Motif ID: T
Z-value: 0.566
Transcription factors associated with T:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
T | ENSG00000164458.5 | T |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
T | hg19_v2_chr6_-_166582107_166582188 | 0.15 | 4.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.4 | GO:0016103 | diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653) |
0.3 | 1.3 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
0.2 | 0.9 | GO:0035627 | ceramide transport(GO:0035627) |
0.2 | 1.5 | GO:0001661 | conditioned taste aversion(GO:0001661) |
0.1 | 0.7 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) protein K29-linked ubiquitination(GO:0035519) |
0.1 | 1.0 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
0.1 | 0.6 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
0.1 | 0.6 | GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268) |
0.1 | 0.6 | GO:0035803 | egg coat formation(GO:0035803) |
0.1 | 0.3 | GO:1900108 | negative regulation of nodal signaling pathway(GO:1900108) |
0.1 | 0.7 | GO:0009753 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
0.1 | 0.3 | GO:0045210 | negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210) |
0.1 | 0.5 | GO:0002018 | renin-angiotensin regulation of aldosterone production(GO:0002018) |
0.1 | 0.2 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
0.1 | 1.0 | GO:0019388 | galactose catabolic process(GO:0019388) |
0.0 | 0.3 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
0.0 | 0.3 | GO:0030805 | regulation of cyclic nucleotide catabolic process(GO:0030805) regulation of cAMP catabolic process(GO:0030820) regulation of purine nucleotide catabolic process(GO:0033121) regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
0.0 | 0.2 | GO:0050668 | cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668) |
0.0 | 0.2 | GO:0003241 | growth involved in heart morphogenesis(GO:0003241) |
0.0 | 1.4 | GO:0006491 | N-glycan processing(GO:0006491) |
0.0 | 1.1 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
0.0 | 3.1 | GO:0018149 | peptide cross-linking(GO:0018149) |
0.0 | 0.4 | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049) |
0.0 | 0.5 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
0.0 | 1.3 | GO:0007398 | ectoderm development(GO:0007398) |
0.0 | 0.1 | GO:1901069 | guanosine-containing compound catabolic process(GO:1901069) |
0.0 | 0.8 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
0.0 | 0.1 | GO:0060492 | foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) |
0.0 | 0.1 | GO:0039019 | pronephric nephron development(GO:0039019) |
0.0 | 0.3 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
0.0 | 0.6 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
0.0 | 0.2 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
0.0 | 0.1 | GO:0098759 | response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) |
0.0 | 0.3 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
0.0 | 0.1 | GO:0001757 | somite specification(GO:0001757) |
0.0 | 0.3 | GO:0051451 | myoblast migration(GO:0051451) |
0.0 | 0.2 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
0.0 | 0.1 | GO:0001207 | histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039) |
0.0 | 0.2 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
0.0 | 0.2 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
0.0 | 0.1 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
0.0 | 0.1 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
0.0 | 0.1 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
0.0 | 0.1 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
0.0 | 1.2 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
0.0 | 0.2 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
0.0 | 0.3 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
0.0 | 0.1 | GO:0033686 | positive regulation of luteinizing hormone secretion(GO:0033686) |
0.0 | 0.2 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
0.0 | 0.1 | GO:2000490 | negative regulation of hepatic stellate cell activation(GO:2000490) |
0.0 | 0.1 | GO:0048539 | bone marrow development(GO:0048539) |
0.0 | 1.0 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) |
0.0 | 0.4 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
0.0 | 0.1 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
0.0 | 0.5 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
0.0 | 0.1 | GO:0043461 | proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272) |
0.0 | 0.3 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
0.0 | 0.2 | GO:0098779 | mitophagy in response to mitochondrial depolarization(GO:0098779) |
0.0 | 0.5 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
0.0 | 0.5 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
0.0 | 0.2 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
0.0 | 0.1 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
0.0 | 0.2 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.5 | GO:0035976 | AP1 complex(GO:0035976) |
0.1 | 0.9 | GO:0097209 | epidermal lamellar body(GO:0097209) |
0.1 | 1.3 | GO:0071438 | invadopodium membrane(GO:0071438) |
0.1 | 0.3 | GO:0043259 | laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260) |
0.1 | 1.0 | GO:0033010 | paranodal junction(GO:0033010) |
0.1 | 0.3 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
0.1 | 0.8 | GO:0030478 | actin cap(GO:0030478) |
0.0 | 2.8 | GO:0001533 | cornified envelope(GO:0001533) |
0.0 | 0.6 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
0.0 | 0.1 | GO:0005927 | muscle tendon junction(GO:0005927) |
0.0 | 1.8 | GO:0045095 | keratin filament(GO:0045095) |
0.0 | 0.2 | GO:0070531 | BRCA1-A complex(GO:0070531) |
0.0 | 1.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
0.0 | 0.2 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.3 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
0.3 | 1.4 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
0.2 | 1.0 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
0.2 | 0.9 | GO:0034040 | lipid-transporting ATPase activity(GO:0034040) |
0.2 | 0.5 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
0.1 | 0.7 | GO:0018636 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) |
0.1 | 1.3 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
0.1 | 0.8 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
0.1 | 0.2 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
0.1 | 0.2 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
0.1 | 0.6 | GO:0032190 | acrosin binding(GO:0032190) |
0.0 | 0.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.0 | 0.6 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
0.0 | 1.2 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.0 | 0.7 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.0 | 0.3 | GO:0016015 | morphogen activity(GO:0016015) |
0.0 | 1.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.2 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
0.0 | 1.1 | GO:0008327 | methyl-CpG binding(GO:0008327) |
0.0 | 0.3 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
0.0 | 0.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
0.0 | 0.1 | GO:0019959 | interleukin-8 binding(GO:0019959) |
0.0 | 0.2 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
0.0 | 0.8 | GO:0005523 | tropomyosin binding(GO:0005523) |
0.0 | 1.4 | GO:0005080 | protein kinase C binding(GO:0005080) |
0.0 | 0.1 | GO:0047888 | fatty acid peroxidase activity(GO:0047888) |
0.0 | 0.5 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
0.0 | 0.2 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
0.0 | 0.1 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
0.0 | 1.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
0.0 | 0.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
0.0 | 0.3 | GO:0004707 | MAP kinase activity(GO:0004707) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.5 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
0.0 | 1.3 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
0.0 | 0.3 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
0.0 | 1.6 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
0.0 | 0.3 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
0.0 | 0.4 | ST_GA12_PATHWAY | G alpha 12 Pathway |
0.0 | 0.4 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.4 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
0.1 | 1.5 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
0.0 | 0.8 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
0.0 | 0.9 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.0 | 1.3 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
0.0 | 0.3 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
0.0 | 1.4 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
0.0 | 0.4 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
0.0 | 0.5 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
0.0 | 0.6 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
0.0 | 0.4 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
0.0 | 0.8 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
0.0 | 0.2 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
0.0 | 0.2 | REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR | Genes involved in Signaling by constitutively active EGFR |