Motif ID: DMBX1

Z-value: 0.256


Transcription factors associated with DMBX1:

Gene SymbolEntrez IDGene Name
DMBX1 ENSG00000197587.6 DMBX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
DMBX1hg19_v2_chr1_+_46972668_469726690.311.4e-01Click!


Activity profile for motif DMBX1.

activity profile for motif DMBX1


Sorted Z-values histogram for motif DMBX1

Sorted Z-values for motif DMBX1



Network of associatons between targets according to the STRING database.



First level regulatory network of DMBX1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_38859996 0.689 ENST00000264651.2
KRT24
keratin 24
chr3_+_188664988 0.616 ENST00000433971.1
TPRG1
tumor protein p63 regulated 1
chr10_+_118187379 0.601 ENST00000369230.3
PNLIPRP3
pancreatic lipase-related protein 3
chr8_-_125577940 0.510 ENST00000519168.1
ENST00000395508.2
MTSS1

metastasis suppressor 1

chr2_-_70780572 0.405 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr18_+_29027696 0.354 ENST00000257189.4
DSG3
desmoglein 3
chr2_-_70780770 0.313 ENST00000444975.1
ENST00000445399.1
ENST00000418333.2
TGFA


transforming growth factor, alpha


chr19_-_51538118 0.296 ENST00000529888.1
KLK12
kallikrein-related peptidase 12
chr19_-_51538148 0.294 ENST00000319590.4
ENST00000250351.4
KLK12

kallikrein-related peptidase 12

chr15_+_93443419 0.234 ENST00000557381.1
ENST00000420239.2
CHD2

chromodomain helicase DNA binding protein 2

chr6_+_130339710 0.226 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr9_-_21995249 0.221 ENST00000494262.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr9_-_21995300 0.213 ENST00000498628.2
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr1_-_143913143 0.185 ENST00000400889.1
FAM72D
family with sequence similarity 72, member D
chr1_+_206138457 0.172 ENST00000367128.3
ENST00000431655.2
FAM72A

family with sequence similarity 72, member A

chr7_+_1727755 0.164 ENST00000424383.2
ELFN1
extracellular leucine-rich repeat and fibronectin type III domain containing 1
chr1_+_120839005 0.163 ENST00000369390.3
ENST00000452190.1
FAM72B

family with sequence similarity 72, member B

chr9_-_21994597 0.162 ENST00000579755.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr2_+_37571845 0.156 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr3_-_137851220 0.155 ENST00000236709.3
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chrX_-_32173579 0.153 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD




dystrophin




chr9_-_21994344 0.148 ENST00000530628.2
ENST00000361570.3
CDKN2A

cyclin-dependent kinase inhibitor 2A

chr3_-_121468513 0.145 ENST00000494517.1
ENST00000393667.3
GOLGB1

golgin B1

chr1_+_109756523 0.144 ENST00000234677.2
ENST00000369923.4
SARS

seryl-tRNA synthetase

chr3_-_10362725 0.139 ENST00000397109.3
ENST00000428626.1
ENST00000445064.1
ENST00000431352.1
ENST00000397117.1
ENST00000337354.4
ENST00000383801.2
ENST00000432213.1
ENST00000350697.3
SEC13








SEC13 homolog (S. cerevisiae)








chr19_+_36157715 0.136 ENST00000379013.2
ENST00000222275.2
UPK1A

uroplakin 1A

chr10_+_103986085 0.136 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr3_-_121468602 0.136 ENST00000340645.5
GOLGB1
golgin B1
chr15_+_74165945 0.133 ENST00000535547.2
ENST00000300504.2
ENST00000562056.1
TBC1D21


TBC1 domain family, member 21


chr14_+_22265444 0.131 ENST00000390430.2
TRAV8-1
T cell receptor alpha variable 8-1
chr6_-_111927062 0.128 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr12_+_7941989 0.122 ENST00000229307.4
NANOG
Nanog homeobox
chr15_+_63414760 0.118 ENST00000557972.1
LACTB
lactamase, beta
chr6_-_26250835 0.117 ENST00000446824.2
HIST1H3F
histone cluster 1, H3f
chr3_-_16524357 0.115 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr12_+_53693812 0.112 ENST00000549488.1
C12orf10
chromosome 12 open reading frame 10
chr12_+_54718904 0.109 ENST00000262061.2
ENST00000549043.1
ENST00000552218.1
ENST00000553231.1
ENST00000552362.1
ENST00000455864.2
ENST00000416254.2
ENST00000549116.1
ENST00000551779.1
COPZ1








coatomer protein complex, subunit zeta 1








chr1_-_47655686 0.108 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr10_+_74451883 0.097 ENST00000373053.3
ENST00000357157.6
MCU

mitochondrial calcium uniporter

chr12_-_56321397 0.097 ENST00000557259.1
ENST00000549939.1
WIBG

within bgcn homolog (Drosophila)

chr18_-_35145728 0.088 ENST00000361795.5
ENST00000603232.1
CELF4

CUGBP, Elav-like family member 4

chr2_+_223725652 0.087 ENST00000357430.3
ENST00000392066.3
ACSL3

acyl-CoA synthetase long-chain family member 3

chr1_-_28384598 0.086 ENST00000373864.1
EYA3
eyes absent homolog 3 (Drosophila)
chr15_+_63413990 0.085 ENST00000261893.4
LACTB
lactamase, beta
chr2_-_165812028 0.084 ENST00000303735.4
SLC38A11
solute carrier family 38, member 11
chr7_-_48068671 0.076 ENST00000297325.4
SUN3
Sad1 and UNC84 domain containing 3
chr12_+_115800817 0.075 ENST00000547948.1
RP11-116D17.1
HCG2038717; Uncharacterized protein
chr2_-_165811983 0.073 ENST00000409058.1
ENST00000409149.3
SLC38A11

solute carrier family 38, member 11

chrX_+_72062802 0.068 ENST00000373533.1
DMRTC1B
DMRT-like family C1B
chr7_-_99774945 0.068 ENST00000292377.2
GPC2
glypican 2
chr1_+_12851545 0.064 ENST00000332296.7
PRAMEF1
PRAME family member 1
chr7_-_48068643 0.064 ENST00000453192.2
SUN3
Sad1 and UNC84 domain containing 3
chr12_-_118628350 0.063 ENST00000537952.1
ENST00000537822.1
TAOK3

TAO kinase 3

chrX_-_72097698 0.061 ENST00000373530.1
DMRTC1
DMRT-like family C1
chr12_-_56321649 0.055 ENST00000454792.2
ENST00000408946.2
WIBG

within bgcn homolog (Drosophila)

chr12_-_21487829 0.052 ENST00000445053.1
ENST00000452078.1
ENST00000458504.1
ENST00000422327.1
ENST00000421294.1
SLCO1A2




solute carrier organic anion transporter family, member 1A2




chr2_-_165811756 0.049 ENST00000409662.1
SLC38A11
solute carrier family 38, member 11
chr6_-_138893661 0.049 ENST00000427025.2
NHSL1
NHS-like 1
chr12_-_110937351 0.049 ENST00000552130.2
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr3_+_111393501 0.047 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr19_+_46001697 0.046 ENST00000451287.2
ENST00000324688.4
PPM1N

protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)

chr20_+_34556488 0.042 ENST00000373973.3
ENST00000349339.1
ENST00000538900.1
CNBD2


cyclic nucleotide binding domain containing 2


chr3_+_136649311 0.042 ENST00000469404.1
ENST00000467911.1
NCK1

NCK adaptor protein 1

chr2_-_14541060 0.035 ENST00000418420.1
ENST00000417751.1
LINC00276

long intergenic non-protein coding RNA 276

chrX_+_72062617 0.032 ENST00000440247.1
DMRTC1B
DMRT-like family C1B
chr3_-_196242233 0.029 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr16_-_20338748 0.027 ENST00000575582.1
ENST00000341642.5
ENST00000381362.4
ENST00000572347.1
ENST00000572478.1
ENST00000302555.5
GP2





glycoprotein 2 (zymogen granule membrane)





chr17_-_39324424 0.025 ENST00000391356.2
KRTAP4-3
keratin associated protein 4-3
chr18_-_70532906 0.024 ENST00000299430.2
ENST00000397929.1
NETO1

neuropilin (NRP) and tolloid (TLL)-like 1

chrX_-_71792477 0.023 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8








histone deacetylase 8








chr10_-_101491828 0.022 ENST00000370483.5
ENST00000016171.5
COX15

cytochrome c oxidase assembly homolog 15 (yeast)

chr15_-_85201779 0.020 ENST00000360476.3
ENST00000394588.3
NMB

neuromedin B

chr18_-_35145689 0.015 ENST00000591287.1
ENST00000601019.1
ENST00000601392.1
CELF4


CUGBP, Elav-like family member 4


chr4_-_120225600 0.011 ENST00000399075.4
C4orf3
chromosome 4 open reading frame 3
chr20_+_59654146 0.011 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr17_-_12921270 0.009 ENST00000578071.1
ENST00000426905.3
ENST00000395962.2
ENST00000583371.1
ENST00000338034.4
ELAC2




elaC ribonuclease Z 2




chr17_-_48207157 0.008 ENST00000330175.4
ENST00000503131.1
SAMD14

sterile alpha motif domain containing 14

chr3_-_150920979 0.007 ENST00000309180.5
ENST00000480322.1
GPR171

G protein-coupled receptor 171

chr18_-_35145593 0.003 ENST00000334919.5
ENST00000591282.1
ENST00000588597.1
CELF4


CUGBP, Elav-like family member 4


chr15_-_60771280 0.002 ENST00000560072.1
ENST00000560406.1
ENST00000560520.1
ENST00000261520.4
ENST00000439632.1
NARG2




NMDA receptor regulated 2





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0030035 microspike assembly(GO:0030035)
0.1 0.7 GO:2000111 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 0.2 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.7 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.0 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 1.6 GO:0070268 cornification(GO:0070268)
0.0 0.1 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.1 GO:0061700 GATOR2 complex(GO:0061700)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0042835 BRE binding(GO:0042835)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.7 REACTOME_G1_PHASE Genes involved in G1 Phase