Motif ID: PKNOX1_TGIF2

Z-value: 0.470

Transcription factors associated with PKNOX1_TGIF2:

Gene SymbolEntrez IDGene Name
PKNOX1 ENSG00000160199.10 PKNOX1
TGIF2 ENSG00000118707.5 TGIF2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PKNOX1hg19_v2_chr21_+_44394620_443947370.424.2e-02Click!
TGIF2hg19_v2_chr20_+_35202909_35203075-0.281.8e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of PKNOX1_TGIF2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_39564993 1.330 ENST00000423210.1
STOML3
stomatin (EPB72)-like 3
chr21_-_34185944 1.095 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr11_+_827553 1.039 ENST00000528542.2
ENST00000450448.1
EFCAB4A

EF-hand calcium binding domain 4A

chr17_+_68071458 0.968 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 0.955 ENST00000283936.1
ENST00000392671.1
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr6_+_163148973 0.935 ENST00000366888.2
PACRG
PARK2 co-regulated
chr7_-_99869799 0.835 ENST00000436886.2
GATS
GATS, stromal antigen 3 opposite strand
chr6_-_24911195 0.725 ENST00000259698.4
FAM65B
family with sequence similarity 65, member B
chr18_+_3449330 0.693 ENST00000549253.1
TGIF1
TGFB-induced factor homeobox 1
chr2_-_74779744 0.545 ENST00000409249.1
LOXL3
lysyl oxidase-like 3
chr22_+_39052632 0.526 ENST00000411557.1
ENST00000396811.2
ENST00000216029.3
ENST00000416285.1
CBY1



chibby homolog 1 (Drosophila)



chr4_-_83483395 0.521 ENST00000515780.2
TMEM150C
transmembrane protein 150C
chr5_-_132073111 0.512 ENST00000403231.1
KIF3A
kinesin family member 3A
chr17_+_39405939 0.463 ENST00000334109.2
KRTAP9-4
keratin associated protein 9-4
chr4_-_149365827 0.461 ENST00000344721.4
NR3C2
nuclear receptor subfamily 3, group C, member 2
chr2_-_74780176 0.451 ENST00000409549.1
LOXL3
lysyl oxidase-like 3
chr19_-_10764509 0.449 ENST00000591501.1
ILF3-AS1
ILF3 antisense RNA 1 (head to head)
chr21_-_34185989 0.447 ENST00000487113.1
ENST00000382373.4
C21orf62

chromosome 21 open reading frame 62

chr1_+_63989004 0.443 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr19_+_49496705 0.442 ENST00000595090.1
RUVBL2
RuvB-like AAA ATPase 2
chr1_-_22469459 0.435 ENST00000290167.6
WNT4
wingless-type MMTV integration site family, member 4
chr3_-_113160334 0.398 ENST00000393845.2
ENST00000295868.2
WDR52

WD repeat domain 52

chr4_-_105416039 0.396 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr16_+_16484691 0.388 ENST00000344087.4
NPIPA7
nuclear pore complex interacting protein family, member A7
chr12_-_31882108 0.382 ENST00000281471.6
AMN1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr16_+_618837 0.380 ENST00000409439.2
PIGQ
phosphatidylinositol glycan anchor biosynthesis, class Q
chr21_-_43735446 0.379 ENST00000398431.2
TFF3
trefoil factor 3 (intestinal)
chr14_+_100842735 0.357 ENST00000554998.1
ENST00000402312.3
ENST00000335290.6
ENST00000554175.1
WDR25



WD repeat domain 25



chr18_+_54318566 0.352 ENST00000589935.1
ENST00000357574.3
WDR7

WD repeat domain 7

chrX_+_49019061 0.352 ENST00000376339.1
ENST00000425661.2
ENST00000458388.1
ENST00000412696.2
MAGIX



MAGI family member, X-linked



chr15_-_37392086 0.348 ENST00000561208.1
MEIS2
Meis homeobox 2
chr12_+_55248289 0.341 ENST00000308796.6
MUCL1
mucin-like 1
chr3_-_182880541 0.340 ENST00000470251.1
ENST00000265598.3
LAMP3

lysosomal-associated membrane protein 3

chr15_-_37391614 0.328 ENST00000219869.9
MEIS2
Meis homeobox 2
chr4_-_47840112 0.311 ENST00000504584.1
CORIN
corin, serine peptidase
chr16_+_30212378 0.308 ENST00000569485.1
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr19_+_49496782 0.308 ENST00000601968.1
ENST00000596837.1
RUVBL2

RuvB-like AAA ATPase 2

chr22_-_37172111 0.307 ENST00000417951.2
ENST00000430701.1
ENST00000433985.2
IFT27


intraflagellar transport 27 homolog (Chlamydomonas)


chr12_-_121019165 0.307 ENST00000341039.2
ENST00000357500.4
POP5

processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)

chr16_+_2588012 0.305 ENST00000354836.5
ENST00000389224.3
PDPK1

3-phosphoinositide dependent protein kinase-1

chr22_-_37172191 0.297 ENST00000340630.5
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
chr18_-_54305658 0.289 ENST00000586262.1
ENST00000217515.6
TXNL1

thioredoxin-like 1

chr14_-_94856987 0.288 ENST00000449399.3
ENST00000404814.4
SERPINA1

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

chr3_-_183273477 0.288 ENST00000341319.3
KLHL6
kelch-like family member 6
chr1_-_53163992 0.285 ENST00000371538.3
SELRC1
cytochrome c oxidase assembly factor 7
chr2_+_71163051 0.279 ENST00000412314.1
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr16_+_4784273 0.279 ENST00000299320.5
ENST00000586724.1
C16orf71

chromosome 16 open reading frame 71

chr2_+_71162995 0.278 ENST00000234396.4
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr11_+_27062502 0.262 ENST00000263182.3
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr1_+_210406121 0.255 ENST00000367012.3
SERTAD4
SERTA domain containing 4
chr9_-_124989804 0.250 ENST00000373755.2
ENST00000373754.2
LHX6

LIM homeobox 6

chr6_-_32920794 0.246 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA


XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha


Uncharacterized protein
chr12_-_67197760 0.245 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
GRIP1



glutamate receptor interacting protein 1



chr19_+_49497121 0.241 ENST00000413176.2
RUVBL2
RuvB-like AAA ATPase 2
chr10_+_94608245 0.239 ENST00000443748.2
ENST00000260762.6
EXOC6

exocyst complex component 6

chr5_+_125758813 0.235 ENST00000285689.3
ENST00000515200.1
GRAMD3

GRAM domain containing 3

chr16_+_2587998 0.235 ENST00000441549.3
ENST00000268673.7
PDPK1

3-phosphoinositide dependent protein kinase-1

chr21_-_34186006 0.226 ENST00000490358.1
C21orf62
chromosome 21 open reading frame 62
chr9_-_86432547 0.220 ENST00000376365.3
ENST00000376371.2
GKAP1

G kinase anchoring protein 1

chr9_-_115653176 0.220 ENST00000374228.4
SLC46A2
solute carrier family 46, member 2
chrX_-_101397433 0.219 ENST00000372774.3
TCEAL6
transcription elongation factor A (SII)-like 6
chr18_+_905104 0.218 ENST00000579794.1
ADCYAP1
adenylate cyclase activating polypeptide 1 (pituitary)
chr4_-_46391805 0.217 ENST00000540012.1
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr5_+_125758865 0.216 ENST00000542322.1
ENST00000544396.1
GRAMD3

GRAM domain containing 3

chr1_+_207262170 0.214 ENST00000367078.3
C4BPB
complement component 4 binding protein, beta
chr11_+_27062272 0.213 ENST00000529202.1
ENST00000533566.1
BBOX1

butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1

chr3_+_52828805 0.212 ENST00000416872.2
ENST00000449956.2
ITIH3

inter-alpha-trypsin inhibitor heavy chain 3

chr17_+_38296576 0.211 ENST00000264645.7
CASC3
cancer susceptibility candidate 3
chr16_-_69418649 0.211 ENST00000566257.1
TERF2
telomeric repeat binding factor 2
chr12_-_91398796 0.210 ENST00000261172.3
ENST00000551767.1
EPYC

epiphycan

chr14_-_94857004 0.205 ENST00000557492.1
ENST00000448921.1
ENST00000437397.1
ENST00000355814.4
ENST00000393088.4
SERPINA1




serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1




chr1_+_207262578 0.205 ENST00000243611.5
ENST00000367076.3
C4BPB

complement component 4 binding protein, beta

chr17_-_26220366 0.203 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9


RP1-66C13.4
LYR motif containing 9


Uncharacterized protein
chr1_+_207262627 0.199 ENST00000391923.1
C4BPB
complement component 4 binding protein, beta
chr1_-_54872059 0.198 ENST00000371320.3
SSBP3
single stranded DNA binding protein 3
chr1_+_207262540 0.197 ENST00000452902.2
C4BPB
complement component 4 binding protein, beta
chr14_-_94856951 0.195 ENST00000553327.1
ENST00000556955.1
ENST00000557118.1
ENST00000440909.1
SERPINA1



serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1



chr17_+_76374714 0.192 ENST00000262764.6
ENST00000589689.1
ENST00000329897.7
ENST00000592043.1
ENST00000587356.1
PGS1




phosphatidylglycerophosphate synthase 1




chr11_-_5255861 0.189 ENST00000380299.3
HBD
hemoglobin, delta
chr6_-_84418860 0.186 ENST00000521743.1
SNAP91
synaptosomal-associated protein, 91kDa
chr4_+_86396265 0.185 ENST00000395184.1
ARHGAP24
Rho GTPase activating protein 24
chr19_+_49375649 0.184 ENST00000200453.5
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr16_-_50715196 0.184 ENST00000423026.2
SNX20
sorting nexin 20
chr7_+_73442487 0.180 ENST00000380575.4
ENST00000380584.4
ENST00000458204.1
ENST00000357036.5
ENST00000417091.1
ENST00000429192.1
ENST00000442310.1
ENST00000380553.4
ENST00000380576.5
ENST00000428787.1
ENST00000320399.6
ELN










elastin










chr6_-_31651817 0.179 ENST00000375863.3
ENST00000375860.2
LY6G5C

lymphocyte antigen 6 complex, locus G5C

chr7_+_23637763 0.179 ENST00000410069.1
CCDC126
coiled-coil domain containing 126
chr6_-_84418841 0.178 ENST00000369694.2
ENST00000195649.6
SNAP91

synaptosomal-associated protein, 91kDa

chr16_+_2587965 0.178 ENST00000342085.4
ENST00000566659.1
PDPK1

3-phosphoinositide dependent protein kinase-1

chr3_-_52488048 0.176 ENST00000232975.3
TNNC1
troponin C type 1 (slow)
chr16_-_30457048 0.170 ENST00000500504.2
ENST00000542752.1
SEPHS2

selenophosphate synthetase 2

chr12_+_104458235 0.167 ENST00000229330.4
HCFC2
host cell factor C2
chr4_+_146539415 0.163 ENST00000281317.5
MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type
chr15_-_31283798 0.160 ENST00000435680.1
ENST00000425768.1
MTMR10

myotubularin related protein 10

chr7_+_39605966 0.159 ENST00000223273.2
ENST00000448268.1
ENST00000432096.2
YAE1D1


Yae1 domain containing 1


chr4_+_123653807 0.158 ENST00000314218.3
ENST00000542236.1
BBS12

Bardet-Biedl syndrome 12

chr11_-_6440283 0.158 ENST00000299402.6
ENST00000609360.1
ENST00000389906.2
ENST00000532020.2
APBB1



amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)



chr22_+_17082732 0.153 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1





transmembrane phosphatase with tensin homology pseudogene 1





chr5_-_94620239 0.152 ENST00000515393.1
MCTP1
multiple C2 domains, transmembrane 1
chr3_+_185080908 0.151 ENST00000265026.3
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr1_+_246729724 0.146 ENST00000366513.4
ENST00000366512.3
CNST

consortin, connexin sorting protein

chr7_+_73442422 0.146 ENST00000358929.4
ENST00000431562.1
ENST00000320492.7
ENST00000438906.1
ELN



elastin



chr12_+_122667658 0.143 ENST00000339777.4
ENST00000425921.1
LRRC43

leucine rich repeat containing 43

chr3_-_3152031 0.142 ENST00000383846.1
ENST00000427088.1
ENST00000446632.2
ENST00000438560.1
IL5RA



interleukin 5 receptor, alpha



chr12_-_15114191 0.141 ENST00000541380.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr12_-_104531785 0.140 ENST00000551727.1
NFYB
nuclear transcription factor Y, beta
chr4_+_48485341 0.134 ENST00000273861.4
SLC10A4
solute carrier family 10, member 4
chr19_+_39759154 0.130 ENST00000331982.5
IFNL2
interferon, lambda 2
chr3_+_111260954 0.128 ENST00000283285.5
CD96
CD96 molecule
chr5_+_43603229 0.123 ENST00000344920.4
ENST00000512996.2
NNT

nicotinamide nucleotide transhydrogenase

chr15_-_78538025 0.122 ENST00000560817.1
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr3_-_27763803 0.122 ENST00000449599.1
EOMES
eomesodermin
chr3_-_27764190 0.120 ENST00000537516.1
EOMES
eomesodermin
chr1_+_3668962 0.118 ENST00000294600.2
CCDC27
coiled-coil domain containing 27
chr6_-_132967142 0.116 ENST00000275216.1
TAAR1
trace amine associated receptor 1
chr16_+_20817839 0.115 ENST00000348433.6
ENST00000568501.1
ENST00000566276.1
AC004381.6


Putative RNA exonuclease NEF-sp


chr22_-_50219548 0.114 ENST00000404034.1
BRD1
bromodomain containing 1
chr3_-_3221358 0.114 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN



cereblon



chr1_-_246729544 0.114 ENST00000544618.1
ENST00000366514.4
TFB2M

transcription factor B2, mitochondrial

chr10_+_49514698 0.113 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
MAPK8


mitogen-activated protein kinase 8


chr13_+_33160553 0.112 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr18_+_39535152 0.112 ENST00000262039.4
ENST00000398870.3
ENST00000586545.1
PIK3C3


phosphatidylinositol 3-kinase, catalytic subunit type 3


chr2_-_71454185 0.108 ENST00000244221.8
PAIP2B
poly(A) binding protein interacting protein 2B
chr6_+_168841817 0.107 ENST00000356284.2
ENST00000354536.5
SMOC2

SPARC related modular calcium binding 2

chr16_-_50715239 0.107 ENST00000330943.4
ENST00000300590.3
SNX20

sorting nexin 20

chr19_+_1000418 0.106 ENST00000234389.3
GRIN3B
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
chr7_-_156685890 0.105 ENST00000353442.5
LMBR1
limb development membrane protein 1
chr1_+_154966058 0.105 ENST00000392487.1
LENEP
lens epithelial protein
chr6_+_31865552 0.105 ENST00000469372.1
ENST00000497706.1
C2

complement component 2

chr7_+_63774321 0.104 ENST00000423484.2
ZNF736
zinc finger protein 736
chr5_-_173043591 0.103 ENST00000285908.5
ENST00000480951.1
ENST00000311086.4
BOD1


biorientation of chromosomes in cell division 1


chr11_+_112046190 0.103 ENST00000357685.5
ENST00000393032.2
ENST00000361053.4
BCO2


beta-carotene oxygenase 2


chr5_-_58882219 0.103 ENST00000505453.1
ENST00000360047.5
PDE4D

phosphodiesterase 4D, cAMP-specific

chr7_+_73442457 0.103 ENST00000438880.1
ENST00000414324.1
ENST00000380562.4
ELN


elastin


chr3_-_3151664 0.102 ENST00000256452.3
ENST00000311981.8
ENST00000430514.2
ENST00000456302.1
IL5RA



interleukin 5 receptor, alpha



chr16_+_20817761 0.102 ENST00000568046.1
ENST00000261377.6
AC004381.6

Putative RNA exonuclease NEF-sp

chr16_-_1429627 0.102 ENST00000248104.7
UNKL
unkempt family zinc finger-like
chr6_-_119031228 0.101 ENST00000392500.3
ENST00000368488.5
ENST00000434604.1
CEP85L


centrosomal protein 85kDa-like


chr18_+_32073253 0.098 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
DTNA


dystrobrevin, alpha


chr12_-_121734489 0.098 ENST00000412367.2
ENST00000402834.4
ENST00000404169.3
CAMKK2


calcium/calmodulin-dependent protein kinase kinase 2, beta


chr2_+_234959376 0.098 ENST00000425558.1
SPP2
secreted phosphoprotein 2, 24kDa
chr19_-_12595586 0.097 ENST00000397732.3
ZNF709
zinc finger protein 709
chr5_-_169725231 0.097 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_+_171217622 0.097 ENST00000433267.1
ENST00000367750.3
FMO1

flavin containing monooxygenase 1

chr16_-_30569584 0.095 ENST00000252797.2
ENST00000568114.1
ZNF764
AC002310.13
zinc finger protein 764
Uncharacterized protein
chr6_+_31674639 0.094 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F

MEGT1
lymphocyte antigen 6 complex, locus G6F

HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr15_+_57668695 0.094 ENST00000281282.5
CGNL1
cingulin-like 1
chr15_+_25068773 0.092 ENST00000400100.1
ENST00000400098.1
SNRPN

small nuclear ribonucleoprotein polypeptide N

chrX_+_135730297 0.092 ENST00000370629.2
CD40LG
CD40 ligand
chrX_+_135730373 0.092 ENST00000370628.2
CD40LG
CD40 ligand
chr7_-_156685841 0.091 ENST00000354505.4
ENST00000540390.1
LMBR1

limb development membrane protein 1

chr4_-_47839966 0.091 ENST00000273857.4
ENST00000505909.1
ENST00000502252.1
CORIN


corin, serine peptidase


chr14_-_50474238 0.090 ENST00000399206.1
C14orf182
chromosome 14 open reading frame 182
chr1_-_179112189 0.088 ENST00000512653.1
ENST00000344730.3
ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr16_+_50776021 0.087 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD


cylindromatosis (turban tumor syndrome)


chr4_+_88928777 0.086 ENST00000237596.2
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr15_+_88120158 0.085 ENST00000560153.1
LINC00052
long intergenic non-protein coding RNA 52
chr17_-_66951474 0.085 ENST00000269080.2
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr13_-_46716969 0.084 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_3504587 0.083 ENST00000415131.1
ADI1
acireductone dioxygenase 1
chr21_+_31768348 0.081 ENST00000355459.2
KRTAP13-1
keratin associated protein 13-1
chr16_-_30569801 0.081 ENST00000395091.2
ZNF764
zinc finger protein 764
chr8_-_17555164 0.081 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr1_-_51425902 0.081 ENST00000396153.2
FAF1
Fas (TNFRSF6) associated factor 1
chr9_-_134615443 0.078 ENST00000372195.1
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr6_-_131949200 0.078 ENST00000539158.1
ENST00000368058.1
MED23

mediator complex subunit 23

chr16_-_4784128 0.077 ENST00000592711.1
ENST00000590147.1
ENST00000304283.4
ENST00000592190.1
ENST00000589065.1
ENST00000585773.1
ENST00000450067.2
ENST00000592698.1
ENST00000586166.1
ENST00000586605.1
ENST00000592421.1
ANKS3










ankyrin repeat and sterile alpha motif domain containing 3










chr4_+_86396321 0.077 ENST00000503995.1
ARHGAP24
Rho GTPase activating protein 24
chr6_-_52926539 0.077 ENST00000350082.5
ENST00000356971.3
ICK

intestinal cell (MAK-like) kinase

chr19_-_13044494 0.075 ENST00000593021.1
ENST00000587981.1
ENST00000423140.2
ENST00000314606.4
FARSA



phenylalanyl-tRNA synthetase, alpha subunit



chr15_-_43785303 0.074 ENST00000382039.3
ENST00000450115.2
ENST00000382044.4
TP53BP1


tumor protein p53 binding protein 1


chr6_-_28220002 0.074 ENST00000377294.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr6_+_138188551 0.074 ENST00000237289.4
ENST00000433680.1
TNFAIP3

tumor necrosis factor, alpha-induced protein 3

chr14_-_69619689 0.074 ENST00000389997.6
ENST00000557386.1
ENST00000554681.1
DCAF5


DDB1 and CUL4 associated factor 5


chr7_+_94536898 0.072 ENST00000433360.1
ENST00000340694.4
ENST00000424654.1
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr14_-_21994525 0.071 ENST00000538754.1
SALL2
spalt-like transcription factor 2
chr12_+_69004619 0.071 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B













RAP1B, member of RAS oncogene family













chr9_-_33447584 0.070 ENST00000297991.4
AQP3
aquaporin 3 (Gill blood group)
chr14_-_106330458 0.069 ENST00000461719.1
IGHJ4
immunoglobulin heavy joining 4
chr5_-_81046904 0.069 ENST00000515395.1
SSBP2
single-stranded DNA binding protein 2
chr21_-_30257669 0.068 ENST00000303775.5
ENST00000351429.3
N6AMT1

N-6 adenine-specific DNA methyltransferase 1 (putative)

chr6_-_163148700 0.067 ENST00000366894.1
ENST00000338468.3
PARK2

parkin RBR E3 ubiquitin protein ligase

chr11_+_6411670 0.066 ENST00000530395.1
ENST00000527275.1
SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr20_+_42187682 0.066 ENST00000373092.3
ENST00000373077.1
SGK2

serum/glucocorticoid regulated kinase 2

chr5_-_139283982 0.065 ENST00000340391.3
NRG2
neuregulin 2
chr12_-_75784669 0.064 ENST00000552497.1
ENST00000551829.1
ENST00000436898.1
ENST00000442339.2
CAPS2



calcyphosine 2



chr5_-_81046841 0.064 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
SSBP2


single-stranded DNA binding protein 2


chr3_+_111260856 0.064 ENST00000352690.4
CD96
CD96 molecule
chr11_-_64052111 0.064 ENST00000394532.3
ENST00000394531.3
ENST00000309032.3
BAD


BCL2-associated agonist of cell death


chr9_-_127703333 0.064 ENST00000373555.4
GOLGA1
golgin A1
chr16_+_4896659 0.064 ENST00000592120.1
UBN1
ubinuclein 1
chr2_-_24149977 0.063 ENST00000238789.5
ATAD2B
ATPase family, AAA domain containing 2B
chr3_+_150804676 0.063 ENST00000474524.1
ENST00000273432.4
MED12L

mediator complex subunit 12-like

chr5_-_81046922 0.062 ENST00000514493.1
ENST00000320672.4
SSBP2

single-stranded DNA binding protein 2

chr16_-_89556942 0.062 ENST00000301030.4
ANKRD11
ankyrin repeat domain 11
chr11_-_84028180 0.062 ENST00000280241.8
DLG2
discs, large homolog 2 (Drosophila)
chr5_+_115298165 0.062 ENST00000357872.4
AQPEP
Aminopeptidase Q
chr20_+_42187608 0.060 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr2_+_242127924 0.059 ENST00000402530.3
ENST00000274979.8
ENST00000402430.3
ANO7


anoctamin 7


chr14_-_105635090 0.059 ENST00000331782.3
ENST00000347004.2
JAG2

jagged 2

chr17_+_8191815 0.058 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
RANGRF



RAN guanine nucleotide release factor




Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.2 1.0 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 0.4 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) renal vesicle induction(GO:0072034)
0.1 0.4 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.1 0.2 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.1 0.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.7 GO:1903027 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.1 0.2 GO:1903517 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.1 0.4 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.2 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 0.2 GO:1902310 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.2 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 0.7 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.2 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.0 0.2 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.5 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.3 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.0 0.2 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.0 0.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0 0.2 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.0 1.9 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.1 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.0 0.1 GO:0042214 terpene metabolic process(GO:0042214)
0.0 0.3 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.2 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.1 GO:0070428 B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.1 GO:1904048 regulation of spontaneous neurotransmitter secretion(GO:1904048)
0.0 0.1 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.0 0.1 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.1 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.0 0.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.3 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.1 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.6 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.0 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.0 0.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.0 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.1 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.0 0.6 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.0 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.0 0.3 GO:0002467 germinal center formation(GO:0002467)
0.0 0.3 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.2 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0016939 kinesin II complex(GO:0016939)
0.1 0.3 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 1.0 GO:0097255 R2TP complex(GO:0097255)
0.1 1.5 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.4 GO:0071953 elastic fiber(GO:0071953)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.2 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.1 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.2 1.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.0 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.5 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 1.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.2 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 0.2 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.2 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.1 0.3 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.0 0.1 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.1 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398) calcium-induced calcium release activity(GO:0048763)
0.0 0.6 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.0 0.1 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.0 0.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.4 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.0 PID_MYC_PATHWAY C-MYC pathway
0.0 1.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.8 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.0 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules