Motif ID: TCF7L2

Z-value: 0.446


Transcription factors associated with TCF7L2:

Gene SymbolEntrez IDGene Name
TCF7L2 ENSG00000148737.11 TCF7L2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF7L2hg19_v2_chr10_+_114710516_1147106750.368.4e-02Click!


Activity profile for motif TCF7L2.

activity profile for motif TCF7L2


Sorted Z-values histogram for motif TCF7L2

Sorted Z-values for motif TCF7L2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF7L2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_63557309 1.362 ENST00000580513.1
AXIN2
axin 2
chr17_-_63556414 1.286 ENST00000585045.1
AXIN2
axin 2
chr13_+_24144509 1.260 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr13_+_24144796 0.947 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr13_-_36429763 0.751 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr17_+_68100989 0.665 ENST00000585558.1
ENST00000392670.1
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr17_-_63557759 0.665 ENST00000307078.5
AXIN2
axin 2
chr3_-_45957088 0.611 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr1_+_61330931 0.572 ENST00000371191.1
NFIA
nuclear factor I/A
chr1_+_162351503 0.533 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr20_+_18794370 0.527 ENST00000377428.2
SCP2D1
SCP2 sterol-binding domain containing 1
chr3_-_45957534 0.516 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr2_+_204801471 0.516 ENST00000316386.6
ENST00000435193.1
ICOS

inducible T-cell co-stimulator

chr17_-_39165366 0.470 ENST00000391588.1
KRTAP3-1
keratin associated protein 3-1
chr12_-_49582978 0.447 ENST00000301071.7
TUBA1A
tubulin, alpha 1a
chr10_+_114133773 0.421 ENST00000354655.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_-_123542224 0.377 ENST00000264497.3
IL21
interleukin 21
chr15_-_93632421 0.367 ENST00000329082.7
RGMA
repulsive guidance molecule family member a
chr2_+_69240302 0.350 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chr10_+_7745232 0.347 ENST00000358415.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr11_-_62474803 0.341 ENST00000533982.1
ENST00000360796.5
BSCL2

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

chr7_-_25702669 0.333 ENST00000446840.1
AC003090.1
AC003090.1
chr11_-_108422926 0.318 ENST00000428840.1
ENST00000526312.1
EXPH5

exophilin 5

chr6_+_12717892 0.316 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chrX_-_43832711 0.307 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr16_+_19222479 0.301 ENST00000568433.1
SYT17
synaptotagmin XVII
chr17_-_46035187 0.299 ENST00000300557.2
PRR15L
proline rich 15-like
chr9_-_130712995 0.299 ENST00000373084.4
FAM102A
family with sequence similarity 102, member A
chr10_-_61900762 0.283 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chrX_-_100183894 0.279 ENST00000328526.5
ENST00000372956.2
XKRX

XK, Kell blood group complex subunit-related, X-linked

chr6_-_11779840 0.274 ENST00000506810.1
ADTRP
androgen-dependent TFPI-regulating protein
chr11_-_41481135 0.265 ENST00000528697.1
ENST00000530763.1
LRRC4C

leucine rich repeat containing 4C

chr17_+_59529743 0.247 ENST00000589003.1
ENST00000393853.4
TBX4

T-box 4

chr12_+_1738363 0.246 ENST00000397196.2
WNT5B
wingless-type MMTV integration site family, member 5B
chr3_+_137483579 0.243 ENST00000306087.1
SOX14
SRY (sex determining region Y)-box 14
chr9_-_32635667 0.240 ENST00000242310.4
TAF1L
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like
chrX_+_15525426 0.227 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr12_-_6982442 0.227 ENST00000523102.1
ENST00000524270.1
ENST00000519357.1
SPSB2


splA/ryanodine receptor domain and SOCS box containing 2


chr12_-_23737534 0.224 ENST00000396007.2
SOX5
SRY (sex determining region Y)-box 5
chr22_+_29279552 0.224 ENST00000544604.2
ZNRF3
zinc and ring finger 3
chr20_-_13971255 0.219 ENST00000284951.5
ENST00000378072.5
SEL1L2

sel-1 suppressor of lin-12-like 2 (C. elegans)

chr11_-_40315640 0.216 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr1_-_40367668 0.210 ENST00000397332.2
ENST00000429311.1
MYCL

v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog

chr13_-_67802549 0.209 ENST00000328454.5
ENST00000377865.2
PCDH9

protocadherin 9

chr15_-_82338460 0.207 ENST00000558133.1
ENST00000329713.4
MEX3B

mex-3 RNA binding family member B

chr21_-_32185570 0.206 ENST00000329621.4
KRTAP8-1
keratin associated protein 8-1
chr16_-_73082274 0.200 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chrX_-_10588595 0.200 ENST00000423614.1
ENST00000317552.4
MID1

midline 1 (Opitz/BBB syndrome)

chr2_-_71357344 0.196 ENST00000494660.2
ENST00000244217.5
ENST00000486135.1
MCEE


methylmalonyl CoA epimerase


chr12_+_6982725 0.184 ENST00000433346.1
LRRC23
leucine rich repeat containing 23
chr17_-_38256973 0.184 ENST00000246672.3
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr5_+_133450365 0.181 ENST00000342854.5
ENST00000321603.6
ENST00000321584.4
ENST00000378564.1
ENST00000395029.1
TCF7




transcription factor 7 (T-cell specific, HMG-box)




chr14_-_61124977 0.180 ENST00000554986.1
SIX1
SIX homeobox 1
chr13_+_76334498 0.179 ENST00000534657.1
LMO7
LIM domain 7
chr8_-_16859690 0.176 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr7_+_27282319 0.175 ENST00000222761.3
EVX1
even-skipped homeobox 1
chr1_+_147013182 0.175 ENST00000234739.3
BCL9
B-cell CLL/lymphoma 9
chr2_+_69240415 0.174 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chrX_-_10588459 0.173 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr14_-_53258180 0.169 ENST00000554230.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr17_-_56065484 0.161 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr1_-_115053781 0.159 ENST00000358465.2
ENST00000369543.2
TRIM33

tripartite motif containing 33

chr5_-_111093167 0.158 ENST00000446294.2
ENST00000419114.2
NREP

neuronal regeneration related protein

chr3_+_183353356 0.153 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24








kelch-like family member 24








chr8_-_95220775 0.153 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17


cadherin 17, LI cadherin (liver-intestine)


chr4_+_30721968 0.152 ENST00000361762.2
PCDH7
protocadherin 7
chr1_-_32801825 0.148 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr9_-_27005686 0.148 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chr16_+_53242350 0.148 ENST00000565442.1
CHD9
chromodomain helicase DNA binding protein 9
chr15_+_43885252 0.145 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B



creatine kinase, mitochondrial 1B



chr3_+_29323043 0.142 ENST00000452462.1
ENST00000456853.1
RBMS3

RNA binding motif, single stranded interacting protein 3

chr5_+_170846640 0.140 ENST00000274625.5
FGF18
fibroblast growth factor 18
chr15_+_43985084 0.135 ENST00000434505.1
ENST00000411750.1
CKMT1A

creatine kinase, mitochondrial 1A

chr2_+_71357434 0.135 ENST00000244230.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr5_-_160973649 0.134 ENST00000393959.1
ENST00000517547.1
GABRB2

gamma-aminobutyric acid (GABA) A receptor, beta 2

chr11_+_7597639 0.131 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_+_69240511 0.131 ENST00000409349.3
ANTXR1
anthrax toxin receptor 1
chr11_-_76155700 0.129 ENST00000572035.1
RP11-111M22.3
RP11-111M22.3
chr15_+_43985725 0.124 ENST00000413453.2
CKMT1A
creatine kinase, mitochondrial 1A
chr5_+_140235469 0.123 ENST00000506939.2
ENST00000307360.5
PCDHA10

protocadherin alpha 10

chr18_-_52989217 0.120 ENST00000570287.2
TCF4
transcription factor 4
chr5_-_153857819 0.120 ENST00000231121.2
HAND1
heart and neural crest derivatives expressed 1
chr5_+_149546334 0.119 ENST00000231656.8
CDX1
caudal type homeobox 1
chr7_+_99613195 0.118 ENST00000324306.6
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr5_-_24645078 0.115 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr5_+_175288631 0.115 ENST00000509837.1
CPLX2
complexin 2
chr8_+_29952914 0.114 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
LEPROTL1




leptin receptor overlapping transcript-like 1




chr9_-_15510287 0.114 ENST00000397519.2
PSIP1
PC4 and SFRS1 interacting protein 1
chr4_-_85419603 0.109 ENST00000295886.4
NKX6-1
NK6 homeobox 1
chr12_+_85673868 0.109 ENST00000316824.3
ALX1
ALX homeobox 1
chr4_-_69215699 0.107 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1


YTH domain containing 1


chr4_+_95972822 0.106 ENST00000509540.1
ENST00000440890.2
BMPR1B

bone morphogenetic protein receptor, type IB

chr17_+_1674982 0.105 ENST00000572048.1
ENST00000573763.1
SERPINF1

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

chr10_+_114710425 0.103 ENST00000352065.5
ENST00000369395.1
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chr6_-_11779174 0.101 ENST00000379413.2
ADTRP
androgen-dependent TFPI-regulating protein
chr6_-_25930819 0.100 ENST00000360488.3
SLC17A2
solute carrier family 17, member 2
chr12_+_31477250 0.100 ENST00000313737.4
AC024940.1
AC024940.1
chr5_+_102201430 0.100 ENST00000438793.3
ENST00000346918.2
PAM

peptidylglycine alpha-amidating monooxygenase

chr1_-_201096312 0.100 ENST00000449188.2
ASCL5
achaete-scute family bHLH transcription factor 5
chr20_+_57875658 0.098 ENST00000371025.3
EDN3
endothelin 3
chr2_+_71357744 0.097 ENST00000498451.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr7_+_99613212 0.096 ENST00000426572.1
ENST00000535170.1
ZKSCAN1

zinc finger with KRAB and SCAN domains 1

chr4_+_170581213 0.096 ENST00000507875.1
CLCN3
chloride channel, voltage-sensitive 3
chr17_-_39316983 0.096 ENST00000390661.3
KRTAP4-4
keratin associated protein 4-4
chr4_+_86525299 0.095 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr6_-_112575838 0.094 ENST00000455073.1
LAMA4
laminin, alpha 4
chr10_+_7745303 0.093 ENST00000429820.1
ENST00000379587.4
ITIH2

inter-alpha-trypsin inhibitor heavy chain 2

chr12_-_49582593 0.093 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr14_-_75179774 0.090 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1


AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1


Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr5_+_102201509 0.090 ENST00000348126.2
ENST00000379787.4
PAM

peptidylglycine alpha-amidating monooxygenase

chr2_+_201936458 0.090 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr8_-_119964434 0.088 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr18_+_46065483 0.088 ENST00000382998.4
CTIF
CBP80/20-dependent translation initiation factor
chr6_-_25930904 0.088 ENST00000377850.3
SLC17A2
solute carrier family 17, member 2
chr13_-_72440901 0.087 ENST00000359684.2
DACH1
dachshund homolog 1 (Drosophila)
chr17_+_79679299 0.087 ENST00000331531.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chrX_-_122866874 0.086 ENST00000245838.8
ENST00000355725.4
THOC2

THO complex 2

chr1_+_223101757 0.085 ENST00000284476.6
DISP1
dispatched homolog 1 (Drosophila)
chr8_-_42234745 0.084 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr10_+_114710516 0.084 ENST00000542695.1
ENST00000346198.4
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chr17_+_37618257 0.083 ENST00000447079.4
CDK12
cyclin-dependent kinase 12
chr15_-_65670360 0.083 ENST00000327987.4
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chrX_+_152760397 0.082 ENST00000331595.4
ENST00000431891.1
BGN

biglycan

chr10_-_104179682 0.080 ENST00000406432.1
PSD
pleckstrin and Sec7 domain containing
chr11_-_62572901 0.080 ENST00000439713.2
ENST00000531131.1
ENST00000530875.1
ENST00000531709.2
ENST00000294172.2
NXF1




nuclear RNA export factor 1




chr9_+_136399929 0.079 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chr11_-_76155618 0.078 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr1_-_40367530 0.077 ENST00000372816.2
ENST00000372815.1
MYCL

v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog

chr3_+_174577070 0.073 ENST00000454872.1
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr19_-_3061397 0.071 ENST00000586839.1
AES
amino-terminal enhancer of split
chr1_-_231005310 0.070 ENST00000470540.1
C1orf198
chromosome 1 open reading frame 198
chr2_+_177028805 0.069 ENST00000249440.3
HOXD3
homeobox D3
chr5_+_175815732 0.068 ENST00000274787.2
HIGD2A
HIG1 hypoxia inducible domain family, member 2A
chr9_+_125796806 0.067 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chr6_-_28220002 0.067 ENST00000377294.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chrX_-_47004437 0.064 ENST00000276062.8
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr20_+_57875457 0.059 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3


endothelin 3


chr13_-_72441315 0.058 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
DACH1


dachshund homolog 1 (Drosophila)


chr3_-_134093395 0.056 ENST00000249883.5
AMOTL2
angiomotin like 2
chr1_+_16330723 0.056 ENST00000329454.2
C1orf64
chromosome 1 open reading frame 64
chr5_-_175815565 0.056 ENST00000509257.1
ENST00000507413.1
ENST00000510123.1
NOP16


NOP16 nucleolar protein


chr5_+_66300446 0.054 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr4_-_69215467 0.049 ENST00000579690.1
YTHDC1
YTH domain containing 1
chr22_+_31742875 0.049 ENST00000504184.2
AC005003.1
CDNA FLJ20464 fis, clone KAT06158; HCG1777549; Uncharacterized protein
chr2_+_89890533 0.048 ENST00000429992.2
IGKV2D-40
immunoglobulin kappa variable 2D-40
chr19_+_50084561 0.048 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr14_+_75230011 0.047 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1


YLP motif containing 1


chr1_-_160549235 0.046 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84




CD84 molecule




chr6_+_132873832 0.045 ENST00000275200.1
TAAR8
trace amine associated receptor 8
chr3_-_42452050 0.044 ENST00000441172.1
ENST00000287748.3
LYZL4

lysozyme-like 4

chr18_+_46065393 0.044 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr6_-_89927151 0.042 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr20_+_57875758 0.041 ENST00000395654.3
EDN3
endothelin 3
chr2_+_33701286 0.041 ENST00000403687.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr10_-_87551311 0.041 ENST00000536331.1
GRID1
glutamate receptor, ionotropic, delta 1
chr7_-_27219849 0.038 ENST00000396344.4
HOXA10
homeobox A10
chrX_-_47004878 0.036 ENST00000377811.3
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr7_+_150076406 0.035 ENST00000329630.5
ZNF775
zinc finger protein 775
chr20_+_59654146 0.032 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr13_+_76334795 0.032 ENST00000526202.1
ENST00000465261.2
LMO7

LIM domain 7

chr1_-_20250110 0.031 ENST00000375116.3
PLA2G2E
phospholipase A2, group IIE
chr12_+_52056548 0.031 ENST00000545061.1
ENST00000355133.3
SCN8A

sodium channel, voltage gated, type VIII, alpha subunit

chr15_-_90294523 0.030 ENST00000300057.4
MESP1
mesoderm posterior 1 homolog (mouse)
chr12_-_54694807 0.030 ENST00000435572.2
NFE2
nuclear factor, erythroid 2
chr10_+_114710211 0.029 ENST00000349937.2
ENST00000369397.4
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chr6_-_112575758 0.028 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4



laminin, alpha 4



chrX_+_100646190 0.027 ENST00000471855.1
RPL36A
ribosomal protein L36a
chr17_-_67138015 0.026 ENST00000284425.2
ENST00000590645.1
ABCA6

ATP-binding cassette, sub-family A (ABC1), member 6

chr7_+_73868439 0.022 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr12_+_9067123 0.021 ENST00000543824.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr17_+_80416482 0.021 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
NARF





nuclear prelamin A recognition factor





chr1_-_11907829 0.019 ENST00000376480.3
NPPA
natriuretic peptide A
chr2_+_201936707 0.019 ENST00000433898.1
ENST00000454214.1
NDUFB3

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa

chr2_-_233641265 0.018 ENST00000438786.1
ENST00000409779.1
ENST00000233826.3
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr12_-_31477072 0.017 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr11_-_6677018 0.016 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chr2_+_171571827 0.015 ENST00000375281.3
SP5
Sp5 transcription factor
chr1_+_207039154 0.015 ENST00000367096.3
ENST00000391930.2
IL20

interleukin 20

chr11_+_45944190 0.015 ENST00000401752.1
ENST00000389968.3
ENST00000325468.5
ENST00000536139.1
GYLTL1B



glycosyltransferase-like 1B



chr6_+_35704855 0.015 ENST00000288065.2
ENST00000373866.3
ARMC12

armadillo repeat containing 12

chrX_+_54835493 0.015 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr9_-_23826298 0.014 ENST00000380117.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chrX_-_110655306 0.013 ENST00000371993.2
DCX
doublecortin
chr16_+_29819372 0.013 ENST00000568544.1
ENST00000569978.1
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr17_-_39646116 0.013 ENST00000328119.6
KRT36
keratin 36
chr6_+_29427548 0.010 ENST00000377132.1
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr16_+_29819446 0.008 ENST00000568282.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr7_-_16505440 0.008 ENST00000307068.4
SOSTDC1
sclerostin domain containing 1
chr10_-_104192405 0.008 ENST00000369937.4
CUEDC2
CUE domain containing 2
chr1_+_62417957 0.007 ENST00000307297.7
ENST00000543708.1
INADL

InaD-like (Drosophila)

chr6_+_152130240 0.007 ENST00000427531.2
ESR1
estrogen receptor 1
chr10_+_114709999 0.006 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
TCF7L2






transcription factor 7-like 2 (T-cell specific, HMG-box)






chr2_+_204732487 0.005 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr14_+_32798462 0.005 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chrX_+_100645812 0.004 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A


RPL36A-HNRNPH2

ribosomal protein L36a


RPL36A-HNRNPH2 readthrough

chr14_+_74815116 0.003 ENST00000256362.4
VRTN
vertebrae development associated
chr13_+_76334567 0.002 ENST00000321797.8
LMO7
LIM domain 7
chr14_+_93118813 0.002 ENST00000556418.1
RIN3
Ras and Rab interactor 3
chr1_+_16693578 0.000 ENST00000401088.4
ENST00000471507.1
ENST00000401089.3
ENST00000375590.3
ENST00000492354.1
SZRD1




SUZ RNA binding domain containing 1




chr3_+_155838337 0.000 ENST00000490337.1
ENST00000389636.5
KCNAB1

potassium voltage-gated channel, shaker-related subfamily, beta member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.4 1.1 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.2 0.7 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.1 0.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.3 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.2 GO:0060086 circadian temperature homeostasis(GO:0060086) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.1 0.2 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.2 GO:0018032 protein amidation(GO:0018032)
0.0 0.2 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.2 GO:0038018 Wnt receptor catabolic process(GO:0038018) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.1 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.0 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.2 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.2 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0 0.3 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.2 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.2 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.1 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.0 0.1 GO:0015729 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.0 0.4 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.5 GO:0002517 T cell tolerance induction(GO:0002517)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.6 GO:0072189 ureter development(GO:0072189)
0.0 0.3 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.1 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.4 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.1 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.1 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0 0.0 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.0 GO:0003129 heart induction(GO:0003129) negative regulation of mesodermal cell fate specification(GO:0042662) regulation of endodermal cell fate specification(GO:0042663)
0.0 1.9 GO:0001942 hair follicle development(GO:0001942)
0.0 0.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.7 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.0 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 0.1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.1 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.3 GO:0070411 I-SMAD binding(GO:0070411)
0.1 2.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.0 0.2 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.0 0.4 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.7 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation