Motif ID: PKNOX2

Z-value: 0.615


Transcription factors associated with PKNOX2:

Gene SymbolEntrez IDGene Name
PKNOX2 ENSG00000165495.11 PKNOX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PKNOX2hg19_v2_chr11_+_125034586_1250346040.096.9e-01Click!


Activity profile for motif PKNOX2.

activity profile for motif PKNOX2


Sorted Z-values histogram for motif PKNOX2

Sorted Z-values for motif PKNOX2



Network of associatons between targets according to the STRING database.



First level regulatory network of PKNOX2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_149365827 2.773 ENST00000344721.4
NR3C2
nuclear receptor subfamily 3, group C, member 2
chr16_+_2880296 2.727 ENST00000571723.1
ZG16B
zymogen granule protein 16B
chr16_+_2880254 2.667 ENST00000570670.1
ZG16B
zymogen granule protein 16B
chr16_+_2880157 2.645 ENST00000382280.3
ZG16B
zymogen granule protein 16B
chr16_+_2880369 2.609 ENST00000572863.1
ZG16B
zymogen granule protein 16B
chr2_-_73460334 1.446 ENST00000258083.2
PRADC1
protease-associated domain containing 1
chr14_-_54421190 1.379 ENST00000417573.1
BMP4
bone morphogenetic protein 4
chr11_+_6411670 1.335 ENST00000530395.1
ENST00000527275.1
SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr11_+_6411636 1.259 ENST00000299397.3
ENST00000356761.2
ENST00000342245.4
SMPD1


sphingomyelin phosphodiesterase 1, acid lysosomal


chr5_-_139283982 0.918 ENST00000340391.3
NRG2
neuregulin 2
chr10_+_94608245 0.827 ENST00000443748.2
ENST00000260762.6
EXOC6

exocyst complex component 6

chr6_+_138188551 0.721 ENST00000237289.4
ENST00000433680.1
TNFAIP3

tumor necrosis factor, alpha-induced protein 3

chr18_-_54305658 0.720 ENST00000586262.1
ENST00000217515.6
TXNL1

thioredoxin-like 1

chr17_+_68071458 0.682 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 0.675 ENST00000283936.1
ENST00000392671.1
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr2_-_202316260 0.645 ENST00000332624.3
TRAK2
trafficking protein, kinesin binding 2
chr15_+_57668695 0.627 ENST00000281282.5
CGNL1
cingulin-like 1
chr7_-_137028534 0.616 ENST00000348225.2
PTN
pleiotrophin
chr4_+_3076388 0.609 ENST00000355072.5
HTT
huntingtin
chr4_+_166300084 0.560 ENST00000402744.4
CPE
carboxypeptidase E
chr7_-_137028498 0.556 ENST00000393083.2
PTN
pleiotrophin
chr3_+_140981456 0.545 ENST00000504264.1
ACPL2
acid phosphatase-like 2
chr1_+_170904612 0.542 ENST00000367759.4
ENST00000367758.3
MROH9

maestro heat-like repeat family member 9

chr21_-_34185944 0.531 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr22_+_17082732 0.530 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1





transmembrane phosphatase with tensin homology pseudogene 1





chr6_-_87804815 0.521 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr6_+_29910301 0.517 ENST00000376809.5
ENST00000376802.2
HLA-A

major histocompatibility complex, class I, A

chr16_+_57481382 0.516 ENST00000564655.1
ENST00000567072.1
ENST00000567933.1
ENST00000563166.1
COQ9



coenzyme Q9



chr18_+_3449330 0.508 ENST00000549253.1
TGIF1
TGFB-induced factor homeobox 1
chr1_+_110577229 0.491 ENST00000369795.3
ENST00000369794.2
STRIP1

striatin interacting protein 1

chr2_-_74779744 0.438 ENST00000409249.1
LOXL3
lysyl oxidase-like 3
chr16_+_57481349 0.423 ENST00000262507.6
ENST00000565964.1
COQ9

coenzyme Q9

chr5_+_125758813 0.419 ENST00000285689.3
ENST00000515200.1
GRAMD3

GRAM domain containing 3

chr8_+_57124245 0.412 ENST00000521831.1
ENST00000355315.3
ENST00000303759.3
ENST00000517636.1
ENST00000517933.1
ENST00000518801.1
ENST00000523975.1
ENST00000396723.5
ENST00000523061.1
ENST00000521524.1
CHCHD7









coiled-coil-helix-coiled-coil-helix domain containing 7









chr14_-_21994525 0.409 ENST00000538754.1
SALL2
spalt-like transcription factor 2
chr18_+_54318566 0.401 ENST00000589935.1
ENST00000357574.3
WDR7

WD repeat domain 7

chr5_+_125758865 0.398 ENST00000542322.1
ENST00000544396.1
GRAMD3

GRAM domain containing 3

chr5_-_94620239 0.397 ENST00000515393.1
MCTP1
multiple C2 domains, transmembrane 1
chr16_-_57481278 0.364 ENST00000567751.1
ENST00000568940.1
ENST00000563341.1
ENST00000565961.1
ENST00000569370.1
ENST00000567518.1
ENST00000565786.1
ENST00000394391.4
CIAPIN1







cytokine induced apoptosis inhibitor 1







chr3_+_32147997 0.355 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr22_-_31885514 0.353 ENST00000397525.1
EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr14_-_21492113 0.353 ENST00000554094.1
NDRG2
NDRG family member 2
chr2_-_74780176 0.350 ENST00000409549.1
LOXL3
lysyl oxidase-like 3
chr4_-_157892167 0.342 ENST00000541126.1
PDGFC
platelet derived growth factor C
chr15_-_37392086 0.334 ENST00000561208.1
MEIS2
Meis homeobox 2
chr3_+_185080908 0.333 ENST00000265026.3
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr1_-_54872059 0.319 ENST00000371320.3
SSBP3
single stranded DNA binding protein 3
chr13_+_33160553 0.316 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr19_+_41281060 0.306 ENST00000594436.1
ENST00000597784.1
MIA

melanoma inhibitory activity

chr16_-_30457048 0.302 ENST00000500504.2
ENST00000542752.1
SEPHS2

selenophosphate synthetase 2

chr4_-_157892498 0.300 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr17_-_26220366 0.294 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9


RP1-66C13.4
LYR motif containing 9


Uncharacterized protein
chr19_+_41281282 0.283 ENST00000263369.3
MIA
melanoma inhibitory activity
chr19_+_41281416 0.282 ENST00000597140.1
MIA
melanoma inhibitory activity
chr5_-_81046904 0.277 ENST00000515395.1
SSBP2
single-stranded DNA binding protein 2
chr6_-_32140886 0.276 ENST00000395496.1
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr12_+_113495492 0.266 ENST00000257600.3
DTX1
deltex homolog 1 (Drosophila)
chrX_-_39923656 0.263 ENST00000413905.1
BCOR
BCL6 corepressor
chr11_-_71810258 0.249 ENST00000544594.1
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr1_-_179112189 0.241 ENST00000512653.1
ENST00000344730.3
ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr5_-_81046841 0.237 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
SSBP2


single-stranded DNA binding protein 2


chr3_-_3221358 0.237 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN



cereblon



chr2_+_219524473 0.231 ENST00000439945.1
ENST00000431802.1
BCS1L

BC1 (ubiquinol-cytochrome c reductase) synthesis-like

chr4_-_157892055 0.223 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr1_-_35658736 0.221 ENST00000357214.5
SFPQ
splicing factor proline/glutamine-rich
chr15_+_33010175 0.220 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1


gremlin 1, DAN family BMP antagonist


chr4_-_46391805 0.215 ENST00000540012.1
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr6_+_111195973 0.211 ENST00000368885.3
ENST00000368882.3
ENST00000451850.2
ENST00000368877.5
AMD1



adenosylmethionine decarboxylase 1



chr18_+_3449821 0.204 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1


TGFB-induced factor homeobox 1


chr6_-_116575226 0.203 ENST00000420283.1
TSPYL4
TSPY-like 4
chr2_-_219524193 0.203 ENST00000450560.1
ENST00000449707.1
ENST00000432460.1
ENST00000411696.2
ZNF142



zinc finger protein 142



chr19_+_36142147 0.200 ENST00000590618.1
COX6B1
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
chr16_+_50776021 0.196 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD


cylindromatosis (turban tumor syndrome)


chr20_+_43514320 0.194 ENST00000372839.3
ENST00000428262.1
ENST00000445830.1
YWHAB


tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta


chr6_-_149867122 0.192 ENST00000253329.2
PPIL4
peptidylprolyl isomerase (cyclophilin)-like 4
chr3_-_52719810 0.191 ENST00000424867.1
ENST00000394830.3
ENST00000431678.1
ENST00000450271.1
PBRM1



polybromo 1



chr1_+_154966058 0.191 ENST00000392487.1
LENEP
lens epithelial protein
chr3_-_33481835 0.188 ENST00000283629.3
UBP1
upstream binding protein 1 (LBP-1a)
chr20_-_61847586 0.186 ENST00000370339.3
YTHDF1
YTH domain family, member 1
chr19_+_7733929 0.185 ENST00000221515.2
RETN
resistin
chr17_-_35969409 0.181 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
SYNRG







synergin, gamma







chr1_+_161736072 0.178 ENST00000367942.3
ATF6
activating transcription factor 6
chr2_+_128848881 0.175 ENST00000259253.6
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr6_-_84418860 0.172 ENST00000521743.1
SNAP91
synaptosomal-associated protein, 91kDa
chr6_+_42123141 0.167 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
GUCA1A



RP1-139D8.6
guanylate cyclase activator 1A (retina)



RP1-139D8.6
chr16_+_88636789 0.166 ENST00000301011.5
ENST00000452588.2
ZC3H18

zinc finger CCCH-type containing 18

chr5_-_81046922 0.163 ENST00000514493.1
ENST00000320672.4
SSBP2

single-stranded DNA binding protein 2

chr10_+_49514698 0.163 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
MAPK8


mitogen-activated protein kinase 8


chr6_-_84418841 0.162 ENST00000369694.2
ENST00000195649.6
SNAP91

synaptosomal-associated protein, 91kDa

chr6_+_17600576 0.160 ENST00000259963.3
FAM8A1
family with sequence similarity 8, member A1
chrX_+_16804544 0.154 ENST00000380122.5
ENST00000398155.4
TXLNG

taxilin gamma

chr15_-_61521495 0.151 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr2_+_128848740 0.141 ENST00000375990.3
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr5_+_118407053 0.127 ENST00000311085.8
ENST00000539542.1
DMXL1

Dmx-like 1

chr2_-_61765315 0.116 ENST00000406957.1
ENST00000401558.2
XPO1

exportin 1 (CRM1 homolog, yeast)

chr7_-_156803329 0.112 ENST00000252971.6
MNX1
motor neuron and pancreas homeobox 1
chr17_-_4046257 0.103 ENST00000381638.2
ZZEF1
zinc finger, ZZ-type with EF-hand domain 1
chr18_+_54318616 0.099 ENST00000254442.3
WDR7
WD repeat domain 7
chr11_-_842509 0.095 ENST00000322028.4
POLR2L
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
chr10_+_51565188 0.093 ENST00000430396.2
ENST00000374087.4
ENST00000414907.2
NCOA4


nuclear receptor coactivator 4


chr5_-_132073111 0.091 ENST00000403231.1
KIF3A
kinesin family member 3A
chr20_-_3065362 0.088 ENST00000380293.3
AVP
arginine vasopressin
chr18_+_3449695 0.086 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr9_-_79307096 0.083 ENST00000376717.2
ENST00000223609.6
ENST00000443509.2
PRUNE2


prune homolog 2 (Drosophila)


chr3_+_52719936 0.080 ENST00000418458.1
ENST00000394799.2
GNL3

guanine nucleotide binding protein-like 3 (nucleolar)

chr12_+_69201923 0.071 ENST00000462284.1
ENST00000258149.5
ENST00000356290.4
ENST00000540827.1
ENST00000428863.2
ENST00000393412.3
MDM2





MDM2 oncogene, E3 ubiquitin protein ligase





chr19_+_39759154 0.069 ENST00000331982.5
IFNL2
interferon, lambda 2
chrX_-_71792477 0.067 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8








histone deacetylase 8








chr15_+_68346501 0.067 ENST00000249636.6
PIAS1
protein inhibitor of activated STAT, 1
chr6_+_37225540 0.065 ENST00000373491.3
TBC1D22B
TBC1 domain family, member 22B
chr11_+_12132117 0.063 ENST00000256194.4
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr7_-_100253993 0.062 ENST00000461605.1
ENST00000160382.5
ACTL6B

actin-like 6B

chr8_-_99837856 0.059 ENST00000518165.1
ENST00000419617.2
STK3

serine/threonine kinase 3

chr8_+_133787586 0.057 ENST00000395379.1
ENST00000395386.2
ENST00000337920.4
PHF20L1


PHD finger protein 20-like 1


chr3_-_127541194 0.054 ENST00000453507.2
MGLL
monoglyceride lipase
chr6_+_150070831 0.054 ENST00000367380.5
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr17_-_40337470 0.041 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr21_-_34185989 0.040 ENST00000487113.1
ENST00000382373.4
C21orf62

chromosome 21 open reading frame 62

chr8_-_37594944 0.040 ENST00000330539.1
RP11-863K10.7
Uncharacterized protein
chr19_-_39735646 0.037 ENST00000413851.2
IFNL3
interferon, lambda 3
chr19_-_6424783 0.035 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr11_-_59383617 0.034 ENST00000263847.1
OSBP
oxysterol binding protein
chr12_+_49621658 0.033 ENST00000541364.1
TUBA1C
tubulin, alpha 1c
chr17_-_42452063 0.031 ENST00000588098.1
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr4_+_140222609 0.030 ENST00000296543.5
ENST00000398947.1
NAA15

N(alpha)-acetyltransferase 15, NatA auxiliary subunit

chr3_+_52828805 0.027 ENST00000416872.2
ENST00000449956.2
ITIH3

inter-alpha-trypsin inhibitor heavy chain 3

chr1_+_145549203 0.024 ENST00000355594.4
ENST00000544626.1
ANKRD35

ankyrin repeat domain 35

chr6_-_29324054 0.023 ENST00000543825.1
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr5_-_52405564 0.019 ENST00000510818.2
ENST00000396954.3
ENST00000508922.1
ENST00000361377.4
ENST00000582677.1
ENST00000584946.1
ENST00000450852.3
MOCS2






molybdenum cofactor synthesis 2






chr9_+_137772652 0.014 ENST00000350339.2
ENST00000291744.6
FCN2

ficolin (collagen/fibrinogen domain containing lectin) 2

chr22_+_50946645 0.011 ENST00000420993.2
ENST00000395698.3
ENST00000395701.3
ENST00000523045.1
ENST00000299821.11
NCAPH2




non-SMC condensin II complex, subunit H2




chr1_-_100598444 0.010 ENST00000535161.1
ENST00000287482.5
SASS6

spindle assembly 6 homolog (C. elegans)

chr5_-_58882219 0.008 ENST00000505453.1
ENST00000360047.5
PDE4D

phosphodiesterase 4D, cAMP-specific

chr11_-_64013288 0.005 ENST00000542235.1
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr11_-_132813566 0.002 ENST00000331898.7
OPCML
opioid binding protein/cell adhesion molecule-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.4 1.2 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.4 2.6 GO:0023021 termination of signal transduction(GO:0023021)
0.3 0.9 GO:0090291 negative regulation of osteoclast proliferation(GO:0090291)
0.3 0.8 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.2 0.6 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.2 0.6 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.1 0.6 GO:0030070 insulin processing(GO:0030070)
0.1 10.6 GO:0001895 retina homeostasis(GO:0001895)
0.1 0.3 GO:0097359 UDP-glucosylation(GO:0097359)
0.1 0.3 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 0.4 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 0.3 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.2 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.2 GO:2000870 positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
0.1 0.5 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 0.2 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.2 GO:0060620 regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.0 0.9 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.2 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.3 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.2 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.1 GO:0002125 maternal aggressive behavior(GO:0002125)
0.0 1.4 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.1 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.0 0.1 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.4 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.5 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.4 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.1 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055) ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.5 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.5 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.3 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.0 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.2 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 GO:0042599 lamellar body(GO:0042599)
0.1 0.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0043291 RAVE complex(GO:0043291)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.8 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.2 2.6 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 0.8 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.4 GO:0070700 co-receptor binding(GO:0039706) BMP receptor binding(GO:0070700)
0.1 0.3 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.1 0.3 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.1 1.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.6 GO:0034452 dynactin binding(GO:0034452)
0.0 0.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.5 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.8 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.2 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.2 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.1 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.0 9.2 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.1 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 1.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.1 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 2.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.9 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 1.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.2 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.6 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.9 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha