Motif ID: SIX4

Z-value: 0.557


Transcription factors associated with SIX4:

Gene SymbolEntrez IDGene Name
SIX4 ENSG00000100625.8 SIX4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SIX4hg19_v2_chr14_-_61190754_611908520.611.4e-03Click!


Activity profile for motif SIX4.

activity profile for motif SIX4


Sorted Z-values histogram for motif SIX4

Sorted Z-values for motif SIX4



Network of associatons between targets according to the STRING database.



First level regulatory network of SIX4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_207119738 3.172 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr1_+_38022572 1.909 ENST00000541606.1
DNALI1
dynein, axonemal, light intermediate chain 1
chr1_-_151778630 1.340 ENST00000368820.3
LINGO4
leucine rich repeat and Ig domain containing 4
chr3_-_52488048 1.265 ENST00000232975.3
TNNC1
troponin C type 1 (slow)
chr12_-_10282836 1.218 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A


C-type lectin domain family 7, member A


chrY_+_22737678 0.909 ENST00000382772.3
EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chrY_+_22737604 0.882 ENST00000361365.2
EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr19_+_13134772 0.879 ENST00000587760.1
ENST00000585575.1
NFIX

nuclear factor I/X (CCAAT-binding transcription factor)

chr12_+_133758115 0.845 ENST00000541009.2
ENST00000592241.1
ZNF268

zinc finger protein 268

chr12_-_10282742 0.759 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A


C-type lectin domain family 7, member A


chr8_+_144798429 0.757 ENST00000338033.4
ENST00000395107.4
ENST00000395108.2
MAPK15


mitogen-activated protein kinase 15


chr12_+_133757995 0.734 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268









zinc finger protein 268









chr12_-_10282681 0.729 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr3_+_118866222 0.724 ENST00000490594.1
RP11-484M3.5
Uncharacterized protein
chr16_+_640201 0.652 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr6_-_76072719 0.648 ENST00000370020.1
FILIP1
filamin A interacting protein 1
chr8_+_144295067 0.557 ENST00000330824.2
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr11_-_130184555 0.543 ENST00000525842.1
ZBTB44
zinc finger and BTB domain containing 44
chr14_-_67981916 0.522 ENST00000357461.2
TMEM229B
transmembrane protein 229B
chr6_+_1080164 0.498 ENST00000314040.1
AL033381.1
Uncharacterized protein; cDNA FLJ34594 fis, clone KIDNE2009109
chr11_-_96076334 0.483 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr2_+_219135115 0.481 ENST00000248451.3
ENST00000273077.4
PNKD

paroxysmal nonkinesigenic dyskinesia

chr11_-_130184470 0.475 ENST00000357899.4
ENST00000397753.1
ZBTB44

zinc finger and BTB domain containing 44

chr3_+_32147997 0.458 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr1_+_226250379 0.411 ENST00000366815.3
ENST00000366814.3
H3F3A

H3 histone, family 3A

chr6_+_52051171 0.408 ENST00000340057.1
IL17A
interleukin 17A
chr1_+_35734562 0.406 ENST00000314607.6
ENST00000373297.2
ZMYM4

zinc finger, MYM-type 4

chr14_-_92413353 0.396 ENST00000556154.1
FBLN5
fibulin 5
chr7_+_69064300 0.373 ENST00000342771.4
AUTS2
autism susceptibility candidate 2
chr8_+_95907993 0.366 ENST00000523378.1
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr19_+_13135386 0.365 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX


nuclear factor I/X (CCAAT-binding transcription factor)


chr20_-_52687059 0.362 ENST00000371435.2
ENST00000395961.3
BCAS1

breast carcinoma amplified sequence 1

chr22_-_39268192 0.336 ENST00000216083.6
CBX6
chromobox homolog 6
chr17_-_72527605 0.325 ENST00000392621.1
ENST00000314401.3
CD300LB

CD300 molecule-like family member b

chr1_-_247335269 0.317 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
ZNF124



zinc finger protein 124



chr1_+_161123536 0.311 ENST00000368003.5
UFC1
ubiquitin-fold modifier conjugating enzyme 1
chr2_+_128458514 0.302 ENST00000310981.4
SFT2D3
SFT2 domain containing 3
chr14_-_67981870 0.295 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chr13_-_78492955 0.294 ENST00000446573.1
EDNRB
endothelin receptor type B
chr6_-_31704282 0.281 ENST00000375784.3
ENST00000375779.2
CLIC1

chloride intracellular channel 1

chr1_+_231473743 0.257 ENST00000295050.7
SPRTN
SprT-like N-terminal domain
chr3_+_32726620 0.254 ENST00000331889.6
ENST00000328834.5
CNOT10

CCR4-NOT transcription complex, subunit 10

chr1_+_116915855 0.251 ENST00000295598.5
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr9_+_132427883 0.240 ENST00000372469.4
PRRX2
paired related homeobox 2
chr17_-_61523622 0.234 ENST00000448884.2
ENST00000582297.1
ENST00000582034.1
ENST00000578072.1
ENST00000360793.3
CYB561




cytochrome b561




chr2_-_219134822 0.233 ENST00000444053.1
ENST00000248450.4
AAMP

angio-associated, migratory cell protein

chr19_+_19174795 0.225 ENST00000318596.7
SLC25A42
solute carrier family 25, member 42
chr8_+_132916318 0.215 ENST00000254624.5
ENST00000522709.1
EFR3A

EFR3 homolog A (S. cerevisiae)

chr1_+_160097462 0.214 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr2_-_219134343 0.208 ENST00000447885.1
ENST00000420660.1
AAMP

angio-associated, migratory cell protein

chr10_+_88414338 0.205 ENST00000241891.5
ENST00000443292.1
OPN4

opsin 4

chr15_+_41245160 0.205 ENST00000444189.2
ENST00000446533.3
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr22_-_39268308 0.202 ENST00000407418.3
CBX6
chromobox homolog 6
chr19_+_35417939 0.198 ENST00000601142.1
ENST00000426813.2
ZNF30

zinc finger protein 30

chr10_+_88414298 0.198 ENST00000372071.2
OPN4
opsin 4
chr13_+_33160553 0.194 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr19_-_474880 0.194 ENST00000382696.3
ENST00000315489.4
ODF3L2

outer dense fiber of sperm tails 3-like 2

chr19_+_35417844 0.188 ENST00000601957.1
ZNF30
zinc finger protein 30
chr11_-_35547572 0.184 ENST00000378880.2
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr4_-_13546632 0.183 ENST00000382438.5
NKX3-2
NK3 homeobox 2
chr12_-_4488872 0.181 ENST00000237837.1
FGF23
fibroblast growth factor 23
chr4_-_84255935 0.172 ENST00000513463.1
HPSE
heparanase
chr7_-_121944491 0.165 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1


FEZ family zinc finger 1


chr5_-_1295104 0.164 ENST00000334602.6
ENST00000508104.2
ENST00000310581.5
ENST00000296820.5
TERT



telomerase reverse transcriptase



chr8_-_123139423 0.161 ENST00000523792.1
RP11-398G24.2
RP11-398G24.2
chr7_+_69064566 0.154 ENST00000403018.2
AUTS2
autism susceptibility candidate 2
chr22_-_30960876 0.138 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
GAL3ST1


galactose-3-O-sulfotransferase 1


chr12_+_4829507 0.137 ENST00000252318.2
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr1_-_154934200 0.131 ENST00000368457.2
PYGO2
pygopus family PHD finger 2
chr19_-_47128294 0.128 ENST00000596260.1
ENST00000597185.1
ENST00000598865.1
ENST00000594275.1
ENST00000291294.2
PTGIR




prostaglandin I2 (prostacyclin) receptor (IP)




chr4_-_2420335 0.127 ENST00000503000.1
ZFYVE28
zinc finger, FYVE domain containing 28
chr12_-_58135903 0.110 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_+_26737253 0.108 ENST00000326279.6
LIN28A
lin-28 homolog A (C. elegans)
chr17_+_7465216 0.107 ENST00000321337.7
SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr10_+_26505179 0.105 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr10_+_26505594 0.101 ENST00000259271.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_+_26737292 0.100 ENST00000254231.4
LIN28A
lin-28 homolog A (C. elegans)
chrX_-_119763835 0.098 ENST00000371313.2
ENST00000304661.5
C1GALT1C1

C1GALT1-specific chaperone 1

chr1_+_156611704 0.094 ENST00000329117.5
BCAN
brevican
chr1_+_156611960 0.081 ENST00000361588.5
BCAN
brevican
chrX_+_54466829 0.074 ENST00000375151.4
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr5_-_78365437 0.069 ENST00000380311.4
ENST00000540686.1
ENST00000255189.3
DMGDH


dimethylglycine dehydrogenase


chrX_+_108780347 0.068 ENST00000372103.1
NXT2
nuclear transport factor 2-like export factor 2
chr1_-_114414316 0.066 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22





protein tyrosine phosphatase, non-receptor type 22 (lymphoid)





chr11_-_18956556 0.064 ENST00000302797.3
MRGPRX1
MAS-related GPR, member X1
chr15_-_20193370 0.058 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr3_+_72200408 0.052 ENST00000473713.1
LINC00870
long intergenic non-protein coding RNA 870
chr14_-_106692191 0.049 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr1_+_8378140 0.045 ENST00000377479.2
SLC45A1
solute carrier family 45, member 1
chr1_-_231473578 0.042 ENST00000360394.2
ENST00000366645.1
EXOC8

exocyst complex component 8

chr7_+_97361218 0.035 ENST00000319273.5
TAC1
tachykinin, precursor 1
chr7_-_99063769 0.033 ENST00000430982.1
ENST00000555673.1
ENST00000394186.3
ENST00000359832.4
ENST00000449683.1
ENST00000488775.1
ENST00000523680.1
ENST00000292475.3
ENST00000413834.1
PTCD1

ATP5J2





ATP5J2-PTCD1
pentatricopeptide repeat domain 1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2





ATP5J2-PTCD1 readthrough
chr20_+_57875457 0.029 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3


endothelin 3


chr11_+_2415061 0.028 ENST00000481687.1
CD81
CD81 molecule
chr6_-_41040195 0.026 ENST00000463088.1
ENST00000469104.1
ENST00000486443.1
OARD1


O-acyl-ADP-ribose deacylase 1


chr3_-_183967296 0.026 ENST00000455059.1
ENST00000445626.2
ALG3

ALG3, alpha-1,3- mannosyltransferase

chr11_+_7273181 0.026 ENST00000318881.6
SYT9
synaptotagmin IX
chr20_+_57875658 0.025 ENST00000371025.3
EDN3
endothelin 3
chr7_+_97361388 0.025 ENST00000350485.4
ENST00000346867.4
TAC1

tachykinin, precursor 1

chr3_-_49158218 0.024 ENST00000417901.1
ENST00000306026.5
ENST00000434032.2
USP19


ubiquitin specific peptidase 19


chr3_-_87325612 0.018 ENST00000561167.1
ENST00000560656.1
ENST00000344265.3
POU1F1


POU class 1 homeobox 1


chr10_+_7860460 0.014 ENST00000344293.5
TAF3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
chr1_-_42800860 0.011 ENST00000445886.1
ENST00000361346.1
ENST00000361776.1
FOXJ3


forkhead box J3


chr8_+_56014949 0.009 ENST00000327381.6
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr2_-_180427304 0.004 ENST00000336917.5
ZNF385B
zinc finger protein 385B
chr2_+_120687335 0.003 ENST00000544261.1
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr17_-_39684550 0.001 ENST00000455635.1
ENST00000361566.3
KRT19

keratin 19


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.5 1.6 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.3 1.3 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.2 0.5 GO:0098582 innate vocalization behavior(GO:0098582)
0.2 0.5 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.4 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 2.7 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.5 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 0.6 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.4 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.2 GO:0071106 coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.1 0.2 GO:0042369 vitamin D catabolic process(GO:0042369)
0.1 0.2 GO:1900369 transcription, RNA-templated(GO:0001172) negative regulation of RNA interference(GO:1900369)
0.1 0.5 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.2 GO:0007497 posterior midgut development(GO:0007497) endothelin receptor signaling pathway(GO:0086100)
0.0 0.5 GO:1903416 response to glycoside(GO:1903416)
0.0 0.3 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.2 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.2 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.8 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.0 0.1 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.0 0.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.1 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.2 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.4 GO:0001740 Barr body(GO:0001740)
0.1 0.2 GO:0031379 RNA-directed RNA polymerase complex(GO:0031379)
0.0 0.4 GO:0071953 elastic fiber(GO:0071953)
0.0 3.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.9 GO:0030286 dynein complex(GO:0030286)
0.0 0.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.2 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.2 0.5 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 1.3 GO:0031013 troponin I binding(GO:0031013)
0.1 2.7 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 1.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.6 GO:0008035 high-density lipoprotein particle binding(GO:0008035) lipase binding(GO:0035473)
0.1 0.2 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.1 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.2 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 0.4 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 0.2 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 0.2 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.0 0.2 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.0 0.5 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.8 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 1.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 0.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 2.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.4 REACTOME_OPSINS Genes involved in Opsins
0.0 1.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.1 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors