Motif ID: NR4A1
Z-value: 0.531
Transcription factors associated with NR4A1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
NR4A1 | ENSG00000123358.15 | NR4A1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
NR4A1 | hg19_v2_chr12_+_52445191_52445243 | 0.39 | 6.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.0 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
0.2 | 1.0 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) |
0.2 | 0.7 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
0.2 | 0.8 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
0.1 | 0.6 | GO:2001295 | malonyl-CoA biosynthetic process(GO:2001295) |
0.1 | 0.7 | GO:0061055 | myotome development(GO:0061055) |
0.1 | 0.3 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
0.1 | 0.3 | GO:1904199 | positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736) |
0.1 | 0.8 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
0.1 | 0.3 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
0.1 | 0.3 | GO:0036023 | limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023) |
0.0 | 0.2 | GO:1903788 | mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788) |
0.0 | 0.4 | GO:0002759 | regulation of antimicrobial humoral response(GO:0002759) |
0.0 | 0.3 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
0.0 | 0.4 | GO:0015889 | cobalamin transport(GO:0015889) |
0.0 | 0.1 | GO:0050787 | antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787) |
0.0 | 0.1 | GO:0032290 | peripheral nervous system myelin formation(GO:0032290) |
0.0 | 0.3 | GO:1901341 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
0.0 | 0.1 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
0.0 | 0.5 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
0.0 | 1.5 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
0.0 | 0.8 | GO:0072189 | ureter development(GO:0072189) |
0.0 | 0.5 | GO:0006853 | carnitine shuttle(GO:0006853) |
0.0 | 0.4 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
0.0 | 0.3 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
0.0 | 0.1 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
0.0 | 0.2 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
0.0 | 0.3 | GO:0046520 | sphingoid biosynthetic process(GO:0046520) |
0.0 | 0.3 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
0.0 | 0.3 | GO:0016559 | peroxisome fission(GO:0016559) |
0.0 | 0.2 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) regulation of grooming behavior(GO:2000821) |
0.0 | 0.0 | GO:1903630 | regulation of aminoacyl-tRNA ligase activity(GO:1903630) |
0.0 | 0.3 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.0 | 0.3 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
0.0 | 0.2 | GO:0016446 | somatic hypermutation of immunoglobulin genes(GO:0016446) |
0.0 | 1.3 | GO:0019730 | antimicrobial humoral response(GO:0019730) |
0.0 | 0.3 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.0 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
0.1 | 0.3 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
0.1 | 0.4 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
0.0 | 0.8 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
0.0 | 0.3 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
0.0 | 0.3 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
0.0 | 0.3 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.0 | 0.2 | GO:0032389 | MutLalpha complex(GO:0032389) |
0.0 | 0.2 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
0.0 | 0.3 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
0.0 | 0.1 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
0.0 | 0.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
0.0 | 0.3 | GO:0034706 | sodium channel complex(GO:0034706) |
0.0 | 0.1 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.0 | 0.2 | GO:0035102 | PRC1 complex(GO:0035102) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.7 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
0.2 | 1.0 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
0.1 | 0.6 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
0.1 | 0.5 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
0.1 | 0.3 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
0.1 | 0.2 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
0.1 | 0.3 | GO:0002046 | opsin binding(GO:0002046) |
0.1 | 0.3 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
0.0 | 0.4 | GO:0031419 | cobalamin binding(GO:0031419) |
0.0 | 1.3 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
0.0 | 0.1 | GO:0004530 | ribonuclease III activity(GO:0004525) deoxyribonuclease I activity(GO:0004530) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
0.0 | 0.8 | GO:0005521 | lamin binding(GO:0005521) |
0.0 | 0.2 | GO:0032138 | single base insertion or deletion binding(GO:0032138) |
0.0 | 0.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
0.0 | 0.1 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
0.0 | 0.1 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
0.0 | 0.4 | GO:0035173 | histone kinase activity(GO:0035173) |
0.0 | 0.1 | GO:0004969 | histamine receptor activity(GO:0004969) |
0.0 | 0.1 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.0 | 0.3 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.6 | ST_GA12_PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.3 | REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
0.1 | 1.0 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
0.0 | 1.7 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
0.0 | 0.7 | REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT | Genes involved in Initial triggering of complement |
0.0 | 1.1 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
0.0 | 0.5 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
0.0 | 1.0 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
0.0 | 0.3 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
0.0 | 0.3 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
0.0 | 0.3 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
0.0 | 0.4 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |