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• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: MSX2

Z-value: 0.335

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr20_-_54967187	0.519	ENST00000422322.1 ENST00000371356.2 ENST00000451915.1 ENST00000347343.2 ENST00000395911.1 ENST00000395907.1 ENST00000441357.1 ENST00000456249.1 ENST00000420474.1 ENST00000395909.4 ENST00000395914.1 ENST00000312783.6 ENST00000395915.3 ENST00000395913.3	AURKA	aurora kinase A
chr12_-_120315074	0.502	ENST00000261833.7 ENST00000392521.2	CIT	citron (rho-interacting, serine/threonine kinase 21)
chr12_+_53662073	0.386	ENST00000553219.1 ENST00000257934.4	ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)
chr8_+_1993173	0.378	ENST00000523438.1	MYOM2	myomesin 2
chr8_+_1993152	0.376	ENST00000262113.4	MYOM2	myomesin 2
chr12_+_53662110	0.309	ENST00000552462.1	ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)
chr17_-_38574169	0.258	ENST00000423485.1	TOP2A	topoisomerase (DNA) II alpha 170kDa
chr10_-_99447024	0.220	ENST00000370626.3	AVPI1	arginine vasopressin-induced 1
chr6_+_130339710	0.205	ENST00000526087.1 ENST00000533560.1 ENST00000361794.2	L3MBTL3	l(3)mbt-like 3 (Drosophila)
chr11_+_33061543	0.185	ENST00000432887.1 ENST00000528898.1 ENST00000531632.2	TCP11L1	t-complex 11, testis-specific-like 1
chr1_-_197115818	0.181	ENST00000367409.4 ENST00000294732.7	ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr6_+_53948328	0.176	ENST00000370876.2	MLIP	muscular LMNA-interacting protein
chr1_-_232651312	0.176	ENST00000262861.4	SIPA1L2	signal-induced proliferation-associated 1 like 2
chr6_-_111927062	0.168	ENST00000359831.4	TRAF3IP2	TRAF3 interacting protein 2
chr2_-_55646957	0.167	ENST00000263630.8	CCDC88A	coiled-coil domain containing 88A
chr2_-_55647057	0.161	ENST00000436346.1	CCDC88A	coiled-coil domain containing 88A
chr12_+_9102632	0.158	ENST00000539240.1	KLRG1	killer cell lectin-like receptor subfamily G, member 1
chr10_-_105110831	0.155	ENST00000337211.4	PCGF6	polycomb group ring finger 6
chr19_+_42817450	0.147	ENST00000301204.3	TMEM145	transmembrane protein 145
chr10_-_105110890	0.145	ENST00000369847.3	PCGF6	polycomb group ring finger 6
chr12_-_10022735	0.143	ENST00000228438.2	CLEC2B	C-type lectin domain family 2, member B
chr3_-_48672859	0.140	ENST00000395550.2 ENST00000455886.2 ENST00000431739.1 ENST00000426599.1 ENST00000383733.3 ENST00000420764.2 ENST00000337000.8	SLC26A6	solute carrier family 26 (anion exchanger), member 6
chr1_-_47779762	0.136	ENST00000371877.3 ENST00000360380.3 ENST00000337817.5 ENST00000447475.2	STIL	SCL/TAL1 interrupting locus
chr19_-_47137942	0.129	ENST00000300873.4	GNG8	guanine nucleotide binding protein (G protein), gamma 8
chr16_+_58783542	0.124	ENST00000500117.1 ENST00000565722.1	RP11-410D17.2	RP11-410D17.2
chr3_-_120003941	0.123	ENST00000464295.1	GPR156	G protein-coupled receptor 156
chr9_+_80912059	0.113	ENST00000347159.2 ENST00000376588.3	PSAT1	phosphoserine aminotransferase 1
chr9_+_124329336	0.113	ENST00000394340.3 ENST00000436835.1 ENST00000259371.2	DAB2IP	DAB2 interacting protein
chr19_+_4007644	0.109	ENST00000262971.2	PIAS4	protein inhibitor of activated STAT, 4
chr6_-_111927449	0.107	ENST00000368761.5 ENST00000392556.4 ENST00000340026.6	TRAF3IP2	TRAF3 interacting protein 2
chr7_+_99717230	0.106	ENST00000262932.3	CNPY4	canopy FGF signaling regulator 4
chr6_+_25652432	0.105	ENST00000377961.2	SCGN	secretagogin, EF-hand calcium binding protein
chr6_+_25652501	0.102	ENST00000334979.6	SCGN	secretagogin, EF-hand calcium binding protein
chr3_-_151034734	0.099	ENST00000260843.4	GPR87	G protein-coupled receptor 87
chr9_+_34646624	0.098	ENST00000450095.2 ENST00000556278.1	GALT GALT	galactose-1-phosphate uridylyltransferase Uncharacterized protein
chr20_+_54967409	0.098	ENST00000415828.1 ENST00000217109.4 ENST00000428552.1	CSTF1	cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr6_+_34204642	0.095	ENST00000347617.6 ENST00000401473.3 ENST00000311487.5 ENST00000447654.1 ENST00000395004.3	HMGA1	high mobility group AT-hook 1
chr8_-_12612962	0.093	ENST00000398246.3	LONRF1	LON peptidase N-terminal domain and ring finger 1
chr3_-_112127981	0.093	ENST00000486726.2	RP11-231E6.1	RP11-231E6.1
chr4_-_69536346	0.090	ENST00000338206.5	UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15
chr19_-_19249255	0.088	ENST00000587583.2 ENST00000450333.2 ENST00000587096.1 ENST00000162044.9 ENST00000592369.1 ENST00000587915.1	TMEM161A	transmembrane protein 161A
chrX_+_89176881	0.087	ENST00000283891.5 ENST00000561129.2	TGIF2LX	TGFB-induced factor homeobox 2-like, X-linked
chr16_-_29934558	0.081	ENST00000568995.1 ENST00000566413.1	KCTD13	potassium channel tetramerization domain containing 13
chr6_+_160183492	0.080	ENST00000541436.1	ACAT2	acetyl-CoA acetyltransferase 2
chr15_-_37393406	0.079	ENST00000338564.5 ENST00000558313.1 ENST00000340545.5	MEIS2	Meis homeobox 2
chr17_+_74261277	0.077	ENST00000327490.6	UBALD2	UBA-like domain containing 2
chr1_-_68698222	0.077	ENST00000370976.3 ENST00000354777.2 ENST00000262348.4 ENST00000540432.1	WLS	wntless Wnt ligand secretion mediator
chr2_-_89292422	0.076	ENST00000495489.1	IGKV1-8	immunoglobulin kappa variable 1-8
chr1_-_94050668	0.075	ENST00000539242.1	BCAR3	breast cancer anti-estrogen resistance 3
chr8_+_38831683	0.074	ENST00000302495.4	HTRA4	HtrA serine peptidase 4
chr5_+_95998070	0.072	ENST00000421689.2 ENST00000510756.1 ENST00000512620.1	CAST	calpastatin
chr19_+_41869894	0.069	ENST00000413014.2	TMEM91	transmembrane protein 91
chr3_+_140396881	0.067	ENST00000286349.3	TRIM42	tripartite motif containing 42
chr1_-_68698197	0.064	ENST00000370973.2 ENST00000370971.1	WLS	wntless Wnt ligand secretion mediator
chr21_-_32253874	0.064	ENST00000332378.4	KRTAP11-1	keratin associated protein 11-1
chr1_-_151431909	0.059	ENST00000361398.3 ENST00000271715.2	POGZ	pogo transposable element with ZNF domain
chr19_-_41985048	0.059	ENST00000599801.1 ENST00000595063.1 ENST00000598215.1	AC011526.1	AC011526.1
chr3_+_147795932	0.059	ENST00000490465.1	RP11-639B1.1	RP11-639B1.1
chr11_-_13517565	0.057	ENST00000282091.1 ENST00000529816.1	PTH	parathyroid hormone
chr9_+_34646651	0.056	ENST00000378842.3	GALT	galactose-1-phosphate uridylyltransferase
chr5_+_150639360	0.056	ENST00000523004.1	GM2A	GM2 ganglioside activator
chr12_-_9102549	0.056	ENST00000000412.3	M6PR	mannose-6-phosphate receptor (cation dependent)
chr1_-_190446759	0.053	ENST00000367462.3	BRINP3	bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr12_+_28410128	0.052	ENST00000381259.1 ENST00000381256.1	CCDC91	coiled-coil domain containing 91
chr10_-_99205607	0.051	ENST00000477692.2 ENST00000485122.2 ENST00000370886.5 ENST00000370885.4 ENST00000370902.3 ENST00000370884.5	EXOSC1	exosome component 1
chr2_+_187371440	0.049	ENST00000445547.1	ZC3H15	zinc finger CCCH-type containing 15
chr10_-_56560939	0.049	ENST00000373955.1	PCDH15	protocadherin-related 15
chr18_-_44181442	0.047	ENST00000398722.4	LOXHD1	lipoxygenase homology domains 1
chr15_+_41245160	0.046	ENST00000444189.2 ENST00000446533.3	CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)
chr17_-_48785216	0.045	ENST00000285243.6	ANKRD40	ankyrin repeat domain 40
chr18_-_48346298	0.044	ENST00000398439.3	MRO	maestro
chr1_-_151431647	0.043	ENST00000368863.2 ENST00000409503.1 ENST00000491586.1 ENST00000533351.1 ENST00000540984.1	POGZ	pogo transposable element with ZNF domain
chr14_+_32798547	0.042	ENST00000557354.1 ENST00000557102.1 ENST00000557272.1	AKAP6	A kinase (PRKA) anchor protein 6
chr5_+_140797296	0.042	ENST00000398594.2	PCDHGB7	protocadherin gamma subfamily B, 7
chr17_-_10372875	0.041	ENST00000255381.2	MYH4	myosin, heavy chain 4, skeletal muscle
chr10_-_56561022	0.041	ENST00000373965.2 ENST00000414778.1 ENST00000395438.1 ENST00000409834.1 ENST00000395445.1 ENST00000395446.1 ENST00000395442.1 ENST00000395440.1 ENST00000395432.2 ENST00000361849.3 ENST00000395433.1 ENST00000320301.6 ENST00000395430.1 ENST00000437009.1	PCDH15	protocadherin-related 15
chr4_+_71587669	0.040	ENST00000381006.3 ENST00000226328.4	RUFY3	RUN and FYVE domain containing 3
chr14_+_32798462	0.038	ENST00000280979.4	AKAP6	A kinase (PRKA) anchor protein 6
chr4_-_46126093	0.037	ENST00000295452.4	GABRG1	gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr17_+_74261413	0.037	ENST00000587913.1	UBALD2	UBA-like domain containing 2
chr5_-_31532160	0.037	ENST00000511367.2 ENST00000513349.1	DROSHA	drosha, ribonuclease type III
chr1_-_151965048	0.035	ENST00000368809.1	S100A10	S100 calcium binding protein A10
chr20_+_56964169	0.034	ENST00000475243.1	VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C
chr3_+_113251143	0.033	ENST00000264852.4 ENST00000393830.3	SIDT1	SID1 transmembrane family, member 1
chr7_+_134331550	0.032	ENST00000344924.3 ENST00000418040.1 ENST00000393132.2	BPGM	2,3-bisphosphoglycerate mutase
chr10_+_85954377	0.031	ENST00000332904.3 ENST00000372117.3	CDHR1	cadherin-related family member 1
chr8_+_9413410	0.030	ENST00000520408.1 ENST00000310430.6 ENST00000522110.1	TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr7_-_99716952	0.030	ENST00000523306.1 ENST00000344095.4 ENST00000417349.1 ENST00000493322.1 ENST00000520135.1 ENST00000418432.2 ENST00000460673.2 ENST00000452041.1 ENST00000452438.2 ENST00000451699.1 ENST00000453269.2	TAF6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr20_-_50418947	0.030	ENST00000371539.3	SALL4	spalt-like transcription factor 4
chr10_+_99205894	0.029	ENST00000370854.3 ENST00000393760.1 ENST00000414567.1 ENST00000370846.4	ZDHHC16	zinc finger, DHHC-type containing 16
chr1_+_151735431	0.029	ENST00000321531.5 ENST00000315067.8	OAZ3	ornithine decarboxylase antizyme 3
chr7_-_56174161	0.026	ENST00000395422.3	CHCHD2	coiled-coil-helix-coiled-coil-helix domain containing 2
chr20_-_50418972	0.026	ENST00000395997.3	SALL4	spalt-like transcription factor 4
chr11_-_102323740	0.025	ENST00000398136.2	TMEM123	transmembrane protein 123
chr10_+_99205959	0.025	ENST00000352634.4 ENST00000353979.3 ENST00000370842.2 ENST00000345745.5	ZDHHC16	zinc finger, DHHC-type containing 16
chrX_+_113818545	0.025	ENST00000371951.1 ENST00000276198.1 ENST00000371950.3	HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
chr21_-_22175341	0.024	ENST00000416768.1 ENST00000452561.1 ENST00000419299.1 ENST00000437238.1	LINC00320	long intergenic non-protein coding RNA 320
chr12_-_95397442	0.023	ENST00000547157.1 ENST00000547986.1 ENST00000327772.2	NDUFA12	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr16_+_69345243	0.022	ENST00000254950.11	VPS4A	vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr4_-_69434245	0.022	ENST00000317746.2	UGT2B17	UDP glucuronosyltransferase 2 family, polypeptide B17
chr5_+_31532373	0.021	ENST00000325366.9 ENST00000355907.3 ENST00000507818.2	C5orf22	chromosome 5 open reading frame 22
chr10_-_72142345	0.021	ENST00000373224.1 ENST00000446961.1 ENST00000358141.2 ENST00000357631.2	LRRC20	leucine rich repeat containing 20
chr1_-_228613026	0.020	ENST00000366696.1	HIST3H3	histone cluster 3, H3
chr11_-_71823266	0.020	ENST00000538919.1 ENST00000539395.1 ENST00000542531.1	ANAPC15	anaphase promoting complex subunit 15
chr18_+_5748793	0.019	ENST00000566533.1 ENST00000562452.2	RP11-945C19.1	RP11-945C19.1
chr9_-_95056010	0.019	ENST00000443024.2	IARS	isoleucyl-tRNA synthetase
chr14_+_22670455	0.019	ENST00000390460.1	TRAV26-2	T cell receptor alpha variable 26-2
chr2_+_90248739	0.018	ENST00000468879.1	IGKV1D-43	immunoglobulin kappa variable 1D-43
chr7_-_100183742	0.017	ENST00000310300.6	LRCH4	leucine-rich repeats and calponin homology (CH) domain containing 4
chr5_+_95997918	0.017	ENST00000395812.2 ENST00000395813.1 ENST00000359176.4 ENST00000325674.7	CAST	calpastatin
chr6_+_30687978	0.014	ENST00000327892.8 ENST00000435534.1	TUBB	tubulin, beta class I
chr5_+_66254698	0.013	ENST00000405643.1 ENST00000407621.1 ENST00000432426.1	MAST4	microtubule associated serine/threonine kinase family member 4
chr19_-_46088068	0.013	ENST00000263275.4 ENST00000323060.3	OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr14_-_23504337	0.012	ENST00000361611.6	PSMB5	proteasome (prosome, macropain) subunit, beta type, 5
chr11_-_71823796	0.011	ENST00000545680.1 ENST00000543587.1 ENST00000538393.1 ENST00000535234.1 ENST00000227618.4 ENST00000535503.1	ANAPC15	anaphase promoting complex subunit 15
chr7_-_25268104	0.011	ENST00000222674.2	NPVF	neuropeptide VF precursor
chr19_+_17378159	0.010	ENST00000598188.1 ENST00000359435.4 ENST00000599474.1 ENST00000599057.1 ENST00000601043.1 ENST00000447614.2	BABAM1	BRISC and BRCA1 A complex member 1
chr22_+_17956618	0.008	ENST00000262608.8	CECR2	cat eye syndrome chromosome region, candidate 2
chr12_-_57039739	0.008	ENST00000552959.1 ENST00000551020.1 ENST00000553007.2 ENST00000552919.1 ENST00000552104.1 ENST00000262030.3	ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr19_+_17378278	0.008	ENST00000596335.1 ENST00000601436.1 ENST00000595632.1	BABAM1	BRISC and BRCA1 A complex member 1
chr14_-_23504432	0.007	ENST00000425762.2	PSMB5	proteasome (prosome, macropain) subunit, beta type, 5
chr11_+_67250490	0.007	ENST00000528641.2 ENST00000279146.3	AIP	aryl hydrocarbon receptor interacting protein
chr12_+_52695617	0.007	ENST00000293525.5	KRT86	keratin 86
chr11_-_71823715	0.006	ENST00000545944.1 ENST00000502597.2	ANAPC15	anaphase promoting complex subunit 15
chr14_+_39736582	0.005	ENST00000556148.1 ENST00000348007.3	CTAGE5	CTAGE family, member 5
chr4_-_46996424	0.004	ENST00000264318.3	GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr10_-_28571015	0.004	ENST00000375719.3 ENST00000375732.1	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr2_+_172864490	0.004	ENST00000315796.4	METAP1D	methionyl aminopeptidase type 1D (mitochondrial)
chr9_-_4666421	0.002	ENST00000381895.5	SPATA6L	spermatogenesis associated 6-like
chr7_-_99717463	0.001	ENST00000437822.2	TAF6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.2	0.5	GO:0007057	spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.1	0.8	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.1	0.3	GO:1903566	positive regulation of protein localization to cilium(GO:1903566)
0.1	0.2	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.1	0.2	GO:0006258	UDP-glucose catabolic process(GO:0006258)
0.0	0.1	GO:0042938	dipeptide transport(GO:0042938)
0.0	0.1	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
0.0	0.2	GO:0019236	response to pheromone(GO:0019236)
0.0	0.3	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0	0.1	GO:1900158	positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0	0.1	GO:0090402	oncogene-induced cell senescence(GO:0090402)
0.0	0.1	GO:0042816	vitamin B6 metabolic process(GO:0042816)
0.0	0.1	GO:0033504	floor plate development(GO:0033504)
0.0	0.2	GO:0043249	erythrocyte maturation(GO:0043249)
0.0	0.1	GO:1902174	positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0	0.1	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0001674	female germ cell nucleus(GO:0001674)
0.1	0.3	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0	0.1	GO:1990032	parallel fiber(GO:1990032)
0.0	0.8	GO:0032982	myosin filament(GO:0032982)
0.0	0.2	GO:0036449	microtubule minus-end(GO:0036449)
0.0	0.3	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.1	GO:0005889	hydrogen:potassium-exchanging ATPase complex(GO:0005889)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1	0.5	GO:0035174	histone serine kinase activity(GO:0035174)
0.0	0.1	GO:0015563	uptake transmembrane transporter activity(GO:0015563)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.8	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.1	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.3	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0061665	SUMO ligase activity(GO:0061665)
0.0	0.0	GO:0003839	gamma-glutamylcyclotransferase activity(GO:0003839)
0.0	0.1	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0	0.2	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.0	0.0	GO:0033149	FFAT motif binding(GO:0033149)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection

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