Motif ID: SRF

Z-value: 1.584


Transcription factors associated with SRF:

Gene SymbolEntrez IDGene Name
SRF ENSG00000112658.6 SRF

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SRFhg19_v2_chr6_+_43139037_43139094-0.001.0e+00Click!


Activity profile for motif SRF.

activity profile for motif SRF


Sorted Z-values histogram for motif SRF

Sorted Z-values for motif SRF



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_151561506 10.036 ENST00000253332.1
AKAP12
A kinase (PRKA) anchor protein 12
chr5_+_137801160 7.495 ENST00000239938.4
EGR1
early growth response 1
chr6_+_151561085 7.431 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr11_-_65667997 6.710 ENST00000312562.2
ENST00000534222.1
FOSL1

FOS-like antigen 1

chr14_-_94443105 5.932 ENST00000555019.1
ASB2
ankyrin repeat and SOCS box containing 2
chr11_-_65667884 5.729 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOSL1


FOS-like antigen 1


chr14_+_75745477 5.073 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS




FBJ murine osteosarcoma viral oncogene homolog




chr12_+_4382917 4.787 ENST00000261254.3
CCND2
cyclin D2
chr19_-_15344243 4.696 ENST00000602233.1
EPHX3
epoxide hydrolase 3
chr2_-_161056762 4.436 ENST00000428609.2
ENST00000409967.2
ITGB6

integrin, beta 6

chr2_+_74120094 4.301 ENST00000409731.3
ENST00000345517.3
ENST00000409918.1
ENST00000442912.1
ENST00000409624.1
ACTG2




actin, gamma 2, smooth muscle, enteric




chr19_+_54372639 4.195 ENST00000391769.2
MYADM
myeloid-associated differentiation marker
chr19_-_15343773 4.194 ENST00000435261.1
ENST00000594042.1
EPHX3

epoxide hydrolase 3

chrX_-_153602991 4.171 ENST00000369850.3
ENST00000422373.1
FLNA

filamin A, alpha

chr2_-_161056802 3.752 ENST00000283249.2
ENST00000409872.1
ITGB6

integrin, beta 6

chr19_+_16178317 3.723 ENST00000344824.6
ENST00000538887.1
TPM4

tropomyosin 4

chr10_+_112257596 3.367 ENST00000369583.3
DUSP5
dual specificity phosphatase 5
chr5_+_150404904 3.154 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr10_-_90712520 2.998 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_+_167599330 2.956 ENST00000367854.3
ENST00000361496.3
RCSD1

RCSD domain containing 1

chr7_+_143078652 2.899 ENST00000354434.4
ENST00000449423.2
ZYX

zyxin

chr10_-_17659234 2.798 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr8_-_143696833 2.706 ENST00000356613.2
ARC
activity-regulated cytoskeleton-associated protein
chr12_+_75874460 2.661 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr4_+_87928413 2.557 ENST00000544085.1
AFF1
AF4/FMR2 family, member 1
chr11_-_65626753 2.548 ENST00000526975.1
ENST00000531413.1
CFL1

cofilin 1 (non-muscle)

chr2_-_208031943 2.547 ENST00000421199.1
ENST00000457962.1
KLF7

Kruppel-like factor 7 (ubiquitous)

chr12_+_75874580 2.532 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr9_+_131644781 2.466 ENST00000259324.5
LRRC8A
leucine rich repeat containing 8 family, member A
chr1_-_168106536 2.463 ENST00000537209.1
ENST00000361697.2
ENST00000546300.1
ENST00000367835.1
GPR161



G protein-coupled receptor 161



chr22_-_36784035 2.444 ENST00000216181.5
MYH9
myosin, heavy chain 9, non-muscle
chr7_-_107643674 2.302 ENST00000222399.6
LAMB1
laminin, beta 1
chr18_+_61143994 2.166 ENST00000382771.4
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr1_-_229569834 2.105 ENST00000366684.3
ENST00000366683.2
ACTA1

actin, alpha 1, skeletal muscle

chr10_-_17659357 2.082 ENST00000326961.6
ENST00000361271.3
PTPLA

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

chr19_+_45971246 1.988 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FOSB





FBJ murine osteosarcoma viral oncogene homolog B





chr2_-_112237835 1.970 ENST00000442293.1
ENST00000439494.1
MIR4435-1HG

MIR4435-1 host gene (non-protein coding)

chr22_-_36357671 1.932 ENST00000408983.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr6_-_88411911 1.906 ENST00000257787.5
AKIRIN2
akirin 2
chr4_+_87928140 1.901 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr5_-_176923846 1.862 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr10_-_29923893 1.832 ENST00000355867.4
SVIL
supervillin
chr2_-_106054952 1.775 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
FHL2


four and a half LIM domains 2


chr11_-_65626797 1.726 ENST00000525451.2
CFL1
cofilin 1 (non-muscle)
chr3_-_99595037 1.671 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chr17_-_79481666 1.648 ENST00000575659.1
ACTG1
actin, gamma 1
chr5_-_176923803 1.641 ENST00000506161.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr17_-_72358001 1.583 ENST00000375366.3
BTBD17
BTB (POZ) domain containing 17
chr2_+_191792376 1.549 ENST00000409428.1
ENST00000409215.1
GLS

glutaminase

chr2_+_87769459 1.533 ENST00000414030.1
ENST00000437561.1
LINC00152

long intergenic non-protein coding RNA 152

chr1_+_16085244 1.504 ENST00000400773.1
FBLIM1
filamin binding LIM protein 1
chr19_-_17356697 1.492 ENST00000291442.3
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr11_-_2162468 1.458 ENST00000434045.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr19_+_1026298 1.455 ENST00000263097.4
CNN2
calponin 2
chr15_-_35088340 1.449 ENST00000290378.4
ACTC1
actin, alpha, cardiac muscle 1
chr3_-_123339418 1.392 ENST00000583087.1
MYLK
myosin light chain kinase
chr7_-_27183263 1.368 ENST00000222726.3
HOXA5
homeobox A5
chr19_+_1026566 1.358 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
CNN2




calponin 2




chr2_-_106015491 1.356 ENST00000408995.1
ENST00000393353.3
ENST00000322142.8
FHL2


four and a half LIM domains 2


chr3_-_123339343 1.347 ENST00000578202.1
MYLK
myosin light chain kinase
chr8_-_22550815 1.340 ENST00000317216.2
EGR3
early growth response 3
chr1_+_11994715 1.325 ENST00000449038.1
ENST00000376369.3
ENST00000429000.2
ENST00000196061.4
PLOD1



procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1



chr19_+_52102540 1.301 ENST00000601315.1
AC018755.17
AC018755.17
chr2_-_106015527 1.269 ENST00000344213.4
ENST00000358129.4
FHL2

four and a half LIM domains 2

chr9_-_35691017 1.229 ENST00000378292.3
TPM2
tropomyosin 2 (beta)
chr17_-_41132410 1.184 ENST00000409399.1
ENST00000421990.2
ENST00000409446.3
ENST00000453594.1
PTGES3L-AARSD1

PTGES3L

PTGES3L-AARSD1 readthrough

prostaglandin E synthase 3 (cytosolic)-like

chr11_-_2162162 1.159 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_-_4890919 1.147 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
CAMTA2



calmodulin binding transcription activator 2



chr16_-_11375179 1.137 ENST00000312511.3
PRM1
protamine 1
chr15_+_33603147 1.113 ENST00000415757.3
ENST00000389232.4
RYR3

ryanodine receptor 3

chr3_-_46904946 1.107 ENST00000292327.4
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr5_-_179050660 1.088 ENST00000519056.1
ENST00000506721.1
ENST00000503105.1
ENST00000504348.1
ENST00000508103.1
ENST00000510431.1
ENST00000515158.1
ENST00000393432.4
ENST00000442819.2
HNRNPH1








heterogeneous nuclear ribonucleoprotein H1 (H)








chr3_-_46904918 1.077 ENST00000395869.1
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr6_+_27107053 1.043 ENST00000354348.2
HIST1H4I
histone cluster 1, H4i
chr3_-_99594948 1.037 ENST00000471562.1
ENST00000495625.2
FILIP1L

filamin A interacting protein 1-like

chr7_-_121944491 1.035 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1


FEZ family zinc finger 1


chr20_+_35169885 1.003 ENST00000279022.2
ENST00000346786.2
MYL9

myosin, light chain 9, regulatory

chr12_-_11548496 0.990 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2

PRB1
proline-rich protein BstNI subfamily 2

proline-rich protein BstNI subfamily 1
chr15_+_83776324 0.935 ENST00000379390.6
ENST00000379386.4
ENST00000565774.1
ENST00000565982.1
TM6SF1



transmembrane 6 superfamily member 1



chr1_+_50574585 0.914 ENST00000371824.1
ENST00000371823.4
ELAVL4

ELAV like neuron-specific RNA binding protein 4

chr8_+_125954281 0.913 ENST00000510897.2
ENST00000533286.1
LINC00964

long intergenic non-protein coding RNA 964

chr5_-_33892046 0.909 ENST00000352040.3
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr6_-_99797522 0.884 ENST00000389677.5
FAXC
failed axon connections homolog (Drosophila)
chr12_-_50616382 0.877 ENST00000552783.1
LIMA1
LIM domain and actin binding 1
chr8_+_97597148 0.873 ENST00000521590.1
SDC2
syndecan 2
chr17_-_4890649 0.855 ENST00000361571.5
CAMTA2
calmodulin binding transcription activator 2
chr19_-_35166604 0.815 ENST00000601241.1
SCGB2B2
secretoglobin, family 2B, member 2
chr7_+_112120908 0.808 ENST00000439068.2
ENST00000312849.4
ENST00000429049.1
LSMEM1


leucine-rich single-pass membrane protein 1


chr12_-_50616122 0.782 ENST00000552823.1
ENST00000552909.1
LIMA1

LIM domain and actin binding 1

chr2_-_209118974 0.777 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
IDH1


isocitrate dehydrogenase 1 (NADP+), soluble


chr1_-_11907829 0.774 ENST00000376480.3
NPPA
natriuretic peptide A
chr2_-_172087824 0.764 ENST00000521943.1
TLK1
tousled-like kinase 1
chr7_-_44180884 0.760 ENST00000458240.1
ENST00000223364.3
MYL7

myosin, light chain 7, regulatory

chr4_-_10118469 0.716 ENST00000499869.2
WDR1
WD repeat domain 1
chr6_-_123957942 0.712 ENST00000398178.3
TRDN
triadin
chr12_+_62654119 0.702 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15


ubiquitin specific peptidase 15


chr5_+_137774706 0.697 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2


receptor accessory protein 2


chr19_+_35861831 0.687 ENST00000454971.1
GPR42
G protein-coupled receptor 42 (gene/pseudogene)
chr7_-_94285402 0.687 ENST00000428696.2
ENST00000445866.2
SGCE

sarcoglycan, epsilon

chr7_-_94285472 0.680 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
SGCE


sarcoglycan, epsilon


chr12_+_54426637 0.676 ENST00000312492.2
HOXC5
homeobox C5
chr18_-_54318353 0.667 ENST00000590954.1
ENST00000540155.1
TXNL1

thioredoxin-like 1

chr12_+_62654155 0.666 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
USP15


ubiquitin specific peptidase 15


chr11_-_71823266 0.655 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15


anaphase promoting complex subunit 15


chr10_+_75757863 0.652 ENST00000372755.3
ENST00000211998.4
ENST00000417648.2
VCL


vinculin


chr7_-_5570229 0.634 ENST00000331789.5
ACTB
actin, beta
chr6_-_123958141 0.618 ENST00000334268.4
TRDN
triadin
chr4_-_10118573 0.614 ENST00000382452.2
ENST00000382451.2
WDR1

WD repeat domain 1

chr7_-_94285511 0.601 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chr5_+_66254698 0.588 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
MAST4


microtubule associated serine/threonine kinase family member 4


chr7_-_44180673 0.569 ENST00000457314.1
ENST00000447951.1
ENST00000431007.1
MYL7


myosin, light chain 7, regulatory


chr5_+_40679584 0.563 ENST00000302472.3
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr8_+_53850991 0.561 ENST00000331251.3
NPBWR1
neuropeptides B/W receptor 1
chr5_-_142000883 0.548 ENST00000359370.6
FGF1
fibroblast growth factor 1 (acidic)
chr4_-_109087872 0.532 ENST00000510624.1
LEF1
lymphoid enhancer-binding factor 1
chr6_+_158402860 0.529 ENST00000367122.2
ENST00000367121.3
ENST00000355585.4
ENST00000367113.4
SYNJ2



synaptojanin 2



chr3_-_190167571 0.501 ENST00000354905.2
TMEM207
transmembrane protein 207
chr8_-_101965559 0.489 ENST00000353245.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr3_-_185641681 0.487 ENST00000259043.7
TRA2B
transformer 2 beta homolog (Drosophila)
chr10_+_96162242 0.479 ENST00000225235.4
TBC1D12
TBC1 domain family, member 12
chr17_+_3379284 0.446 ENST00000263080.2
ASPA
aspartoacylase
chr11_-_71823715 0.421 ENST00000545944.1
ENST00000502597.2
ANAPC15

anaphase promoting complex subunit 15

chr11_-_71823796 0.408 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15





anaphase promoting complex subunit 15





chr10_+_114043493 0.404 ENST00000369422.3
TECTB
tectorin beta
chrX_-_103499602 0.382 ENST00000372588.4
ESX1
ESX homeobox 1
chr1_+_47881744 0.336 ENST00000335071.2
FOXE3
forkhead box E3
chr17_-_79479789 0.308 ENST00000571691.1
ENST00000571721.1
ENST00000573283.1
ENST00000575842.1
ENST00000575087.1
ENST00000570382.1
ENST00000331925.2
ACTG1






actin, gamma 1






chr16_+_86229728 0.307 ENST00000601250.1
LINC01082
long intergenic non-protein coding RNA 1082
chr22_+_38004473 0.301 ENST00000414350.3
ENST00000343632.4
GGA1

golgi-associated, gamma adaptin ear containing, ARF binding protein 1

chr6_-_159466136 0.269 ENST00000367066.3
ENST00000326965.6
TAGAP

T-cell activation RhoGTPase activating protein

chr11_+_86667117 0.266 ENST00000531827.1
RP11-736K20.6
RP11-736K20.6
chr17_-_55911970 0.262 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3

RP11-60A24.3

chr16_+_30077055 0.252 ENST00000564595.2
ENST00000569798.1
ALDOA

aldolase A, fructose-bisphosphate

chr3_+_9834227 0.247 ENST00000287613.7
ENST00000397261.3
ARPC4

actin related protein 2/3 complex, subunit 4, 20kDa

chr2_+_219283815 0.235 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1


villin 1


chr8_-_101965146 0.221 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
YWHAZ


tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta


chr11_+_34073195 0.219 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr22_+_38004832 0.218 ENST00000405147.3
ENST00000429218.1
ENST00000325180.8
ENST00000337437.4
GGA1



golgi-associated, gamma adaptin ear containing, ARF binding protein 1



chr20_-_62258394 0.217 ENST00000370077.1
GMEB2
glucocorticoid modulatory element binding protein 2
chr3_+_9834179 0.216 ENST00000498623.2
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr16_+_30077098 0.207 ENST00000395240.3
ENST00000566846.1
ALDOA

aldolase A, fructose-bisphosphate

chr2_-_96811170 0.205 ENST00000288943.4
DUSP2
dual specificity phosphatase 2
chrX_-_11284095 0.202 ENST00000303025.6
ENST00000534860.1
ARHGAP6

Rho GTPase activating protein 6

chr5_+_92919043 0.200 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr15_-_55581954 0.189 ENST00000336787.1
RAB27A
RAB27A, member RAS oncogene family
chr17_-_4871085 0.159 ENST00000575142.1
ENST00000206020.3
SPAG7

sperm associated antigen 7

chr11_+_117070037 0.152 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN


transgelin


chr2_-_128432639 0.124 ENST00000545738.2
ENST00000355119.4
ENST00000409808.2
LIMS2


LIM and senescent cell antigen-like domains 2


chr3_+_9834758 0.114 ENST00000485273.1
ENST00000433034.1
ENST00000397256.1
ARPC4

ARPC4-TTLL3
actin related protein 2/3 complex, subunit 4, 20kDa

ARPC4-TTLL3 readthrough
chrX_+_22056165 0.112 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr13_+_27825446 0.112 ENST00000311549.6
RPL21
ribosomal protein L21
chr19_-_47975417 0.091 ENST00000236877.6
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr1_+_6105974 0.083 ENST00000378083.3
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr3_+_143690640 0.079 ENST00000315691.3
C3orf58
chromosome 3 open reading frame 58
chr17_-_41132010 0.075 ENST00000409103.1
ENST00000360221.4
PTGES3L-AARSD1

PTGES3L-AARSD1 readthrough

chr17_-_27949911 0.032 ENST00000492276.2
ENST00000345068.5
ENST00000584602.1
CORO6


coronin 6


chr1_-_152332480 0.017 ENST00000388718.5
FLG2
filaggrin family member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
2.1 12.4 GO:0007296 vitellogenesis(GO:0007296)
1.8 10.9 GO:0090131 mesenchyme migration(GO:0090131)
1.2 17.5 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
1.0 4.2 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.9 4.4 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.7 8.2 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.7 4.2 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.7 2.7 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.6 5.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.6 4.3 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.6 2.3 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.5 3.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.5 1.4 GO:0060435 bronchiole development(GO:0060435)
0.4 1.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.3 1.4 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.3 1.3 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.3 1.3 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.3 2.6 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.3 1.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.3 2.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 1.7 GO:1903923 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.3 2.5 GO:0002329 pre-B cell differentiation(GO:0002329)
0.3 0.8 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 3.0 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.2 1.9 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 3.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 4.8 GO:0071481 cellular response to X-ray(GO:0071481)
0.2 0.6 GO:2000417 negative regulation of eosinophil migration(GO:2000417)
0.2 1.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 1.3 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.2 2.5 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.2 0.8 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.1 0.4 GO:0006533 aspartate catabolic process(GO:0006533)
0.1 0.9 GO:0008218 bioluminescence(GO:0008218)
0.1 0.7 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 1.2 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.3 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 1.1 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.1 1.5 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.5 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 2.0 GO:0051412 response to corticosterone(GO:0051412)
0.1 1.5 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 0.8 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 5.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 1.5 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 2.2 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 1.6 GO:0014887 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 0.7 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.0 2.2 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.0 3.5 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 4.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.6 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 1.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 2.8 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 1.7 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 1.1 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.1 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 3.0 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 1.9 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 0.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0018094 protein polyglycylation(GO:0018094)
0.0 1.6 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 2.8 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 2.4 GO:0001649 osteoblast differentiation(GO:0001649)
0.0 0.6 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.5 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 0.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
1.4 4.2 GO:0031523 Myb complex(GO:0031523)
0.8 4.8 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.8 2.3 GO:0005607 laminin-2 complex(GO:0005607)
0.7 5.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.6 5.1 GO:0035976 AP1 complex(GO:0035976)
0.6 2.8 GO:0042643 actomyosin, actin portion(GO:0042643)
0.5 3.0 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.5 2.4 GO:0005826 actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513)
0.4 3.6 GO:0032982 myosin filament(GO:0032982)
0.3 5.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.2 2.0 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 1.8 GO:0036449 microtubule minus-end(GO:0036449)
0.2 2.6 GO:0097433 dense body(GO:0097433)
0.2 17.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.3 GO:0030314 junctional membrane complex(GO:0030314)
0.1 4.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 12.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.2 GO:0032432 actin filament bundle(GO:0032432)
0.1 4.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 5.0 GO:0031672 A band(GO:0031672)
0.1 0.7 GO:0005916 fascia adherens(GO:0005916)
0.1 5.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 18.0 GO:0005938 cell cortex(GO:0005938)
0.0 1.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 1.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 3.2 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:1990031 pinceau fiber(GO:1990031)
0.0 2.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.8 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 2.8 GO:0043197 dendritic spine(GO:0043197)
0.0 2.9 GO:0055037 recycling endosome(GO:0055037)
0.0 1.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.5 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.0 4.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
1.0 17.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.5 2.2 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.4 1.3 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.3 1.5 GO:0004359 glutaminase activity(GO:0004359)
0.3 3.2 GO:0008430 selenium binding(GO:0008430)
0.3 1.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.3 2.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 0.8 GO:0051990 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.2 3.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 1.4 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 2.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 2.4 GO:0043495 protein anchor(GO:0043495)
0.1 1.5 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 5.1 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.5 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.1 8.2 GO:0001618 virus receptor activity(GO:0001618)
0.1 0.6 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 0.7 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 2.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 1.5 GO:0031005 filamin binding(GO:0031005)
0.1 0.6 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.4 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 18.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.7 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.6 GO:0030957 Tat protein binding(GO:0030957)
0.0 3.0 GO:0017022 myosin binding(GO:0017022)
0.0 4.5 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 2.3 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.5 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 2.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.9 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 4.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.9 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 17.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 8.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 17.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 7.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 4.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 2.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.9 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 1.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 4.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 3.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 5.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 2.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.9 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.7 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 0.5 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 3.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.4 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 2.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 10.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 4.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 6.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.4 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 9.6 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.5 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 0.6 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 1.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.9 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.7 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.8 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.0 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 5.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane