Motif ID: DDIT3

Z-value: 0.288


Transcription factors associated with DDIT3:

Gene SymbolEntrez IDGene Name
DDIT3 ENSG00000175197.6 DDIT3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
DDIT3hg19_v2_chr12_-_57914275_579143040.424.0e-02Click!


Activity profile for motif DDIT3.

activity profile for motif DDIT3


Sorted Z-values histogram for motif DDIT3

Sorted Z-values for motif DDIT3



Network of associatons between targets according to the STRING database.



First level regulatory network of DDIT3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_25102252 0.761 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr12_-_25101920 0.592 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr19_-_35992780 0.553 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
DMKN


dermokine


chr9_+_80912059 0.459 ENST00000347159.2
ENST00000376588.3
PSAT1

phosphoserine aminotransferase 1

chr15_+_41245160 0.386 ENST00000444189.2
ENST00000446533.3
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr14_+_21387508 0.375 ENST00000555624.1
RP11-84C10.2
RP11-84C10.2
chr2_-_216300784 0.347 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1













fibronectin 1













chr1_+_150954493 0.345 ENST00000368947.4
ANXA9
annexin A9
chr2_-_208030647 0.328 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr12_-_52867569 0.302 ENST00000252250.6
KRT6C
keratin 6C
chr2_-_40680578 0.286 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr12_-_53074182 0.207 ENST00000252244.3
KRT1
keratin 1
chr22_-_27456361 0.194 ENST00000453934.1
CTA-992D9.6
CTA-992D9.6
chr7_-_56101826 0.187 ENST00000421626.1
PSPH
phosphoserine phosphatase
chr6_+_151187074 0.186 ENST00000367308.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr1_-_67519782 0.182 ENST00000235345.5
SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr10_-_17659234 0.173 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr10_-_17659357 0.158 ENST00000326961.6
ENST00000361271.3
PTPLA

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

chr11_+_62495997 0.157 ENST00000316461.4
TTC9C
tetratricopeptide repeat domain 9C
chr17_-_47925379 0.140 ENST00000352793.2
ENST00000334568.4
ENST00000398154.1
ENST00000436235.1
ENST00000326219.5
TAC4




tachykinin 4 (hemokinin)




chr3_+_157154578 0.136 ENST00000295927.3
PTX3
pentraxin 3, long
chr16_-_68269971 0.134 ENST00000565858.1
ESRP2
epithelial splicing regulatory protein 2
chr8_-_93029865 0.130 ENST00000422361.2
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_111770278 0.127 ENST00000369748.4
CHI3L2
chitinase 3-like 2
chr5_-_54281407 0.125 ENST00000381403.4
ESM1
endothelial cell-specific molecule 1
chr12_-_7899935 0.125 ENST00000543765.1
CLEC4C
C-type lectin domain family 4, member C
chr1_+_111770232 0.123 ENST00000369744.2
CHI3L2
chitinase 3-like 2
chr3_+_136676851 0.121 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr13_-_24007815 0.121 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr5_-_178017355 0.121 ENST00000390654.3
COL23A1
collagen, type XXIII, alpha 1
chr9_+_112542572 0.115 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr8_-_21669826 0.112 ENST00000517328.1
GFRA2
GDNF family receptor alpha 2
chr19_+_1450112 0.109 ENST00000590469.1
ENST00000233607.2
ENST00000238483.4
ENST00000590877.1
APC2



adenomatosis polyposis coli 2



chr3_+_136676707 0.106 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr17_-_46691990 0.104 ENST00000576562.1
HOXB8
homeobox B8
chr3_+_12392971 0.100 ENST00000287820.6
PPARG
peroxisome proliferator-activated receptor gamma
chr14_+_22265444 0.100 ENST00000390430.2
TRAV8-1
T cell receptor alpha variable 8-1
chr2_-_43453734 0.099 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr2_-_101925055 0.093 ENST00000295317.3
RNF149
ring finger protein 149
chr15_+_85923856 0.090 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
AKAP13



A kinase (PRKA) anchor protein 13



chr9_-_95055956 0.089 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS



isoleucyl-tRNA synthetase



chr9_-_95056010 0.088 ENST00000443024.2
IARS
isoleucyl-tRNA synthetase
chr2_+_192141611 0.087 ENST00000392316.1
MYO1B
myosin IB
chr6_-_48036363 0.086 ENST00000543600.1
ENST00000398738.2
ENST00000339488.4
PTCHD4


patched domain containing 4


chr11_+_62495541 0.085 ENST00000530625.1
ENST00000513247.2
TTC9C

tetratricopeptide repeat domain 9C

chr4_-_99578789 0.083 ENST00000511651.1
ENST00000505184.1
TSPAN5

tetraspanin 5

chr17_+_4336955 0.081 ENST00000355530.2
SPNS3
spinster homolog 3 (Drosophila)
chr19_+_33865218 0.080 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr12_+_57857475 0.078 ENST00000528467.1
GLI1
GLI family zinc finger 1
chr1_-_161277210 0.077 ENST00000491222.2
MPZ
myelin protein zero
chr8_-_11058847 0.077 ENST00000297303.4
ENST00000416569.2
XKR6

XK, Kell blood group complex subunit-related family, member 6

chr17_+_4337199 0.074 ENST00000333476.2
SPNS3
spinster homolog 3 (Drosophila)
chr19_+_49258775 0.072 ENST00000593756.1
FGF21
fibroblast growth factor 21
chr17_+_4855053 0.072 ENST00000518175.1
ENO3
enolase 3 (beta, muscle)
chr7_-_99006443 0.071 ENST00000350498.3
PDAP1
PDGFA associated protein 1
chr11_+_34073269 0.065 ENST00000389645.3
CAPRIN1
cell cycle associated protein 1
chr9_+_110045537 0.060 ENST00000358015.3
RAD23B
RAD23 homolog B (S. cerevisiae)
chr17_-_30228678 0.059 ENST00000261708.4
UTP6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr3_+_44840679 0.059 ENST00000425755.1
KIF15
kinesin family member 15
chr14_+_32798547 0.055 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6


A kinase (PRKA) anchor protein 6


chr16_-_18908196 0.053 ENST00000565324.1
ENST00000561947.1
SMG1

SMG1 phosphatidylinositol 3-kinase-related kinase

chr2_-_183106641 0.050 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr14_+_32798462 0.049 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr3_+_130569429 0.048 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1



ATPase, Ca++ transporting, type 2C, member 1



chr4_+_111397216 0.047 ENST00000265162.5
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
chr19_+_10736183 0.045 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
SLC44A2


solute carrier family 44 (choline transporter), member 2


chrX_-_40506766 0.044 ENST00000378421.1
ENST00000440784.2
ENST00000327877.5
ENST00000378426.1
ENST00000378418.2
CXorf38




chromosome X open reading frame 38




chr6_-_157744531 0.043 ENST00000400788.4
ENST00000367144.4
TMEM242

transmembrane protein 242

chr15_+_85923797 0.042 ENST00000559362.1
AKAP13
A kinase (PRKA) anchor protein 13
chr2_+_227700652 0.041 ENST00000341329.3
ENST00000392062.2
ENST00000437454.1
ENST00000443477.1
ENST00000423616.1
ENST00000448992.1
RHBDD1





rhomboid domain containing 1





chr5_+_154135029 0.040 ENST00000518297.1
LARP1
La ribonucleoprotein domain family, member 1
chr16_-_70323422 0.040 ENST00000261772.8
AARS
alanyl-tRNA synthetase
chr1_-_114447412 0.039 ENST00000369567.1
ENST00000369566.3
AP4B1

adaptor-related protein complex 4, beta 1 subunit

chr17_-_77813186 0.038 ENST00000448310.1
ENST00000269397.4
CBX4

chromobox homolog 4

chr1_-_114447683 0.037 ENST00000256658.4
ENST00000369564.1
AP4B1

adaptor-related protein complex 4, beta 1 subunit

chr6_-_24489842 0.035 ENST00000230036.1
GPLD1
glycosylphosphatidylinositol specific phospholipase D1
chr12_-_12491608 0.033 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr11_+_34073195 0.033 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr22_+_17956618 0.032 ENST00000262608.8
CECR2
cat eye syndrome chromosome region, candidate 2
chr11_-_8680383 0.031 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr2_-_179672142 0.029 ENST00000342992.6
ENST00000360870.5
ENST00000460472.2
ENST00000589042.1
ENST00000591111.1
ENST00000342175.6
ENST00000359218.5
TTN






titin






chr5_-_66492562 0.028 ENST00000256447.4
CD180
CD180 molecule
chr9_+_112542591 0.028 ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
ENST00000483909.1
ENST00000314527.4
PALM2-AKAP2

AKAP2

PALM2

PALM2-AKAP2 readthrough

A kinase (PRKA) anchor protein 2

paralemmin 2

chr7_+_99006550 0.028 ENST00000222969.5
BUD31
BUD31 homolog (S. cerevisiae)
chr11_+_20044096 0.027 ENST00000533917.1
NAV2
neuron navigator 2
chr10_+_102756800 0.025 ENST00000370223.3
LZTS2
leucine zipper, putative tumor suppressor 2
chr1_+_114447763 0.025 ENST00000369563.3
DCLRE1B
DNA cross-link repair 1B
chrX_-_133792480 0.025 ENST00000359237.4
PLAC1
placenta-specific 1
chr20_+_57766075 0.024 ENST00000371030.2
ZNF831
zinc finger protein 831
chr6_-_31864977 0.023 ENST00000395728.3
ENST00000375528.4
EHMT2

euchromatic histone-lysine N-methyltransferase 2

chr4_+_141178440 0.022 ENST00000394205.3
SCOC
short coiled-coil protein
chr10_+_103986085 0.020 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr20_+_24929866 0.020 ENST00000480798.1
ENST00000376835.2
CST7

cystatin F (leukocystatin)

chr19_-_6604094 0.019 ENST00000597430.2
CD70
CD70 molecule
chr7_-_44530479 0.019 ENST00000355451.7
NUDCD3
NudC domain containing 3
chr12_+_50144381 0.017 ENST00000552370.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr17_+_56315787 0.016 ENST00000262290.4
ENST00000421678.2
LPO

lactoperoxidase

chr20_+_54987305 0.016 ENST00000371336.3
ENST00000434344.1
CASS4

Cas scaffolding protein family member 4

chr8_+_24151620 0.014 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr22_+_31518938 0.013 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J






inositol polyphosphate-5-phosphatase J






chr5_+_118812294 0.012 ENST00000509514.1
HSD17B4
hydroxysteroid (17-beta) dehydrogenase 4
chr20_-_31592113 0.012 ENST00000420875.1
ENST00000375519.2
ENST00000375523.3
ENST00000356173.3
SUN5



Sad1 and UNC84 domain containing 5



chrX_-_138724677 0.011 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2


MCF.2 cell line derived transforming sequence


chr11_-_104972158 0.010 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1



CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase



caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr3_+_38017264 0.010 ENST00000436654.1
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr2_-_32390801 0.009 ENST00000608489.1
RP11-563N4.1
RP11-563N4.1
chr17_-_34257771 0.009 ENST00000394529.3
ENST00000293273.6
RDM1

RAD52 motif 1

chr17_+_30594823 0.008 ENST00000536287.1
RHBDL3
rhomboid, veinlet-like 3 (Drosophila)
chr8_+_27629459 0.007 ENST00000523566.1
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr5_-_137878887 0.007 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1



eukaryotic translation termination factor 1



chr5_+_112074029 0.005 ENST00000512211.2
APC
adenomatous polyposis coli
chr20_+_54987168 0.005 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr1_+_169079823 0.004 ENST00000367813.3
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr17_-_34257731 0.003 ENST00000431884.2
ENST00000425909.3
ENST00000394528.3
ENST00000430160.2
RDM1



RAD52 motif 1



chr4_-_2935674 0.002 ENST00000514800.1
MFSD10
major facilitator superfamily domain containing 10
chr5_+_118812237 0.001 ENST00000513628.1
HSD17B4
hydroxysteroid (17-beta) dehydrogenase 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 0.3 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.6 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.5 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.1 0.2 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 0.2 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.0 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.2 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.3 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.1 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.4 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.2 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0021938 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:1904640 response to methionine(GO:1904640)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.0 GO:1901355 response to rapamycin(GO:1901355)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.4 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.0 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.2 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.5 GO:0008483 transaminase activity(GO:0008483)
0.0 0.2 GO:0004568 chitinase activity(GO:0004568)
0.0 0.2 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.3 GO:0015464 acetylcholine receptor activity(GO:0015464)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins