Motif ID: PLAG1

Z-value: 0.490


Transcription factors associated with PLAG1:

Gene SymbolEntrez IDGene Name
PLAG1 ENSG00000181690.3 PLAG1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PLAG1hg19_v2_chr8_-_57123815_57123867-0.341.0e-01Click!


Activity profile for motif PLAG1.

activity profile for motif PLAG1


Sorted Z-values histogram for motif PLAG1

Sorted Z-values for motif PLAG1



Network of associatons between targets according to the STRING database.



First level regulatory network of PLAG1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_7654057 2.459 ENST00000537121.1
ADCY2
adenylate cyclase 2 (brain)
chr8_-_23261589 1.832 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
LOXL2



lysyl oxidase-like 2



chr12_-_58131931 1.743 ENST00000547588.1
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_-_2160180 1.573 ENST00000381406.4
IGF2
insulin-like growth factor 2 (somatomedin A)
chr15_+_90728145 1.326 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
SEMA4B


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B


chr19_+_41725088 1.256 ENST00000301178.4
AXL
AXL receptor tyrosine kinase
chr11_-_1643368 1.083 ENST00000399682.1
KRTAP5-4
keratin associated protein 5-4
chr1_-_24469602 0.973 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr14_-_75079026 0.962 ENST00000261978.4
LTBP2
latent transforming growth factor beta binding protein 2
chr19_+_45844018 0.873 ENST00000585434.1
KLC3
kinesin light chain 3
chr19_+_45843994 0.835 ENST00000391946.2
KLC3
kinesin light chain 3
chr12_+_57522258 0.822 ENST00000553277.1
ENST00000243077.3
LRP1

low density lipoprotein receptor-related protein 1

chr16_+_31483451 0.782 ENST00000565360.1
ENST00000361773.3
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr16_+_31483374 0.772 ENST00000394863.3
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr11_+_65343494 0.631 ENST00000309295.4
ENST00000533237.1
EHBP1L1

EH domain binding protein 1-like 1

chr19_+_45844032 0.630 ENST00000589837.1
KLC3
kinesin light chain 3
chr7_+_73703728 0.619 ENST00000361545.5
ENST00000223398.6
CLIP2

CAP-GLY domain containing linker protein 2

chr15_-_70388943 0.527 ENST00000559048.1
ENST00000560939.1
ENST00000440567.3
ENST00000557907.1
ENST00000558379.1
ENST00000451782.2
ENST00000559929.1
TLE3






transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)






chr15_+_74833518 0.523 ENST00000346246.5
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr9_+_34652164 0.506 ENST00000441545.2
ENST00000553620.1
IL11RA

interleukin 11 receptor, alpha

chr1_+_2407754 0.491 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
PLCH2



phospholipase C, eta 2



chr1_-_94079648 0.489 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr6_+_106534192 0.422 ENST00000369091.2
ENST00000369096.4
PRDM1

PR domain containing 1, with ZNF domain

chr19_-_14201507 0.404 ENST00000533683.2
SAMD1
sterile alpha motif domain containing 1
chr9_-_95527079 0.400 ENST00000356884.6
ENST00000375512.3
BICD2

bicaudal D homolog 2 (Drosophila)

chr11_-_61062762 0.376 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr19_+_41725140 0.375 ENST00000359092.3
AXL
AXL receptor tyrosine kinase
chr8_+_128748466 0.364 ENST00000524013.1
ENST00000520751.1
MYC

v-myc avian myelocytomatosis viral oncogene homolog

chrY_+_22737604 0.329 ENST00000361365.2
EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr7_+_72742162 0.325 ENST00000431982.2
FKBP6
FK506 binding protein 6, 36kDa
chr8_+_128748308 0.325 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr19_+_45973120 0.318 ENST00000592811.1
ENST00000586615.1
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr16_-_65155833 0.316 ENST00000566827.1
ENST00000394156.3
ENST00000562998.1
CDH11


cadherin 11, type 2, OB-cadherin (osteoblast)


chr3_-_197024394 0.316 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
DLG1




discs, large homolog 1 (Drosophila)




chr14_-_75330537 0.310 ENST00000556084.2
ENST00000556489.2
ENST00000445876.1
PROX2


prospero homeobox 2


chr9_+_2621798 0.304 ENST00000382100.3
VLDLR
very low density lipoprotein receptor
chr16_+_30671223 0.292 ENST00000568722.1
FBRS
fibrosin
chrX_+_51927919 0.289 ENST00000416960.1
MAGED4
melanoma antigen family D, 4
chr11_-_45687128 0.288 ENST00000308064.2
CHST1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr6_+_7727030 0.287 ENST00000283147.6
BMP6
bone morphogenetic protein 6
chr16_+_46723552 0.287 ENST00000219097.2
ENST00000568364.2
ORC6

origin recognition complex, subunit 6

chr1_+_151138526 0.284 ENST00000368902.1
SCNM1
sodium channel modifier 1
chr12_+_79258547 0.283 ENST00000457153.2
SYT1
synaptotagmin I
chr1_+_151138500 0.283 ENST00000368905.4
SCNM1
sodium channel modifier 1
chr6_+_38690622 0.283 ENST00000327475.6
DNAH8
dynein, axonemal, heavy chain 8
chr6_+_31939608 0.283 ENST00000375331.2
ENST00000375333.2
STK19

serine/threonine kinase 19

chr19_+_40697514 0.269 ENST00000253055.3
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr2_+_220306745 0.265 ENST00000431523.1
ENST00000396698.1
ENST00000396695.2
SPEG


SPEG complex locus


chr7_-_72742085 0.263 ENST00000333149.2
TRIM50
tripartite motif containing 50
chr1_-_201438282 0.260 ENST00000367311.3
ENST00000367309.1
PHLDA3

pleckstrin homology-like domain, family A, member 3

chr7_+_72742178 0.257 ENST00000442793.1
ENST00000413573.2
ENST00000252037.4
FKBP6


FK506 binding protein 6, 36kDa


chr12_+_107168342 0.253 ENST00000392837.4
RIC8B
RIC8 guanine nucleotide exchange factor B
chr19_-_14201776 0.251 ENST00000269724.5
SAMD1
sterile alpha motif domain containing 1
chr11_-_11374904 0.244 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr17_+_30593195 0.240 ENST00000431505.2
ENST00000269051.4
ENST00000538145.1
RHBDL3


rhomboid, veinlet-like 3 (Drosophila)


chr4_-_114682936 0.240 ENST00000454265.2
ENST00000429180.1
ENST00000418639.2
ENST00000394526.2
ENST00000296402.5
CAMK2D




calcium/calmodulin-dependent protein kinase II delta




chr14_-_51297197 0.238 ENST00000382043.4
NIN
ninein (GSK3B interacting protein)
chr12_+_79258444 0.234 ENST00000261205.4
SYT1
synaptotagmin I
chr16_-_30134524 0.230 ENST00000395202.1
ENST00000395199.3
ENST00000263025.4
ENST00000322266.5
ENST00000403394.1
MAPK3




mitogen-activated protein kinase 3




chr6_+_43044003 0.229 ENST00000230419.4
ENST00000476760.1
ENST00000471863.1
ENST00000349241.2
ENST00000352931.2
ENST00000345201.2
PTK7





protein tyrosine kinase 7





chr4_-_114682597 0.223 ENST00000394524.3
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr5_-_135701164 0.222 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr11_-_2323290 0.217 ENST00000381153.3
C11orf21
chromosome 11 open reading frame 21
chr2_-_30144432 0.212 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chr3_-_73673991 0.212 ENST00000308537.4
ENST00000263666.4
PDZRN3

PDZ domain containing ring finger 3

chr19_+_56116771 0.211 ENST00000568956.1
ZNF865
zinc finger protein 865
chr20_+_62716348 0.207 ENST00000349451.3
OPRL1
opiate receptor-like 1
chr17_+_38278530 0.201 ENST00000398532.4
MSL1
male-specific lethal 1 homolog (Drosophila)
chr1_+_20617362 0.200 ENST00000375079.2
ENST00000289815.8
ENST00000375083.4
ENST00000289825.4
VWA5B1



von Willebrand factor A domain containing 5B1



chr22_+_19744226 0.199 ENST00000332710.4
ENST00000329705.7
ENST00000359500.3
TBX1


T-box 1


chr1_-_204654481 0.194 ENST00000367176.3
LRRN2
leucine rich repeat neuronal 2
chr10_-_99447024 0.192 ENST00000370626.3
AVPI1
arginine vasopressin-induced 1
chr19_-_41220957 0.192 ENST00000596357.1
ENST00000243583.6
ENST00000600080.1
ENST00000595254.1
ENST00000601967.1
ADCK4




aarF domain containing kinase 4




chr12_-_52715179 0.189 ENST00000293670.3
KRT83
keratin 83
chr6_-_43021437 0.188 ENST00000265348.3
CUL7
cullin 7
chrX_+_23682379 0.187 ENST00000379349.1
PRDX4
peroxiredoxin 4
chr4_+_55095264 0.184 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr4_-_57844989 0.178 ENST00000264230.4
NOA1
nitric oxide associated 1
chr19_+_40973049 0.177 ENST00000598249.1
ENST00000338932.3
ENST00000344104.3
SPTBN4


spectrin, beta, non-erythrocytic 4


chr17_-_27139411 0.173 ENST00000452648.3
FAM222B
family with sequence similarity 222, member B
chr20_+_18269121 0.171 ENST00000377671.3
ENST00000360010.5
ENST00000396026.3
ENST00000402618.2
ENST00000401790.1
ENST00000434018.1
ENST00000538547.1
ENST00000535822.1
ZNF133







zinc finger protein 133







chr22_+_29469100 0.166 ENST00000327813.5
ENST00000407188.1
KREMEN1

kringle containing transmembrane protein 1

chr6_+_31543334 0.159 ENST00000449264.2
TNF
tumor necrosis factor
chr10_-_21786179 0.156 ENST00000377113.5
CASC10
cancer susceptibility candidate 10
chr19_+_39904168 0.152 ENST00000438123.1
ENST00000409797.2
ENST00000451354.2
PLEKHG2


pleckstrin homology domain containing, family G (with RhoGef domain) member 2


chr14_+_57857262 0.151 ENST00000555166.1
ENST00000556492.1
ENST00000554703.1
NAA30


N(alpha)-acetyltransferase 30, NatC catalytic subunit


chr6_-_150039170 0.151 ENST00000458696.2
ENST00000392273.3
LATS1

large tumor suppressor kinase 1

chr12_+_56546363 0.146 ENST00000551834.1
ENST00000552568.1
MYL6B

myosin, light chain 6B, alkali, smooth muscle and non-muscle

chr1_-_151138323 0.146 ENST00000368908.5
LYSMD1
LysM, putative peptidoglycan-binding, domain containing 1
chr16_+_2198604 0.145 ENST00000210187.6
RAB26
RAB26, member RAS oncogene family
chr12_-_106641728 0.144 ENST00000378026.4
CKAP4
cytoskeleton-associated protein 4
chr2_-_85788652 0.143 ENST00000430215.3
GGCX
gamma-glutamyl carboxylase
chr6_-_43021612 0.140 ENST00000535468.1
CUL7
cullin 7
chr2_+_153191706 0.139 ENST00000288670.9
FMNL2
formin-like 2
chr21_-_15755446 0.138 ENST00000544452.1
ENST00000285667.3
HSPA13

heat shock protein 70kDa family, member 13

chr10_+_24498060 0.132 ENST00000376454.3
ENST00000376452.3
KIAA1217

KIAA1217

chr1_-_153931052 0.131 ENST00000368630.3
ENST00000368633.1
CRTC2

CREB regulated transcription coactivator 2

chr9_-_136004782 0.131 ENST00000393157.3
RALGDS
ral guanine nucleotide dissociation stimulator
chr15_+_90544532 0.130 ENST00000268154.4
ZNF710
zinc finger protein 710
chr3_-_116163830 0.130 ENST00000333617.4
LSAMP
limbic system-associated membrane protein
chr16_-_46723066 0.129 ENST00000299138.7
VPS35
vacuolar protein sorting 35 homolog (S. cerevisiae)
chr16_-_3030283 0.125 ENST00000572619.1
ENST00000574415.1
ENST00000440027.2
ENST00000572059.1
PKMYT1



protein kinase, membrane associated tyrosine/threonine 1



chr4_-_47840112 0.124 ENST00000504584.1
CORIN
corin, serine peptidase
chr1_-_20306909 0.117 ENST00000375111.3
ENST00000400520.3
PLA2G2A

phospholipase A2, group IIA (platelets, synovial fluid)

chr17_-_79805146 0.114 ENST00000415593.1
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr22_+_29469012 0.113 ENST00000400335.4
ENST00000400338.2
KREMEN1

kringle containing transmembrane protein 1

chr20_-_1974692 0.109 ENST00000217305.2
ENST00000539905.1
PDYN

prodynorphin

chr17_-_3599327 0.107 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
P2RX5


purinergic receptor P2X, ligand-gated ion channel, 5


chr1_-_110613276 0.105 ENST00000369792.4
ALX3
ALX homeobox 3
chr19_-_2702681 0.103 ENST00000382159.3
GNG7
guanine nucleotide binding protein (G protein), gamma 7
chr14_+_93357749 0.103 ENST00000557689.1
RP11-862G15.1
RP11-862G15.1
chr1_-_68698197 0.102 ENST00000370973.2
ENST00000370971.1
WLS

wntless Wnt ligand secretion mediator

chr4_+_55095428 0.094 ENST00000508170.1
ENST00000512143.1
PDGFRA

platelet-derived growth factor receptor, alpha polypeptide

chr22_-_30642782 0.093 ENST00000249075.3
LIF
leukemia inhibitory factor
chr9_+_139874683 0.091 ENST00000444903.1
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr4_-_99850243 0.091 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
EIF4E



eukaryotic translation initiation factor 4E



chr3_+_19988566 0.089 ENST00000273047.4
RAB5A
RAB5A, member RAS oncogene family
chr4_-_155533787 0.088 ENST00000407946.1
ENST00000405164.1
ENST00000336098.3
ENST00000393846.2
ENST00000404648.3
ENST00000443553.1
FGG





fibrinogen gamma chain





chr5_+_159895275 0.084 ENST00000517927.1
MIR146A
microRNA 146a
chr9_-_140115775 0.080 ENST00000391553.1
ENST00000392827.1
RNF208

ring finger protein 208

chr16_-_18573396 0.077 ENST00000543392.1
ENST00000381474.3
ENST00000330537.6
NOMO2


NODAL modulator 2


chr19_-_18653781 0.077 ENST00000596558.2
ENST00000453489.2
FKBP8

FK506 binding protein 8, 38kDa

chr13_+_47127293 0.075 ENST00000311191.6
LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr6_-_71012773 0.074 ENST00000370496.3
ENST00000357250.6
COL9A1

collagen, type IX, alpha 1

chr12_+_52282001 0.073 ENST00000340970.4
ANKRD33
ankyrin repeat domain 33
chr1_-_68698222 0.072 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS



wntless Wnt ligand secretion mediator



chrX_+_110339439 0.071 ENST00000372010.1
ENST00000519681.1
ENST00000372007.5
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr12_+_105724414 0.069 ENST00000443585.1
ENST00000552457.1
ENST00000549893.1
C12orf75


chromosome 12 open reading frame 75


chr14_+_105047478 0.069 ENST00000410013.1
C14orf180
chromosome 14 open reading frame 180
chrX_+_153146127 0.065 ENST00000452593.1
ENST00000357566.1
LCA10

Putative lung carcinoma-associated protein 10

chr6_-_150039249 0.064 ENST00000543571.1
LATS1
large tumor suppressor kinase 1
chr14_+_79745682 0.063 ENST00000557594.1
NRXN3
neurexin 3
chr6_+_31683117 0.062 ENST00000375825.3
ENST00000375824.1
LY6G6D

lymphocyte antigen 6 complex, locus G6D

chr6_-_31940065 0.061 ENST00000375349.3
ENST00000337523.5
DXO

decapping exoribonuclease

chr3_-_52001448 0.060 ENST00000461554.1
ENST00000395013.3
ENST00000428823.2
ENST00000483411.1
ENST00000461544.1
ENST00000355852.2
PCBP4





poly(rC) binding protein 4





chr2_+_27665232 0.060 ENST00000543753.1
ENST00000288873.3
KRTCAP3

keratinocyte associated protein 3

chr16_-_18812746 0.058 ENST00000546206.2
ENST00000562819.1
ENST00000562234.2
ENST00000304414.7
ENST00000567078.2
ARL6IP1



RP11-1035H13.3
ADP-ribosylation factor-like 6 interacting protein 1



Uncharacterized protein
chr19_-_42759300 0.056 ENST00000222329.4
ERF
Ets2 repressor factor
chr7_-_22233442 0.056 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr21_+_17909594 0.055 ENST00000441820.1
ENST00000602280.1
LINC00478

long intergenic non-protein coding RNA 478

chr17_+_48046538 0.052 ENST00000240306.3
DLX4
distal-less homeobox 4
chr2_-_74618964 0.048 ENST00000417090.1
ENST00000409868.1
DCTN1

dynactin 1

chr2_-_74619152 0.044 ENST00000440727.1
ENST00000409240.1
DCTN1

dynactin 1

chr2_-_21266935 0.042 ENST00000233242.1
APOB
apolipoprotein B
chr6_-_37467628 0.042 ENST00000373408.3
CCDC167
coiled-coil domain containing 167
chr11_+_64053311 0.040 ENST00000540370.1
GPR137
G protein-coupled receptor 137
chr19_-_51054299 0.039 ENST00000599957.1
LRRC4B
leucine rich repeat containing 4B
chr3_+_19988885 0.038 ENST00000422242.1
RAB5A
RAB5A, member RAS oncogene family
chr15_-_41408409 0.036 ENST00000361937.3
INO80
INO80 complex subunit
chr10_+_24497704 0.035 ENST00000376456.4
ENST00000458595.1
KIAA1217

KIAA1217

chr14_+_45605127 0.034 ENST00000556036.1
ENST00000267430.5
FANCM

Fanconi anemia, complementation group M

chr9_-_34662651 0.032 ENST00000259631.4
CCL27
chemokine (C-C motif) ligand 27
chr17_-_4607335 0.031 ENST00000570571.1
ENST00000575101.1
ENST00000436683.2
ENST00000574876.1
PELP1



proline, glutamate and leucine rich protein 1



chr19_+_38924316 0.031 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1


ryanodine receptor 1 (skeletal)


chr3_+_14989076 0.030 ENST00000413118.1
ENST00000425241.1
NR2C2

nuclear receptor subfamily 2, group C, member 2

chr15_+_92397051 0.029 ENST00000424469.2
SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr2_-_128399706 0.026 ENST00000426981.1
LIMS2
LIM and senescent cell antigen-like domains 2
chr7_-_76039000 0.024 ENST00000275560.3
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr10_+_50817141 0.022 ENST00000339797.1
CHAT
choline O-acetyltransferase
chr1_+_62902308 0.017 ENST00000339950.4
USP1
ubiquitin specific peptidase 1
chr4_+_39046615 0.016 ENST00000261425.3
ENST00000508137.2
KLHL5

kelch-like family member 5

chr1_+_163038565 0.015 ENST00000421743.2
RGS4
regulator of G-protein signaling 4
chr4_-_47839966 0.014 ENST00000273857.4
ENST00000505909.1
ENST00000502252.1
CORIN


corin, serine peptidase


chr17_+_20483037 0.005 ENST00000399044.1
CDRT15L2
CMT1A duplicated region transcript 15-like 2
chr11_-_124180733 0.004 ENST00000357821.2
OR8D1
olfactory receptor, family 8, subfamily D, member 1
chr3_+_183853052 0.000 ENST00000273783.3
ENST00000432569.1
ENST00000444495.1
EIF2B5


eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:2000669 positive regulation of pinocytosis(GO:0048549) negative regulation of dendritic cell apoptotic process(GO:2000669)
0.2 0.7 GO:0072186 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094)
0.2 2.5 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.2 1.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 1.6 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 0.5 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.2 0.6 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 0.4 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.1 0.3 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.3 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1 0.2 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 2.1 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.1 0.4 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.1 0.2 GO:0060557 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) negative regulation of alkaline phosphatase activity(GO:0010693) positive regulation of translational initiation by iron(GO:0045994) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.2 GO:0036269 swimming behavior(GO:0036269)
0.1 0.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.3 GO:0034436 glycoprotein transport(GO:0034436)
0.0 0.1 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.0 0.3 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.2 GO:0001827 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.3 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.2 GO:0000189 MAPK import into nucleus(GO:0000189) regulation of Golgi inheritance(GO:0090170)
0.0 0.2 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 0.5 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 2.3 GO:0008088 axo-dendritic transport(GO:0008088)
0.0 0.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.3 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.0 1.3 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.3 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 1.0 GO:0097435 fibril organization(GO:0097435)
0.0 0.1 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.1 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.3 GO:0051412 response to corticosterone(GO:0051412)
0.0 0.2 GO:0034378 chylomicron assembly(GO:0034378)
0.0 0.2 GO:0006828 manganese ion transport(GO:0006828)
0.0 1.0 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.5 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 2.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.6 GO:0033643 host cell part(GO:0033643)
0.0 0.3 GO:1990393 3M complex(GO:1990393)
0.0 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.4 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.3 GO:0043219 lateral loop(GO:0043219)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.7 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 1.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.6 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 1.6 GO:0048495 Roundabout binding(GO:0048495)
0.2 1.0 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 2.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.6 GO:0030226 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
0.1 0.3 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.1 1.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 1.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.3 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 1.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 2.3 GO:0019894 kinesin binding(GO:0019894)
0.0 0.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.4 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.1 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.0 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 2.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 PID_MYC_PATHWAY C-MYC pathway
0.0 1.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.3 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins