Motif ID: ZBTB3

Z-value: 0.511


Transcription factors associated with ZBTB3:

Gene SymbolEntrez IDGene Name
ZBTB3 ENSG00000185670.7 ZBTB3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZBTB3hg19_v2_chr11_-_62521614_625216600.639.1e-04Click!


Activity profile for motif ZBTB3.

activity profile for motif ZBTB3


Sorted Z-values histogram for motif ZBTB3

Sorted Z-values for motif ZBTB3



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_152240819 1.537 ENST00000535416.1
ENST00000421798.3
PNMA6A
PNMA6C
paraneoplastic Ma antigen family member 6A
paraneoplastic Ma antigen family member 6C
chrX_+_152338301 1.529 ENST00000453825.2
PNMA6A
paraneoplastic Ma antigen family member 6A
chr11_+_73661364 0.934 ENST00000339764.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr14_-_92413727 0.896 ENST00000267620.10
FBLN5
fibulin 5
chr6_+_29274403 0.758 ENST00000377160.2
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr5_+_76506706 0.736 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
PDE8B




phosphodiesterase 8B




chr16_-_68406161 0.731 ENST00000568373.1
ENST00000563226.1
SMPD3

sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)

chr6_-_46138676 0.718 ENST00000371383.2
ENST00000230565.3
ENPP5

ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)

chr14_-_92413353 0.716 ENST00000556154.1
FBLN5
fibulin 5
chr14_-_92414055 0.716 ENST00000342058.4
FBLN5
fibulin 5
chr2_-_154335300 0.642 ENST00000325926.3
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr16_-_19896220 0.561 ENST00000562469.1
ENST00000300571.2
GPRC5B

G protein-coupled receptor, family C, group 5, member B

chr19_+_49496705 0.507 ENST00000595090.1
RUVBL2
RuvB-like AAA ATPase 2
chr1_+_211433275 0.505 ENST00000367005.4
RCOR3
REST corepressor 3
chr7_+_23719749 0.445 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
FAM221A



family with sequence similarity 221, member A



chr19_+_49496782 0.442 ENST00000601968.1
ENST00000596837.1
RUVBL2

RuvB-like AAA ATPase 2

chr1_+_110036699 0.424 ENST00000496961.1
ENST00000533024.1
ENST00000310611.4
ENST00000527072.1
ENST00000420578.2
ENST00000528785.1
CYB561D1





cytochrome b561 family, member D1





chr5_-_82969405 0.407 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr1_+_110036728 0.403 ENST00000369868.3
ENST00000430195.2
CYB561D1

cytochrome b561 family, member D1

chr17_-_17109579 0.399 ENST00000321560.3
PLD6
phospholipase D family, member 6
chr4_-_123542224 0.396 ENST00000264497.3
IL21
interleukin 21
chr5_+_140514782 0.378 ENST00000231134.5
PCDHB5
protocadherin beta 5
chr10_-_118032979 0.367 ENST00000355422.6
GFRA1
GDNF family receptor alpha 1
chr4_-_7436671 0.339 ENST00000319098.4
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr19_-_40023450 0.335 ENST00000326282.4
EID2B
EP300 interacting inhibitor of differentiation 2B
chr6_-_31939734 0.334 ENST00000375356.3
DXO
decapping exoribonuclease
chr14_-_90085458 0.328 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
FOXN3


forkhead box N3


chr19_+_52848659 0.315 ENST00000327920.8
ZNF610
zinc finger protein 610
chr16_+_87636474 0.291 ENST00000284262.2
JPH3
junctophilin 3
chr2_-_40679186 0.267 ENST00000406785.2
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr5_+_170288856 0.263 ENST00000523189.1
RANBP17
RAN binding protein 17
chr12_-_114843889 0.259 ENST00000405440.2
TBX5
T-box 5
chr1_+_160121356 0.250 ENST00000368081.4
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr2_+_42396472 0.245 ENST00000318522.5
ENST00000402711.2
EML4

echinoderm microtubule associated protein like 4

chr16_+_24266874 0.242 ENST00000005284.3
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr11_-_67980744 0.233 ENST00000401547.2
ENST00000453170.1
ENST00000304363.4
SUV420H1


suppressor of variegation 4-20 homolog 1 (Drosophila)


chr10_-_73533255 0.232 ENST00000394957.3
C10orf54
chromosome 10 open reading frame 54
chr1_-_32801825 0.230 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr6_+_30850697 0.230 ENST00000509639.1
ENST00000412274.2
ENST00000507901.1
ENST00000507046.1
ENST00000437124.2
ENST00000454612.2
ENST00000396342.2
DDR1






discoidin domain receptor tyrosine kinase 1






chr6_-_41122063 0.228 ENST00000426005.2
ENST00000437044.2
ENST00000373127.4
TREML1


triggering receptor expressed on myeloid cells-like 1


chr1_-_154458520 0.225 ENST00000486773.1
SHE
Src homology 2 domain containing E
chr17_+_33895090 0.220 ENST00000592381.1
RP11-1094M14.11
RP11-1094M14.11
chr2_+_42396574 0.218 ENST00000401738.3
EML4
echinoderm microtubule associated protein like 4
chr16_-_2185899 0.215 ENST00000262304.4
ENST00000423118.1
PKD1

polycystic kidney disease 1 (autosomal dominant)

chr9_+_72002837 0.214 ENST00000377216.3
FAM189A2
family with sequence similarity 189, member A2
chr2_+_241631262 0.212 ENST00000337801.4
ENST00000429564.1
AQP12A

aquaporin 12A

chr16_+_53164833 0.208 ENST00000564845.1
CHD9
chromodomain helicase DNA binding protein 9
chr5_+_75379224 0.186 ENST00000322285.7
SV2C
synaptic vesicle glycoprotein 2C
chr5_+_74807581 0.175 ENST00000241436.4
ENST00000352007.5
POLK

polymerase (DNA directed) kappa

chr5_-_74807418 0.168 ENST00000405807.4
ENST00000261415.7
COL4A3BP

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr18_+_32073253 0.165 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
DTNA


dystrobrevin, alpha


chr1_+_210001309 0.156 ENST00000491415.2
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr6_+_123100853 0.148 ENST00000356535.4
FABP7
fatty acid binding protein 7, brain
chr6_+_42141029 0.142 ENST00000372958.1
GUCA1A
guanylate cyclase activator 1A (retina)
chr7_+_100081542 0.136 ENST00000300179.2
ENST00000423930.1
NYAP1

neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1

chr7_-_38403077 0.130 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr19_+_47852538 0.126 ENST00000328771.4
DHX34
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr10_-_71906342 0.126 ENST00000287078.6
ENST00000335494.5
TYSND1

trypsin domain containing 1

chr7_+_16793160 0.125 ENST00000262067.4
TSPAN13
tetraspanin 13
chr1_-_236046872 0.121 ENST00000536965.1
LYST
lysosomal trafficking regulator
chr6_-_107436473 0.120 ENST00000369042.1
BEND3
BEN domain containing 3
chr19_-_55549624 0.117 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
GP6


glycoprotein VI (platelet)


chr11_-_18548426 0.116 ENST00000357193.3
ENST00000536719.1
TSG101

tumor susceptibility 101

chrX_+_23801280 0.116 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
SAT1



spermidine/spermine N1-acetyltransferase 1



chr17_-_39623681 0.115 ENST00000225899.3
KRT32
keratin 32
chr17_+_46018872 0.112 ENST00000583599.1
ENST00000434554.2
ENST00000225573.4
ENST00000544840.1
ENST00000534893.1
PNPO




pyridoxamine 5'-phosphate oxidase




chr11_-_130786400 0.107 ENST00000265909.4
SNX19
sorting nexin 19
chrX_-_154563889 0.103 ENST00000369449.2
ENST00000321926.4
CLIC2

chloride intracellular channel 2

chr5_-_169725231 0.099 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_-_82782952 0.094 ENST00000534141.1
RAB30
RAB30, member RAS oncogene family
chr4_+_159236462 0.092 ENST00000460056.2
RXFP1
relaxin/insulin-like family peptide receptor 1
chr2_-_136594740 0.086 ENST00000264162.2
LCT
lactase
chr4_-_5894777 0.085 ENST00000324989.7
CRMP1
collapsin response mediator protein 1
chr20_+_62289640 0.083 ENST00000508582.2
ENST00000360203.5
ENST00000356810.4
RTEL1


regulator of telomere elongation helicase 1


chr21_-_48024986 0.079 ENST00000291700.4
ENST00000367071.4
S100B

S100 calcium binding protein B

chr7_-_38394118 0.072 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr4_-_140216948 0.064 ENST00000265500.4
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr17_+_72983674 0.062 ENST00000337231.5
CDR2L
cerebellar degeneration-related protein 2-like
chr3_+_178276488 0.060 ENST00000432997.1
ENST00000455865.1
KCNMB2

potassium large conductance calcium-activated channel, subfamily M, beta member 2

chr17_-_10325261 0.053 ENST00000403437.2
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr11_-_130786333 0.051 ENST00000533214.1
ENST00000528555.1
ENST00000530356.1
ENST00000539184.1
SNX19



sorting nexin 19



chr1_-_111148241 0.049 ENST00000440270.1
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr17_-_56595196 0.049 ENST00000579921.1
ENST00000579925.1
ENST00000323456.5
MTMR4


myotubularin related protein 4


chr9_+_74526532 0.044 ENST00000486911.2
C9orf85
chromosome 9 open reading frame 85
chr2_-_25565377 0.042 ENST00000264709.3
ENST00000406659.3
DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha

chr19_-_19006890 0.034 ENST00000247005.6
GDF1
growth differentiation factor 1
chr3_-_149688502 0.034 ENST00000481767.1
ENST00000475518.1
PFN2

profilin 2

chr1_+_159141397 0.033 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
CADM3


cell adhesion molecule 3


chr1_+_154229547 0.033 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr15_-_74659978 0.030 ENST00000541301.1
ENST00000416978.1
ENST00000268053.6
CYP11A1


cytochrome P450, family 11, subfamily A, polypeptide 1


chr5_+_112074029 0.026 ENST00000512211.2
APC
adenomatous polyposis coli
chrX_+_70364667 0.022 ENST00000536169.1
ENST00000395855.2
ENST00000374051.3
ENST00000358741.3
NLGN3



neuroligin 3



chr8_+_42196000 0.020 ENST00000518925.1
ENST00000538005.1
POLB

polymerase (DNA directed), beta

chr3_+_98250743 0.020 ENST00000284311.3
GPR15
G protein-coupled receptor 15
chr20_+_54987168 0.019 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr11_+_67007518 0.017 ENST00000530342.1
ENST00000308783.5
KDM2A

lysine (K)-specific demethylase 2A

chr3_-_149688655 0.014 ENST00000461930.1
ENST00000423691.2
ENST00000490975.1
ENST00000461868.1
ENST00000452853.2
PFN2




profilin 2




chr13_+_27998681 0.012 ENST00000381140.4
GTF3A
general transcription factor IIIA
chr3_-_195163803 0.011 ENST00000326793.6
ACAP2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr5_-_94417314 0.011 ENST00000505208.1
MCTP1
multiple C2 domains, transmembrane 1
chr5_+_74807886 0.011 ENST00000514296.1
POLK
polymerase (DNA directed) kappa
chr14_+_60715928 0.010 ENST00000395076.4
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr1_-_111148969 0.004 ENST00000316361.4
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr8_+_38261880 0.004 ENST00000527175.1
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr6_-_31940065 0.001 ENST00000375349.3
ENST00000337523.5
DXO

decapping exoribonuclease


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.2 0.9 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.2 2.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.3 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.1 0.7 GO:0006685 sphingomyelin catabolic process(GO:0006685) positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1 0.2 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.1 0.2 GO:0072156 distal tubule morphogenesis(GO:0072156) metanephric proximal tubule development(GO:0072237)
0.0 0.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.4 GO:0010635 regulation of mitochondrial fusion(GO:0010635)
0.0 0.2 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.1 GO:2000395 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 0.4 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.6 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.1 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 0.4 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.1 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
0.0 0.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0 0.1 GO:0046208 spermine catabolic process(GO:0046208)
0.0 0.3 GO:0071028 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.3 GO:0060742 epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.0 0.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.1 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 0.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.2 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0071953 elastic fiber(GO:0071953)
0.1 0.9 GO:0097255 R2TP complex(GO:0097255)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.3 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)
0.0 0.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.3 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.1 0.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.4 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 0.8 GO:0005549 odorant binding(GO:0005549)
0.0 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.2 GO:0097001 ceramide binding(GO:0097001)
0.0 0.2 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 2.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.1 GO:0046790 virion binding(GO:0046790)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.7 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism