Motif ID: HESX1
Z-value: 0.825
Transcription factors associated with HESX1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
HESX1 | ENSG00000163666.4 | HESX1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
HESX1 | hg19_v2_chr3_-_57233966_57234014 | -0.59 | 2.2e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.2 | GO:0036353 | histone H2A-K119 monoubiquitination(GO:0036353) |
0.4 | 1.5 | GO:1901895 | negative regulation of calcium-transporting ATPase activity(GO:1901895) |
0.3 | 1.1 | GO:0034445 | regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) phenylpropanoid catabolic process(GO:0046271) |
0.2 | 0.7 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
0.2 | 1.3 | GO:0050428 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
0.2 | 0.9 | GO:0061055 | myotome development(GO:0061055) |
0.2 | 0.6 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
0.1 | 1.0 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
0.1 | 1.1 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
0.1 | 0.2 | GO:0043385 | mycotoxin metabolic process(GO:0043385) aflatoxin metabolic process(GO:0046222) organic heteropentacyclic compound metabolic process(GO:1901376) |
0.1 | 2.0 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
0.1 | 1.7 | GO:0045792 | negative regulation of cell size(GO:0045792) |
0.1 | 1.0 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
0.1 | 0.4 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
0.1 | 0.9 | GO:0009249 | protein lipoylation(GO:0009249) |
0.1 | 0.9 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
0.1 | 0.2 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
0.1 | 0.5 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
0.1 | 5.5 | GO:0021795 | cerebral cortex cell migration(GO:0021795) |
0.1 | 1.3 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
0.1 | 0.2 | GO:0010847 | regulation of chromatin assembly(GO:0010847) negative regulation of protein import into nucleus, translocation(GO:0033159) protein auto-ADP-ribosylation(GO:0070213) |
0.1 | 0.4 | GO:0019626 | short-chain fatty acid catabolic process(GO:0019626) |
0.1 | 1.3 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
0.1 | 0.6 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
0.1 | 0.7 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
0.1 | 1.1 | GO:0015671 | oxygen transport(GO:0015671) |
0.1 | 0.4 | GO:0021678 | third ventricle development(GO:0021678) |
0.1 | 0.3 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) |
0.1 | 0.2 | GO:0042823 | pyridoxal phosphate biosynthetic process(GO:0042823) |
0.1 | 0.2 | GO:0051102 | DNA ligation involved in DNA recombination(GO:0051102) |
0.0 | 0.3 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
0.0 | 0.3 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
0.0 | 0.2 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
0.0 | 2.7 | GO:0035082 | axoneme assembly(GO:0035082) |
0.0 | 0.3 | GO:0006540 | glutamate decarboxylation to succinate(GO:0006540) |
0.0 | 0.1 | GO:0019853 | L-ascorbic acid biosynthetic process(GO:0019853) |
0.0 | 0.1 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
0.0 | 0.3 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
0.0 | 0.4 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
0.0 | 0.7 | GO:0097503 | sialylation(GO:0097503) |
0.0 | 0.1 | GO:0007060 | male meiosis chromosome segregation(GO:0007060) |
0.0 | 0.2 | GO:0034088 | maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088) |
0.0 | 0.9 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
0.0 | 0.1 | GO:0050893 | sensory processing(GO:0050893) |
0.0 | 0.8 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
0.0 | 0.2 | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
0.0 | 1.8 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
0.0 | 0.1 | GO:0036343 | psychomotor behavior(GO:0036343) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) |
0.0 | 0.2 | GO:0006983 | ER overload response(GO:0006983) |
0.0 | 0.1 | GO:0015853 | adenine transport(GO:0015853) |
0.0 | 0.4 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
0.0 | 0.2 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
0.0 | 0.4 | GO:0016246 | RNA interference(GO:0016246) |
0.0 | 0.5 | GO:0021522 | spinal cord motor neuron differentiation(GO:0021522) |
0.0 | 0.6 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
0.0 | 0.2 | GO:0000478 | endonucleolytic cleavage involved in rRNA processing(GO:0000478) |
0.0 | 1.8 | GO:0070268 | cornification(GO:0070268) |
0.0 | 0.3 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.0 | 0.5 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
0.0 | 0.4 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.7 | GO:0001534 | radial spoke(GO:0001534) |
0.2 | 2.0 | GO:0097433 | dense body(GO:0097433) |
0.2 | 1.5 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
0.1 | 0.9 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
0.1 | 0.5 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
0.1 | 1.0 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
0.1 | 0.7 | GO:1990635 | proximal dendrite(GO:1990635) |
0.1 | 1.2 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
0.1 | 1.1 | GO:0005833 | hemoglobin complex(GO:0005833) |
0.1 | 1.1 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
0.0 | 1.7 | GO:0030057 | desmosome(GO:0030057) |
0.0 | 5.6 | GO:0072686 | mitotic spindle(GO:0072686) |
0.0 | 0.4 | GO:0061689 | tricellular tight junction(GO:0061689) |
0.0 | 0.5 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
0.0 | 1.2 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.0 | 1.1 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.0 | 0.7 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.0 | 0.2 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
0.0 | 0.2 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807) |
0.0 | 0.3 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
0.0 | 1.0 | GO:0016592 | mediator complex(GO:0016592) |
0.0 | 0.4 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
0.0 | 0.6 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
0.0 | 0.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.0 | 0.3 | GO:0061200 | clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202) |
0.0 | 1.7 | GO:0005902 | microvillus(GO:0005902) |
0.0 | 0.2 | GO:0000439 | core TFIIH complex(GO:0000439) |
0.0 | 0.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 0.2 | GO:0072546 | ER membrane protein complex(GO:0072546) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.1 | GO:0102007 | lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007) |
0.2 | 2.0 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
0.2 | 0.5 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
0.1 | 0.7 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
0.1 | 1.3 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
0.1 | 0.3 | GO:0005174 | CD40 receptor binding(GO:0005174) |
0.1 | 1.3 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
0.1 | 0.4 | GO:0050253 | retinyl-palmitate esterase activity(GO:0050253) |
0.1 | 0.5 | GO:0034511 | U3 snoRNA binding(GO:0034511) |
0.1 | 0.4 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
0.1 | 1.1 | GO:0005344 | oxygen transporter activity(GO:0005344) |
0.1 | 2.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
0.1 | 0.9 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.1 | 1.1 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
0.0 | 0.1 | GO:0017129 | triglyceride binding(GO:0017129) |
0.0 | 0.4 | GO:0004075 | biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374) |
0.0 | 1.2 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.0 | 0.3 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
0.0 | 0.1 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
0.0 | 0.4 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
0.0 | 0.2 | GO:0032564 | adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564) |
0.0 | 0.3 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
0.0 | 0.1 | GO:0005471 | ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207) |
0.0 | 0.1 | GO:0030627 | pre-mRNA 5'-splice site binding(GO:0030627) |
0.0 | 1.2 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.0 | 0.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
0.0 | 0.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 0.7 | GO:0030506 | ankyrin binding(GO:0030506) |
0.0 | 1.3 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 1.3 | GO:0001221 | transcription cofactor binding(GO:0001221) |
0.0 | 6.3 | GO:0008022 | protein C-terminus binding(GO:0008022) |
0.0 | 0.5 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
0.0 | 0.3 | GO:1903136 | cuprous ion binding(GO:1903136) |
0.0 | 0.3 | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) |
0.0 | 0.1 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
0.0 | 1.0 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
0.0 | 0.1 | GO:0002046 | opsin binding(GO:0002046) |
0.0 | 0.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
0.0 | 0.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 0.9 | GO:0001012 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012) |
0.0 | 0.2 | GO:0010181 | FMN binding(GO:0010181) |
0.0 | 0.2 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
0.0 | 0.3 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
0.0 | 0.0 | GO:0005275 | amine transmembrane transporter activity(GO:0005275) |
0.0 | 0.2 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
0.0 | 0.5 | GO:0030332 | cyclin binding(GO:0030332) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.5 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
0.0 | 0.4 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.0 | 1.3 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.0 | 1.4 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
0.0 | 0.9 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
0.0 | 0.3 | PID_CD40_PATHWAY | CD40/CD40L signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.8 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.0 | 0.4 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
0.0 | 1.4 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.0 | 0.4 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
0.0 | 0.3 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
0.0 | 0.5 | REACTOME_REGULATION_OF_IFNA_SIGNALING | Genes involved in Regulation of IFNA signaling |
0.0 | 0.4 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
0.0 | 0.3 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |