Motif ID: ISL2

Z-value: 0.355


Transcription factors associated with ISL2:

Gene SymbolEntrez IDGene Name
ISL2 ENSG00000159556.5 ISL2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ISL2hg19_v2_chr15_+_76629064_766290730.164.5e-01Click!


Activity profile for motif ISL2.

activity profile for motif ISL2


Sorted Z-values histogram for motif ISL2

Sorted Z-values for motif ISL2



Network of associatons between targets according to the STRING database.



First level regulatory network of ISL2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_163008903 0.800 ENST00000418842.2
ENST00000375497.3
GCG

glucagon

chr4_+_169013666 0.675 ENST00000359299.3
ANXA10
annexin A10
chr13_-_20806440 0.662 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
GJB6


gap junction protein, beta 6, 30kDa


chr11_-_107729887 0.581 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr5_-_139726181 0.576 ENST00000507104.1
ENST00000230990.6
HBEGF

heparin-binding EGF-like growth factor

chr11_-_28129656 0.574 ENST00000263181.6
KIF18A
kinesin family member 18A
chrX_+_96138907 0.443 ENST00000373040.3
RPA4
replication protein A4, 30kDa
chr2_-_10587897 0.429 ENST00000405333.1
ENST00000443218.1
ODC1

ornithine decarboxylase 1

chr4_-_69111401 0.404 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr3_+_172468505 0.360 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2




epithelial cell transforming sequence 2 oncogene




chr2_+_105050794 0.328 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2


long intergenic non-protein coding RNA 1102


chr3_+_172468472 0.321 ENST00000232458.5
ENST00000392692.3
ECT2

epithelial cell transforming sequence 2 oncogene

chr12_-_95945246 0.310 ENST00000258499.3
USP44
ubiquitin specific peptidase 44
chr7_-_111032971 0.301 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr20_+_30102231 0.300 ENST00000335574.5
ENST00000340852.5
ENST00000398174.3
ENST00000376127.3
ENST00000344042.5
HM13




histocompatibility (minor) 13




chr7_+_13141097 0.282 ENST00000411542.1
AC011288.2
AC011288.2
chr21_+_39644305 0.269 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr21_+_39644395 0.264 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_-_141747950 0.262 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_+_130339710 0.261 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr2_-_136633940 0.261 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr4_+_128702969 0.245 ENST00000508776.1
ENST00000439123.2
HSPA4L

heat shock 70kDa protein 4-like

chr19_-_3557570 0.243 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr19_-_36001113 0.243 ENST00000434389.1
DMKN
dermokine
chr6_+_151561085 0.235 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr17_-_64225508 0.234 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr8_-_125577940 0.218 ENST00000519168.1
ENST00000395508.2
MTSS1

metastasis suppressor 1

chr3_+_169629354 0.215 ENST00000428432.2
ENST00000335556.3
SAMD7

sterile alpha motif domain containing 7

chr10_-_95241951 0.209 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF


myoferlin


chr10_-_95242044 0.208 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF


myoferlin


chr10_-_29923893 0.203 ENST00000355867.4
SVIL
supervillin
chr12_+_64798095 0.195 ENST00000332707.5
XPOT
exportin, tRNA
chr4_+_95128748 0.186 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr2_-_40680578 0.184 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr6_-_155776966 0.180 ENST00000159060.2
NOX3
NADPH oxidase 3
chr20_-_50722183 0.173 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr14_-_106781017 0.167 ENST00000390612.2
IGHV4-28
immunoglobulin heavy variable 4-28
chr11_+_113779704 0.165 ENST00000537778.1
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
chr1_-_12946025 0.163 ENST00000235349.5
PRAMEF4
PRAME family member 4
chr10_-_115904361 0.162 ENST00000428953.1
ENST00000543782.1
C10orf118

chromosome 10 open reading frame 118

chr14_-_67878917 0.160 ENST00000216446.4
PLEK2
pleckstrin 2
chr6_+_42989344 0.154 ENST00000244496.5
RRP36
ribosomal RNA processing 36 homolog (S. cerevisiae)
chr13_-_46716969 0.151 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_-_3496171 0.146 ENST00000399756.4
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr1_+_13421176 0.139 ENST00000376152.1
PRAMEF9
PRAME family member 9
chr7_-_45151272 0.137 ENST00000461363.1
ENST00000495078.1
ENST00000494076.1
ENST00000478532.1
ENST00000258770.3
ENST00000361278.3
TBRG4





transforming growth factor beta regulator 4





chr18_-_64271316 0.133 ENST00000540086.1
ENST00000580157.1
CDH19

cadherin 19, type 2

chr22_-_29107919 0.131 ENST00000434810.1
ENST00000456369.1
CHEK2

checkpoint kinase 2

chr3_+_139063372 0.128 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr19_+_4402659 0.128 ENST00000301280.5
ENST00000585854.1
CHAF1A

chromatin assembly factor 1, subunit A (p150)

chr3_-_193096600 0.128 ENST00000446087.1
ENST00000342358.4
ATP13A5

ATPase type 13A5

chr14_-_53258314 0.127 ENST00000216410.3
ENST00000557604.1
GNPNAT1

glucosamine-phosphate N-acetyltransferase 1

chr11_+_28129795 0.125 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15



methyltransferase like 15



chrX_-_77225135 0.113 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chrX_-_21676442 0.111 ENST00000379499.2
KLHL34
kelch-like family member 34
chr3_+_63428752 0.107 ENST00000295894.5
SYNPR
synaptoporin
chr11_-_5323226 0.104 ENST00000380224.1
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr12_-_110937351 0.102 ENST00000552130.2
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr21_-_31864275 0.101 ENST00000334063.4
KRTAP19-3
keratin associated protein 19-3
chr5_+_40841276 0.100 ENST00000254691.5
CARD6
caspase recruitment domain family, member 6
chr2_-_231860596 0.098 ENST00000441063.1
ENST00000434094.1
ENST00000418330.1
ENST00000457803.1
ENST00000414876.1
ENST00000446741.1
ENST00000426904.1
AC105344.2






SPATA3 antisense RNA 1 (head to head)






chr2_+_231921574 0.096 ENST00000308696.6
ENST00000373635.4
ENST00000440838.1
ENST00000409643.1
PSMD1



proteasome (prosome, macropain) 26S subunit, non-ATPase, 1



chr14_+_45605157 0.093 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chrX_-_100872911 0.092 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6


armadillo repeat containing, X-linked 6


chr14_+_57671888 0.090 ENST00000391612.1
AL391152.1
AL391152.1
chr5_+_57787254 0.089 ENST00000502276.1
ENST00000396776.2
ENST00000511930.1
GAPT


GRB2-binding adaptor protein, transmembrane


chr17_-_33390667 0.087 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL


ring finger and FYVE-like domain containing E3 ubiquitin protein ligase


chrX_-_119077695 0.083 ENST00000371410.3
NKAP
NFKB activating protein
chr21_-_31859755 0.081 ENST00000334055.3
KRTAP19-2
keratin associated protein 19-2
chr17_-_7307358 0.077 ENST00000535512.1
ENST00000576017.1
ENST00000302422.3
TMEM256-PLSCR3
TMEM256

TMEM256-PLSCR3 readthrough (NMD candidate)
transmembrane protein 256

chr10_-_5046042 0.077 ENST00000421196.3
ENST00000455190.1
AKR1C2

aldo-keto reductase family 1, member C2

chr18_-_64271363 0.077 ENST00000262150.2
CDH19
cadherin 19, type 2
chr4_+_95128996 0.075 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr5_+_110427983 0.073 ENST00000513710.2
ENST00000505303.1
WDR36

WD repeat domain 36

chr11_+_5410607 0.070 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr10_+_35484793 0.070 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM




cAMP responsive element modulator




chr14_+_38677123 0.069 ENST00000267377.2
SSTR1
somatostatin receptor 1
chr11_-_13517565 0.065 ENST00000282091.1
ENST00000529816.1
PTH

parathyroid hormone

chr1_+_63063152 0.064 ENST00000371129.3
ANGPTL3
angiopoietin-like 3
chr11_+_12132117 0.064 ENST00000256194.4
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr14_-_74025625 0.062 ENST00000553558.1
ENST00000563329.1
ENST00000334988.2
ENST00000560393.1
HEATR4



HEAT repeat containing 4



chr6_+_26087509 0.061 ENST00000397022.3
ENST00000353147.5
ENST00000352392.4
ENST00000349999.4
ENST00000317896.7
ENST00000357618.5
ENST00000470149.1
ENST00000336625.8
ENST00000461397.1
ENST00000488199.1
HFE









hemochromatosis









chr1_-_17766198 0.060 ENST00000375436.4
RCC2
regulator of chromosome condensation 2
chr11_+_73498898 0.059 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48





mitochondrial ribosomal protein L48





chr14_-_23058063 0.059 ENST00000538631.1
ENST00000543337.1
ENST00000250498.4
DAD1


defender against cell death 1


chr4_-_90756769 0.059 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr10_-_50396425 0.058 ENST00000374148.1
C10orf128
chromosome 10 open reading frame 128
chr9_-_95166841 0.058 ENST00000262551.4
OGN
osteoglycin
chr7_-_115670792 0.058 ENST00000265440.7
ENST00000393485.1
TFEC

transcription factor EC

chr4_+_169418255 0.058 ENST00000505667.1
ENST00000511948.1
PALLD

palladin, cytoskeletal associated protein

chr7_-_115670804 0.053 ENST00000320239.7
TFEC
transcription factor EC
chr3_-_127455200 0.052 ENST00000398101.3
MGLL
monoglyceride lipase
chr11_-_62609281 0.048 ENST00000525239.1
ENST00000538098.2
WDR74

WD repeat domain 74

chr9_+_35042205 0.047 ENST00000312292.5
ENST00000378745.3
C9orf131

chromosome 9 open reading frame 131

chr1_-_21377383 0.047 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr11_-_92931098 0.046 ENST00000326402.4
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr9_+_111624577 0.046 ENST00000333999.3
ACTL7A
actin-like 7A
chr10_-_50396407 0.045 ENST00000374153.2
ENST00000374151.3
C10orf128

chromosome 10 open reading frame 128

chr12_+_4829507 0.045 ENST00000252318.2
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr3_-_20227619 0.044 ENST00000425061.1
ENST00000443724.1
ENST00000421451.1
ENST00000452020.1
ENST00000417364.1
ENST00000306698.2
ENST00000419233.2
ENST00000263753.4
ENST00000383774.1
ENST00000437051.1
ENST00000412868.1
ENST00000429446.3
ENST00000442720.1
SGOL1












shugoshin-like 1 (S. pombe)












chr4_+_169418195 0.040 ENST00000261509.6
ENST00000335742.7
PALLD

palladin, cytoskeletal associated protein

chr17_-_39156138 0.040 ENST00000391587.1
KRTAP3-2
keratin associated protein 3-2
chr17_-_48785216 0.040 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr12_+_104337515 0.038 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr19_+_29456034 0.037 ENST00000589921.1
LINC00906
long intergenic non-protein coding RNA 906
chr7_-_37488834 0.036 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr3_-_20053741 0.036 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chr1_-_178840157 0.035 ENST00000367629.1
ENST00000234816.2
ANGPTL1

angiopoietin-like 1

chr6_+_29555683 0.034 ENST00000383640.2
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr3_+_136649311 0.034 ENST00000469404.1
ENST00000467911.1
NCK1

NCK adaptor protein 1

chr5_-_130500922 0.034 ENST00000513012.1
ENST00000508488.1
ENST00000506908.1
ENST00000304043.5
HINT1



histidine triad nucleotide binding protein 1



chr5_+_140201183 0.031 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
PCDHA5


protocadherin alpha 5


chr11_+_101983176 0.029 ENST00000524575.1
YAP1
Yes-associated protein 1
chr1_-_95391315 0.028 ENST00000545882.1
ENST00000415017.1
CNN3

calponin 3, acidic

chrX_+_102840408 0.028 ENST00000468024.1
ENST00000472484.1
ENST00000415568.2
ENST00000490644.1
ENST00000459722.1
ENST00000472745.1
ENST00000494801.1
ENST00000434216.2
ENST00000425011.1
TCEAL4








transcription elongation factor A (SII)-like 4








chr1_+_77333117 0.025 ENST00000477717.1
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr2_-_209010874 0.025 ENST00000260988.4
CRYGB
crystallin, gamma B
chr7_-_55930443 0.022 ENST00000388975.3
SEPT14
septin 14
chr14_-_51027838 0.021 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr8_-_121457608 0.017 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chr15_+_58702742 0.017 ENST00000356113.6
ENST00000414170.3
LIPC

lipase, hepatic

chr13_-_45768841 0.017 ENST00000379108.1
KCTD4
potassium channel tetramerization domain containing 4
chr1_+_99127225 0.017 ENST00000370189.5
ENST00000529992.1
SNX7

sorting nexin 7

chr3_+_159943362 0.016 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr9_+_12693336 0.015 ENST00000381137.2
ENST00000388918.5
TYRP1

tyrosinase-related protein 1

chr14_+_22670455 0.014 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr17_+_3118915 0.014 ENST00000304094.1
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr4_+_113568207 0.014 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr11_-_124190184 0.013 ENST00000357438.2
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr12_+_26164645 0.013 ENST00000542004.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr17_-_10325261 0.012 ENST00000403437.2
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr19_-_51920952 0.010 ENST00000356298.5
ENST00000339313.5
ENST00000529627.1
ENST00000439889.2
ENST00000353836.5
ENST00000432469.2
SIGLEC10





sialic acid binding Ig-like lectin 10





chr4_-_122085469 0.010 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chrX_-_48931648 0.010 ENST00000376386.3
ENST00000376390.4
PRAF2

PRA1 domain family, member 2

chr21_-_30445886 0.009 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8


chaperonin containing TCP1, subunit 8 (theta)


chr19_-_46234119 0.008 ENST00000317683.3
FBXO46
F-box protein 46
chr11_+_71544246 0.007 ENST00000328698.1
DEFB108B
defensin, beta 108B
chr2_-_145277569 0.006 ENST00000303660.4
ZEB2
zinc finger E-box binding homeobox 2
chr15_-_83378638 0.004 ENST00000261722.3
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chrM_+_10053 0.004 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr1_-_232651312 0.004 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr5_+_68860949 0.003 ENST00000507595.1
GTF2H2C
general transcription factor IIH, polypeptide 2C
chr6_+_161123270 0.002 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG


plasminogen


chr12_-_118628350 0.002 ENST00000537952.1
ENST00000537822.1
TAOK3

TAO kinase 3

chr2_-_217559517 0.000 ENST00000449583.1
IGFBP5
insulin-like growth factor binding protein 5
chr20_-_29978286 0.000 ENST00000376315.2
DEFB119
defensin, beta 119

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.6 GO:0051541 elastin metabolic process(GO:0051541)
0.1 0.4 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 0.3 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.1 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.1 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.2 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.6 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 0.2 GO:0030035 microspike assembly(GO:0030035)
0.0 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.1 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.1 GO:1903989 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0048840 otolith development(GO:0048840)
0.0 0.2 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.3 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.0 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.3 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.1 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.0 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.1 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107)
0.0 0.7 GO:0051602 response to electrical stimulus(GO:0051602)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0097149 centralspindlin complex(GO:0097149)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.3 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.7 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:1990357 terminal web(GO:1990357)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.0 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 0.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.7 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.7 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.6 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.6 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits