Motif ID: PAX1_PAX9

Z-value: 0.576

Transcription factors associated with PAX1_PAX9:

Gene SymbolEntrez IDGene Name
PAX1 ENSG00000125813.9 PAX1
PAX9 ENSG00000198807.8 PAX9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PAX9hg19_v2_chr14_+_37126765_371267990.546.9e-03Click!
PAX1hg19_v2_chr20_+_21686290_216863110.232.8e-01Click!


Activity profile for motif PAX1_PAX9.

activity profile for motif PAX1_PAX9


Sorted Z-values histogram for motif PAX1_PAX9

Sorted Z-values for motif PAX1_PAX9



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX1_PAX9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_23261589 3.584 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
 LOXL2



lysyl oxidase-like 2



chr4_+_75230853 3.393 ENST00000244869.2
 EREG
epiregulin
chr9_+_33750667 1.806 ENST00000457896.1
ENST00000342836.4
ENST00000429677.3
 PRSS3


protease, serine, 3


chr9_+_33750515 1.803 ENST00000361005.5
 PRSS3
protease, serine, 3
chr7_+_36429424 1.800 ENST00000396068.2
 ANLN
anillin, actin binding protein
chr7_+_36429409 1.768 ENST00000265748.2
 ANLN
anillin, actin binding protein
chr9_+_33795533 1.333 ENST00000379405.3
 PRSS3
protease, serine, 3
chr11_+_12308447 1.181 ENST00000256186.2
 MICALCL
MICAL C-terminal like
chr19_-_40791211 0.933 ENST00000579047.1
 AKT2
v-akt murine thymoma viral oncogene homolog 2
chr18_-_33077556 0.914 ENST00000589273.1
ENST00000586489.1
 INO80C

INO80 complex subunit C

chr13_+_98086445 0.671 ENST00000245304.4
 RAP2A
RAP2A, member of RAS oncogene family
chr7_+_142457315 0.621 ENST00000486171.1
ENST00000311737.7
 PRSS1

protease, serine, 1 (trypsin 1)

chr17_+_39969183 0.609 ENST00000321562.4
 FKBP10
FK506 binding protein 10, 65 kDa
chr17_-_33814851 0.606 ENST00000449046.1
ENST00000260908.7
 SLFN12L

schlafen family member 12-like

chr6_-_137494775 0.541 ENST00000349184.4
ENST00000296980.2
ENST00000339602.3
 IL22RA2


interleukin 22 receptor, alpha 2


chr17_+_15848231 0.445 ENST00000304222.2
 ADORA2B
adenosine A2b receptor
chr8_-_125384927 0.431 ENST00000297632.6
 TMEM65
transmembrane protein 65
chr17_-_7137582 0.352 ENST00000575756.1
ENST00000575458.1
 DVL2

dishevelled segment polarity protein 2

chr6_-_137366163 0.330 ENST00000367748.1
 IL20RA
interleukin 20 receptor, alpha
chr5_+_72251857 0.325 ENST00000507345.2
ENST00000512348.1
ENST00000287761.6
 FCHO2


FCH domain only 2


chr8_-_101965559 0.309 ENST00000353245.3
 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr5_-_133747589 0.283 ENST00000458198.2
 CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr9_-_124991124 0.277 ENST00000394319.4
ENST00000340587.3
 LHX6

LIM homeobox 6

chr19_-_40791302 0.259 ENST00000392038.2
ENST00000578123.1
 AKT2

v-akt murine thymoma viral oncogene homolog 2

chr1_-_204165610 0.237 ENST00000367194.4
 KISS1
KiSS-1 metastasis-suppressor
chr2_+_234160217 0.235 ENST00000392017.4
ENST00000347464.5
ENST00000444735.1
ENST00000373525.5
ENST00000419681.1
 ATG16L1




autophagy related 16-like 1 (S. cerevisiae)




chr2_+_119699864 0.212 ENST00000541757.1
ENST00000412481.1
 MARCO

macrophage receptor with collagenous structure

chr2_+_234160340 0.207 ENST00000417017.1
ENST00000392020.4
ENST00000392018.1
 ATG16L1


autophagy related 16-like 1 (S. cerevisiae)


chr7_-_112758589 0.205 ENST00000413744.1
ENST00000439551.1
ENST00000441359.1
 LINC00998


long intergenic non-protein coding RNA 998


chr7_-_112758665 0.204 ENST00000397764.3
 LINC00998
long intergenic non-protein coding RNA 998
chr7_-_144533074 0.191 ENST00000360057.3
ENST00000378099.3
 TPK1

thiamin pyrophosphokinase 1

chr19_+_14184370 0.186 ENST00000590772.1
 hsa-mir-1199
hsa-mir-1199
chr14_-_69261310 0.184 ENST00000336440.3
 ZFP36L1
ZFP36 ring finger protein-like 1
chr17_-_39968406 0.182 ENST00000393928.1
 LEPREL4
leprecan-like 4
chr3_-_57113314 0.173 ENST00000338458.4
ENST00000468727.1
 ARHGEF3

Rho guanine nucleotide exchange factor (GEF) 3

chr11_+_6947720 0.171 ENST00000414517.2
 ZNF215
zinc finger protein 215
chr10_-_99393242 0.170 ENST00000370635.3
ENST00000478953.1
ENST00000335628.3
 MORN4


MORN repeat containing 4


chr4_+_123747834 0.155 ENST00000264498.3
 FGF2
fibroblast growth factor 2 (basic)
chr9_-_104249400 0.149 ENST00000374848.3
 TMEM246
transmembrane protein 246
chr14_+_64854958 0.147 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
 MTHFD1



methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase



chr10_-_43904608 0.134 ENST00000337970.3
 HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr11_+_6947647 0.131 ENST00000278319.5
 ZNF215
zinc finger protein 215
chr17_-_39968855 0.121 ENST00000355468.3
ENST00000590496.1
 LEPREL4

leprecan-like 4

chr4_-_77997126 0.116 ENST00000537948.1
ENST00000507788.1
ENST00000237654.4
 CCNI


cyclin I


chr12_+_57828521 0.114 ENST00000309668.2
 INHBC
inhibin, beta C
chr15_+_63569785 0.111 ENST00000380343.4
ENST00000560353.1
 APH1B

APH1B gamma secretase subunit

chr4_-_171011084 0.105 ENST00000337664.4
 AADAT
aminoadipate aminotransferase
chr4_-_171011323 0.102 ENST00000509167.1
ENST00000353187.2
ENST00000507375.1
ENST00000515480.1
 AADAT



aminoadipate aminotransferase



chr8_-_101965146 0.100 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
 YWHAZ


tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta


chr10_-_99393208 0.094 ENST00000307450.6
 MORN4
MORN repeat containing 4
chr17_+_37356555 0.094 ENST00000579374.1
 RPL19
ribosomal protein L19
chr7_-_19157248 0.091 ENST00000242261.5
 TWIST1
twist family bHLH transcription factor 1
chr9_-_21142144 0.090 ENST00000380229.2
 IFNW1
interferon, omega 1
chr17_+_37356586 0.088 ENST00000579260.1
ENST00000582193.1
 RPL19

ribosomal protein L19

chr1_+_26758790 0.086 ENST00000427245.2
ENST00000525682.2
ENST00000236342.7
ENST00000526219.1
ENST00000374185.3
ENST00000360009.2
 DHDDS





dehydrodolichyl diphosphate synthase





chr17_+_37356528 0.082 ENST00000225430.4
 RPL19
ribosomal protein L19
chr19_-_409134 0.075 ENST00000332235.6
 C2CD4C
C2 calcium-dependent domain containing 4C
chr11_+_63870660 0.062 ENST00000246841.3
 FLRT1
fibronectin leucine rich transmembrane protein 1
chr1_+_26759295 0.053 ENST00000430232.1
 DHDDS
dehydrodolichyl diphosphate synthase
chr18_+_39766626 0.037 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
 LINC00907








long intergenic non-protein coding RNA 907








chr8_+_39792474 0.032 ENST00000502986.2
 IDO2
indoleamine 2,3-dioxygenase 2
chr14_+_24540046 0.025 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
 CPNE6



copine VI (neuronal)



chr14_+_39703112 0.016 ENST00000555143.1
ENST00000280082.3
 MIA2

melanoma inhibitory activity 2

chr3_-_25824872 0.007 ENST00000308710.5
 NGLY1
N-glycanase 1
chr6_+_159291090 0.006 ENST00000367073.4
ENST00000608817.1
 C6orf99

chromosome 6 open reading frame 99

chr1_+_45140360 0.006 ENST00000418644.1
ENST00000458657.2
ENST00000441519.1
ENST00000535358.1
ENST00000445071.1
 C1orf228




chromosome 1 open reading frame 228




chr18_-_47017956 0.001 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
 RPL17-C18orf32

RPL17

RPL17-C18orf32 readthrough

ribosomal protein L17

chr4_+_123747979 0.001 ENST00000608478.1
 FGF2
fibroblast growth factor 2 (basic)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:1904170 regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
1.1 3.4 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.3 1.2 GO:0071484 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484)
0.2 0.6 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.2 5.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.4 GO:0002545 chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880)
0.1 3.6 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.1 0.4 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 0.4 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 0.2 GO:1904580 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.1 0.7 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.2 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.0 0.2 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.2 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.0 0.1 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.0 0.1 GO:2000793 cell proliferation involved in heart valve development(GO:2000793)
0.0 0.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.4 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.2 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.3 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.6 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 4.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.9 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 3.6 GO:0005604 basement membrane(GO:0005604)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.2 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1 0.3 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 3.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.3 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.1 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.0 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 1.2 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 5.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.0 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.2 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 9.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 3.4 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.6 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.2 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo