Motif ID: PITX2

Z-value: 0.474


Transcription factors associated with PITX2:

Gene SymbolEntrez IDGene Name
PITX2 ENSG00000164093.11 PITX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111544254_111544270,
hg19_v2_chr4_-_111558135_111558198,
hg19_v2_chr4_-_111563076_111563172
-0.368.9e-02Click!


Activity profile for motif PITX2.

activity profile for motif PITX2


Sorted Z-values histogram for motif PITX2

Sorted Z-values for motif PITX2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_34458771 2.054 ENST00000437363.1
ENST00000242317.4
DNAI1

dynein, axonemal, intermediate chain 1

chr13_-_36429763 2.038 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr11_-_5248294 1.697 ENST00000335295.4
HBB
hemoglobin, beta
chr6_-_111804905 0.862 ENST00000358835.3
ENST00000435970.1
REV3L

REV3-like, polymerase (DNA directed), zeta, catalytic subunit

chr16_-_5116025 0.796 ENST00000472572.3
ENST00000315997.5
ENST00000422873.1
ENST00000350219.4
C16orf89



chromosome 16 open reading frame 89



chr3_+_119421849 0.730 ENST00000273390.5
ENST00000463700.1
MAATS1

MYCBP-associated, testis expressed 1

chr19_-_49843539 0.710 ENST00000602554.1
ENST00000358234.4
CTC-301O7.4

CTC-301O7.4

chr12_-_90049878 0.671 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr12_-_90049828 0.656 ENST00000261173.2
ENST00000348959.3
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr14_+_75988768 0.648 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr8_-_27462822 0.641 ENST00000522098.1
CLU
clusterin
chr10_-_61900762 0.618 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_-_75017734 0.578 ENST00000532525.1
ARRB1
arrestin, beta 1
chr10_-_49482907 0.463 ENST00000374201.3
ENST00000407470.4
FRMPD2

FERM and PDZ domain containing 2

chr8_-_10512569 0.462 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr14_+_75988851 0.435 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr1_+_201979645 0.402 ENST00000367284.5
ENST00000367283.3
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr1_-_165414414 0.374 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr11_-_119217365 0.365 ENST00000445041.2
ENST00000360167.4
ENST00000555262.1
ENST00000449574.2
C1QTNF5
MFRP


C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein


chr19_-_51893827 0.364 ENST00000574814.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr17_+_4643337 0.344 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr17_-_4643114 0.338 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr17_+_4643300 0.332 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr13_+_73632897 0.330 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chrM_+_9207 0.326 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr6_-_53013620 0.325 ENST00000259803.7
GCM1
glial cells missing homolog 1 (Drosophila)
chr5_+_64920543 0.322 ENST00000399438.3
ENST00000510585.2
TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr1_+_22303503 0.290 ENST00000337107.6
CELA3B
chymotrypsin-like elastase family, member 3B
chr19_+_2476116 0.283 ENST00000215631.4
ENST00000587345.1
GADD45B

growth arrest and DNA-damage-inducible, beta

chr12_-_323689 0.265 ENST00000428720.1
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr3_-_191000172 0.256 ENST00000427544.2
UTS2B
urotensin 2B
chr11_-_96076334 0.249 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr19_-_19314162 0.248 ENST00000420605.3
ENST00000544883.1
ENST00000538165.2
ENST00000331552.7
NR2C2AP



nuclear receptor 2C2-associated protein



chr17_-_10633535 0.236 ENST00000341871.3
TMEM220
transmembrane protein 220
chr7_-_122339162 0.235 ENST00000340112.2
RNF133
ring finger protein 133
chr16_+_28722684 0.234 ENST00000331666.6
ENST00000395587.1
ENST00000569690.1
ENST00000564243.1
EIF3C



eukaryotic translation initiation factor 3, subunit C



chr15_+_41221536 0.200 ENST00000249749.5
DLL4
delta-like 4 (Drosophila)
chr9_+_12693336 0.187 ENST00000381137.2
ENST00000388918.5
TYRP1

tyrosinase-related protein 1

chr12_+_40787194 0.164 ENST00000425730.2
ENST00000454784.4
MUC19

mucin 19, oligomeric

chr1_-_31230650 0.160 ENST00000294507.3
LAPTM5
lysosomal protein transmembrane 5
chr3_-_50388522 0.139 ENST00000232501.3
NPRL2
nitrogen permease regulator-like 2 (S. cerevisiae)
chr16_-_68014732 0.135 ENST00000268793.4
DPEP3
dipeptidase 3
chrX_+_15767971 0.100 ENST00000479740.1
ENST00000454127.2
CA5B

carbonic anhydrase VB, mitochondrial

chr21_-_34915147 0.097 ENST00000381831.3
ENST00000381839.3
GART

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

chr7_+_73868439 0.092 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr11_+_61522844 0.088 ENST00000265460.5
MYRF
myelin regulatory factor
chr10_+_18240834 0.087 ENST00000377371.3
ENST00000539911.1
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr18_-_3880051 0.069 ENST00000584874.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chrX_-_48931648 0.065 ENST00000376386.3
ENST00000376390.4
PRAF2

PRA1 domain family, member 2

chr7_+_73868220 0.049 ENST00000455841.2
GTF2IRD1
GTF2I repeat domain containing 1
chr17_-_40021656 0.044 ENST00000319121.3
KLHL11
kelch-like family member 11
chr10_+_18240814 0.038 ENST00000377374.4
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr4_+_146560245 0.037 ENST00000541599.1
MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type
chr4_-_68620053 0.032 ENST00000420975.2
ENST00000226413.4
GNRHR

gonadotropin-releasing hormone receptor

chr11_-_36619771 0.016 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2


recombination activating gene 2


chr4_-_76912070 0.014 ENST00000395711.4
ENST00000356260.5
SDAD1

SDA1 domain containing 1

chr10_+_18240753 0.006 ENST00000377369.2
SLC39A12
solute carrier family 39 (zinc transporter), member 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0030185 nitric oxide transport(GO:0030185)
0.2 1.3 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.2 0.6 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.6 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 2.1 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.3 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.2 GO:0072554 blood vessel lumenization(GO:0072554)
0.0 2.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.6 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 1.1 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.4 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.2 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.9 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.1 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.5 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.7 GO:0003341 cilium movement(GO:0003341)
0.0 0.3 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.3 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 0.7 GO:0001534 radial spoke(GO:0001534)
0.2 2.1 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.9 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 1.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0030492 hemoglobin binding(GO:0030492)
0.2 0.6 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 0.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 2.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.3 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 1.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.6 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.6 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters