Motif ID: MBD2

Z-value: 0.596


Transcription factors associated with MBD2:

Gene SymbolEntrez IDGene Name
MBD2 ENSG00000134046.7 MBD2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MBD2hg19_v2_chr18_-_51751132_517511580.106.4e-01Click!


Activity profile for motif MBD2.

activity profile for motif MBD2


Sorted Z-values histogram for motif MBD2

Sorted Z-values for motif MBD2



Network of associatons between targets according to the STRING database.



First level regulatory network of MBD2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_17659234 0.661 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr20_-_56284816 0.569 ENST00000395819.3
ENST00000341744.3
PMEPA1

prostate transmembrane protein, androgen induced 1

chr19_+_18496957 0.552 ENST00000252809.3
GDF15
growth differentiation factor 15
chr6_-_43596899 0.419 ENST00000307126.5
ENST00000452781.1
GTPBP2

GTP binding protein 2

chr19_+_39904168 0.408 ENST00000438123.1
ENST00000409797.2
ENST00000451354.2
PLEKHG2


pleckstrin homology domain containing, family G (with RhoGef domain) member 2


chr19_-_19051103 0.346 ENST00000542541.2
ENST00000433218.2
HOMER3

homer homolog 3 (Drosophila)

chr17_-_27278445 0.344 ENST00000268756.3
ENST00000584685.1
PHF12

PHD finger protein 12

chrX_+_68725084 0.321 ENST00000252338.4
FAM155B
family with sequence similarity 155, member B
chr19_+_56152262 0.320 ENST00000325333.5
ENST00000590190.1
ZNF580

zinc finger protein 580

chr5_+_153570285 0.318 ENST00000425427.2
ENST00000297107.6
GALNT10

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)

chr19_+_35491174 0.309 ENST00000317991.5
ENST00000504615.2
GRAMD1A

GRAM domain containing 1A

chr12_+_122064673 0.302 ENST00000537188.1
ORAI1
ORAI calcium release-activated calcium modulator 1
chr2_-_129076151 0.288 ENST00000259241.6
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr5_+_153570319 0.286 ENST00000377661.2
GALNT10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr5_-_72744336 0.284 ENST00000499003.3
FOXD1
forkhead box D1
chr14_+_74417192 0.279 ENST00000554320.1
COQ6
coenzyme Q6 monooxygenase
chr1_-_43232649 0.277 ENST00000372526.2
ENST00000236040.4
ENST00000296388.5
ENST00000397054.3
LEPRE1



leucine proline-enriched proteoglycan (leprecan) 1



chr3_+_88108381 0.269 ENST00000473136.1
RP11-159G9.5
Uncharacterized protein
chr3_-_196295437 0.269 ENST00000429115.1
WDR53
WD repeat domain 53
chr17_+_17942684 0.269 ENST00000376345.3
GID4
GID complex subunit 4
chr15_+_80215477 0.268 ENST00000542003.1
C15ORF37
C15orf37 protein; Uncharacterized protein
chr6_+_125474992 0.267 ENST00000528193.1
TPD52L1
tumor protein D52-like 1
chr18_+_56530794 0.262 ENST00000590285.1
ENST00000586085.1
ENST00000589288.1
ZNF532


zinc finger protein 532


chr6_+_4776580 0.257 ENST00000397588.3
CDYL
chromodomain protein, Y-like
chr15_+_40763150 0.254 ENST00000306243.5
ENST00000559991.1
CHST14

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14

chr12_-_117318788 0.252 ENST00000550505.1
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr19_+_35491330 0.247 ENST00000411896.2
ENST00000424536.2
GRAMD1A

GRAM domain containing 1A

chr7_-_94285472 0.247 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
SGCE


sarcoglycan, epsilon


chr7_-_94285402 0.246 ENST00000428696.2
ENST00000445866.2
SGCE

sarcoglycan, epsilon

chr3_-_48471454 0.245 ENST00000296440.6
ENST00000448774.2
PLXNB1

plexin B1

chr9_+_124413873 0.243 ENST00000408936.3
DAB2IP
DAB2 interacting protein
chr3_-_27525865 0.242 ENST00000445684.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr7_-_94285511 0.240 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chr3_-_88108212 0.238 ENST00000482016.1
CGGBP1
CGG triplet repeat binding protein 1
chrX_+_24167746 0.237 ENST00000428571.1
ENST00000539115.1
ZFX

zinc finger protein, X-linked

chr12_-_120554534 0.234 ENST00000538903.1
ENST00000534951.1
RAB35

RAB35, member RAS oncogene family

chr10_-_17659357 0.233 ENST00000326961.6
ENST00000361271.3
PTPLA

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

chr20_-_590944 0.229 ENST00000246080.3
TCF15
transcription factor 15 (basic helix-loop-helix)
chr6_+_125475335 0.229 ENST00000532429.1
ENST00000534199.1
TPD52L1

tumor protein D52-like 1

chr9_+_34989638 0.224 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
DNAJB5


DnaJ (Hsp40) homolog, subfamily B, member 5


chr14_-_77787198 0.221 ENST00000261534.4
POMT2
protein-O-mannosyltransferase 2
chrX_+_24167828 0.217 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
ZFX



zinc finger protein, X-linked



chr11_-_64684672 0.216 ENST00000377264.3
ENST00000421419.2
ATG2A

autophagy related 2A

chr3_-_27525826 0.215 ENST00000454389.1
ENST00000440156.1
ENST00000437179.1
ENST00000446700.1
ENST00000455077.1
ENST00000435667.2
ENST00000388777.4
ENST00000425128.2
SLC4A7







solute carrier family 4, sodium bicarbonate cotransporter, member 7







chr10_-_25012115 0.215 ENST00000446003.1
ARHGAP21
Rho GTPase activating protein 21
chr20_-_46415341 0.209 ENST00000484875.1
ENST00000361612.4
SULF2

sulfatase 2

chr3_-_196295468 0.208 ENST00000332629.5
ENST00000433160.1
WDR53

WD repeat domain 53

chr16_+_3019552 0.205 ENST00000572687.1
PAQR4
progestin and adipoQ receptor family member IV
chr20_-_48532046 0.205 ENST00000543716.1
SPATA2
spermatogenesis associated 2
chr15_+_101142722 0.203 ENST00000332783.7
ENST00000558747.1
ENST00000343276.4
ASB7


ankyrin repeat and SOCS box containing 7


chr17_-_7141490 0.202 ENST00000574236.1
ENST00000572789.1
PHF23

PHD finger protein 23

chr18_-_31803169 0.202 ENST00000590712.1
NOL4
nucleolar protein 4
chr3_-_197024394 0.199 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
DLG1




discs, large homolog 1 (Drosophila)




chr16_+_3019246 0.197 ENST00000318782.8
ENST00000293978.8
PAQR4

progestin and adipoQ receptor family member IV

chr2_+_173292390 0.196 ENST00000442250.1
ENST00000458358.1
ENST00000409080.1
ITGA6


integrin, alpha 6


chr8_+_30241934 0.195 ENST00000538486.1
RBPMS
RNA binding protein with multiple splicing
chr17_-_42441204 0.194 ENST00000293443.7
FAM171A2
family with sequence similarity 171, member A2
chr20_-_46415297 0.192 ENST00000467815.1
ENST00000359930.4
SULF2

sulfatase 2

chr3_+_133292759 0.190 ENST00000431519.2
CDV3
CDV3 homolog (mouse)
chr10_-_123357910 0.188 ENST00000336553.6
ENST00000457416.2
ENST00000360144.3
ENST00000369059.1
ENST00000356226.4
ENST00000351936.6
FGFR2





fibroblast growth factor receptor 2





chr1_-_165325939 0.186 ENST00000342310.3
LMX1A
LIM homeobox transcription factor 1, alpha
chr3_+_133292851 0.184 ENST00000503932.1
CDV3
CDV3 homolog (mouse)
chr9_+_35829208 0.184 ENST00000439587.2
ENST00000377991.4
TMEM8B

transmembrane protein 8B

chr7_-_19157248 0.183 ENST00000242261.5
TWIST1
twist family bHLH transcription factor 1
chr5_+_133861790 0.182 ENST00000395003.1
PHF15
jade family PHD finger 2
chr1_-_160232312 0.177 ENST00000440682.1
DCAF8
DDB1 and CUL4 associated factor 8
chr7_+_94285637 0.176 ENST00000482108.1
ENST00000488574.1
PEG10

paternally expressed 10

chr2_-_54014127 0.171 ENST00000394717.2
GPR75-ASB3
GPR75-ASB3 readthrough
chr2_-_54014055 0.169 ENST00000263634.3
ENST00000406687.1
GPR75-ASB3

GPR75-ASB3 readthrough

chr6_-_91296737 0.168 ENST00000369332.3
ENST00000369329.3
MAP3K7

mitogen-activated protein kinase kinase kinase 7

chr21_-_44495919 0.168 ENST00000398158.1
CBS
cystathionine-beta-synthase
chr3_-_128206759 0.166 ENST00000430265.2
GATA2
GATA binding protein 2
chr6_-_91296602 0.166 ENST00000369325.3
ENST00000369327.3
MAP3K7

mitogen-activated protein kinase kinase kinase 7

chr1_+_9599540 0.164 ENST00000302692.6
SLC25A33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chrX_-_152939252 0.164 ENST00000340888.3
PNCK
pregnancy up-regulated nonubiquitous CaM kinase
chr11_-_89224488 0.163 ENST00000534731.1
ENST00000527626.1
NOX4

NADPH oxidase 4

chr11_+_67033881 0.162 ENST00000308595.5
ENST00000526285.1
ADRBK1

adrenergic, beta, receptor kinase 1

chr14_+_21538517 0.161 ENST00000298693.3
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr12_-_120554622 0.161 ENST00000229340.5
RAB35
RAB35, member RAS oncogene family
chr11_-_68609377 0.161 ENST00000265641.5
ENST00000376618.2
CPT1A

carnitine palmitoyltransferase 1A (liver)

chr3_+_133292574 0.161 ENST00000264993.3
CDV3
CDV3 homolog (mouse)
chr1_-_22469459 0.159 ENST00000290167.6
WNT4
wingless-type MMTV integration site family, member 4
chr17_+_65374075 0.157 ENST00000581322.1
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr7_-_112579869 0.153 ENST00000297145.4
C7orf60
chromosome 7 open reading frame 60
chr11_+_35965531 0.152 ENST00000528989.1
ENST00000524419.1
ENST00000315571.5
LDLRAD3


low density lipoprotein receptor class A domain containing 3


chr2_+_46769798 0.151 ENST00000238738.4
RHOQ
ras homolog family member Q
chr14_+_102829300 0.150 ENST00000359520.7
TECPR2
tectonin beta-propeller repeat containing 2
chr3_-_98620500 0.149 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr2_+_208576259 0.149 ENST00000392209.3
CCNYL1
cyclin Y-like 1
chr3_+_33155525 0.145 ENST00000449224.1
CRTAP
cartilage associated protein
chr5_+_14143728 0.144 ENST00000344204.4
ENST00000537187.1
TRIO

trio Rho guanine nucleotide exchange factor

chr7_+_73082152 0.144 ENST00000324941.4
ENST00000451519.1
VPS37D

vacuolar protein sorting 37 homolog D (S. cerevisiae)

chr11_+_66025938 0.144 ENST00000394066.2
KLC2
kinesin light chain 2
chr3_+_112930387 0.143 ENST00000485230.1
BOC
BOC cell adhesion associated, oncogene regulated
chr10_+_104180580 0.142 ENST00000425536.1
FBXL15
F-box and leucine-rich repeat protein 15
chrX_-_134049233 0.141 ENST00000370779.4
MOSPD1
motile sperm domain containing 1
chr1_-_43855444 0.140 ENST00000372455.4
MED8
mediator complex subunit 8
chr11_+_67056867 0.140 ENST00000514166.1
ANKRD13D
ankyrin repeat domain 13 family, member D
chr3_-_48470838 0.140 ENST00000358459.4
ENST00000358536.4
PLXNB1

plexin B1

chr5_+_122847908 0.140 ENST00000511130.2
ENST00000512718.3
CSNK1G3

casein kinase 1, gamma 3

chr20_+_36531499 0.139 ENST00000373458.3
ENST00000373461.4
ENST00000373459.4
VSTM2L


V-set and transmembrane domain containing 2 like


chr14_+_21538429 0.138 ENST00000298694.4
ENST00000555038.1
ARHGEF40

Rho guanine nucleotide exchange factor (GEF) 40

chr7_-_17980091 0.137 ENST00000409389.1
ENST00000409604.1
ENST00000428135.3
SNX13


sorting nexin 13


chr2_+_11052054 0.135 ENST00000295082.1
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr11_+_67056755 0.134 ENST00000511455.2
ENST00000308440.6
ANKRD13D

ankyrin repeat domain 13 family, member D

chr14_+_77787227 0.133 ENST00000216465.5
ENST00000361389.4
ENST00000554279.1
ENST00000557639.1
ENST00000349555.3
ENST00000556627.1
ENST00000557053.1
GSTZ1






glutathione S-transferase zeta 1






chr2_+_173292301 0.132 ENST00000264106.6
ENST00000375221.2
ENST00000343713.4
ITGA6


integrin, alpha 6


chr2_-_208031542 0.129 ENST00000423015.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr22_-_19419205 0.128 ENST00000340170.4
ENST00000263208.5
HIRA

histone cell cycle regulator

chr11_+_65383227 0.128 ENST00000355703.3
PCNXL3
pecanex-like 3 (Drosophila)
chr6_-_45983549 0.124 ENST00000544153.1
CLIC5
chloride intracellular channel 5
chr17_+_68165657 0.124 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr5_+_176237478 0.124 ENST00000329542.4
UNC5A
unc-5 homolog A (C. elegans)
chrX_+_49644470 0.124 ENST00000508866.2
USP27X
ubiquitin specific peptidase 27, X-linked
chr16_-_2059797 0.123 ENST00000563630.1
ZNF598
zinc finger protein 598
chr11_+_65408273 0.123 ENST00000394227.3
SIPA1
signal-induced proliferation-associated 1
chr11_+_43380459 0.123 ENST00000299240.6
ENST00000039989.4
TTC17

tetratricopeptide repeat domain 17

chr1_-_247495045 0.123 ENST00000294753.4
ENST00000366498.2
ZNF496

zinc finger protein 496

chr1_-_156252590 0.122 ENST00000361813.5
ENST00000368267.5
SMG5

SMG5 nonsense mediated mRNA decay factor

chr12_-_50222187 0.120 ENST00000335999.6
NCKAP5L
NCK-associated protein 5-like
chr16_-_2059748 0.120 ENST00000562103.1
ENST00000431526.1
ZNF598

zinc finger protein 598

chr1_-_154531095 0.119 ENST00000292211.4
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr10_+_75545391 0.118 ENST00000604524.1
ENST00000605216.1
ENST00000398706.2
ZSWIM8


zinc finger, SWIM-type containing 8


chr1_-_6545502 0.118 ENST00000535355.1
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr12_+_27396901 0.117 ENST00000541191.1
ENST00000389032.3
STK38L

serine/threonine kinase 38 like

chr18_-_34408802 0.117 ENST00000590842.1
TPGS2
tubulin polyglutamylase complex subunit 2
chr1_-_31712401 0.116 ENST00000373736.2
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr2_+_48541776 0.116 ENST00000413569.1
ENST00000340553.3
FOXN2

forkhead box N2

chr10_+_75545329 0.114 ENST00000604729.1
ENST00000603114.1
ZSWIM8

zinc finger, SWIM-type containing 8

chr5_-_180076580 0.114 ENST00000502649.1
FLT4
fms-related tyrosine kinase 4
chr2_-_219537134 0.114 ENST00000295704.2
RNF25
ring finger protein 25
chr2_-_220408430 0.113 ENST00000243776.6
CHPF
chondroitin polymerizing factor
chr10_-_123357598 0.113 ENST00000358487.5
ENST00000369058.3
ENST00000369060.4
ENST00000359354.2
FGFR2



fibroblast growth factor receptor 2



chr17_+_48638371 0.110 ENST00000360761.4
ENST00000352832.5
ENST00000354983.4
CACNA1G


calcium channel, voltage-dependent, T type, alpha 1G subunit


chr9_+_35605274 0.110 ENST00000336395.5
TESK1
testis-specific kinase 1
chr1_+_4714792 0.109 ENST00000378190.3
AJAP1
adherens junctions associated protein 1
chr10_+_126490354 0.109 ENST00000298492.5
FAM175B
family with sequence similarity 175, member B
chr12_+_29542557 0.108 ENST00000550906.1
OVCH1-AS1
OVCH1 antisense RNA 1
chr13_+_27131798 0.108 ENST00000361042.4
WASF3
WAS protein family, member 3
chr17_+_46126135 0.108 ENST00000361665.3
ENST00000585062.1
NFE2L1

nuclear factor, erythroid 2-like 1

chr10_+_129845823 0.107 ENST00000306042.5
PTPRE
protein tyrosine phosphatase, receptor type, E
chr20_-_61885826 0.106 ENST00000370316.3
NKAIN4
Na+/K+ transporting ATPase interacting 4
chr12_-_48213568 0.105 ENST00000080059.7
ENST00000354334.3
ENST00000430670.1
ENST00000552960.1
ENST00000440293.1
HDAC7




histone deacetylase 7




chr19_-_41222775 0.105 ENST00000324464.3
ENST00000450541.1
ENST00000594720.1
ADCK4


aarF domain containing kinase 4


chr16_-_23160591 0.104 ENST00000219689.7
USP31
ubiquitin specific peptidase 31
chr2_+_220299547 0.104 ENST00000312358.7
SPEG
SPEG complex locus
chr15_+_72766651 0.104 ENST00000379887.4
ARIH1
ariadne RBR E3 ubiquitin protein ligase 1
chr4_-_16228083 0.104 ENST00000399920.3
TAPT1
transmembrane anterior posterior transformation 1
chr6_-_99797522 0.104 ENST00000389677.5
FAXC
failed axon connections homolog (Drosophila)
chr3_+_120461484 0.103 ENST00000484715.1
ENST00000469772.1
ENST00000283875.5
ENST00000492959.1
GTF2E1



general transcription factor IIE, polypeptide 1, alpha 56kDa



chr11_-_89224508 0.102 ENST00000525196.1
NOX4
NADPH oxidase 4
chr16_+_28303804 0.102 ENST00000341901.4
SBK1
SH3 domain binding kinase 1
chr11_-_67275542 0.101 ENST00000531506.1
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr17_-_42277203 0.100 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr5_-_171433579 0.100 ENST00000265094.5
ENST00000393802.2
FBXW11

F-box and WD repeat domain containing 11

chr8_+_30241995 0.099 ENST00000397323.4
ENST00000339877.4
ENST00000320203.4
ENST00000287771.5
RBPMS



RNA binding protein with multiple splicing



chr14_-_99737822 0.099 ENST00000345514.2
ENST00000443726.2
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chr20_-_30311703 0.099 ENST00000450273.1
ENST00000456404.1
ENST00000420488.1
ENST00000439267.1
BCL2L1



BCL2-like 1



chr10_+_105253661 0.099 ENST00000369780.4
NEURL
neuralized E3 ubiquitin protein ligase 1
chr11_-_89224299 0.098 ENST00000343727.5
ENST00000531342.1
ENST00000375979.3
NOX4


NADPH oxidase 4


chr20_-_30310797 0.098 ENST00000422920.1
BCL2L1
BCL2-like 1
chr11_+_67055986 0.097 ENST00000447274.2
ANKRD13D
ankyrin repeat domain 13 family, member D
chr17_+_17942594 0.097 ENST00000268719.4
GID4
GID complex subunit 4
chr14_+_93799556 0.096 ENST00000256339.4
UNC79
unc-79 homolog (C. elegans)
chrX_-_152939133 0.096 ENST00000370150.1
PNCK
pregnancy up-regulated nonubiquitous CaM kinase
chr13_+_27131887 0.096 ENST00000335327.5
WASF3
WAS protein family, member 3
chr1_+_3689325 0.094 ENST00000444870.2
ENST00000452264.1
SMIM1

small integral membrane protein 1 (Vel blood group)

chr10_+_128593978 0.094 ENST00000280333.6
DOCK1
dedicator of cytokinesis 1
chr22_+_25348671 0.094 ENST00000406486.4
KIAA1671
KIAA1671
chr17_+_6544356 0.093 ENST00000574838.1
TXNDC17
thioredoxin domain containing 17
chr19_-_10341948 0.093 ENST00000592342.1
ENST00000588952.1
ENST00000590320.1
DNMT1

S1PR2
DNA (cytosine-5-)-methyltransferase 1

sphingosine-1-phosphate receptor 2
chr11_-_73471655 0.093 ENST00000400470.2
RAB6A
RAB6A, member RAS oncogene family
chr10_-_25012597 0.093 ENST00000396432.2
ARHGAP21
Rho GTPase activating protein 21
chr11_-_67271723 0.092 ENST00000533391.1
ENST00000534749.1
ENST00000532703.1
PITPNM1


phosphatidylinositol transfer protein, membrane-associated 1


chr17_+_6544328 0.091 ENST00000570330.1
TXNDC17
thioredoxin domain containing 17
chr19_-_17137625 0.091 ENST00000443236.1
ENST00000388925.4
CPAMD8

C3 and PZP-like, alpha-2-macroglobulin domain containing 8

chr19_-_17356697 0.090 ENST00000291442.3
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr5_-_171433819 0.090 ENST00000296933.6
FBXW11
F-box and WD repeat domain containing 11
chr6_+_84569359 0.090 ENST00000369681.5
ENST00000369679.4
CYB5R4

cytochrome b5 reductase 4

chr17_-_42276574 0.090 ENST00000589805.1
ATXN7L3
ataxin 7-like 3
chr19_+_50353944 0.089 ENST00000594151.1
ENST00000600603.1
ENST00000601638.1
ENST00000221557.9
PTOV1



prostate tumor overexpressed 1



chr11_-_130786333 0.089 ENST00000533214.1
ENST00000528555.1
ENST00000530356.1
ENST00000539184.1
SNX19



sorting nexin 19



chr1_-_6546001 0.088 ENST00000400913.1
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr17_+_65373531 0.088 ENST00000580974.1
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr10_-_92617437 0.087 ENST00000336152.3
ENST00000277874.6
ENST00000371719.2
HTR7


5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled


chr19_-_11373128 0.086 ENST00000294618.7
DOCK6
dedicator of cytokinesis 6
chr3_-_149688896 0.086 ENST00000239940.7
PFN2
profilin 2
chr18_-_45457192 0.086 ENST00000586514.1
ENST00000591214.1
ENST00000589877.1
SMAD2


SMAD family member 2


chr7_-_103848405 0.086 ENST00000447452.2
ENST00000545943.1
ENST00000297431.4
ORC5


origin recognition complex, subunit 5


chr4_+_39046615 0.085 ENST00000261425.3
ENST00000508137.2
KLHL5

kelch-like family member 5

chr12_+_120972606 0.085 ENST00000413266.2
RNF10
ring finger protein 10
chr19_-_2151523 0.083 ENST00000350812.6
ENST00000355272.6
ENST00000356926.4
ENST00000345016.5
AP3D1



adaptor-related protein complex 3, delta 1 subunit



chr13_-_80915059 0.083 ENST00000377104.3
SPRY2
sprouty homolog 2 (Drosophila)
chr2_+_219824357 0.082 ENST00000302625.4
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr3_-_88108192 0.082 ENST00000309534.6
CGGBP1
CGG triplet repeat binding protein 1
chr17_+_46125707 0.081 ENST00000584137.1
ENST00000362042.3
ENST00000585291.1
ENST00000357480.5
NFE2L1



nuclear factor, erythroid 2-like 1



chr2_+_54014168 0.081 ENST00000405123.3
ENST00000185150.4
ENST00000378239.5
ERLEC1


endoplasmic reticulum lectin 1


chr16_+_67062996 0.080 ENST00000561924.2
CBFB
core-binding factor, beta subunit
chr8_-_67525524 0.079 ENST00000517885.1
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr7_-_8301682 0.079 ENST00000396675.3
ENST00000430867.1
ICA1

islet cell autoantigen 1, 69kDa


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 0.3 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604)
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.3 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.1 0.2 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.1 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.2 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.1 0.2 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725) eosinophil fate commitment(GO:0035854)
0.1 0.2 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1 0.2 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) renal vesicle induction(GO:0072034)
0.1 0.3 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 0.2 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.2 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.6 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.0 0.2 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.1 GO:1901873 regulation of post-translational protein modification(GO:1901873)
0.0 0.1 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.0 0.1 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.0 0.0 GO:0010159 specification of organ position(GO:0010159)
0.0 0.1 GO:0036518 chemorepulsion of dopaminergic neuron axon(GO:0036518)
0.0 0.1 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.0 0.4 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.2 GO:0051660 cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660) regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.1 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) negative regulation of lymphangiogenesis(GO:1901491) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.0 0.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.1 GO:0042631 cellular response to water deprivation(GO:0042631)
0.0 0.2 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.1 GO:0072053 renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054) inner medullary collecting duct development(GO:0072061)
0.0 0.2 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.1 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.1 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.6 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.1 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.3 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.6 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.1 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0 0.1 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.0 GO:0022009 establishment of endothelial blood-brain barrier(GO:0014045) central nervous system vasculogenesis(GO:0022009)
0.0 0.0 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.2 GO:1904948 midbrain dopaminergic neuron differentiation(GO:1904948)
0.0 0.3 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.3 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.3 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.0 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.0 GO:0002856 natural killer cell tolerance induction(GO:0002519) regulation of tolerance induction dependent upon immune response(GO:0002652) negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
0.0 0.3 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0003409 optic cup structural organization(GO:0003409)
0.0 0.1 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.0 0.0 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.4 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.3 GO:0031643 positive regulation of myelination(GO:0031643)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.1 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.0 0.0 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.2 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0034676 integrin alpha6-beta4 complex(GO:0034676)
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.2 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:0016938 kinesin I complex(GO:0016938)
0.0 0.2 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0043219 lateral loop(GO:0043219)
0.0 0.0 GO:0072563 endothelial microparticle(GO:0072563)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.0 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0097413 Lewy body(GO:0097413)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 0.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.2 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.1 0.2 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.1 0.2 GO:0032427 GBD domain binding(GO:0032427)
0.0 0.3 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.3 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.0 0.3 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.0 0.3 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 0.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.0 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 0.2 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.0 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.0 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.0 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.3 GO:0071949 FAD binding(GO:0071949)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.1 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.2 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.4 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling