily 1, group I, member 3

chr14_-_106967788 0.307 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr12_-_11287243 0.306 ENST00000539585.1
TAS2R30
taste receptor, type 2, member 30
chr2_-_202508169 0.304 ENST00000409883.2
TMEM237
transmembrane protein 237
chr12_+_20848486 0.296 ENST00000545102.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr19_-_23869970 0.294 ENST00000601010.1
ZNF675
zinc finger protein 675
chr19_-_59084922 0.286 ENST00000215057.2
ENST00000599369.1
MZF1

myeloid zinc finger 1

chr1_+_248201474 0.280 ENST00000366479.2
OR2L2
olfactory receptor, family 2, subfamily L, member 2
chr8_-_16043780 0.277 ENST00000445506.2
MSR1
macrophage scavenger receptor 1
chr20_+_44036620 0.276 ENST00000372710.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr14_-_75330537 0.273 ENST00000556084.2
ENST00000556489.2
ENST00000445876.1
PROX2


prospero homeobox 2


chr9_+_90112117 0.271 ENST00000358077.5
DAPK1
death-associated protein kinase 1
chr4_-_114682936 0.270 ENST00000454265.2
ENST00000429180.1
ENST00000418639.2
ENST00000394526.2
ENST00000296402.5
CAMK2D




calcium/calmodulin-dependent protein kinase II delta




chr16_+_50059125 0.269 ENST00000427478.2
CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr7_-_36764004 0.266 ENST00000431169.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr3_-_139199565 0.265 ENST00000511956.1
RBP2
retinol binding protein 2, cellular
chr3_-_33686925 0.264 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2


cytoplasmic linker associated protein 2


chr6_+_42584847 0.260 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr15_-_22448819 0.260 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr19_-_47249679 0.257 ENST00000263280.6
STRN4
striatin, calmodulin binding protein 4
chr19_-_48753028 0.249 ENST00000522431.1
CARD8
caspase recruitment domain family, member 8
chr2_+_201981527 0.247 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr12_-_6579833 0.247 ENST00000396308.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr16_-_31147020 0.245 ENST00000568261.1
ENST00000567797.1
ENST00000317508.6
PRSS8


protease, serine, 8


chr16_+_56672571 0.239 ENST00000290705.8
MT1A
metallothionein 1A
chr9_-_21482312 0.236 ENST00000448696.3
IFNE
interferon, epsilon
chr6_+_26538566 0.235 ENST00000377575.2
HMGN4
high mobility group nucleosomal binding domain 4
chr1_+_36038971 0.231 ENST00000373235.3
TFAP2E
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
chr22_+_36649170 0.231 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
APOL1





apolipoprotein L, 1





chr15_+_85523671 0.228 ENST00000310298.4
ENST00000557957.1
PDE8A

phosphodiesterase 8A

chr6_+_160327974 0.227 ENST00000252660.4
MAS1
MAS1 oncogene
chr11_-_85376121 0.225 ENST00000527447.1
CREBZF
CREB/ATF bZIP transcription factor
chr2_+_204732487 0.223 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr1_-_52456352 0.221 ENST00000371655.3
RAB3B
RAB3B, member RAS oncogene family
chr1_-_243326612 0.220 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
CEP170


centrosomal protein 170kDa


chr11_-_18956556 0.218 ENST00000302797.3
MRGPRX1
MAS-related GPR, member X1
chr4_-_120243545 0.211 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr6_-_32806506 0.202 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr19_-_36304201 0.200 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr14_-_65409438 0.198 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr22_-_32767017 0.195 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr19_-_23869999 0.183 ENST00000601935.1
ENST00000359788.4
ENST00000600313.1
ENST00000596211.1
ENST00000599168.1
ZNF675




zinc finger protein 675




chr5_+_32788945 0.179 ENST00000326958.1
AC026703.1
AC026703.1
chr8_-_7220490 0.178 ENST00000400078.2
ZNF705G
zinc finger protein 705G
chr4_+_71587669 0.178 ENST00000381006.3
ENST00000226328.4
RUFY3

RUN and FYVE domain containing 3

chr12_+_7282795 0.176 ENST00000266546.6
CLSTN3
calsyntenin 3
chrX_-_139866723 0.171 ENST00000370532.2
CDR1
cerebellar degeneration-related protein 1, 34kDa
chr17_-_295730 0.170 ENST00000329099.4
FAM101B
family with sequence similarity 101, member B
chr3_-_36781352 0.169 ENST00000416516.2
DCLK3
doublecortin-like kinase 3
chr19_-_16606988 0.167 ENST00000269881.3
CALR3
calreticulin 3
chr2_+_234686976 0.163 ENST00000389758.3
MROH2A
maestro heat-like repeat family member 2A
chr6_+_167525277 0.160 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr2_+_219840955 0.158 ENST00000598002.1
ENST00000432733.1
LINC00608

long intergenic non-protein coding RNA 608

chr14_-_46185155 0.157 ENST00000555442.1
RP11-369C8.1
RP11-369C8.1
chr5_-_36242119 0.155 ENST00000511088.1
ENST00000282512.3
ENST00000506945.1
NADK2


NAD kinase 2, mitochondrial


chr6_-_33864684 0.153 ENST00000506222.2
ENST00000533304.1
LINC01016

long intergenic non-protein coding RNA 1016

chr22_+_40322623 0.148 ENST00000399090.2
GRAP2
GRB2-related adaptor protein 2
chr1_+_241815577 0.144 ENST00000366552.2
ENST00000437684.2
WDR64

WD repeat domain 64

chr22_+_40322595 0.144 ENST00000420971.1
ENST00000544756.1
GRAP2

GRB2-related adaptor protein 2

chr6_+_36839616 0.144 ENST00000359359.2
ENST00000510325.2
C6orf89

chromosome 6 open reading frame 89

chr1_+_100810575 0.140 ENST00000542213.1
CDC14A
cell division cycle 14A
chr4_-_17513851 0.131 ENST00000281243.5
QDPR
quinoid dihydropteridine reductase
chr19_-_36643329 0.127 ENST00000589154.1
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr16_-_28503327 0.127 ENST00000535392.1
ENST00000395653.4
CLN3

ceroid-lipofuscinosis, neuronal 3

chr20_-_33735070 0.126 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2


ER degradation enhancer, mannosidase alpha-like 2


chr10_-_46030787 0.124 ENST00000395769.2
MARCH8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr1_+_152627927 0.121 ENST00000444515.1
ENST00000536536.1
LINC00302

long intergenic non-protein coding RNA 302

chr2_-_166060571 0.121 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr22_+_25202232 0.121 ENST00000400358.4
ENST00000400359.4
SGSM1

small G protein signaling modulator 1

chr11_+_6947647 0.116 ENST00000278319.5
ZNF215
zinc finger protein 215
chr9_-_4666421 0.115 ENST00000381895.5
SPATA6L
spermatogenesis associated 6-like
chr2_+_207804278 0.112 ENST00000272852.3
CPO
carboxypeptidase O
chr20_+_54823788 0.108 ENST00000243911.2
MC3R
melanocortin 3 receptor
chr1_-_152297679 0.106 ENST00000368799.1
FLG
filaggrin
chr12_-_50677255 0.105 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1


LIM domain and actin binding 1


chr2_-_166060552 0.099 ENST00000283254.7
ENST00000453007.1
SCN3A

sodium channel, voltage-gated, type III, alpha subunit

chr20_-_43093968 0.098 ENST00000306731.4
ENST00000372910.3
C20orf62

chromosome 20 open reading frame 62

chr18_-_37380230 0.095 ENST00000591629.1
LINC00669
long intergenic non-protein coding RNA 669
chr18_+_39766626 0.095 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
LINC00907








long intergenic non-protein coding RNA 907








chr12_+_52643077 0.094 ENST00000553310.2
ENST00000544024.1
KRT86

keratin 86

chr16_+_72088376 0.091 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP








HPR
haptoglobin








haptoglobin-related protein
chr7_+_20686946 0.086 ENST00000443026.2
ENST00000406935.1
ABCB5

ATP-binding cassette, sub-family B (MDR/TAP), member 5

chr4_+_71588372 0.086 ENST00000536664.1
RUFY3
RUN and FYVE domain containing 3
chr13_-_46756351 0.079 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr15_-_38519066 0.077 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1

RP11-346D14.1

chr12_-_75603482 0.076 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr7_-_55606346 0.075 ENST00000545390.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr6_+_118869452 0.071 ENST00000357525.5
PLN
phospholamban
chr17_+_36452989 0.068 ENST00000312513.5
ENST00000582535.1
MRPL45

mitochondrial ribosomal protein L45

chr1_-_52344471 0.067 ENST00000352171.7
ENST00000354831.7
NRD1

nardilysin (N-arginine dibasic convertase)

chr12_-_64784471 0.066 ENST00000333722.5
C12orf56
chromosome 12 open reading frame 56
chr5_+_122181279 0.065 ENST00000395451.4
ENST00000506996.1
SNX24

sorting nexin 24

chr4_-_88450612 0.060 ENST00000418378.1
ENST00000282470.6
SPARCL1

SPARC-like 1 (hevin)

chr15_-_83209210 0.057 ENST00000561157.1
ENST00000330244.6
RPS17L

ribosomal protein S17-like

chr3_-_121264848 0.051 ENST00000264233.5
POLQ
polymerase (DNA directed), theta
chr6_-_169582835 0.049 ENST00000564830.1
RP11-417E7.2
RP11-417E7.2
chr14_+_45605127 0.049 ENST00000556036.1
ENST00000267430.5
FANCM

Fanconi anemia, complementation group M

chr12_-_6579808 0.045 ENST00000535180.1
ENST00000400911.3
VAMP1

vesicle-associated membrane protein 1 (synaptobrevin 1)

chr11_+_64794875 0.045 ENST00000377244.3
ENST00000534637.1
ENST00000524831.1
SNX15


sorting nexin 15


chr9_+_117904097 0.043 ENST00000374016.1
DEC1
deleted in esophageal cancer 1
chr5_-_107703556 0.042 ENST00000496714.1
FBXL17
F-box and leucine-rich repeat protein 17
chr1_+_207669573 0.042 ENST00000400960.2
ENST00000534202.1
CR1

complement component (3b/4b) receptor 1 (Knops blood group)

chrX_+_70503433 0.042 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO



non-POU domain containing, octamer-binding



chr9_-_104198042 0.039 ENST00000374855.4
ALDOB
aldolase B, fructose-bisphosphate
chr3_-_133648656 0.039 ENST00000408895.2
C3orf36
chromosome 3 open reading frame 36
chr2_+_166150541 0.039 ENST00000283256.6
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr8_+_104384616 0.036 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr11_+_30252549 0.036 ENST00000254122.3
ENST00000417547.1
FSHB

follicle stimulating hormone, beta polypeptide

chr11_-_5345582 0.036 ENST00000328813.2
OR51B2
olfactory receptor, family 51, subfamily B, member 2
chr2_-_89568263 0.034 ENST00000473726.1
IGKV1-33
immunoglobulin kappa variable 1-33
chr1_-_35497506 0.030 ENST00000317538.5
ENST00000373340.2
ENST00000357182.4
ZMYM6


zinc finger, MYM-type 6


chr5_+_122181184 0.028 ENST00000513881.1
SNX24
sorting nexin 24
chr2_+_1417228 0.027 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
TPO







thyroid peroxidase







chr3_+_88199099 0.027 ENST00000486971.1
C3orf38
chromosome 3 open reading frame 38
chr14_+_21236586 0.026 ENST00000326783.3
EDDM3B
epididymal protein 3B
chr1_+_206223941 0.026 ENST00000367126.4
AVPR1B
arginine vasopressin receptor 1B
chr9_+_100615536 0.025 ENST00000375123.3
FOXE1
forkhead box E1 (thyroid transcription factor 2)
chr8_-_141774467 0.025 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
PTK2


protein tyrosine kinase 2


chr9_-_114361665 0.024 ENST00000309195.5
PTGR1
prostaglandin reductase 1
chr3_+_140981456 0.024 ENST00000504264.1
ACPL2
acid phosphatase-like 2
chr10_-_46030841 0.019 ENST00000453424.2
MARCH8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr3_+_46412345 0.019 ENST00000292303.4
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chrX_-_102941596 0.016 ENST00000441076.2
ENST00000422355.1
ENST00000442614.1
ENST00000422154.2
ENST00000451301.1
MORF4L2




mortality factor 4 like 2




chr19_-_10491234 0.012 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
TYK2


tyrosine kinase 2


chr4_-_47465666 0.002 ENST00000381571.4
COMMD8
COMM domain containing 8
chr17_+_41857793 0.002 ENST00000449302.3
C17orf105
chromosome 17 open reading frame 105
chr12_-_76462713 0.001 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr1_+_207669613 0.001 ENST00000367049.4
ENST00000529814.1
CR1

complement component (3b/4b) receptor 1 (Knops blood group)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.4 2.3 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.3 1.2 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.2 1.3 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 0.8 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.1 0.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.3 GO:0072186 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094)
0.1 0.8 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.7 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.7 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 1.9 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 0.2 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.1 0.3 GO:0030070 insulin processing(GO:0030070)
0.1 3.0 GO:0010107 potassium ion import(GO:0010107)
0.1 0.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.1 0.5 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.3 GO:0009597 detection of virus(GO:0009597)
0.0 0.2 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.2 GO:0018125 peptidyl-cysteine methylation(GO:0018125) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.0 0.1 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.0 0.1 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.3 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.4 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.4 GO:1901725 regulation of histone deacetylase activity(GO:1901725)
0.0 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.3 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.2 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:1901876 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.0 0.8 GO:0000732 strand displacement(GO:0000732)
0.0 0.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 1.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.2 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.3 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.3 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 0.3 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.0 GO:0045957 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.0 0.2 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.3 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 1.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.3 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.7 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.7 GO:0005642 annulate lamellae(GO:0005642)
0.1 1.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 1.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 2.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0060091 kinocilium(GO:0060091)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.2 1.3 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 0.6 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.2 3.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.8 GO:0004882 androgen receptor activity(GO:0004882)
0.1 0.7 GO:0043515 kinetochore binding(GO:0043515)
0.1 1.2 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 0.8 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.4 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.3 GO:0032089 NACHT domain binding(GO:0032089)
0.0 0.2 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.0 0.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.2 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0070404 NADH binding(GO:0070404)
0.0 1.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.0 GO:0004877 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.5 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 1.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.2 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.5 PID_IFNG_PATHWAY IFN-gamma pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.2 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.8 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.3 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.7 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 2.3 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins