Motif ID: REST
Z-value: 0.989
Transcription factors associated with REST:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
REST | ENSG00000084093.11 | REST |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
REST | hg19_v2_chr4_+_57774042_57774114 | -0.08 | 6.9e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 0.8 | GO:0021718 | superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
0.3 | 1.1 | GO:0032416 | negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883) |
0.2 | 0.7 | GO:0006500 | N-terminal protein palmitoylation(GO:0006500) |
0.2 | 0.7 | GO:2000705 | dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705) |
0.2 | 0.7 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
0.2 | 0.9 | GO:0007198 | adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) |
0.2 | 1.8 | GO:0035502 | metanephric part of ureteric bud development(GO:0035502) |
0.2 | 0.6 | GO:1990258 | box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258) |
0.2 | 0.3 | GO:0021586 | pons maturation(GO:0021586) |
0.2 | 0.6 | GO:0036269 | swimming behavior(GO:0036269) |
0.1 | 1.6 | GO:0034465 | response to carbon monoxide(GO:0034465) |
0.1 | 1.4 | GO:2001013 | epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013) |
0.1 | 1.3 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
0.1 | 0.8 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
0.1 | 0.8 | GO:0008218 | bioluminescence(GO:0008218) |
0.1 | 0.6 | GO:0036515 | serotonergic neuron axon guidance(GO:0036515) |
0.1 | 1.0 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
0.1 | 0.3 | GO:0021526 | medial motor column neuron differentiation(GO:0021526) |
0.1 | 0.4 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
0.1 | 1.5 | GO:0060088 | detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) auditory receptor cell stereocilium organization(GO:0060088) |
0.1 | 4.1 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
0.1 | 0.4 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
0.1 | 0.3 | GO:0071393 | cellular response to progesterone stimulus(GO:0071393) |
0.1 | 0.6 | GO:0033603 | positive regulation of dopamine secretion(GO:0033603) |
0.1 | 0.3 | GO:0015891 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) detection of chemical stimulus involved in sensory perception of pain(GO:0050968) |
0.1 | 0.2 | GO:2000824 | negative regulation of androgen receptor activity(GO:2000824) |
0.1 | 0.5 | GO:0010579 | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) |
0.1 | 0.4 | GO:0014063 | negative regulation of glutamate secretion(GO:0014050) regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063) |
0.0 | 0.1 | GO:0003192 | mitral valve formation(GO:0003192) |
0.0 | 0.4 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
0.0 | 0.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.0 | 1.0 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
0.0 | 0.1 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
0.0 | 0.3 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
0.0 | 0.1 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
0.0 | 0.4 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
0.0 | 0.3 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
0.0 | 0.6 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
0.0 | 0.1 | GO:0019046 | release from viral latency(GO:0019046) |
0.0 | 0.6 | GO:0016048 | detection of temperature stimulus(GO:0016048) |
0.0 | 0.5 | GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241) |
0.0 | 1.5 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
0.0 | 1.1 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
0.0 | 0.8 | GO:0002021 | response to dietary excess(GO:0002021) |
0.0 | 0.3 | GO:0016188 | synaptic vesicle maturation(GO:0016188) |
0.0 | 0.6 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
0.0 | 0.2 | GO:0048149 | behavioral response to ethanol(GO:0048149) |
0.0 | 1.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
0.0 | 0.8 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
0.0 | 0.1 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
0.0 | 0.2 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
0.0 | 0.1 | GO:0032096 | negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099) |
0.0 | 1.1 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
0.0 | 1.8 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154) |
0.0 | 0.5 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
0.0 | 0.1 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
0.0 | 0.5 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
0.0 | 0.2 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.5 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
0.2 | 0.8 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
0.1 | 0.4 | GO:0016935 | glycine-gated chloride channel complex(GO:0016935) |
0.1 | 0.6 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
0.1 | 0.3 | GO:0002139 | stereocilia coupling link(GO:0002139) |
0.1 | 1.3 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
0.1 | 1.2 | GO:0032426 | stereocilium tip(GO:0032426) |
0.1 | 1.0 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
0.0 | 0.3 | GO:0032280 | symmetric synapse(GO:0032280) |
0.0 | 0.7 | GO:0033010 | paranodal junction(GO:0033010) |
0.0 | 0.7 | GO:0042583 | chromaffin granule(GO:0042583) |
0.0 | 0.5 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
0.0 | 0.6 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 0.2 | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
0.0 | 2.7 | GO:0043195 | terminal bouton(GO:0043195) |
0.0 | 0.2 | GO:0070852 | cell body fiber(GO:0070852) |
0.0 | 0.3 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.0 | 1.9 | GO:0005901 | caveola(GO:0005901) |
0.0 | 0.1 | GO:0043196 | varicosity(GO:0043196) |
0.0 | 0.5 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.0 | 0.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 4.1 | GO:0004966 | galanin receptor activity(GO:0004966) |
0.4 | 1.8 | GO:0005499 | vitamin D binding(GO:0005499) |
0.3 | 0.8 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
0.2 | 1.1 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
0.2 | 1.6 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
0.2 | 0.6 | GO:1990259 | protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259) |
0.1 | 1.0 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
0.1 | 1.5 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
0.1 | 0.9 | GO:0043176 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
0.1 | 0.5 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
0.1 | 1.0 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.1 | 0.3 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
0.1 | 0.6 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
0.1 | 0.3 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
0.1 | 0.6 | GO:0008430 | selenium binding(GO:0008430) |
0.0 | 0.2 | GO:0035939 | microsatellite binding(GO:0035939) |
0.0 | 0.3 | GO:0001515 | opioid peptide activity(GO:0001515) |
0.0 | 0.6 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
0.0 | 1.8 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
0.0 | 1.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 1.3 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.0 | 0.4 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
0.0 | 0.4 | GO:0004969 | histamine receptor activity(GO:0004969) |
0.0 | 0.8 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
0.0 | 0.2 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
0.0 | 0.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.0 | 0.3 | GO:0071253 | connexin binding(GO:0071253) |
0.0 | 0.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.0 | 0.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.0 | 0.4 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172) |
0.0 | 0.7 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
0.0 | 0.1 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
0.0 | 0.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.5 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.0 | 0.8 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.0 | 0.3 | ST_STAT3_PATHWAY | STAT3 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.9 | REACTOME_SEROTONIN_RECEPTORS | Genes involved in Serotonin receptors |
0.1 | 1.9 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
0.0 | 1.5 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
0.0 | 0.5 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
0.0 | 0.8 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
0.0 | 1.2 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
0.0 | 4.3 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 0.3 | REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
0.0 | 0.3 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
0.0 | 0.2 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
0.0 | 0.2 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
0.0 | 0.5 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |