Motif ID: NR1D1

Z-value: 0.438


Transcription factors associated with NR1D1:

Gene SymbolEntrez IDGene Name
NR1D1 ENSG00000126368.5 NR1D1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR1D1hg19_v2_chr17_-_38256973_382569900.019.8e-01Click!


Activity profile for motif NR1D1.

activity profile for motif NR1D1


Sorted Z-values histogram for motif NR1D1

Sorted Z-values for motif NR1D1



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1D1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_20915409 1.244 ENST00000375071.3
CDA
cytidine deaminase
chr2_+_127656486 0.644 ENST00000568484.1
ENST00000450035.1
AC114783.1

Protein LOC339760

chr14_+_24540046 0.599 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6



copine VI (neuronal)



chr14_+_24540731 0.533 ENST00000558859.1
ENST00000559197.1
ENST00000560828.1
ENST00000216775.2
ENST00000560884.1
CPNE6




copine VI (neuronal)




chr1_-_111991850 0.458 ENST00000411751.2
WDR77
WD repeat domain 77
chr16_+_71392616 0.437 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2


calbindin 2


chr14_-_50999190 0.436 ENST00000557390.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr1_-_6557156 0.424 ENST00000537245.1
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr3_-_182703688 0.406 ENST00000466812.1
ENST00000487822.1
ENST00000460412.1
ENST00000469954.1
DCUN1D1



DCN1, defective in cullin neddylation 1, domain containing 1



chr2_-_89442621 0.406 ENST00000492167.1
IGKV3-20
immunoglobulin kappa variable 3-20
chr14_-_94595993 0.379 ENST00000238609.3
IFI27L2
interferon, alpha-inducible protein 27-like 2
chr10_-_43762329 0.363 ENST00000395810.1
RASGEF1A
RasGEF domain family, member 1A
chr22_-_37880543 0.359 ENST00000442496.1
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr16_+_77225071 0.348 ENST00000439557.2
ENST00000545553.1
MON1B

MON1 secretory trafficking family member B

chr1_-_111991908 0.330 ENST00000235090.5
WDR77
WD repeat domain 77
chr1_-_11865982 0.328 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr5_-_43313574 0.328 ENST00000325110.6
ENST00000433297.2
HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr1_-_26232951 0.327 ENST00000426559.2
ENST00000455785.2
STMN1

stathmin 1

chr1_-_26232522 0.324 ENST00000399728.1
STMN1
stathmin 1
chr4_+_169842707 0.322 ENST00000503290.1
PALLD
palladin, cytoskeletal associated protein
chr9_-_136242909 0.321 ENST00000371991.3
ENST00000545297.1
SURF4

surfeit 4

chr15_+_26360970 0.276 ENST00000556159.1
ENST00000557523.1
LINC00929

long intergenic non-protein coding RNA 929

chr1_+_110210644 0.268 ENST00000369831.2
ENST00000442650.1
ENST00000369827.3
ENST00000460717.3
ENST00000241337.4
ENST00000467579.3
ENST00000414179.2
ENST00000369829.2
GSTM2







glutathione S-transferase mu 2 (muscle)







chr4_+_1873100 0.262 ENST00000508803.1
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr19_-_42927251 0.251 ENST00000597001.1
LIPE
lipase, hormone-sensitive
chr17_-_36347030 0.244 ENST00000518551.1
TBC1D3
TBC1 domain family, member 3
chr19_-_19932501 0.243 ENST00000540806.2
ENST00000590766.1
ENST00000587452.1
ENST00000545006.1
ENST00000590319.1
ENST00000587461.1
ENST00000450683.2
ENST00000443905.2
ENST00000590274.1
ZNF506







CTC-559E9.4
zinc finger protein 506







CTC-559E9.4
chr14_-_50999307 0.234 ENST00000013125.4
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr1_-_11865351 0.224 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
MTHFR



methylenetetrahydrofolate reductase (NAD(P)H)



chr2_+_220306745 0.220 ENST00000431523.1
ENST00000396698.1
ENST00000396695.2
SPEG


SPEG complex locus


chr19_-_14629224 0.215 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr1_-_11866034 0.200 ENST00000376590.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chrX_+_54947229 0.200 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
TRO











trophinin











chr3_-_52002403 0.199 ENST00000490063.1
ENST00000468324.1
ENST00000497653.1
ENST00000484633.1
PCBP4



poly(rC) binding protein 4



chr1_-_41131326 0.196 ENST00000372684.3
RIMS3
regulating synaptic membrane exocytosis 3
chr17_-_3599492 0.185 ENST00000435558.1
ENST00000345901.3
P2RX5

purinergic receptor P2X, ligand-gated ion channel, 5

chr8_+_11561660 0.185 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA4


GATA binding protein 4


chr19_-_51220176 0.181 ENST00000359082.3
ENST00000293441.1
SHANK1

SH3 and multiple ankyrin repeat domains 1

chr17_-_3599327 0.180 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
P2RX5


purinergic receptor P2X, ligand-gated ion channel, 5


chr1_+_168250194 0.172 ENST00000367821.3
TBX19
T-box 19
chr17_+_39405939 0.168 ENST00000334109.2
KRTAP9-4
keratin associated protein 9-4
chr1_-_38218577 0.165 ENST00000540011.1
EPHA10
EPH receptor A10
chr6_+_31543334 0.164 ENST00000449264.2
TNF
tumor necrosis factor
chr2_-_89513402 0.160 ENST00000498435.1
IGKV1-27
immunoglobulin kappa variable 1-27
chr1_+_2398876 0.159 ENST00000449969.1
PLCH2
phospholipase C, eta 2
chr19_+_21324863 0.159 ENST00000598331.1
ZNF431
zinc finger protein 431
chr22_-_47882857 0.157 ENST00000405369.3
LL22NC03-75H12.2
Novel protein; Uncharacterized protein
chr15_+_65903680 0.152 ENST00000537259.1
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr10_-_103880209 0.147 ENST00000425280.1
LDB1
LIM domain binding 1
chr17_-_79139817 0.143 ENST00000326724.4
AATK
apoptosis-associated tyrosine kinase
chr1_-_26233423 0.140 ENST00000357865.2
STMN1
stathmin 1
chrX_+_68725084 0.138 ENST00000252338.4
FAM155B
family with sequence similarity 155, member B
chr1_+_203764742 0.135 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
ZC3H11A




zinc finger CCCH-type containing 11A




chr2_+_90153696 0.131 ENST00000417279.2
IGKV3D-15
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr2_-_73053126 0.126 ENST00000272427.6
ENST00000410104.1
EXOC6B

exocyst complex component 6B

chr7_+_45039783 0.126 ENST00000258781.6
ENST00000541586.1
ENST00000544363.1
CCM2


cerebral cavernous malformation 2


chr10_+_11047259 0.123 ENST00000379261.4
ENST00000416382.2
CELF2

CUGBP, Elav-like family member 2

chr19_+_21203481 0.122 ENST00000595401.1
ZNF430
zinc finger protein 430
chr16_+_67233412 0.120 ENST00000477898.1
ELMO3
engulfment and cell motility 3
chr16_+_67233007 0.120 ENST00000360833.1
ENST00000393997.2
ELMO3

engulfment and cell motility 3

chr12_-_110883346 0.115 ENST00000547365.1
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr17_+_39394250 0.115 ENST00000254072.6
KRTAP9-8
keratin associated protein 9-8
chr1_-_226374373 0.114 ENST00000366812.5
ACBD3
acyl-CoA binding domain containing 3
chrX_+_130192318 0.113 ENST00000370922.1
ARHGAP36
Rho GTPase activating protein 36
chr22_+_37415700 0.110 ENST00000397129.1
MPST
mercaptopyruvate sulfurtransferase
chr19_-_12833361 0.107 ENST00000592287.1
TNPO2
transportin 2
chr14_+_100789669 0.105 ENST00000361529.3
ENST00000557052.1
SLC25A47

solute carrier family 25, member 47

chr17_-_76128488 0.104 ENST00000322914.3
TMC6
transmembrane channel-like 6
chr6_+_167525277 0.104 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr7_-_128695147 0.104 ENST00000482320.1
ENST00000393245.1
ENST00000471234.1
TNPO3


transportin 3


chr7_-_44229022 0.103 ENST00000403799.3
GCK
glucokinase (hexokinase 4)
chr1_+_161719552 0.096 ENST00000367943.4
DUSP12
dual specificity phosphatase 12
chr16_+_30006615 0.094 ENST00000563197.1
INO80E
INO80 complex subunit E
chr7_-_128694927 0.093 ENST00000471166.1
ENST00000265388.5
TNPO3

transportin 3

chr22_+_37415728 0.093 ENST00000404802.3
MPST
mercaptopyruvate sulfurtransferase
chr10_+_90346519 0.090 ENST00000371939.3
LIPJ
lipase, family member J
chr1_+_44398943 0.088 ENST00000372359.5
ENST00000414809.3
ARTN

artemin

chr19_-_23433144 0.084 ENST00000418100.1
ENST00000597537.1
ENST00000597037.1
ZNF724P


zinc finger protein 724, pseudogene


chr9_+_136243264 0.083 ENST00000371955.1
C9orf96
chromosome 9 open reading frame 96
chr14_+_74815116 0.082 ENST00000256362.4
VRTN
vertebrae development associated
chr6_+_99282570 0.082 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chr22_+_37415776 0.081 ENST00000341116.3
ENST00000429360.2
ENST00000404393.1
MPST


mercaptopyruvate sulfurtransferase


chr7_+_114562616 0.081 ENST00000448022.1
MDFIC
MyoD family inhibitor domain containing
chr1_-_11007927 0.080 ENST00000468348.1
C1orf127
chromosome 1 open reading frame 127
chr3_+_171758344 0.079 ENST00000336824.4
ENST00000423424.1
FNDC3B

fibronectin type III domain containing 3B

chr11_+_125365110 0.077 ENST00000527818.1
AP000708.1
AP000708.1
chr19_+_22235279 0.074 ENST00000594363.1
ENST00000597927.1
ENST00000594947.1
ZNF257


zinc finger protein 257


chr4_-_147043058 0.072 ENST00000512063.1
ENST00000507726.1
RP11-6L6.3

long intergenic non-protein coding RNA 1095

chr11_-_64013663 0.067 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr9_-_136242956 0.067 ENST00000371989.3
ENST00000485435.2
SURF4

surfeit 4

chr9_+_136243117 0.066 ENST00000426926.2
ENST00000371957.3
C9orf96

chromosome 9 open reading frame 96

chr6_+_63921351 0.064 ENST00000370659.1
FKBP1C
FK506 binding protein 1C
chr19_+_21203426 0.061 ENST00000261560.5
ENST00000599548.1
ENST00000594110.1
ZNF430


zinc finger protein 430


chr16_+_1832902 0.061 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
NUBP2





nucleotide binding protein 2





chr19_-_43702231 0.060 ENST00000597374.1
ENST00000599371.1
PSG4

pregnancy specific beta-1-glycoprotein 4

chr3_-_48723268 0.059 ENST00000439518.1
ENST00000416649.2
ENST00000341520.4
ENST00000294129.2
NCKIPSD



NCK interacting protein with SH3 domain



chr7_-_142630820 0.055 ENST00000442623.1
ENST00000265310.1
TRPV5

transient receptor potential cation channel, subfamily V, member 5

chr2_-_103353277 0.053 ENST00000258436.5
MFSD9
major facilitator superfamily domain containing 9
chr22_+_27017921 0.050 ENST00000354760.3
CRYBA4
crystallin, beta A4
chr15_-_81282133 0.048 ENST00000261758.4
MESDC2
mesoderm development candidate 2
chr4_+_88529681 0.046 ENST00000399271.1
DSPP
dentin sialophosphoprotein
chr14_+_50999744 0.043 ENST00000441560.2
ATL1
atlastin GTPase 1
chrX_+_24167828 0.038 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
ZFX



zinc finger protein, X-linked



chr17_-_56358287 0.037 ENST00000225275.3
ENST00000340482.3
MPO

myeloperoxidase

chr13_+_113623509 0.036 ENST00000535094.2
MCF2L
MCF.2 cell line derived transforming sequence-like
chr12_-_7125770 0.035 ENST00000261407.4
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr6_+_76458909 0.034 ENST00000369981.3
ENST00000369985.4
MYO6

myosin VI

chr10_-_105156198 0.034 ENST00000369815.1
ENST00000309579.3
ENST00000337003.4
USMG5


up-regulated during skeletal muscle growth 5 homolog (mouse)


chr19_+_21324827 0.033 ENST00000600692.1
ENST00000599296.1
ENST00000594425.1
ENST00000311048.7
ZNF431



zinc finger protein 431



chr9_-_35112376 0.030 ENST00000488109.2
FAM214B
family with sequence similarity 214, member B
chr17_-_38256973 0.027 ENST00000246672.3
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr17_+_39411636 0.026 ENST00000394008.1
KRTAP9-9
keratin associated protein 9-9
chr1_+_159796534 0.023 ENST00000289707.5
SLAMF8
SLAM family member 8
chr19_-_52035044 0.021 ENST00000359982.4
ENST00000436458.1
ENST00000425629.3
ENST00000391797.3
ENST00000343300.4
SIGLEC6




sialic acid binding Ig-like lectin 6




chr7_+_62809239 0.020 ENST00000456890.1
AC006455.1
AC006455.1
chr2_+_103353367 0.019 ENST00000454536.1
ENST00000409528.1
ENST00000409173.1
TMEM182


transmembrane protein 182


chrX_+_24167746 0.017 ENST00000428571.1
ENST00000539115.1
ZFX

zinc finger protein, X-linked

chr9_+_91150016 0.016 ENST00000375854.3
ENST00000375855.3
NXNL2

nucleoredoxin-like 2

chr6_+_76458990 0.016 ENST00000369977.3
MYO6
myosin VI
chr19_-_12833164 0.016 ENST00000356861.5
TNPO2
transportin 2
chr4_-_21699380 0.014 ENST00000382148.3
KCNIP4
Kv channel interacting protein 4
chr9_-_37592561 0.012 ENST00000544379.1
ENST00000377773.5
ENST00000401811.3
ENST00000321301.6
TOMM5



translocase of outer mitochondrial membrane 5 homolog (yeast)



chr19_+_21264980 0.012 ENST00000596053.1
ENST00000597086.1
ENST00000596143.1
ENST00000596367.1
ENST00000601416.1
ZNF714




zinc finger protein 714




chr13_+_100741269 0.012 ENST00000376286.4
ENST00000376279.3
ENST00000376285.1
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr1_+_165513231 0.004 ENST00000294818.1
LRRC52
leucine rich repeat containing 52
chr2_-_64371546 0.002 ENST00000358912.4
PELI1
pellino E3 ubiquitin protein ligase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0019858 cytosine metabolic process(GO:0019858)
0.2 0.2 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.2 0.8 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.2 0.8 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.1 0.8 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1 0.3 GO:0019085 early viral transcription(GO:0019085)
0.1 0.2 GO:0003285 septum secundum development(GO:0003285)
0.1 0.2 GO:0050894 determination of affect(GO:0050894)
0.1 0.3 GO:0009439 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.1 0.3 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.3 GO:0070458 cellular detoxification of nitrogen compound(GO:0070458)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 1.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.1 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.5 GO:0009642 response to light intensity(GO:0009642)
0.0 0.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.4 GO:0045116 protein neddylation(GO:0045116)
0.0 0.1 GO:0097021 Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021)
0.0 0.1 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.1 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071749 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.0 0.8 GO:0034709 methylosome(GO:0034709)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 0.8 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.3 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.3 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.1 0.2 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 0.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.1 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.0 0.8 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.1 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.4 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.3 GO:0043295 glutathione binding(GO:0043295)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.2 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.4 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.8 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis