Motif ID: ISL1
Z-value: 0.494
Transcription factors associated with ISL1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
ISL1 | ENSG00000016082.10 | ISL1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
ISL1 | hg19_v2_chr5_+_50678921_50678921 | -0.20 | 3.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.3 | GO:0002644 | negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
0.1 | 0.3 | GO:0071400 | cellular response to oleic acid(GO:0071400) |
0.1 | 0.3 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
0.1 | 0.3 | GO:0048749 | compound eye development(GO:0048749) |
0.1 | 0.3 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
0.1 | 0.2 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
0.0 | 0.2 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651) |
0.0 | 0.2 | GO:0032416 | negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883) |
0.0 | 0.4 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
0.0 | 0.2 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
0.0 | 0.2 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
0.0 | 0.1 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
0.0 | 0.2 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
0.0 | 0.4 | GO:0001778 | plasma membrane repair(GO:0001778) |
0.0 | 0.1 | GO:1904562 | phosphatidylinositol 5-phosphate metabolic process(GO:1904562) |
0.0 | 0.2 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
0.0 | 0.1 | GO:0018312 | peptidyl-serine ADP-ribosylation(GO:0018312) |
0.0 | 0.2 | GO:0007258 | JUN phosphorylation(GO:0007258) |
0.0 | 0.6 | GO:0003334 | keratinocyte development(GO:0003334) |
0.0 | 0.3 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
0.0 | 0.2 | GO:0010193 | response to ozone(GO:0010193) |
0.0 | 0.2 | GO:1903923 | protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923) |
0.0 | 0.2 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
0.0 | 0.9 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
0.0 | 0.2 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
0.0 | 0.2 | GO:0042492 | gamma-delta T cell differentiation(GO:0042492) |
0.0 | 1.7 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
0.0 | 0.1 | GO:0001880 | Mullerian duct regression(GO:0001880) |
0.0 | 0.1 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
0.0 | 0.2 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
0.0 | 0.2 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
0.0 | 0.7 | GO:0060325 | face morphogenesis(GO:0060325) |
0.0 | 0.6 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
0.0 | 0.4 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
0.0 | 0.2 | GO:0051026 | chiasma assembly(GO:0051026) |
0.0 | 0.1 | GO:0055059 | asymmetric neuroblast division(GO:0055059) |
0.0 | 0.1 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
0.0 | 0.1 | GO:0048014 | Tie signaling pathway(GO:0048014) |
0.0 | 0.3 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
0.0 | 0.1 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) |
0.0 | 0.1 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
0.0 | 0.1 | GO:0002158 | osteoclast proliferation(GO:0002158) |
0.0 | 0.1 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.4 | GO:0097486 | multivesicular body lumen(GO:0097486) |
0.0 | 0.2 | GO:0070695 | FHF complex(GO:0070695) |
0.0 | 0.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
0.0 | 0.2 | GO:0005826 | actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513) |
0.0 | 0.1 | GO:0098536 | deuterosome(GO:0098536) |
0.0 | 0.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.0 | 0.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
0.0 | 0.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.0 | 0.1 | GO:0071986 | Ragulator complex(GO:0071986) |
0.0 | 0.1 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
0.0 | 0.2 | GO:0008091 | spectrin(GO:0008091) |
0.0 | 0.2 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
0.0 | 0.1 | GO:0032039 | integrator complex(GO:0032039) |
0.0 | 0.2 | GO:0032300 | mismatch repair complex(GO:0032300) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.7 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
0.1 | 0.3 | GO:0004087 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
0.1 | 0.2 | GO:0008955 | peptidoglycan glycosyltransferase activity(GO:0008955) |
0.0 | 0.3 | GO:1990254 | keratin filament binding(GO:1990254) |
0.0 | 0.3 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
0.0 | 0.2 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
0.0 | 0.3 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
0.0 | 0.2 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
0.0 | 0.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.0 | 0.1 | GO:1990404 | protein ADP-ribosylase activity(GO:1990404) |
0.0 | 0.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
0.0 | 0.2 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
0.0 | 0.3 | GO:0051525 | NFAT protein binding(GO:0051525) |
0.0 | 1.3 | GO:0051393 | alpha-actinin binding(GO:0051393) |
0.0 | 0.1 | GO:0032093 | SAM domain binding(GO:0032093) |
0.0 | 0.1 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
0.0 | 0.1 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
0.0 | 0.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
0.0 | 0.4 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
0.0 | 0.3 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.0 | 0.1 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
0.0 | 0.1 | GO:0032184 | SUMO polymer binding(GO:0032184) |
0.0 | 0.1 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
0.0 | 0.2 | GO:0015377 | cation:chloride symporter activity(GO:0015377) |
0.0 | 0.1 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
0.0 | 0.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 0.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.0 | 0.1 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
0.0 | 0.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.1 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
0.0 | 0.1 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
0.0 | 0.2 | GO:0004985 | opioid receptor activity(GO:0004985) |
0.0 | 0.2 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.0 | 0.0 | GO:0008431 | vitamin E binding(GO:0008431) |
0.0 | 0.2 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.4 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 0.4 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
0.0 | 0.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.7 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
0.0 | 0.9 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 0.5 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.0 | 0.5 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
0.0 | 0.3 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
0.0 | 0.4 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
0.0 | 0.2 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |