Motif ID: REST

Z-value: 0.989


Transcription factors associated with REST:

Gene SymbolEntrez IDGene Name
REST ENSG00000084093.11 REST

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.086.9e-01Click!


Activity profile for motif REST.

activity profile for motif REST


Sorted Z-values histogram for motif REST

Sorted Z-values for motif REST



Network of associatons between targets according to the STRING database.



First level regulatory network of REST

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_33936491 4.083 ENST00000330120.3
RXFP3
relaxin/insulin-like family peptide receptor 3
chr19_-_51845378 2.066 ENST00000335624.4
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr8_-_91095099 1.811 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr20_+_62327996 1.765 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr4_+_8582287 1.488 ENST00000382487.4
GPR78
G protein-coupled receptor 78
chr12_+_71833756 1.376 ENST00000536515.1
ENST00000540815.2
LGR5

leucine-rich repeat containing G protein-coupled receptor 5

chr9_+_135457530 1.310 ENST00000263610.2
BARHL1
BarH-like homeobox 1
chr10_+_99609996 1.286 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr6_+_35773070 1.193 ENST00000373853.1
ENST00000360215.1
LHFPL5

lipoma HMGIC fusion partner-like 5

chr10_-_79398250 0.939 ENST00000286627.5
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr7_+_154862028 0.905 ENST00000287907.2
HTR5A
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
chr17_+_30813576 0.839 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr2_+_115199876 0.795 ENST00000436732.1
ENST00000410059.1
DPP10

dipeptidyl-peptidase 10 (non-functional)

chr12_-_29936731 0.784 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
TMTC1


transmembrane and tetratricopeptide repeat containing 1


chr5_-_151304337 0.771 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
GLRA1


glycine receptor, alpha 1


chr20_+_30555805 0.763 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr3_-_42743006 0.725 ENST00000310417.5
HHATL
hedgehog acyltransferase-like
chr14_+_93389425 0.721 ENST00000216492.5
ENST00000334654.4
CHGA

chromogranin A (parathyroid secretory protein 1)

chr15_-_72612470 0.712 ENST00000287202.5
CELF6
CUGBP, Elav-like family member 6
chr3_+_9745510 0.703 ENST00000383831.3
CPNE9
copine family member IX
chr7_+_145813453 0.703 ENST00000361727.3
CNTNAP2
contactin associated protein-like 2
chr10_-_79398127 0.653 ENST00000372443.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr9_-_74061751 0.649 ENST00000357533.2
ENST00000423814.3
TRPM3

transient receptor potential cation channel, subfamily M, member 3

chr3_-_113897899 0.639 ENST00000383673.2
ENST00000295881.7
DRD3

dopamine receptor D3

chr2_-_30143525 0.610 ENST00000431873.1
ALK
anaplastic lymphoma receptor tyrosine kinase
chr3_-_48700310 0.596 ENST00000164024.4
ENST00000544264.1
CELSR3

cadherin, EGF LAG seven-pass G-type receptor 3

chr4_+_158141843 0.572 ENST00000509417.1
ENST00000296526.7
GRIA2

glutamate receptor, ionotropic, AMPA 2

chr6_+_110299501 0.561 ENST00000414000.2
GPR6
G protein-coupled receptor 6
chr5_+_167956121 0.554 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr4_+_158141899 0.542 ENST00000264426.9
ENST00000506284.1
GRIA2

glutamate receptor, ionotropic, AMPA 2

chr15_-_22473353 0.527 ENST00000557788.2
IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr3_+_9745487 0.525 ENST00000383832.3
CPNE9
copine family member IX
chr19_+_4769117 0.503 ENST00000540211.1
ENST00000317292.3
ENST00000586721.1
ENST00000592709.1
ENST00000588711.1
ENST00000589639.1
ENST00000591008.1
ENST00000592663.1
ENST00000588758.1
MIR7-3HG








MIR7-3 host gene (non-protein coding)








chr19_-_3971050 0.499 ENST00000545797.2
ENST00000596311.1
DAPK3

death-associated protein kinase 3

chr1_-_102462565 0.494 ENST00000370103.4
OLFM3
olfactomedin 3
chr6_+_153071925 0.491 ENST00000367244.3
ENST00000367243.3
VIP

vasoactive intestinal peptide

chr14_+_93897199 0.479 ENST00000553484.1
UNC79
unc-79 homolog (C. elegans)
chr2_-_51259641 0.472 ENST00000406316.2
ENST00000405581.1
NRXN1

neurexin 1

chr2_-_51259528 0.470 ENST00000404971.1
NRXN1
neurexin 1
chr7_+_63361201 0.465 ENST00000450544.1
RP11-340I6.8
RP11-340I6.8
chr17_-_3301704 0.439 ENST00000322608.2
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr4_+_158141806 0.436 ENST00000393815.2
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr20_+_44657845 0.433 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr7_-_100808394 0.424 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr3_-_113897545 0.411 ENST00000467632.1
DRD3
dopamine receptor D3
chr12_+_119419294 0.406 ENST00000267260.4
SRRM4
serine/arginine repetitive matrix 4
chr14_-_106478603 0.405 ENST00000390596.2
IGHV4-4
immunoglobulin heavy variable 4-4
chr5_-_176037105 0.401 ENST00000303991.4
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr12_+_113796347 0.393 ENST00000545182.2
ENST00000280800.3
PLBD2

phospholipase B domain containing 2

chr4_-_175750364 0.370 ENST00000340217.5
ENST00000274093.3
GLRA3

glycine receptor, alpha 3

chr10_-_44880491 0.365 ENST00000374426.2
ENST00000395795.4
ENST00000395794.2
ENST00000374429.2
ENST00000395793.3
ENST00000343575.6
CXCL12





chemokine (C-X-C motif) ligand 12





chr11_+_22359562 0.359 ENST00000263160.3
SLC17A6
solute carrier family 17 (vesicular glutamate transporter), member 6
chr7_-_100808843 0.359 ENST00000249330.2
VGF
VGF nerve growth factor inducible
chr15_-_83378638 0.359 ENST00000261722.3
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr15_-_83378611 0.345 ENST00000542200.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr7_+_150748288 0.335 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr10_-_102790852 0.332 ENST00000470414.1
ENST00000370215.3
PDZD7

PDZ domain containing 7

chr15_-_83378526 0.331 ENST00000535348.1
ENST00000535359.1
AP3B2

adaptor-related protein complex 3, beta 2 subunit

chr9_-_139096955 0.331 ENST00000371748.5
LHX3
LIM homeobox 3
chrX_-_47479246 0.330 ENST00000295987.7
ENST00000340666.4
SYN1

synapsin I

chr11_-_75141206 0.329 ENST00000376292.4
KLHL35
kelch-like family member 35
chr20_-_60795296 0.311 ENST00000340177.5
HRH3
histamine receptor H3
chr17_-_3337135 0.308 ENST00000248384.1
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr9_+_140033862 0.307 ENST00000350902.5
ENST00000371550.4
ENST00000371546.4
ENST00000371555.4
ENST00000371553.3
ENST00000371559.4
ENST00000371560.3
GRIN1






glutamate receptor, ionotropic, N-methyl D-aspartate 1






chr5_+_175298487 0.306 ENST00000393745.3
CPLX2
complexin 2
chr12_-_12837423 0.299 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chrX_-_49056635 0.288 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
SYP



synaptophysin



chr8_-_57358432 0.288 ENST00000517415.1
ENST00000314922.3
PENK

proenkephalin

chr20_+_36012051 0.282 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr22_+_23054174 0.279 ENST00000390308.2
IGLV3-21
immunoglobulin lambda variable 3-21
chr14_-_94759408 0.266 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr12_+_113229452 0.261 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chr10_-_50970322 0.257 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr14_-_94759595 0.251 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr20_-_62284766 0.250 ENST00000370053.1
STMN3
stathmin-like 3
chr1_+_154540246 0.245 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr1_-_241520385 0.244 ENST00000366564.1
RGS7
regulator of G-protein signaling 7
chr14_-_94759361 0.237 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr5_+_63802109 0.228 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr12_-_99288536 0.221 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B


ankyrin repeat and sterile alpha motif domain containing 1B


chr17_-_27333163 0.219 ENST00000360295.9
SEZ6
seizure related 6 homolog (mouse)
chr8_+_6565854 0.200 ENST00000285518.6
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5
chr10_-_50970382 0.199 ENST00000419399.1
ENST00000432695.1
OGDHL

oxoglutarate dehydrogenase-like

chr1_-_40105617 0.195 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr17_-_27333311 0.195 ENST00000317338.12
ENST00000585644.1
SEZ6

seizure related 6 homolog (mouse)

chr12_+_113229543 0.195 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr1_+_212606219 0.190 ENST00000366988.3
NENF
neudesin neurotrophic factor
chr17_-_27332931 0.189 ENST00000442608.3
ENST00000335960.6
SEZ6

seizure related 6 homolog (mouse)

chr19_+_41036371 0.169 ENST00000392023.1
SPTBN4
spectrin, beta, non-erythrocytic 4
chr5_-_135701164 0.163 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr11_-_66115032 0.153 ENST00000311181.4
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chrX_-_153141302 0.152 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1CAM




L1 cell adhesion molecule




chr22_+_22749343 0.148 ENST00000390298.2
IGLV7-43
immunoglobulin lambda variable 7-43
chr3_+_75955817 0.146 ENST00000487694.3
ENST00000602589.1
ROBO2

roundabout, axon guidance receptor, homolog 2 (Drosophila)

chr11_-_6677018 0.141 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chr12_-_24737089 0.130 ENST00000483544.1
LINC00477
long intergenic non-protein coding RNA 477
chr1_-_151689259 0.123 ENST00000420342.1
ENST00000290583.4
CELF3

CUGBP, Elav-like family member 3

chr1_+_65775204 0.120 ENST00000371069.4
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr2_+_131513864 0.119 ENST00000458606.1
ENST00000423981.1
AMER3

APC membrane recruitment protein 3

chr2_-_27531313 0.118 ENST00000296099.2
UCN
urocortin
chrX_-_153237258 0.118 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr14_-_51561784 0.116 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr9_-_104357277 0.115 ENST00000374806.1
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr14_-_106781017 0.112 ENST00000390612.2
IGHV4-28
immunoglobulin heavy variable 4-28
chr14_+_96039882 0.100 ENST00000556346.1
ENST00000553785.1
RP11-1070N10.4

RP11-1070N10.4

chr3_+_120626919 0.099 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
STXBP5L




syntaxin binding protein 5-like




chr12_+_113229737 0.097 ENST00000551052.1
ENST00000415485.3
RPH3A

rabphilin 3A homolog (mouse)

chr20_-_60795316 0.095 ENST00000317393.6
HRH3
histamine receptor H3
chr20_-_44144249 0.085 ENST00000217428.6
SPINT3
serine peptidase inhibitor, Kunitz type, 3
chr15_-_27018884 0.065 ENST00000299267.4
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr1_+_210111534 0.064 ENST00000422431.1
ENST00000534859.1
ENST00000399639.2
ENST00000537238.1
SYT14



synaptotagmin XIV



chr11_-_125773085 0.063 ENST00000227474.3
ENST00000534158.1
ENST00000529801.1
PUS3


pseudouridylate synthase 3


chr6_+_25652501 0.058 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr11_+_64808675 0.057 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr19_-_45926739 0.052 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
ERCC1



excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)



chr6_+_25652432 0.051 ENST00000377961.2
SCGN
secretagogin, EF-hand calcium binding protein
chr9_+_138606400 0.045 ENST00000486577.2
KCNT1
potassium channel, subfamily T, member 1
chr12_+_71833550 0.044 ENST00000266674.5
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr2_-_51259292 0.037 ENST00000401669.2
NRXN1
neurexin 1
chrX_+_153237740 0.036 ENST00000369982.4
TMEM187
transmembrane protein 187
chr10_+_60936921 0.034 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr2_-_51259229 0.015 ENST00000405472.3
NRXN1
neurexin 1
chr2_+_226265364 0.012 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr19_-_45927097 0.006 ENST00000340192.7
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr3_+_193853927 0.003 ENST00000232424.3
HES1
hes family bHLH transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.3 1.1 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.2 0.7 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.2 0.7 GO:2000705 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.2 0.7 GO:0071109 superior temporal gyrus development(GO:0071109)
0.2 0.9 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.2 1.8 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.2 0.6 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.2 0.3 GO:0021586 pons maturation(GO:0021586)
0.2 0.6 GO:0036269 swimming behavior(GO:0036269)
0.1 1.6 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 1.4 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 1.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.8 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.8 GO:0008218 bioluminescence(GO:0008218)
0.1 0.6 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.1 1.0 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.3 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.1 0.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 1.5 GO:0060088 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) auditory receptor cell stereocilium organization(GO:0060088)
0.1 4.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.4 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 0.3 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.6 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.1 0.3 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.1 0.2 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.1 0.5 GO:0010579 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 0.4 GO:0014063 negative regulation of glutamate secretion(GO:0014050) regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063)
0.0 0.1 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 1.0 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.1 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.0 0.3 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.4 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.6 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.6 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.5 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 1.5 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 1.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.8 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.3 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.6 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 1.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.8 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.1 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.0 1.1 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 1.8 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.5 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.2 0.8 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.4 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.1 0.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.3 GO:0002139 stereocilia coupling link(GO:0002139)
0.1 1.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.2 GO:0032426 stereocilium tip(GO:0032426)
0.1 1.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.3 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.7 GO:0033010 paranodal junction(GO:0033010)
0.0 0.7 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.0 0.2 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 2.7 GO:0043195 terminal bouton(GO:0043195)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.9 GO:0005901 caveola(GO:0005901)
0.0 0.1 GO:0043196 varicosity(GO:0043196)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0004966 galanin receptor activity(GO:0004966)
0.4 1.8 GO:0005499 vitamin D binding(GO:0005499)
0.3 0.8 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.2 1.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2 1.6 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 0.6 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.1 1.0 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 1.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.9 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 1.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.3 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.6 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.3 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 0.6 GO:0008430 selenium binding(GO:0008430)
0.0 0.2 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.3 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 1.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.4 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 0.7 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.1 1.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.5 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.2 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 4.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors