Motif ID: HMX1

Z-value: 0.599


Transcription factors associated with HMX1:

Gene SymbolEntrez IDGene Name
HMX1 ENSG00000215612.5 HMX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HMX1hg19_v2_chr4_-_8873531_88735430.301.6e-01Click!


Activity profile for motif HMX1.

activity profile for motif HMX1


Sorted Z-values histogram for motif HMX1

Sorted Z-values for motif HMX1



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_21494654 1.576 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr2_+_106682103 1.380 ENST00000238044.3
C2orf40
chromosome 2 open reading frame 40
chr2_+_106682135 1.188 ENST00000437659.1
C2orf40
chromosome 2 open reading frame 40
chr16_-_776431 1.042 ENST00000293889.6
CCDC78
coiled-coil domain containing 78
chr1_-_46598371 0.909 ENST00000372006.1
ENST00000425892.1
ENST00000420542.1
ENST00000354242.4
ENST00000340332.6
PIK3R3




phosphoinositide-3-kinase, regulatory subunit 3 (gamma)




chr1_-_46598284 0.874 ENST00000423209.1
ENST00000262741.5
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr20_+_44098346 0.849 ENST00000372676.3
WFDC2
WAP four-disulfide core domain 2
chr13_+_25254545 0.807 ENST00000218548.6
ATP12A
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr18_-_45935663 0.766 ENST00000589194.1
ENST00000591279.1
ENST00000590855.1
ENST00000587107.1
ENST00000588970.1
ENST00000586525.1
ENST00000592387.1
ENST00000590800.1
ZBTB7C







zinc finger and BTB domain containing 7C







chr5_+_156693159 0.765 ENST00000347377.6
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr5_+_156693091 0.741 ENST00000318218.6
ENST00000442283.2
ENST00000522463.1
ENST00000521420.1
CYFIP2



cytoplasmic FMR1 interacting protein 2



chr13_+_35516390 0.693 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
NBEA


neurobeachin


chr19_-_14316980 0.674 ENST00000361434.3
ENST00000340736.6
LPHN1

latrophilin 1

chr16_-_70712229 0.659 ENST00000562883.2
MTSS1L
metastasis suppressor 1-like
chr3_+_69788576 0.657 ENST00000352241.4
ENST00000448226.2
MITF

microphthalmia-associated transcription factor

chr3_-_107941209 0.640 ENST00000492106.1
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr22_-_29196030 0.604 ENST00000405219.3
XBP1
X-box binding protein 1
chr2_-_27712583 0.572 ENST00000260570.3
ENST00000359466.6
ENST00000416524.2
IFT172


intraflagellar transport 172 homolog (Chlamydomonas)


chr13_+_25254693 0.570 ENST00000381946.3
ATP12A
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr22_-_29196546 0.536 ENST00000403532.3
ENST00000216037.6
XBP1

X-box binding protein 1

chr22_-_18923655 0.535 ENST00000438924.1
ENST00000457083.1
ENST00000420436.1
ENST00000334029.2
ENST00000357068.6
PRODH




proline dehydrogenase (oxidase) 1




chr17_-_72709050 0.503 ENST00000583937.1
ENST00000301573.9
ENST00000326165.6
ENST00000469092.1
CD300LF



CD300 molecule-like family member f



chr14_+_56585048 0.497 ENST00000267460.4
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr20_+_44098385 0.482 ENST00000217425.5
ENST00000339946.3
WFDC2

WAP four-disulfide core domain 2

chr1_-_177133818 0.452 ENST00000424564.2
ENST00000361833.2
ASTN1

astrotactin 1

chr11_+_1411503 0.447 ENST00000526678.1
BRSK2
BR serine/threonine kinase 2
chr8_-_17270809 0.443 ENST00000180173.5
ENST00000521857.1
MTMR7

myotubularin related protein 7

chr1_-_110052302 0.440 ENST00000369864.4
ENST00000369862.1
AMIGO1

adhesion molecule with Ig-like domain 1

chr2_-_46769694 0.433 ENST00000522587.1
ATP6V1E2
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr11_-_110561721 0.423 ENST00000357139.3
ARHGAP20
Rho GTPase activating protein 20
chr19_+_41305330 0.421 ENST00000593972.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr16_+_28996364 0.417 ENST00000564277.1
LAT
linker for activation of T cells
chr17_-_6947225 0.416 ENST00000574600.1
ENST00000308009.1
ENST00000447225.1
SLC16A11


solute carrier family 16, member 11


chr5_-_81046922 0.400 ENST00000514493.1
ENST00000320672.4
SSBP2

single-stranded DNA binding protein 2

chr16_+_56385290 0.399 ENST00000564727.1
GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr19_+_41305627 0.396 ENST00000593525.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr16_+_30212378 0.396 ENST00000569485.1
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr19_+_41305740 0.385 ENST00000596517.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr19_+_38085731 0.385 ENST00000589117.1
ZNF540
zinc finger protein 540
chr16_+_30210552 0.385 ENST00000338971.5
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr19_+_41305612 0.382 ENST00000594380.1
ENST00000593397.1
ENST00000601733.1
EGLN2


egl-9 family hypoxia-inducible factor 2


chr17_-_72968809 0.376 ENST00000530857.1
ENST00000425042.2
HID1

HID1 domain containing

chr12_+_8234807 0.372 ENST00000339754.5
NECAP1
NECAP endocytosis associated 1
chr16_+_11038403 0.363 ENST00000409552.3
CLEC16A
C-type lectin domain family 16, member A
chr3_-_107941230 0.361 ENST00000264538.3
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr12_-_15374343 0.360 ENST00000256953.2
ENST00000546331.1
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr1_+_9648921 0.357 ENST00000377376.4
ENST00000340305.5
ENST00000340381.6
TMEM201


transmembrane protein 201


chr11_+_6502675 0.354 ENST00000254616.6
ENST00000530751.1
TIMM10B

translocase of inner mitochondrial membrane 10 homolog B (yeast)

chr19_+_41305085 0.353 ENST00000303961.4
EGLN2
egl-9 family hypoxia-inducible factor 2
chr4_-_122854193 0.352 ENST00000513531.1
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr9_+_976964 0.352 ENST00000190165.2
DMRT3
doublesex and mab-3 related transcription factor 3
chr12_+_41831485 0.342 ENST00000539469.2
ENST00000298919.7
PDZRN4

PDZ domain containing ring finger 4

chr19_+_41305406 0.336 ENST00000406058.2
ENST00000593726.1
EGLN2

egl-9 family hypoxia-inducible factor 2

chr7_-_37488834 0.334 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr2_-_233352531 0.334 ENST00000304546.1
ECEL1
endothelin converting enzyme-like 1
chr20_-_3140490 0.327 ENST00000449731.1
ENST00000380266.3
UBOX5
FASTKD5
U-box domain containing 5
FAST kinase domains 5
chr1_+_156338993 0.326 ENST00000368249.1
ENST00000368246.2
ENST00000537040.1
ENST00000400992.2
ENST00000255013.3
ENST00000451864.2
RHBG





Rh family, B glycoprotein (gene/pseudogene)





chr2_+_204801471 0.322 ENST00000316386.6
ENST00000435193.1
ICOS

inducible T-cell co-stimulator

chr7_-_105332084 0.321 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr15_-_58306295 0.317 ENST00000559517.1
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr17_-_47755436 0.316 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
SPOP






speckle-type POZ protein






chr7_-_19184929 0.310 ENST00000275461.3
FERD3L
Fer3-like bHLH transcription factor
chr20_-_41818373 0.308 ENST00000373187.1
ENST00000356100.2
ENST00000373184.1
ENST00000373190.1
PTPRT



protein tyrosine phosphatase, receptor type, T



chr16_+_29472707 0.304 ENST00000565290.1
SULT1A4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
chr13_-_97646604 0.302 ENST00000298440.1
ENST00000543457.1
ENST00000541038.1
OXGR1


oxoglutarate (alpha-ketoglutarate) receptor 1


chr3_-_192445289 0.298 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
FGF12



fibroblast growth factor 12



chr15_+_89346657 0.286 ENST00000439576.2
ACAN
aggrecan
chr4_-_141348789 0.286 ENST00000414773.1
CLGN
calmegin
chr9_-_140082983 0.283 ENST00000323927.2
ANAPC2
anaphase promoting complex subunit 2
chr22_-_39268192 0.280 ENST00000216083.6
CBX6
chromobox homolog 6
chr16_-_49315731 0.279 ENST00000219197.6
CBLN1
cerebellin 1 precursor
chr5_-_81046904 0.277 ENST00000515395.1
SSBP2
single-stranded DNA binding protein 2
chr20_-_41818536 0.275 ENST00000373193.3
ENST00000373198.4
ENST00000373201.1
PTPRT


protein tyrosine phosphatase, receptor type, T


chr5_-_81046841 0.274 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
SSBP2


single-stranded DNA binding protein 2


chr17_-_27278304 0.268 ENST00000577226.1
PHF12
PHD finger protein 12
chr5_+_10353780 0.267 ENST00000449913.2
ENST00000503788.1
ENST00000274140.5
MARCH6


membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase


chr4_-_141348999 0.265 ENST00000325617.5
CLGN
calmegin
chr10_-_99531709 0.264 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr8_-_26724784 0.262 ENST00000380573.3
ADRA1A
adrenoceptor alpha 1A
chr1_-_217311090 0.258 ENST00000493603.1
ENST00000366940.2
ESRRG

estrogen-related receptor gamma

chr3_+_127391769 0.258 ENST00000393363.3
ENST00000232744.8
ENST00000453791.2
ABTB1


ankyrin repeat and BTB (POZ) domain containing 1


chr19_-_45579762 0.256 ENST00000303809.2
ZNF296
zinc finger protein 296
chrX_+_13587712 0.247 ENST00000361306.1
ENST00000380602.3
EGFL6

EGF-like-domain, multiple 6

chr8_+_145726472 0.241 ENST00000528430.1
PPP1R16A
protein phosphatase 1, regulatory subunit 16A
chr16_-_70713928 0.237 ENST00000576338.1
MTSS1L
metastasis suppressor 1-like
chr18_-_47721447 0.233 ENST00000285039.7
MYO5B
myosin VB
chr15_+_33010175 0.230 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1


gremlin 1, DAN family BMP antagonist


chr6_+_33043703 0.230 ENST00000418931.2
ENST00000535465.1
HLA-DPB1

major histocompatibility complex, class II, DP beta 1

chr2_-_24583314 0.230 ENST00000443927.1
ENST00000406921.3
ENST00000412011.1
ITSN2


intersectin 2


chr1_-_207095324 0.230 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3


Fas apoptotic inhibitory molecule 3


chr17_+_40440481 0.228 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
STAT5A



signal transducer and activator of transcription 5A



chr9_+_100000717 0.227 ENST00000375205.2
ENST00000357054.1
ENST00000395220.1
ENST00000375202.2
ENST00000411667.2
CCDC180




coiled-coil domain containing 180




chr2_-_220435963 0.224 ENST00000373876.1
ENST00000404537.1
ENST00000603926.1
ENST00000373873.4
ENST00000289656.3
OBSL1




obscurin-like 1




chr1_-_28241226 0.222 ENST00000373912.3
ENST00000373909.3
RPA2

replication protein A2, 32kDa

chr12_-_55378452 0.221 ENST00000449076.1
TESPA1
thymocyte expressed, positive selection associated 1
chr5_+_141016508 0.217 ENST00000444782.1
ENST00000521367.1
ENST00000297164.3
RELL2


RELT-like 2


chr15_+_89346699 0.212 ENST00000558207.1
ACAN
aggrecan
chr15_-_90198659 0.211 ENST00000394412.3
KIF7
kinesin family member 7
chr5_+_141016969 0.210 ENST00000518856.1
RELL2
RELT-like 2
chr3_-_156534754 0.210 ENST00000472943.1
ENST00000473352.1
LINC00886

long intergenic non-protein coding RNA 886

chr16_+_28996416 0.208 ENST00000395456.2
ENST00000454369.2
LAT

linker for activation of T cells

chr16_+_67226019 0.203 ENST00000379378.3
E2F4
E2F transcription factor 4, p107/p130-binding
chr8_-_75233563 0.203 ENST00000342232.4
JPH1
junctophilin 1
chr1_-_207095212 0.203 ENST00000420007.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr15_+_24920541 0.202 ENST00000329468.2
NPAP1
nuclear pore associated protein 1
chr16_-_20753114 0.190 ENST00000396083.2
THUMPD1
THUMP domain containing 1
chr6_-_2245892 0.189 ENST00000380815.4
GMDS
GDP-mannose 4,6-dehydratase
chr7_-_127032363 0.189 ENST00000393312.1
ZNF800
zinc finger protein 800
chr11_+_43702322 0.187 ENST00000395700.4
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12
chr6_-_10882174 0.187 ENST00000379491.4
GCM2
glial cells missing homolog 2 (Drosophila)
chr2_-_220436248 0.184 ENST00000265318.4
OBSL1
obscurin-like 1
chr1_-_28241024 0.183 ENST00000313433.7
ENST00000444045.1
RPA2

replication protein A2, 32kDa

chr7_-_156685841 0.182 ENST00000354505.4
ENST00000540390.1
LMBR1

limb development membrane protein 1

chr22_-_38349552 0.182 ENST00000422191.1
ENST00000249079.2
ENST00000418863.1
ENST00000403305.1
ENST00000403026.1
C22orf23




chromosome 22 open reading frame 23




chr19_+_41313017 0.181 ENST00000595621.1
ENST00000595051.1
EGLN2

egl-9 family hypoxia-inducible factor 2

chr4_-_151936865 0.179 ENST00000535741.1
LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr14_+_63671577 0.178 ENST00000555125.1
RHOJ
ras homolog family member J
chr7_-_16844611 0.177 ENST00000401412.1
ENST00000419304.2
AGR2

anterior gradient 2

chr2_+_46769798 0.177 ENST00000238738.4
RHOQ
ras homolog family member Q
chr12_+_70133152 0.176 ENST00000550536.1
ENST00000362025.5
RAB3IP

RAB3A interacting protein

chr7_-_150675372 0.175 ENST00000262186.5
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr17_-_62097904 0.173 ENST00000583366.1
ICAM2
intercellular adhesion molecule 2
chr4_+_86396265 0.173 ENST00000395184.1
ARHGAP24
Rho GTPase activating protein 24
chr20_-_22559211 0.173 ENST00000564492.1
LINC00261
long intergenic non-protein coding RNA 261
chr18_+_63418068 0.171 ENST00000397968.2
CDH7
cadherin 7, type 2
chr8_+_38854368 0.171 ENST00000466936.1
ADAM9
ADAM metallopeptidase domain 9
chr11_+_61129456 0.169 ENST00000278826.6
TMEM138
transmembrane protein 138
chr15_+_89402148 0.167 ENST00000560601.1
ACAN
aggrecan
chr22_-_39268308 0.166 ENST00000407418.3
CBX6
chromobox homolog 6
chr13_-_84456527 0.165 ENST00000377084.2
SLITRK1
SLIT and NTRK-like family, member 1
chr20_-_35374456 0.162 ENST00000373803.2
ENST00000359675.2
ENST00000540765.1
ENST00000349004.1
NDRG3



NDRG family member 3



chr2_-_175462934 0.157 ENST00000392546.2
ENST00000436221.1
WIPF1

WAS/WASL interacting protein family, member 1

chr6_+_2245982 0.157 ENST00000530346.1
ENST00000524770.1
ENST00000532124.1
ENST00000531092.1
ENST00000456943.2
ENST00000529893.1
GMDS-AS1





GMDS antisense RNA 1 (head to head)





chr20_+_60813535 0.153 ENST00000358053.2
ENST00000313733.3
ENST00000439951.2
OSBPL2


oxysterol binding protein-like 2


chr15_-_41166414 0.151 ENST00000220507.4
RHOV
ras homolog family member V
chr6_+_2246023 0.149 ENST00000530833.1
ENST00000525811.1
ENST00000534441.1
ENST00000533653.1
ENST00000534468.1
GMDS-AS1




GMDS antisense RNA 1 (head to head)




chr21_-_40685504 0.149 ENST00000380800.3
BRWD1
bromodomain and WD repeat domain containing 1
chr8_+_121137333 0.148 ENST00000309791.4
ENST00000297848.3
ENST00000247781.3
COL14A1


collagen, type XIV, alpha 1


chr16_+_19535235 0.148 ENST00000565376.2
ENST00000396208.2
CCP110

centriolar coiled coil protein 110kDa

chr16_+_19535133 0.146 ENST00000396212.2
ENST00000381396.5
CCP110

centriolar coiled coil protein 110kDa

chr19_+_38085768 0.142 ENST00000316433.4
ENST00000590588.1
ENST00000586134.1
ENST00000586792.1
ZNF540



zinc finger protein 540



chr8_+_145438870 0.141 ENST00000527931.1
FAM203B
family with sequence similarity 203, member B
chr7_-_132261223 0.140 ENST00000423507.2
PLXNA4
plexin A4
chr21_-_40685477 0.140 ENST00000342449.3
BRWD1
bromodomain and WD repeat domain containing 1
chr6_-_89927151 0.138 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr1_-_25256368 0.136 ENST00000308873.6
RUNX3
runt-related transcription factor 3
chr13_-_38443860 0.136 ENST00000426868.2
ENST00000379681.3
ENST00000338947.5
ENST00000355779.2
ENST00000358477.2
ENST00000379673.2
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr1_-_197744322 0.134 ENST00000235453.4
DENND1B
DENN/MADD domain containing 1B
chr3_-_18466787 0.134 ENST00000338745.6
ENST00000450898.1
SATB1

SATB homeobox 1

chr12_+_100867694 0.134 ENST00000392986.3
ENST00000549996.1
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr1_+_160336851 0.133 ENST00000302101.5
NHLH1
nescient helix loop helix 1
chr14_+_58666824 0.132 ENST00000254286.4
ACTR10
actin-related protein 10 homolog (S. cerevisiae)
chr1_-_167059830 0.132 ENST00000367868.3
GPA33
glycoprotein A33 (transmembrane)
chr19_+_496454 0.131 ENST00000346144.4
ENST00000215637.3
ENST00000382683.4
MADCAM1


mucosal vascular addressin cell adhesion molecule 1


chr13_-_76111945 0.129 ENST00000355801.4
ENST00000406936.3
COMMD6

COMM domain containing 6

chr5_-_24645078 0.129 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr11_+_66624527 0.128 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chrX_+_22050546 0.127 ENST00000379374.4
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr1_-_197744390 0.127 ENST00000367396.3
DENND1B
DENN/MADD domain containing 1B
chr1_+_202431859 0.126 ENST00000391959.3
ENST00000367270.4
PPP1R12B

protein phosphatase 1, regulatory subunit 12B

chr9_+_137967268 0.124 ENST00000371799.4
ENST00000277415.11
OLFM1

olfactomedin 1

chr16_+_28996572 0.124 ENST00000360872.5
ENST00000566177.1
ENST00000354453.4
LAT


linker for activation of T cells


chr5_+_139027877 0.123 ENST00000302517.3
CXXC5
CXXC finger protein 5
chr17_-_8151353 0.119 ENST00000315684.8
CTC1
CTS telomere maintenance complex component 1
chr12_+_7060432 0.119 ENST00000318974.9
ENST00000456013.1
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr3_-_67705006 0.118 ENST00000492795.1
ENST00000493112.1
ENST00000307227.5
SUCLG2


succinate-CoA ligase, GDP-forming, beta subunit


chrX_+_53123314 0.118 ENST00000605526.1
ENST00000604062.1
ENST00000604369.1
ENST00000366185.2
ENST00000604849.1
RP11-258C19.5




long intergenic non-protein coding RNA 1155




chr3_+_49711777 0.118 ENST00000442186.1
ENST00000438011.1
ENST00000457042.1
APEH


acylaminoacyl-peptide hydrolase


chr17_-_41132010 0.117 ENST00000409103.1
ENST00000360221.4
PTGES3L-AARSD1

PTGES3L-AARSD1 readthrough

chr17_-_42298201 0.116 ENST00000527034.1
UBTF
upstream binding transcription factor, RNA polymerase I
chr18_-_56940611 0.114 ENST00000256852.7
ENST00000334889.3
RAX

retina and anterior neural fold homeobox

chrX_-_71933888 0.113 ENST00000373542.4
ENST00000339490.3
ENST00000541944.1
ENST00000373539.3
ENST00000373545.3
PHKA1




phosphorylase kinase, alpha 1 (muscle)




chr17_+_42836329 0.112 ENST00000200557.6
ADAM11
ADAM metallopeptidase domain 11
chr16_+_29984962 0.111 ENST00000308893.4
TAOK2
TAO kinase 2
chr11_-_76155700 0.109 ENST00000572035.1
RP11-111M22.3
RP11-111M22.3
chr19_-_38085633 0.108 ENST00000593133.1
ENST00000590751.1
ENST00000358744.3
ENST00000328550.2
ENST00000451802.2
ZNF571




zinc finger protein 571




chr8_+_120428546 0.108 ENST00000259526.3
NOV
nephroblastoma overexpressed
chr1_-_54405773 0.107 ENST00000371376.1
HSPB11
heat shock protein family B (small), member 11
chr1_-_24194771 0.105 ENST00000374479.3
FUCA1
fucosidase, alpha-L- 1, tissue
chr14_-_101034407 0.105 ENST00000443071.2
ENST00000557378.1
BEGAIN

brain-enriched guanylate kinase-associated

chr2_-_219925189 0.104 ENST00000295731.6
IHH
indian hedgehog
chr22_-_24093267 0.104 ENST00000341976.3
ZNF70
zinc finger protein 70
chr20_+_30640004 0.103 ENST00000520553.1
ENST00000518730.1
ENST00000375852.2
HCK


hemopoietic cell kinase


chr3_-_13461807 0.103 ENST00000254508.5
NUP210
nucleoporin 210kDa
chr4_-_151936416 0.102 ENST00000510413.1
ENST00000507224.1
LRBA

LPS-responsive vesicle trafficking, beach and anchor containing

chr17_+_79679299 0.101 ENST00000331531.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr19_-_18385221 0.101 ENST00000595654.2
ENST00000593659.1
ENST00000599528.1
KIAA1683


KIAA1683


chr12_+_125478241 0.100 ENST00000341446.8
BRI3BP
BRI3 binding protein
chr1_-_31196427 0.098 ENST00000373765.4
MATN1
matrilin 1, cartilage matrix protein
chr14_+_23776167 0.096 ENST00000554635.1
ENST00000557008.1
BCL2L2
BCL2L2-PABPN1
BCL2-like 2
BCL2L2-PABPN1 readthrough
chr4_-_74486109 0.096 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr14_+_105781048 0.096 ENST00000458164.2
ENST00000447393.1
PACS2

phosphofurin acidic cluster sorting protein 2

chr17_+_41132564 0.096 ENST00000361677.1
ENST00000589705.1
RUNDC1

RUN domain containing 1

chr3_+_39093481 0.096 ENST00000302313.5
ENST00000544962.1
ENST00000396258.3
ENST00000418020.1
WDR48



WD repeat domain 48



chr16_-_18937726 0.095 ENST00000389467.3
ENST00000446231.2
SMG1

SMG1 phosphatidylinositol 3-kinase-related kinase

chr17_-_27278445 0.093 ENST00000268756.3
ENST00000584685.1
PHF12

PHD finger protein 12

chr1_-_85930246 0.093 ENST00000426972.3
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr14_-_103523745 0.092 ENST00000361246.2
CDC42BPB
CDC42 binding protein kinase beta (DMPK-like)
chr9_-_130616915 0.092 ENST00000344849.3
ENG
endoglin
chr7_-_156803329 0.092 ENST00000252971.6
MNX1
motor neuron and pancreas homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.4 1.1 GO:0035470 positive regulation of vascular wound healing(GO:0035470) regulation of lactation(GO:1903487)
0.2 2.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.2 0.5 GO:1902214 negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125) regulation of interleukin-4-mediated signaling pathway(GO:1902214)
0.2 2.6 GO:0070314 G1 to G0 transition(GO:0070314)
0.1 1.0 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 1.4 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.8 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.1 0.3 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.1 0.5 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.1 0.1 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 0.3 GO:0001983 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.1 0.2 GO:1900158 negative regulation of osteoclast proliferation(GO:0090291) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 0.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 0.3 GO:0032053 ciliary basal body organization(GO:0032053)
0.1 0.4 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.3 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 0.2 GO:0015729 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.1 0.2 GO:0042351 'de novo' GDP-L-fucose biosynthetic process(GO:0042351)
0.1 0.4 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.2 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.1 0.2 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
0.1 1.4 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.1 0.6 GO:0061525 hindgut development(GO:0061525)
0.1 0.2 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 0.3 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.1 0.2 GO:0001300 chronological cell aging(GO:0001300)
0.1 0.2 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.8 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 1.7 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 0.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.1 GO:0021793 chemorepulsion of branchiomotor axon(GO:0021793)
0.0 0.4 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.0 0.3 GO:0033504 floor plate development(GO:0033504)
0.0 1.2 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.2 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.3 GO:0035799 ureter maturation(GO:0035799)
0.0 0.1 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.0 0.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.1 GO:1990418 response to insulin-like growth factor stimulus(GO:1990418)
0.0 0.2 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.1 GO:0034239 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.0 0.2 GO:0032439 endosome localization(GO:0032439)
0.0 0.1 GO:0090027 negative regulation of monocyte chemotaxis(GO:0090027)
0.0 0.3 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.4 GO:1904152 regulation of retrograde protein transport, ER to cytosol(GO:1904152)
0.0 0.1 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.1 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.0 0.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.3 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.3 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.2 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.3 GO:0002517 T cell tolerance induction(GO:0002517)
0.0 0.3 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.0 0.2 GO:0003190 atrioventricular valve formation(GO:0003190)
0.0 0.0 GO:0080154 regulation of fertilization(GO:0080154)
0.0 0.5 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.4 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.7 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.1 GO:0003418 growth plate cartilage chondrocyte differentiation(GO:0003418)
0.0 0.0 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.0 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.1 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.0 0.7 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.4 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991) phagosome acidification(GO:0090383) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.2 1.0 GO:0098536 deuterosome(GO:0098536)
0.2 0.6 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.1 0.4 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 1.0 GO:0044292 dendrite terminus(GO:0044292)
0.1 1.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.4 GO:1990393 3M complex(GO:1990393)
0.1 0.2 GO:0072563 endothelial microparticle(GO:0072563)
0.0 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.3 GO:0000835 ER ubiquitin ligase complex(GO:0000835)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.7 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.4 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.4 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.2 1.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.2 2.5 GO:0019826 oxygen sensor activity(GO:0019826)
0.2 0.5 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.2 1.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.5 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.8 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.1 0.3 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 0.6 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.2 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.1 0.4 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 0.2 GO:0032427 GBD domain binding(GO:0032427)
0.0 0.1 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.0 0.5 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.1 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.1 GO:0005330 dopamine:sodium symporter activity(GO:0005330)
0.0 0.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.4 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.2 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.1 GO:0015928 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.0 0.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.5 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.4 GO:0036122 BMP binding(GO:0036122)
0.0 0.3 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.4 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.4 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 1.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.1 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.5 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 1.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.0 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.1 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.0 0.5 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.4 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline