Motif ID: DMC1

Z-value: 0.471


Transcription factors associated with DMC1:

Gene SymbolEntrez IDGene Name
DMC1 ENSG00000100206.5 DMC1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966172_38966291-0.341.0e-01Click!


Activity profile for motif DMC1.

activity profile for motif DMC1


Sorted Z-values histogram for motif DMC1

Sorted Z-values for motif DMC1



Network of associatons between targets according to the STRING database.



First level regulatory network of DMC1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_94727048 2.291 ENST00000283357.5
 FAM81B
family with sequence similarity 81, member B
chr7_+_6793740 1.761 ENST00000403107.1
ENST00000404077.1
ENST00000435395.1
ENST00000418406.1
 RSPH10B2



radial spoke head 10 homolog B2 (Chlamydomonas)



chr7_-_6010263 1.754 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
 RSPH10B



radial spoke head 10 homolog B (Chlamydomonas)



chr4_+_15471489 1.282 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
 CC2D2A








coiled-coil and C2 domain containing 2A








chr21_-_46348694 1.189 ENST00000355153.4
ENST00000397850.2
 ITGB2

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

chr10_-_62332357 0.666 ENST00000503366.1
 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_+_101785727 0.655 ENST00000263468.8
 KIAA1377
KIAA1377
chr2_+_120187465 0.600 ENST00000409826.1
ENST00000417645.1
 TMEM37

transmembrane protein 37

chr10_+_74870206 0.585 ENST00000357321.4
ENST00000349051.5
 NUDT13

nudix (nucleoside diphosphate linked moiety X)-type motif 13

chr11_+_71238313 0.539 ENST00000398536.4
 KRTAP5-7
keratin associated protein 5-7
chr10_+_74870253 0.516 ENST00000544879.1
ENST00000537969.1
ENST00000372997.3
 NUDT13


nudix (nucleoside diphosphate linked moiety X)-type motif 13


chrX_+_105855160 0.509 ENST00000372544.2
ENST00000372548.4
 CXorf57

chromosome X open reading frame 57

chr12_-_9268707 0.464 ENST00000318602.7
 A2M
alpha-2-macroglobulin
chr1_+_166958346 0.438 ENST00000367872.4
 MAEL
maelstrom spermatogenic transposon silencer
chr1_+_166958497 0.380 ENST00000367870.2
 MAEL
maelstrom spermatogenic transposon silencer
chr2_+_233497931 0.358 ENST00000264059.3
 EFHD1
EF-hand domain family, member D1
chr20_+_11008408 0.308 ENST00000378252.1
 C20orf187
chromosome 20 open reading frame 187
chr14_+_74318513 0.306 ENST00000555228.1
ENST00000555661.1
 PTGR2

prostaglandin reductase 2

chr14_+_74318611 0.306 ENST00000555976.1
ENST00000267568.4
 PTGR2

prostaglandin reductase 2

chr2_-_18741882 0.298 ENST00000381249.3
 RDH14
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chrX_+_65382433 0.289 ENST00000374727.3
 HEPH
hephaestin
chr20_-_21378666 0.258 ENST00000351817.4
 NKX2-4
NK2 homeobox 4
chr14_-_21492113 0.239 ENST00000554094.1
 NDRG2
NDRG family member 2
chr14_-_21492251 0.214 ENST00000554398.1
 NDRG2
NDRG family member 2
chr3_-_108672742 0.209 ENST00000261047.3
 GUCA1C
guanylate cyclase activator 1C
chr3_-_108672609 0.206 ENST00000393963.3
ENST00000471108.1
 GUCA1C

guanylate cyclase activator 1C

chr14_-_21491477 0.190 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
 NDRG2


NDRG family member 2


chr17_+_77018896 0.181 ENST00000578229.1
 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr17_+_77019030 0.159 ENST00000580454.1
 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr10_-_74856608 0.154 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
 P4HA1





prolyl 4-hydroxylase, alpha polypeptide I





chr4_+_106473768 0.140 ENST00000265154.2
ENST00000420470.2
 ARHGEF38

Rho guanine nucleotide exchange factor (GEF) 38

chr6_-_62996066 0.135 ENST00000281156.4
 KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr1_-_182642017 0.134 ENST00000367557.4
ENST00000258302.4
 RGS8

regulator of G-protein signaling 8

chr6_-_31670723 0.132 ENST00000440843.2
ENST00000375842.4
 ABHD16A

abhydrolase domain containing 16A

chrX_+_65382381 0.129 ENST00000519389.1
 HEPH
hephaestin
chr9_-_34729457 0.123 ENST00000378788.3
 FAM205A
family with sequence similarity 205, member A
chr6_+_80129989 0.119 ENST00000429444.1
 RP1-232L24.3
RP1-232L24.3
chr10_+_17851362 0.116 ENST00000331429.2
ENST00000457317.1
 MRC1L1

cDNA FLJ56855, highly similar to Macrophage mannose receptor 1

chr12_-_8803128 0.110 ENST00000543467.1
 MFAP5
microfibrillar associated protein 5
chr11_-_73720122 0.097 ENST00000426995.2
 UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chrX_-_134305322 0.086 ENST00000276241.6
ENST00000344129.2
 CXorf48

cancer/testis antigen 55

chr12_-_71031220 0.072 ENST00000334414.6
 PTPRB
protein tyrosine phosphatase, receptor type, B
chr1_-_47131521 0.071 ENST00000542495.1
ENST00000532925.1
 ATPAF1

ATP synthase mitochondrial F1 complex assembly factor 1

chr1_+_12290121 0.069 ENST00000358136.3
ENST00000356315.4
 VPS13D

vacuolar protein sorting 13 homolog D (S. cerevisiae)

chr10_-_98031265 0.069 ENST00000224337.5
ENST00000371176.2
 BLNK

B-cell linker

chr11_+_71846748 0.062 ENST00000445078.2
 FOLR3
folate receptor 3 (gamma)
chr12_-_71031185 0.057 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
 PTPRB


protein tyrosine phosphatase, receptor type, B


chr1_+_18958008 0.057 ENST00000420770.2
ENST00000400661.3
 PAX7

paired box 7

chr19_+_44617511 0.053 ENST00000262894.6
ENST00000588926.1
ENST00000592780.1
 ZNF225


zinc finger protein 225


chr11_+_71846764 0.052 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
 FOLR3


folate receptor 3 (gamma)


chr12_-_53901266 0.049 ENST00000609999.1
ENST00000267017.3
 NPFF

neuropeptide FF-amide peptide precursor

chr16_-_30122717 0.049 ENST00000566613.1
 GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr17_-_60142609 0.044 ENST00000397786.2
 MED13
mediator complex subunit 13
chr15_-_49103235 0.043 ENST00000380950.2
 CEP152
centrosomal protein 152kDa
chr10_-_98031310 0.042 ENST00000427367.2
ENST00000413476.2
 BLNK

B-cell linker

chr11_-_73720276 0.038 ENST00000348534.4
 UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr17_+_4846101 0.033 ENST00000576965.1
 RNF167
ring finger protein 167
chr5_-_82969405 0.033 ENST00000510978.1
 HAPLN1
hyaluronan and proteoglycan link protein 1
chr6_+_26383318 0.027 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
 BTN2A2








butyrophilin, subfamily 2, member A2








chr1_-_11863571 0.022 ENST00000376583.3
 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr8_-_101734907 0.022 ENST00000318607.5
ENST00000521865.1
ENST00000520804.1
ENST00000522720.1
ENST00000521067.1
 PABPC1




poly(A) binding protein, cytoplasmic 1




chr5_+_55149356 0.021 ENST00000490985.1
ENST00000354961.4
 IL31RA

interleukin 31 receptor A

chr12_-_50677255 0.017 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
 LIMA1


LIM domain and actin binding 1


chr19_-_42947121 0.015 ENST00000601181.1
 CXCL17
chemokine (C-X-C motif) ligand 17
chr10_-_104597286 0.013 ENST00000369887.3
 CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr6_+_88054530 0.011 ENST00000388923.4
 C6orf163
chromosome 6 open reading frame 163
chr2_-_21022818 0.007 ENST00000440866.2
ENST00000541941.1
ENST00000402479.2
ENST00000435420.2
ENST00000432947.1
ENST00000403006.2
ENST00000419825.2
ENST00000381090.3
ENST00000237822.3
ENST00000412261.1
 C2orf43









chromosome 2 open reading frame 43









chr10_+_62538248 0.003 ENST00000448257.2
 CDK1
cyclin-dependent kinase 1
chr7_+_47694842 0.002 ENST00000408988.2
 C7orf65
chromosome 7 open reading frame 65

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.2 0.7 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.3 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 1.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.6 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.8 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.4 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 1.1 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.0 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0030849 autosome(GO:0030849)
0.1 1.0 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.1 1.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0019959 interleukin-8 binding(GO:0019959)
0.1 1.0 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.1 0.6 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.4 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.4 PID_CONE_PATHWAY Visual signal transduction: Cones

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins