Motif ID: TLX1_NFIC

Z-value: 1.191

Transcription factors associated with TLX1_NFIC:

Gene SymbolEntrez IDGene Name
NFIC ENSG00000141905.13 NFIC
TLX1 ENSG00000107807.8 TLX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX1hg19_v2_chr10_+_102891048_1028910780.331.1e-01Click!
NFIChg19_v2_chr19_+_3359561_3359681-0.058.2e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1_NFIC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_74372662 2.896 ENST00000591651.1
ENST00000545180.1
SPHK1

sphingosine kinase 1

chr18_+_21529811 2.552 ENST00000588004.1
LAMA3
laminin, alpha 3
chr8_-_42065075 2.388 ENST00000429089.2
ENST00000519510.1
ENST00000429710.2
ENST00000524009.1
PLAT



plasminogen activator, tissue



chr8_-_42065187 2.212 ENST00000270189.6
ENST00000352041.3
ENST00000220809.4
PLAT


plasminogen activator, tissue


chr7_+_143079000 1.985 ENST00000392910.2
ZYX
zyxin
chr19_+_10397621 1.934 ENST00000380770.3
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397648 1.916 ENST00000340992.4
ENST00000393717.2
ICAM4

intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)

chr8_+_22022800 1.819 ENST00000397814.3
BMP1
bone morphogenetic protein 1
chr12_-_54813229 1.759 ENST00000293379.4
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr17_+_7344057 1.722 ENST00000575398.1
ENST00000575082.1
FGF11

fibroblast growth factor 11

chr7_+_143078652 1.709 ENST00000354434.4
ENST00000449423.2
ZYX

zyxin

chr20_+_58251716 1.705 ENST00000355648.4
PHACTR3
phosphatase and actin regulator 3
chr7_+_116165038 1.660 ENST00000393470.1
CAV1
caveolin 1, caveolae protein, 22kDa
chr14_+_85996471 1.634 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr20_+_33759854 1.518 ENST00000216968.4
PROCR
protein C receptor, endothelial
chr12_+_13349650 1.492 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
EMP1



epithelial membrane protein 1



chr14_+_24867992 1.406 ENST00000382554.3
NYNRIN
NYN domain and retroviral integrase containing
chr2_-_192711968 1.390 ENST00000304141.4
SDPR
serum deprivation response
chr3_+_186915274 1.339 ENST00000312295.4
RTP1
receptor (chemosensory) transporter protein 1
chrX_-_128788914 1.335 ENST00000429967.1
ENST00000307484.6
APLN

apelin

chr3_+_52350335 1.302 ENST00000420323.2
DNAH1
dynein, axonemal, heavy chain 1
chr4_-_103266219 1.289 ENST00000394833.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr1_+_203595689 1.239 ENST00000357681.5
ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr1_-_153363452 1.237 ENST00000368732.1
ENST00000368733.3
S100A8

S100 calcium binding protein A8

chr4_+_110834033 1.195 ENST00000509793.1
ENST00000265171.5
EGF

epidermal growth factor

chr3_+_46742823 1.159 ENST00000326431.3
TMIE
transmembrane inner ear
chr14_+_75746781 1.148 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr9_+_136399929 1.110 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chr20_-_60942361 1.104 ENST00000252999.3
LAMA5
laminin, alpha 5
chr6_-_43595039 1.093 ENST00000307114.7
GTPBP2
GTP binding protein 2
chr17_-_3182268 0.967 ENST00000408891.2
OR3A2
olfactory receptor, family 3, subfamily A, member 2
chr12_+_53491220 0.965 ENST00000548547.1
ENST00000301464.3
IGFBP6

insulin-like growth factor binding protein 6

chr8_+_22022653 0.963 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1


bone morphogenetic protein 1


chr12_+_66217911 0.963 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr14_+_85996507 0.960 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr11_-_65325664 0.927 ENST00000301873.5
LTBP3
latent transforming growth factor beta binding protein 3
chr15_+_90728145 0.871 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
SEMA4B


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B


chr18_+_33877654 0.849 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3



formin homology 2 domain containing 3



chr12_-_109025849 0.842 ENST00000228463.6
SELPLG
selectin P ligand
chr11_-_128457446 0.823 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr14_+_73704201 0.811 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
PAPLN


papilin, proteoglycan-like sulfated glycoprotein


chr11_-_10715163 0.779 ENST00000541483.1
MRVI1
murine retrovirus integration site 1 homolog
chr1_+_203595903 0.765 ENST00000367218.3
ENST00000367219.3
ENST00000391954.2
ATP2B4


ATPase, Ca++ transporting, plasma membrane 4


chr14_-_85996332 0.758 ENST00000380722.1
RP11-497E19.1
RP11-497E19.1
chr1_-_161193349 0.741 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2






apolipoprotein A-II






chr6_-_34524049 0.736 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr22_-_39640756 0.735 ENST00000331163.6
PDGFB
platelet-derived growth factor beta polypeptide
chr19_-_42927251 0.726 ENST00000597001.1
LIPE
lipase, hormone-sensitive
chrX_+_99899180 0.707 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr12_+_113682066 0.706 ENST00000392569.4
ENST00000552542.1
TPCN1

two pore segment channel 1

chr11_-_65325430 0.693 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chr11_+_18417813 0.689 ENST00000540430.1
ENST00000379412.5
LDHA

lactate dehydrogenase A

chr10_+_5454505 0.678 ENST00000355029.4
NET1
neuroepithelial cell transforming 1
chr12_+_21168630 0.675 ENST00000421593.2
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr17_+_19314505 0.671 ENST00000461366.1
RNF112
ring finger protein 112
chr1_+_177140633 0.652 ENST00000361539.4
BRINP2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr6_-_30043539 0.632 ENST00000376751.3
ENST00000244360.6
RNF39

ring finger protein 39

chr21_-_28217721 0.631 ENST00000284984.3
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr17_+_37894179 0.627 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7


growth factor receptor-bound protein 7


chr1_+_113217309 0.617 ENST00000544796.1
ENST00000369644.1
MOV10

Mov10, Moloney leukemia virus 10, homolog (mouse)

chr17_+_37894570 0.614 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr12_+_100867486 0.612 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr1_+_39456895 0.603 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1


akirin 1


chr10_+_124320195 0.597 ENST00000359586.6
DMBT1
deleted in malignant brain tumors 1
chr2_+_219187871 0.593 ENST00000258362.3
PNKD
paroxysmal nonkinesigenic dyskinesia
chr11_-_62313090 0.591 ENST00000528508.1
ENST00000533365.1
AHNAK

AHNAK nucleoprotein

chr10_+_124320156 0.591 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
DMBT1





deleted in malignant brain tumors 1





chr7_-_45128472 0.590 ENST00000490531.2
NACAD
NAC alpha domain containing
chr1_+_113217345 0.580 ENST00000357443.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr2_+_228337079 0.563 ENST00000409315.1
ENST00000373671.3
ENST00000409171.1
AGFG1


ArfGAP with FG repeats 1


chr1_+_113217043 0.546 ENST00000413052.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr6_-_34524093 0.545 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr10_+_88718314 0.541 ENST00000348795.4
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr11_-_62457371 0.539 ENST00000317449.4
LRRN4CL
LRRN4 C-terminal like
chrX_-_54522558 0.526 ENST00000375135.3
FGD1
FYVE, RhoGEF and PH domain containing 1
chr5_+_72251793 0.522 ENST00000430046.2
ENST00000341845.6
FCHO2

FCH domain only 2

chr22_-_20368028 0.522 ENST00000404912.1
GGTLC3
gamma-glutamyltransferase light chain 3
chr1_+_113217073 0.520 ENST00000369645.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr4_-_140544386 0.506 ENST00000561977.1
RP11-308D13.3
RP11-308D13.3
chr14_+_24540046 0.502 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6



copine VI (neuronal)



chr7_+_86274145 0.502 ENST00000439827.1
ENST00000394720.2
ENST00000421579.1
GRM3


glutamate receptor, metabotropic 3


chr13_+_113030625 0.495 ENST00000283550.3
SPACA7
sperm acrosome associated 7
chr5_+_176784837 0.492 ENST00000408923.3
RGS14
regulator of G-protein signaling 14
chr7_-_100076873 0.482 ENST00000300181.2
TSC22D4
TSC22 domain family, member 4
chr7_+_22766766 0.481 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
IL6






interleukin 6 (interferon, beta 2)






chr15_-_68724490 0.480 ENST00000315757.7
ENST00000423218.2
ITGA11

integrin, alpha 11

chr2_+_113875466 0.471 ENST00000361779.3
ENST00000259206.5
ENST00000354115.2
IL1RN


interleukin 1 receptor antagonist


chr11_-_57089671 0.470 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr9_-_130617029 0.464 ENST00000373203.4
ENG
endoglin
chr7_-_100076765 0.458 ENST00000393991.1
TSC22D4
TSC22 domain family, member 4
chr7_-_81399411 0.457 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr20_+_48884002 0.456 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3

RP11-290F20.3

chr3_-_50340996 0.451 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
HYAL1





hyaluronoglucosaminidase 1





chr17_-_76921459 0.450 ENST00000262768.7
TIMP2
TIMP metallopeptidase inhibitor 2
chr19_-_49864746 0.450 ENST00000598810.1
TEAD2
TEA domain family member 2
chr19_-_40324255 0.449 ENST00000593685.1
ENST00000600611.1
DYRK1B

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

chr15_-_40213080 0.447 ENST00000561100.1
GPR176
G protein-coupled receptor 176
chr15_+_89182178 0.447 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_-_242612779 0.445 ENST00000427495.1
PLD5
phospholipase D family, member 5
chr10_+_106034637 0.429 ENST00000401888.2
GSTO2
glutathione S-transferase omega 2
chr7_-_100065686 0.427 ENST00000423266.1
ENST00000456330.1
TSC22D4

TSC22 domain family, member 4

chr19_+_49258775 0.423 ENST00000593756.1
FGF21
fibroblast growth factor 21
chr7_+_143013198 0.420 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr2_+_128293323 0.417 ENST00000389524.4
ENST00000428314.1
MYO7B

myosin VIIB

chr2_-_238322770 0.417 ENST00000472056.1
COL6A3
collagen, type VI, alpha 3
chr2_+_223536428 0.414 ENST00000446656.3
MOGAT1
monoacylglycerol O-acyltransferase 1
chr2_+_7017796 0.413 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr9_-_132515302 0.412 ENST00000340607.4
PTGES
prostaglandin E synthase
chr9_-_130616915 0.411 ENST00000344849.3
ENG
endoglin
chr1_-_153588765 0.409 ENST00000368701.1
ENST00000344616.2
S100A14

S100 calcium binding protein A14

chr2_-_238322800 0.406 ENST00000392004.3
ENST00000433762.1
ENST00000347401.3
ENST00000353578.4
ENST00000346358.4
ENST00000392003.2
COL6A3





collagen, type VI, alpha 3





chrX_+_102631248 0.406 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
NGFRAP1


nerve growth factor receptor (TNFRSF16) associated protein 1


chr1_+_151512775 0.403 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
TUFT1




tuftelin 1




chr16_-_27899478 0.402 ENST00000380897.3
GSG1L
GSG1-like
chr2_-_238323007 0.402 ENST00000295550.4
COL6A3
collagen, type VI, alpha 3
chr5_+_32531893 0.401 ENST00000512913.1
SUB1
SUB1 homolog (S. cerevisiae)
chr2_-_47142884 0.399 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2



multiple coagulation factor deficiency 2



chr17_-_48474828 0.397 ENST00000576448.1
ENST00000225972.7
LRRC59

leucine rich repeat containing 59

chr22_+_40390930 0.396 ENST00000333407.6
FAM83F
family with sequence similarity 83, member F
chr7_-_81399355 0.392 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr4_+_144303093 0.385 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chrX_+_49126294 0.385 ENST00000466508.1
ENST00000438316.1
ENST00000055335.6
ENST00000495799.1
PPP1R3F



protein phosphatase 1, regulatory subunit 3F



chr2_-_47143160 0.383 ENST00000409800.1
ENST00000409218.1
MCFD2

multiple coagulation factor deficiency 2

chr17_+_42429493 0.382 ENST00000586242.1
GRN
granulin
chr4_+_86748898 0.381 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr22_+_25003626 0.379 ENST00000451366.1
ENST00000406383.2
ENST00000428855.1
GGT1


gamma-glutamyltransferase 1


chr1_-_41950342 0.375 ENST00000372587.4
EDN2
endothelin 2
chr19_-_11450249 0.374 ENST00000222120.3
RAB3D
RAB3D, member RAS oncogene family
chr5_+_72251857 0.374 ENST00000507345.2
ENST00000512348.1
ENST00000287761.6
FCHO2


FCH domain only 2


chr3_-_98620500 0.372 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chrX_-_52258669 0.366 ENST00000441417.1
XAGE1A
X antigen family, member 1A
chrX_+_52513455 0.366 ENST00000446098.1
XAGE1C
X antigen family, member 1C
chrX_+_102631844 0.365 ENST00000372634.1
ENST00000299872.7
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr12_+_57522258 0.365 ENST00000553277.1
ENST00000243077.3
LRP1

low density lipoprotein receptor-related protein 1

chr20_-_50722183 0.365 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr5_-_115872142 0.364 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr12_+_8662057 0.359 ENST00000382064.2
CLEC4D
C-type lectin domain family 4, member D
chr1_-_160040038 0.359 ENST00000368089.3
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr16_-_51185172 0.358 ENST00000251020.4
SALL1
spalt-like transcription factor 1
chrX_-_128977364 0.356 ENST00000371064.3
ZDHHC9
zinc finger, DHHC-type containing 9
chrX_-_52531609 0.354 ENST00000438079.1
XAGE1D
X antigen family, member 1D
chr15_+_89181974 0.351 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chrX_+_52240504 0.349 ENST00000399805.2
XAGE1B
X antigen family, member 1B
chr3_+_57882024 0.349 ENST00000494088.1
SLMAP
sarcolemma associated protein
chr7_-_27187393 0.342 ENST00000222728.3
HOXA6
homeobox A6
chr1_+_12538594 0.339 ENST00000543710.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr6_+_123100620 0.338 ENST00000368444.3
FABP7
fatty acid binding protein 7, brain
chr17_+_48503603 0.337 ENST00000502667.1
ACSF2
acyl-CoA synthetase family member 2
chr21_+_17792672 0.337 ENST00000602620.1
LINC00478
long intergenic non-protein coding RNA 478
chr15_+_89182156 0.332 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr11_+_64004888 0.331 ENST00000541681.1
VEGFB
vascular endothelial growth factor B
chr4_+_54966198 0.331 ENST00000326902.2
ENST00000503800.1
GSX2

GS homeobox 2

chr8_-_10512569 0.328 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr17_+_48503519 0.326 ENST00000300441.4
ENST00000541920.1
ENST00000506582.1
ENST00000504392.1
ENST00000427954.2
ACSF2




acyl-CoA synthetase family member 2




chrX_+_2746850 0.326 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
GYG2


glycogenin 2


chr17_-_26903900 0.318 ENST00000395319.3
ENST00000581807.1
ENST00000584086.1
ENST00000395321.2
ALDOC



aldolase C, fructose-bisphosphate



chr1_+_70034081 0.316 ENST00000310961.5
ENST00000370958.1
LRRC7

leucine rich repeat containing 7

chr14_+_95047725 0.315 ENST00000554760.1
ENST00000554866.1
ENST00000329597.7
ENST00000556775.1
SERPINA5



serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5



chr11_+_45825616 0.311 ENST00000442528.2
ENST00000456334.1
ENST00000526817.1
SLC35C1


solute carrier family 35 (GDP-fucose transporter), member C1


chr6_-_111927062 0.311 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr7_-_5569588 0.310 ENST00000417101.1
ACTB
actin, beta
chr5_-_176923846 0.308 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr2_-_37899323 0.305 ENST00000295324.3
ENST00000457889.1
CDC42EP3

CDC42 effector protein (Rho GTPase binding) 3

chr7_-_81399438 0.303 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr1_-_32169920 0.303 ENST00000373672.3
ENST00000373668.3
COL16A1

collagen, type XVI, alpha 1

chr20_-_30060816 0.301 ENST00000317676.2
DEFB124
defensin, beta 124
chr1_-_32169761 0.301 ENST00000271069.6
COL16A1
collagen, type XVI, alpha 1
chr6_-_46922659 0.299 ENST00000265417.7
GPR116
G protein-coupled receptor 116
chr17_+_38599693 0.299 ENST00000542955.1
ENST00000269593.4
IGFBP4

insulin-like growth factor binding protein 4

chr14_+_95047744 0.298 ENST00000553511.1
ENST00000554633.1
ENST00000555681.1
ENST00000554276.1
SERPINA5



serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5



chr14_-_75330537 0.295 ENST00000556084.2
ENST00000556489.2
ENST00000445876.1
PROX2


prospero homeobox 2


chr12_+_119616447 0.295 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr19_+_50936142 0.292 ENST00000357701.5
MYBPC2
myosin binding protein C, fast type
chr8_+_85097110 0.286 ENST00000517638.1
ENST00000522647.1
RALYL

RALY RNA binding protein-like

chr11_+_45825896 0.285 ENST00000314134.3
SLC35C1
solute carrier family 35 (GDP-fucose transporter), member C1
chr20_-_44519839 0.284 ENST00000372518.4
NEURL2
neuralized E3 ubiquitin protein ligase 2
chr17_+_7211656 0.279 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr5_-_176923803 0.279 ENST00000506161.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr1_+_64059332 0.277 ENST00000540265.1
PGM1
phosphoglucomutase 1
chr8_+_104384616 0.268 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr14_-_50999190 0.266 ENST00000557390.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr5_+_92919043 0.261 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr2_-_219151487 0.261 ENST00000444881.1
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr14_+_24540731 0.260 ENST00000558859.1
ENST00000559197.1
ENST00000560828.1
ENST00000216775.2
ENST00000560884.1
CPNE6




copine VI (neuronal)




chr16_+_57662419 0.257 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
GPR56






G protein-coupled receptor 56






chr12_+_6644443 0.256 ENST00000396858.1
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr13_-_25745857 0.253 ENST00000381853.3
AMER2
APC membrane recruitment protein 2
chr19_-_8675559 0.250 ENST00000597188.1
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr2_+_69001913 0.249 ENST00000409030.3
ENST00000409220.1
ARHGAP25

Rho GTPase activating protein 25

chr2_+_220325441 0.249 ENST00000396688.1
SPEG
SPEG complex locus
chr2_+_228336849 0.249 ENST00000409979.2
ENST00000310078.8
AGFG1

ArfGAP with FG repeats 1

chr20_-_25207370 0.245 ENST00000593352.1
AL035252.1
HCG2018895; Uncharacterized protein
chr17_-_37764128 0.245 ENST00000302584.4
NEUROD2
neuronal differentiation 2
chr1_-_27216729 0.243 ENST00000431781.2
ENST00000374135.4
GPN2

GPN-loop GTPase 2

chr6_+_34204642 0.241 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1




high mobility group AT-hook 1




chr19_+_40194946 0.240 ENST00000392052.3
LGALS14
lectin, galactoside-binding, soluble, 14
chr11_-_117186946 0.240 ENST00000313005.6
ENST00000528053.1
BACE1

beta-site APP-cleaving enzyme 1

chr19_+_40195101 0.238 ENST00000360675.3
ENST00000601802.1
LGALS14

lectin, galactoside-binding, soluble, 14

chr16_+_30662050 0.235 ENST00000568754.1
PRR14
proline rich 14
chr12_-_52585765 0.234 ENST00000313234.5
ENST00000394815.2
KRT80

keratin 80


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0046521 sphingoid catabolic process(GO:0046521)
0.7 2.0 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.6 1.7 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.4 1.3 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of G-protein coupled receptor internalization(GO:1904020)
0.4 2.6 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.4 1.6 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.3 1.5 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.3 0.9 GO:0001300 chronological cell aging(GO:0001300)
0.3 0.8 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.2 1.9 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.2 1.9 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.2 1.1 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.2 1.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 0.7 GO:0090294 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.2 0.6 GO:0002384 hepatic immune response(GO:0002384)
0.2 2.3 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 0.6 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 1.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 4.6 GO:0031639 plasminogen activation(GO:0031639)
0.2 0.6 GO:0061107 seminal vesicle development(GO:0061107)
0.2 1.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.6 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1 1.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 1.5 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.3 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.1 0.4 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 1.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.5 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 1.2 GO:0032119 sequestering of zinc ion(GO:0032119)
0.1 1.8 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 2.9 GO:0001502 cartilage condensation(GO:0001502)
0.1 1.4 GO:0015074 DNA integration(GO:0015074)
0.1 0.4 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 0.8 GO:0030578 PML body organization(GO:0030578)
0.1 1.3 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 0.5 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 0.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 2.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.4 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1 0.5 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.1 0.3 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 0.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 0.2 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.5 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 0.2 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.1 0.4 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.4 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 0.5 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.2 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.1 0.2 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.1 0.2 GO:0097359 UDP-glucosylation(GO:0097359)
0.1 0.8 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.1 0.3 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 1.2 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.3 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.1 0.3 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.1 0.5 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 1.1 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 0.4 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 0.4 GO:0060737 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.1 0.5 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 0.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.7 GO:0006089 lactate metabolic process(GO:0006089)
0.1 1.5 GO:0032060 bleb assembly(GO:0032060)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.3 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.1 0.8 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.4 GO:1904970 brush border assembly(GO:1904970)
0.0 0.2 GO:1901355 response to rapamycin(GO:1901355)
0.0 1.1 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.7 GO:0051451 myoblast migration(GO:0051451)
0.0 0.3 GO:0048241 epinephrine transport(GO:0048241)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 1.0 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.3 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.3 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.6 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.6 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:1902731 negative regulation of chondrocyte proliferation(GO:1902731)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 1.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.4 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.0 0.1 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.1 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.5 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.0 0.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.1 GO:0018874 benzoate metabolic process(GO:0018874)
0.0 0.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.6 GO:0033622 integrin activation(GO:0033622)
0.0 0.2 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0003335 corneocyte development(GO:0003335)
0.0 0.1 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.6 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.2 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.9 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.4 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.2 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 0.4 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.4 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 3.8 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.4 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.0 0.3 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.4 GO:0002544 chronic inflammatory response(GO:0002544)
0.0 0.7 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.2 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.2 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.2 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.0 0.1 GO:0045719 inorganic diphosphate transport(GO:0030505) negative regulation of glycogen biosynthetic process(GO:0045719)
0.0 1.2 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.1 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.0 0.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.0 0.9 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.6 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 1.4 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.7 GO:0045687 positive regulation of glial cell differentiation(GO:0045687)
0.0 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:1904647 response to rotenone(GO:1904647)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.4 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.0 0.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 1.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.2 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.5 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.1 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.0 0.4 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.2 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.1 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.0 0.2 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 0.6 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.5 GO:0030818 negative regulation of cAMP biosynthetic process(GO:0030818)
0.0 0.3 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.3 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.0 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.0 0.0 GO:0021847 ventricular zone neuroblast division(GO:0021847)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.7 GO:0005610 laminin-5 complex(GO:0005610)
0.4 1.8 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.3 1.3 GO:0036156 inner dynein arm(GO:0036156)
0.3 0.9 GO:0072563 endothelial microparticle(GO:0072563)
0.2 0.6 GO:0036025 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.2 0.6 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 0.5 GO:0034681 integrin alpha11-beta1 complex(GO:0034681)
0.1 1.1 GO:0035976 AP1 complex(GO:0035976)
0.1 1.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 0.1 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.1 1.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 1.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.6 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 1.6 GO:0042588 zymogen granule(GO:0042588)
0.1 0.6 GO:0005593 FACIT collagen trimer(GO:0005593)
0.1 2.0 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.0 0.4 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.3 GO:0097452 GAIT complex(GO:0097452)
0.0 0.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 4.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.1 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.7 GO:0042627 chylomicron(GO:0042627)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.8 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.0 2.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.4 GO:0043194 axon initial segment(GO:0043194)
0.0 0.4 GO:0010369 chromocenter(GO:0010369)
0.0 9.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.7 GO:0000791 euchromatin(GO:0000791)
0.0 1.4 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 1.1 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.3 GO:0032982 myosin filament(GO:0032982)
0.0 0.6 GO:0043025 neuronal cell body(GO:0043025)
0.0 1.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.6 1.7 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.5 2.9 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.4 1.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.4 1.1 GO:0008859 exoribonuclease II activity(GO:0008859)
0.3 1.3 GO:0031849 olfactory receptor binding(GO:0031849)
0.2 0.7 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 0.9 GO:0035501 MH1 domain binding(GO:0035501)
0.2 1.1 GO:0050436 microfibril binding(GO:0050436)
0.2 0.7 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.2 0.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 2.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.2 0.7 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.2 1.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 0.7 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.2 2.6 GO:0045499 chemorepellent activity(GO:0045499)
0.2 0.5 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 0.6 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.9 GO:0005534 galactose binding(GO:0005534)
0.1 0.3 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.1 0.4 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.6 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.4 GO:0030226 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
0.1 0.3 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.1 0.4 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 0.2 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.1 0.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.3 GO:0008513 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.1 0.4 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.4 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.6 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.2 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.1 0.8 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 0.3 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.4 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.1 0.6 GO:0032190 acrosin binding(GO:0032190)
0.1 1.1 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 1.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.7 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 1.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.4 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 1.4 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 1.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.4 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.9 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.2 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.6 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 1.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.9 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 4.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 5.7 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 4.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.4 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0035325 Toll-like receptor binding(GO:0035325)
0.0 0.2 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.2 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 1.5 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 1.0 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 1.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.1 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 1.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.3 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.4 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.0 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.2 GO:0030414 peptidase inhibitor activity(GO:0030414) peptidase regulator activity(GO:0061134)
0.0 1.0 GO:0001618 virus receptor activity(GO:0001618)
0.0 2.0 GO:0008083 growth factor activity(GO:0008083)
0.0 0.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 1.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.3 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.2 GO:0043022 ribosome binding(GO:0043022)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 8.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 3.8 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 3.6 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 2.1 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 2.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 0.6 ST_STAT3_PATHWAY STAT3 Pathway
0.0 2.5 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 2.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 2.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.3 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 2.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 3.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.4 REACTOME_GAB1_SIGNALOSOME Genes involved in GAB1 signalosome
0.1 2.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.2 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.1 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.6 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 7.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.2 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 1.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 7.1 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.0 0.7 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.6 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 0.6 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.2 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 2.7 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.0 0.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.8 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression