Motif ID: SMAD2

Z-value: 0.628


Transcription factors associated with SMAD2:

Gene SymbolEntrez IDGene Name
SMAD2 ENSG00000175387.11 SMAD2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMAD2hg19_v2_chr18_-_45457192_454572780.281.8e-01Click!


Activity profile for motif SMAD2.

activity profile for motif SMAD2


Sorted Z-values histogram for motif SMAD2

Sorted Z-values for motif SMAD2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_53443963 1.350 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1


tensin like C1 domain containing phosphatase (tensin 2)


chr10_+_72972281 1.269 ENST00000335350.6
UNC5B
unc-5 homolog B (C. elegans)
chrX_-_48328551 1.261 ENST00000376876.3
SLC38A5
solute carrier family 38, member 5
chrX_-_48328631 1.229 ENST00000429543.1
ENST00000317669.5
SLC38A5

solute carrier family 38, member 5

chr12_-_6740802 1.201 ENST00000431922.1
LPAR5
lysophosphatidic acid receptor 5
chr2_-_72375167 1.191 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr9_+_125137565 1.178 ENST00000373698.5
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr12_-_47473642 1.115 ENST00000266581.4
AMIGO2
adhesion molecule with Ig-like domain 2
chr12_-_47473425 1.100 ENST00000550413.1
AMIGO2
adhesion molecule with Ig-like domain 2
chrX_-_107018969 1.099 ENST00000372383.4
TSC22D3
TSC22 domain family, member 3
chr2_+_113735575 1.087 ENST00000376489.2
ENST00000259205.4
IL36G

interleukin 36, gamma

chr1_-_9189229 1.019 ENST00000377411.4
GPR157
G protein-coupled receptor 157
chr12_+_47473369 0.984 ENST00000546455.1
PCED1B
PC-esterase domain containing 1B
chr12_-_47473557 0.925 ENST00000321382.3
AMIGO2
adhesion molecule with Ig-like domain 2
chr11_-_107729887 0.880 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr16_+_31483374 0.860 ENST00000394863.3
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr19_-_44285401 0.851 ENST00000262888.3
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr19_-_11688447 0.847 ENST00000590420.1
ACP5
acid phosphatase 5, tartrate resistant
chr1_-_149908710 0.790 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
MTMR11


myotubularin related protein 11


chr17_-_7297519 0.751 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3

TMEM256-PLSCR3 readthrough (NMD candidate)

chr1_-_149908217 0.724 ENST00000369140.3
MTMR11
myotubularin related protein 11
chr20_+_43343476 0.713 ENST00000372868.2
WISP2
WNT1 inducible signaling pathway protein 2
chr3_+_130569592 0.692 ENST00000533801.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr16_+_28889801 0.688 ENST00000395503.4
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr7_-_102257139 0.688 ENST00000521076.1
ENST00000462172.1
ENST00000522801.1
ENST00000449970.2
ENST00000262940.7
RASA4




RAS p21 protein activator 4




chr12_+_53443680 0.679 ENST00000314250.6
ENST00000451358.1
TENC1

tensin like C1 domain containing phosphatase (tensin 2)

chr20_+_43343517 0.660 ENST00000372865.4
WISP2
WNT1 inducible signaling pathway protein 2
chr17_-_7297833 0.648 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3



TMEM256-PLSCR3 readthrough (NMD candidate)



chr20_+_43343886 0.648 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr16_+_28889703 0.633 ENST00000357084.3
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chrX_-_107019181 0.621 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3



TSC22 domain family, member 3



chrX_+_38420783 0.589 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7


tetraspanin 7


chr19_-_14224969 0.589 ENST00000589994.1
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr12_+_1800179 0.577 ENST00000357103.4
ADIPOR2
adiponectin receptor 2
chr11_+_117857063 0.566 ENST00000227752.3
ENST00000541785.1
ENST00000545409.1
IL10RA


interleukin 10 receptor, alpha


chr12_-_53207842 0.563 ENST00000458244.2
KRT4
keratin 4
chr9_+_34990219 0.560 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
DNAJB5


DnaJ (Hsp40) homolog, subfamily B, member 5


chr22_-_44287875 0.553 ENST00000438734.1
ENST00000597664.1
ENST00000216177.4
ENST00000593866.1
ENST00000381198.2
PNPLA5




patatin-like phospholipase domain containing 5




chr3_+_50316458 0.535 ENST00000316436.3
LSMEM2
leucine-rich single-pass membrane protein 2
chr22_+_24891210 0.511 ENST00000382760.2
UPB1
ureidopropionase, beta
chr4_-_41216492 0.496 ENST00000503503.1
ENST00000509446.1
ENST00000503264.1
ENST00000508707.1
ENST00000508593.1
APBB2




amyloid beta (A4) precursor protein-binding, family B, member 2




chr22_+_48027423 0.495 ENST00000423737.1
RP11-191L9.4
RP11-191L9.4
chr1_-_155270770 0.492 ENST00000392414.3
PKLR
pyruvate kinase, liver and RBC
chr21_-_36259445 0.488 ENST00000399240.1
RUNX1
runt-related transcription factor 1
chr4_-_41216473 0.476 ENST00000513140.1
APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr12_+_101188547 0.467 ENST00000546991.1
ENST00000392979.3
ANO4

anoctamin 4

chr4_-_39979576 0.464 ENST00000303538.8
ENST00000503396.1
PDS5A

PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)

chr12_+_101188718 0.460 ENST00000299222.9
ENST00000392977.3
ANO4

anoctamin 4

chr1_+_36772691 0.458 ENST00000312808.4
ENST00000505871.1
SH3D21

SH3 domain containing 21

chr22_-_37823468 0.447 ENST00000402918.2
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr6_-_143771799 0.441 ENST00000237283.8
ADAT2
adenosine deaminase, tRNA-specific 2
chr2_-_228028829 0.440 ENST00000396625.3
ENST00000329662.7
COL4A4

collagen, type IV, alpha 4

chr5_-_64064508 0.426 ENST00000513458.4
SREK1IP1
SREK1-interacting protein 1
chr7_-_102158157 0.425 ENST00000541662.1
ENST00000306682.6
ENST00000465829.1
RASA4B


RAS p21 protein activator 4B


chr20_+_30598231 0.415 ENST00000300415.8
ENST00000262659.8
CCM2L

cerebral cavernous malformation 2-like

chr11_-_107590383 0.412 ENST00000525934.1
ENST00000531293.1
SLN

sarcolipin

chr8_+_82192501 0.402 ENST00000297258.6
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr4_-_41216619 0.396 ENST00000508676.1
ENST00000506352.1
ENST00000295974.8
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr17_+_73629500 0.390 ENST00000375215.3
SMIM5
small integral membrane protein 5
chr10_-_14372870 0.382 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr2_-_220174166 0.367 ENST00000409251.3
ENST00000451506.1
ENST00000295718.2
ENST00000446182.1
PTPRN



protein tyrosine phosphatase, receptor type, N



chr1_+_36771946 0.366 ENST00000373139.2
ENST00000453908.2
ENST00000426732.2
SH3D21


SH3 domain containing 21


chr5_+_70751442 0.364 ENST00000358731.4
ENST00000380675.2
BDP1

B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB

chr12_-_8765446 0.360 ENST00000537228.1
ENST00000229335.6
AICDA

activation-induced cytidine deaminase

chr6_+_34482630 0.355 ENST00000538621.1
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr11_-_101454658 0.349 ENST00000344327.3
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr1_-_44497118 0.345 ENST00000537678.1
ENST00000466926.1
SLC6A9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr11_+_2923423 0.344 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr6_-_134861089 0.335 ENST00000606039.1
RP11-557H15.4
RP11-557H15.4
chr8_-_125384927 0.335 ENST00000297632.6
TMEM65
transmembrane protein 65
chr16_-_4987065 0.335 ENST00000590782.2
ENST00000345988.2
PPL

periplakin

chr20_-_36889127 0.334 ENST00000279024.4
KIAA1755
KIAA1755
chr19_+_56186606 0.331 ENST00000085079.7
EPN1
epsin 1
chr1_-_44482979 0.327 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9


solute carrier family 6 (neurotransmitter transporter, glycine), member 9


chr9_-_137809718 0.326 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr17_-_1389419 0.321 ENST00000575158.1
MYO1C
myosin IC
chr19_+_56186557 0.321 ENST00000270460.6
EPN1
epsin 1
chr12_+_68042517 0.313 ENST00000393555.3
DYRK2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr6_+_30689401 0.300 ENST00000396389.1
ENST00000396384.1
TUBB

tubulin, beta class I

chr20_-_48532046 0.297 ENST00000543716.1
SPATA2
spermatogenesis associated 2
chr16_-_56459354 0.292 ENST00000290649.5
AMFR
autocrine motility factor receptor, E3 ubiquitin protein ligase
chr2_-_73053126 0.288 ENST00000272427.6
ENST00000410104.1
EXOC6B

exocyst complex component 6B

chr3_+_130569429 0.288 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1



ATPase, Ca++ transporting, type 2C, member 1



chr17_+_3627185 0.285 ENST00000325418.4
GSG2
germ cell associated 2 (haspin)
chr13_+_96743093 0.277 ENST00000376705.2
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr12_+_93965609 0.269 ENST00000549887.1
ENST00000551556.1
SOCS2

suppressor of cytokine signaling 2

chr17_-_46623441 0.269 ENST00000330070.4
HOXB2
homeobox B2
chr14_-_57277163 0.266 ENST00000555006.1
OTX2
orthodenticle homeobox 2
chr1_+_2407754 0.264 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
PLCH2



phospholipase C, eta 2



chr9_+_125281420 0.263 ENST00000340750.1
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chrX_-_47489244 0.260 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
CFP


complement factor properdin


chr14_-_57277178 0.248 ENST00000339475.5
ENST00000554559.1
ENST00000555804.1
OTX2


orthodenticle homeobox 2


chr1_-_155271213 0.246 ENST00000342741.4
PKLR
pyruvate kinase, liver and RBC
chr11_-_3859089 0.244 ENST00000396979.1
RHOG
ras homolog family member G
chr4_-_114682597 0.240 ENST00000394524.3
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr4_-_103749205 0.239 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr1_-_1243252 0.236 ENST00000353662.3
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr2_-_74667612 0.232 ENST00000305557.5
ENST00000233330.6
RTKN

rhotekin

chr12_+_93965451 0.231 ENST00000548537.1
SOCS2
suppressor of cytokine signaling 2
chr17_-_58469474 0.230 ENST00000300896.4
USP32
ubiquitin specific peptidase 32
chr4_+_93225550 0.229 ENST00000282020.4
GRID2
glutamate receptor, ionotropic, delta 2
chr20_+_35974532 0.226 ENST00000373578.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr1_+_15783222 0.225 ENST00000359621.4
CELA2A
chymotrypsin-like elastase family, member 2A
chr9_-_136006496 0.225 ENST00000372062.3
RALGDS
ral guanine nucleotide dissociation stimulator
chr21_-_38639813 0.223 ENST00000309117.6
ENST00000398998.1
DSCR3

Down syndrome critical region gene 3

chr4_-_103749179 0.221 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr20_+_36888551 0.217 ENST00000418004.1
ENST00000451435.1
BPI

bactericidal/permeability-increasing protein

chr16_+_2198604 0.217 ENST00000210187.6
RAB26
RAB26, member RAS oncogene family
chr9_-_14910990 0.207 ENST00000380881.4
ENST00000422223.2
FREM1

FRAS1 related extracellular matrix 1

chr20_-_56284816 0.205 ENST00000395819.3
ENST00000341744.3
PMEPA1

prostate transmembrane protein, androgen induced 1

chr3_+_194406603 0.205 ENST00000329759.4
FAM43A
family with sequence similarity 43, member A
chr12_-_71003568 0.204 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB




protein tyrosine phosphatase, receptor type, B




chr9_+_140145713 0.203 ENST00000388931.3
ENST00000412566.1
C9orf173

chromosome 9 open reading frame 173

chr4_+_102268904 0.202 ENST00000527564.1
ENST00000529296.1
AP001816.1

Uncharacterized protein

chr12_-_22094336 0.202 ENST00000326684.4
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr5_+_33441053 0.201 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
TARS


threonyl-tRNA synthetase


chr17_-_58469687 0.199 ENST00000590133.1
USP32
ubiquitin specific peptidase 32
chr14_-_106494587 0.198 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr6_+_99282570 0.197 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chr9_-_34523027 0.188 ENST00000399775.2
ENHO
energy homeostasis associated
chr17_-_40761375 0.187 ENST00000543197.1
ENST00000309428.5
FAM134C

family with sequence similarity 134, member C

chr14_+_81421355 0.181 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr13_-_27334879 0.180 ENST00000405846.3
GPR12
G protein-coupled receptor 12
chr17_-_58469591 0.174 ENST00000589335.1
USP32
ubiquitin specific peptidase 32
chr2_+_113033164 0.174 ENST00000409871.1
ENST00000343936.4
ZC3H6

zinc finger CCCH-type containing 6

chr14_+_81421861 0.173 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr1_+_15802594 0.170 ENST00000375910.3
CELA2B
chymotrypsin-like elastase family, member 2B
chr15_+_68570062 0.169 ENST00000306917.4
FEM1B
fem-1 homolog b (C. elegans)
chr2_+_191045656 0.166 ENST00000443551.2
C2orf88
chromosome 2 open reading frame 88
chr9_-_73029540 0.165 ENST00000377126.2
KLF9
Kruppel-like factor 9
chr3_-_195603566 0.165 ENST00000424563.1
ENST00000411741.1
TNK2

tyrosine kinase, non-receptor, 2

chr3_+_52529346 0.164 ENST00000321725.6
STAB1
stabilin 1
chr8_-_95907423 0.163 ENST00000396133.3
ENST00000308108.4
CCNE2

cyclin E2

chr6_+_41010293 0.162 ENST00000373161.1
ENST00000373158.2
ENST00000470917.1
TSPO2


translocator protein 2


chr19_+_15619299 0.161 ENST00000269703.3
CYP4F22
cytochrome P450, family 4, subfamily F, polypeptide 22
chr12_-_57410304 0.161 ENST00000441881.1
ENST00000458521.2
TAC3

tachykinin 3

chr7_-_105516923 0.160 ENST00000478915.1
ATXN7L1
ataxin 7-like 1
chr1_+_28052518 0.160 ENST00000530324.1
ENST00000234549.7
ENST00000373949.1
ENST00000010299.6
FAM76A



family with sequence similarity 76, member A



chr20_-_48532019 0.159 ENST00000289431.5
SPATA2
spermatogenesis associated 2
chr3_-_195163803 0.159 ENST00000326793.6
ACAP2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr20_+_1875942 0.158 ENST00000358771.4
SIRPA
signal-regulatory protein alpha
chrX_+_153029633 0.158 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
PLXNB3



plexin B3



chrX_+_38420623 0.158 ENST00000378482.2
TSPAN7
tetraspanin 7
chr5_+_133861339 0.157 ENST00000282605.4
ENST00000361895.2
ENST00000402835.1
PHF15


jade family PHD finger 2


chr17_+_30593195 0.156 ENST00000431505.2
ENST00000269051.4
ENST00000538145.1
RHBDL3


rhomboid, veinlet-like 3 (Drosophila)


chr4_-_185139062 0.156 ENST00000296741.2
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr21_+_46066331 0.155 ENST00000334670.8
KRTAP10-11
keratin associated protein 10-11
chr12_+_110338323 0.153 ENST00000312777.5
ENST00000536408.2
TCHP

trichoplein, keratin filament binding

chr10_-_75193308 0.152 ENST00000299432.2
MSS51
MSS51 mitochondrial translational activator
chr10_-_102046098 0.151 ENST00000441611.1
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr9_+_101867359 0.145 ENST00000374994.4
TGFBR1
transforming growth factor, beta receptor 1
chr2_-_17981462 0.142 ENST00000402989.1
ENST00000428868.1
SMC6

structural maintenance of chromosomes 6

chr19_+_11466062 0.137 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410


Lipid phosphate phosphatase-related protein type 2


chr12_-_57472522 0.137 ENST00000379391.3
ENST00000300128.4
TMEM194A

transmembrane protein 194A

chr9_+_101867387 0.134 ENST00000374990.2
ENST00000552516.1
TGFBR1

transforming growth factor, beta receptor 1

chr4_-_103749313 0.132 ENST00000394803.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr20_-_23066953 0.130 ENST00000246006.4
CD93
CD93 molecule
chr6_+_6588902 0.129 ENST00000230568.4
LY86
lymphocyte antigen 86
chr16_+_2286726 0.127 ENST00000382437.4
ENST00000569184.1
DNASE1L2

deoxyribonuclease I-like 2

chr14_-_106478603 0.126 ENST00000390596.2
IGHV4-4
immunoglobulin heavy variable 4-4
chr5_-_150521192 0.125 ENST00000523714.1
ENST00000521749.1
ANXA6

annexin A6

chr1_+_100111479 0.125 ENST00000263174.4
PALMD
palmdelphin
chr10_-_102046417 0.124 ENST00000370372.2
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr8_+_11561660 0.121 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA4


GATA binding protein 4


chr13_+_25670268 0.119 ENST00000281589.3
PABPC3
poly(A) binding protein, cytoplasmic 3
chr1_-_160040038 0.117 ENST00000368089.3
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr4_-_56458374 0.117 ENST00000295645.4
PDCL2
phosducin-like 2
chr4_-_103749105 0.115 ENST00000394801.4
ENST00000394804.2
UBE2D3

ubiquitin-conjugating enzyme E2D 3

chr1_+_100111580 0.115 ENST00000605497.1
PALMD
palmdelphin
chr9_+_15422702 0.108 ENST00000380821.3
ENST00000421710.1
SNAPC3

small nuclear RNA activating complex, polypeptide 3, 50kDa

chr11_+_74951948 0.106 ENST00000562197.2
TPBGL
trophoblast glycoprotein-like
chr17_-_3571934 0.103 ENST00000225525.3
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr13_+_114238997 0.102 ENST00000538138.1
ENST00000375370.5
TFDP1

transcription factor Dp-1

chr9_-_28670283 0.101 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr1_+_226411319 0.100 ENST00000542034.1
ENST00000366810.5
MIXL1

Mix paired-like homeobox

chr12_-_29936731 0.100 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
TMTC1


transmembrane and tetratricopeptide repeat containing 1


chr16_-_17564738 0.099 ENST00000261381.6
XYLT1
xylosyltransferase I
chr19_-_14606900 0.096 ENST00000393029.3
ENST00000393028.1
ENST00000393033.4
ENST00000345425.2
ENST00000586027.1
ENST00000591349.1
ENST00000587210.1
GIPC1






GIPC PDZ domain containing family, member 1






chr10_+_105315102 0.095 ENST00000369777.2
NEURL
neuralized E3 ubiquitin protein ligase 1
chr17_+_40761660 0.093 ENST00000251413.3
ENST00000591509.1
TUBG1

tubulin, gamma 1

chr12_-_52604607 0.093 ENST00000551894.1
ENST00000553017.1
C12orf80

chromosome 12 open reading frame 80

chr1_+_185703513 0.091 ENST00000271588.4
ENST00000367492.2
HMCN1

hemicentin 1

chr17_-_40337470 0.090 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr4_-_113437328 0.090 ENST00000313341.3
NEUROG2
neurogenin 2
chr22_+_29876197 0.087 ENST00000310624.6
NEFH
neurofilament, heavy polypeptide
chr9_+_33524240 0.087 ENST00000290943.6
ANKRD18B
ankyrin repeat domain 18B
chr17_-_74533963 0.085 ENST00000293230.5
CYGB
cytoglobin
chr6_-_159466136 0.080 ENST00000367066.3
ENST00000326965.6
TAGAP

T-cell activation RhoGTPase activating protein

chr20_+_34680620 0.079 ENST00000430276.1
ENST00000373950.2
ENST00000452261.1
EPB41L1


erythrocyte membrane protein band 4.1-like 1


chr5_+_64064748 0.074 ENST00000381070.3
ENST00000508024.1
CWC27

CWC27 spliceosome-associated protein homolog (S. cerevisiae)

chr12_-_120554534 0.073 ENST00000538903.1
ENST00000534951.1
RAB35

RAB35, member RAS oncogene family

chr4_-_164534657 0.069 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr7_+_155250824 0.068 ENST00000297375.4
EN2
engrailed homeobox 2
chr19_-_43383819 0.066 ENST00000312439.6
ENST00000403380.3
PSG1

pregnancy specific beta-1-glycoprotein 1

chr20_+_42143053 0.062 ENST00000373135.3
ENST00000444063.1
L3MBTL1

l(3)mbt-like 1 (Drosophila)

chr1_-_151119087 0.061 ENST00000341697.3
ENST00000368914.3
SEMA6C

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

chr2_+_74881398 0.057 ENST00000339773.5
ENST00000434486.1
SEMA4F

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F

chr11_+_75273101 0.053 ENST00000533603.1
ENST00000358171.3
ENST00000526242.1
SERPINH1


serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)


chr15_+_75498739 0.050 ENST00000565074.1
C15orf39
chromosome 15 open reading frame 39
chr20_+_57226841 0.050 ENST00000358029.4
ENST00000361830.3
STX16

syntaxin 16


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.4 1.2 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.2 3.2 GO:0015816 glycine transport(GO:0015816)
0.2 1.7 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 0.8 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 1.0 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.2 1.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 0.4 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 0.4 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1 0.5 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.4 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.1 0.4 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.1 0.9 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 0.3 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 0.4 GO:1990502 dense core granule maturation(GO:1990502)
0.1 0.9 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.7 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.1 0.3 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 1.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.5 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.1 0.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 1.0 GO:0060019 radial glial cell differentiation(GO:0060019)
0.1 0.9 GO:0046541 saliva secretion(GO:0046541)
0.1 0.1 GO:0003285 septum secundum development(GO:0003285)
0.1 0.2 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.3 GO:1905075 proepicardium development(GO:0003342) septum transversum development(GO:0003343) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.1 0.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.3 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.2 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.1 0.2 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 3.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.6 GO:1901621 cellular response to parathyroid hormone stimulus(GO:0071374) negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.2 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.3 GO:0046618 drug export(GO:0046618)
0.0 0.7 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.1 GO:0003335 corneocyte development(GO:0003335)
0.0 0.1 GO:0048936 neurofilament bundle assembly(GO:0033693) peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.4 GO:0002097 tRNA wobble base modification(GO:0002097)
0.0 0.4 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.2 GO:0051414 response to cortisol(GO:0051414)
0.0 0.1 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.3 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 1.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.2 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.0 0.2 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) regulation of histone deacetylase activity(GO:1901725) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.3 GO:0006828 manganese ion transport(GO:0006828) negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.2 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.9 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.1 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.2 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.2 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.9 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.4 GO:0060749 mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377)
0.0 0.2 GO:0060155 platelet dense granule organization(GO:0060155)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.3 GO:0045160 myosin I complex(GO:0045160)
0.1 1.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 1.0 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.3 3.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.2 1.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.2 1.7 GO:0043426 MRF binding(GO:0043426)
0.2 0.7 GO:0004743 pyruvate kinase activity(GO:0004743)
0.2 0.9 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.4 GO:0001026 TFIIIB-type transcription factor activity(GO:0001026)
0.1 0.3 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.9 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 2.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 0.6 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.8 GO:0008199 ferric iron binding(GO:0008199)
0.1 0.3 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.1 0.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.2 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 1.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.4 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.3 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.1 GO:0031493 nucleosomal histone binding(GO:0031493) SAM domain binding(GO:0032093)
0.0 0.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.2 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.3 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.8 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.7 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.2 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.5 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors