Motif ID: DLX5

Z-value: 0.785


Transcription factors associated with DLX5:

Gene SymbolEntrez IDGene Name
DLX5 ENSG00000105880.4 DLX5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
DLX5hg19_v2_chr7_-_96654133_966544090.184.1e-01Click!


Activity profile for motif DLX5.

activity profile for motif DLX5


Sorted Z-values histogram for motif DLX5

Sorted Z-values for motif DLX5



Network of associatons between targets according to the STRING database.



First level regulatory network of DLX5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_7013897 4.067 ENST00000007969.8
ENST00000323702.5
LRRC23

leucine rich repeat containing 23

chr12_+_7014064 4.056 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr2_+_228736321 3.606 ENST00000309931.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr13_+_36050881 3.553 ENST00000537702.1
NBEA
neurobeachin
chr2_+_228735763 3.535 ENST00000373666.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr12_+_7014126 3.073 ENST00000415834.1
ENST00000436789.1
LRRC23

leucine rich repeat containing 23

chr2_+_228736335 2.871 ENST00000440997.1
ENST00000545118.1
DAW1

dynein assembly factor with WDR repeat domains 1

chr11_-_26593779 1.949 ENST00000529533.1
MUC15
mucin 15, cell surface associated
chr16_+_53133070 1.778 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr5_-_160279207 1.705 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr3_+_186560462 1.422 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr3_+_186560476 1.420 ENST00000320741.2
ENST00000444204.2
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr4_+_77356248 1.413 ENST00000296043.6
SHROOM3
shroom family member 3
chr12_-_10151773 1.335 ENST00000298527.6
ENST00000348658.4
CLEC1B

C-type lectin domain family 1, member B

chr11_-_26593649 1.262 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr11_-_26593677 1.185 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr8_-_10512569 1.148 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr4_-_105416039 1.120 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr5_-_42811986 1.087 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1


selenoprotein P, plasma, 1


chr5_-_20575959 1.083 ENST00000507958.1
CDH18
cadherin 18, type 2
chr20_+_58571419 1.079 ENST00000244049.3
ENST00000350849.6
ENST00000456106.1
CDH26


cadherin 26


chr11_-_33913708 1.046 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_61547405 1.024 ENST00000371189.4
NFIA
nuclear factor I/A
chr5_-_42812143 0.964 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr4_-_138453559 0.924 ENST00000511115.1
PCDH18
protocadherin 18
chr3_-_105587879 0.818 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB


Cbl proto-oncogene B, E3 ubiquitin protein ligase


chr1_+_61547894 0.803 ENST00000403491.3
NFIA
nuclear factor I/A
chr1_-_23670817 0.702 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr11_+_818902 0.647 ENST00000336615.4
PNPLA2
patatin-like phospholipase domain containing 2
chr15_+_89631381 0.644 ENST00000352732.5
ABHD2
abhydrolase domain containing 2
chr14_+_22739823 0.594 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr4_-_66536196 0.586 ENST00000511294.1
EPHA5
EPH receptor A5
chr7_+_70597109 0.576 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr3_+_2933893 0.573 ENST00000397459.2
CNTN4
contactin 4
chr6_-_78173490 0.529 ENST00000369947.2
HTR1B
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
chr12_+_54378923 0.526 ENST00000303460.4
HOXC10
homeobox C10
chr7_-_86849883 0.509 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr3_-_186288097 0.504 ENST00000446782.1
TBCCD1
TBCC domain containing 1
chr7_+_99717230 0.473 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr12_+_52695617 0.462 ENST00000293525.5
KRT86
keratin 86
chr1_-_150669500 0.453 ENST00000271732.3
GOLPH3L
golgi phosphoprotein 3-like
chr1_+_160160283 0.414 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_-_23670813 0.412 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr1_-_23670752 0.408 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR




heterogeneous nuclear ribonucleoprotein R




chr1_+_160160346 0.393 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr15_+_41913690 0.386 ENST00000563576.1
MGA
MGA, MAX dimerization protein
chr1_+_101003687 0.374 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr2_+_169757750 0.317 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
G6PC2


glucose-6-phosphatase, catalytic, 2


chr4_-_66536057 0.310 ENST00000273854.3
EPHA5
EPH receptor A5
chr19_-_36606181 0.309 ENST00000221859.4
POLR2I
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
chr3_-_105588231 0.305 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB




Cbl proto-oncogene B, E3 ubiquitin protein ligase




chr5_-_58571935 0.289 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_-_68283291 0.284 ENST00000555452.1
ENST00000347230.4
ZFYVE26

zinc finger, FYVE domain containing 26

chr21_-_32253874 0.260 ENST00000332378.4
KRTAP11-1
keratin associated protein 11-1
chr17_-_39324424 0.251 ENST00000391356.2
KRTAP4-3
keratin associated protein 4-3
chr1_+_202317815 0.238 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B


protein phosphatase 1, regulatory subunit 12B


chr2_+_95963052 0.223 ENST00000295225.5
KCNIP3
Kv channel interacting protein 3, calsenilin
chr18_-_33709268 0.177 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6


solute carrier family 39 (zinc transporter), member 6


chr17_-_47785504 0.177 ENST00000514907.1
ENST00000503334.1
ENST00000508520.1
SLC35B1


solute carrier family 35, member B1


chr2_+_30369859 0.171 ENST00000402003.3
YPEL5
yippee-like 5 (Drosophila)
chrX_-_16887963 0.169 ENST00000380084.4
RBBP7
retinoblastoma binding protein 7
chr14_+_96000930 0.164 ENST00000331334.4
GLRX5
glutaredoxin 5
chr5_+_63802109 0.160 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr1_+_202317855 0.158 ENST00000356764.2
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr19_+_6372444 0.146 ENST00000245812.3
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr1_-_150669604 0.145 ENST00000427665.1
ENST00000540514.1
GOLPH3L

golgi phosphoprotein 3-like

chr3_+_186288454 0.144 ENST00000265028.3
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr10_-_56561022 0.140 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
PCDH15













protocadherin-related 15













chr2_-_183387430 0.140 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr2_+_30369807 0.135 ENST00000379520.3
ENST00000379519.3
ENST00000261353.4
YPEL5


yippee-like 5 (Drosophila)


chr13_-_36788718 0.134 ENST00000317764.6
ENST00000379881.3
SOHLH2

spermatogenesis and oogenesis specific basic helix-loop-helix 2

chr7_-_99717463 0.130 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr17_+_42264556 0.127 ENST00000319511.6
ENST00000589785.1
ENST00000592825.1
ENST00000589184.1
TMUB2



transmembrane and ubiquitin-like domain containing 2



chr6_-_27860956 0.125 ENST00000359611.2
HIST1H2AM
histone cluster 1, H2am
chr7_-_7575477 0.102 ENST00000399429.3
COL28A1
collagen, type XXVIII, alpha 1
chr8_-_124553437 0.099 ENST00000517956.1
ENST00000443022.2
FBXO32

F-box protein 32

chr12_-_57039739 0.097 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP5B





ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide





chr6_-_33160231 0.075 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2









collagen, type XI, alpha 2









chr19_-_19302931 0.074 ENST00000444486.3
ENST00000514819.3
ENST00000162023.5
ENST00000585679.1
MEF2BNB-MEF2B

MEF2B
MEF2BNB
MEF2BNB-MEF2B readthrough

myocyte enhancer factor 2B
MEF2B neighbor
chr14_-_95236551 0.074 ENST00000238558.3
GSC
goosecoid homeobox
chr19_+_54641444 0.063 ENST00000221232.5
ENST00000358389.3
CNOT3

CCR4-NOT transcription complex, subunit 3

chr15_+_89164520 0.061 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chr11_+_118398178 0.050 ENST00000302783.4
ENST00000539546.1
TTC36

tetratricopeptide repeat domain 36

chrX_+_150565653 0.048 ENST00000330374.6
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr3_+_158519654 0.040 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1


major facilitator superfamily domain containing 1


chr11_-_102651343 0.029 ENST00000279441.4
ENST00000539681.1
MMP10

matrix metallopeptidase 10 (stromelysin 2)

chr1_-_242612779 0.025 ENST00000427495.1
PLD5
phospholipase D family, member 5
chr18_+_55888767 0.023 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase


chr9_+_34646651 0.023 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr4_-_8873531 0.019 ENST00000400677.3
HMX1
H6 family homeobox 1
chr4_+_66536248 0.014 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1

RP11-807H7.1

chr2_-_183387283 0.004 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:2000583 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.2 1.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.5 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 0.4 GO:0061743 motor learning(GO:0061743)
0.1 1.4 GO:0045176 apical protein localization(GO:0045176)
0.1 0.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.9 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 1.8 GO:0072189 ureter development(GO:0072189)
0.1 10.0 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 1.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 0.6 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 0.2 GO:0072334 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.1 1.7 GO:0045332 phospholipid translocation(GO:0045332)
0.1 4.4 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.6 GO:0036155 positive regulation of triglyceride catabolic process(GO:0010898) acylglycerol acyl-chain remodeling(GO:0036155)
0.0 1.0 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 0.5 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 1.3 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.0 1.5 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.9 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.2 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.3 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 1.3 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.1 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.0 0.1 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.6 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 3.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.4 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0014802 terminal cisterna(GO:0014802)
0.1 0.5 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 4.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 3.0 GO:0005581 collagen trimer(GO:0005581)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 10.1 GO:0005929 cilium(GO:0005929)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 4.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.8 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.9 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.3 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 1.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.5 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 5.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.1 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.5 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.3 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing