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GSE58827: Dynamics of the Mouse Liver

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Results for AAGGUGC

Z-value: 0.33

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miRNA associated with seed AAGGUGC

NamemiRBASE accession
mmu-miR-18a-5p
MIMAT0000528
mmu-miR-18b-5p
MIMAT0004858

Activity profile of AAGGUGC motif

Sorted Z-values of AAGGUGC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_76669811 2.07 ENSMUST00000037824.4
Foxh1
forkhead box H1
chr16_-_92826004 1.00 ENSMUST00000023673.7
Runx1
runt related transcription factor 1
chr16_-_22163299 0.92 ENSMUST00000100052.4
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr7_-_116038734 0.84 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr5_-_73256555 0.74 ENSMUST00000171179.1
ENSMUST00000101127.5
Fryl
Fryl
furry homolog-like (Drosophila)
furry homolog-like (Drosophila)
chr10_-_78244602 0.74 ENSMUST00000000384.6
Trappc10
trafficking protein particle complex 10
chr1_-_161876656 0.71 ENSMUST00000048377.5
Suco
SUN domain containing ossification factor
chr2_+_118111876 0.69 ENSMUST00000039559.8
Thbs1
thrombospondin 1
chrX_+_9199865 0.68 ENSMUST00000069763.2
Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr2_-_34913976 0.67 ENSMUST00000028232.3
Phf19
PHD finger protein 19
chr17_-_29888570 0.57 ENSMUST00000171691.1
Mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr2_+_156420837 0.54 ENSMUST00000103137.3
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr2_+_164074122 0.53 ENSMUST00000018353.7
Stk4
serine/threonine kinase 4
chr1_+_170644523 0.53 ENSMUST00000046792.8
Olfml2b
olfactomedin-like 2B
chr4_-_134018829 0.51 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chr1_-_97661950 0.49 ENSMUST00000053033.7
ENSMUST00000149927.1
D1Ertd622e
DNA segment, Chr 1, ERATO Doi 622, expressed
chr3_+_105452326 0.44 ENSMUST00000098761.3
Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr8_-_35495487 0.41 ENSMUST00000033927.6
Eri1
exoribonuclease 1
chr5_+_96997676 0.41 ENSMUST00000112974.1
ENSMUST00000035635.7
Bmp2k
BMP2 inducible kinase
chr5_+_75574916 0.40 ENSMUST00000144270.1
ENSMUST00000005815.6
Kit
kit oncogene
chr8_-_120589304 0.38 ENSMUST00000034278.5
Gins2
GINS complex subunit 2 (Psf2 homolog)
chr14_+_47472547 0.35 ENSMUST00000168833.1
ENSMUST00000163324.1
ENSMUST00000043112.7
Fbxo34
F-box protein 34
chr19_+_53140430 0.34 ENSMUST00000111741.2
Add3
adducin 3 (gamma)
chr15_+_80711292 0.34 ENSMUST00000067689.7
Tnrc6b
trinucleotide repeat containing 6b
chr15_+_73723131 0.34 ENSMUST00000165541.1
ENSMUST00000167582.1
Ptp4a3
protein tyrosine phosphatase 4a3
chr6_+_119236507 0.33 ENSMUST00000037434.6
Cacna2d4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr13_+_109903089 0.33 ENSMUST00000120664.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr10_+_40349265 0.32 ENSMUST00000044672.4
ENSMUST00000095743.2
Cdk19
cyclin-dependent kinase 19
chr1_-_63114516 0.27 ENSMUST00000097718.2
Ino80d
INO80 complex subunit D
chr10_-_53379816 0.26 ENSMUST00000095691.5
Cep85l
centrosomal protein 85-like
chr9_-_14381242 0.25 ENSMUST00000167549.1
Endod1
endonuclease domain containing 1
chr11_+_29373618 0.24 ENSMUST00000040182.6
ENSMUST00000109477.1
Ccdc88a
coiled coil domain containing 88A
chr15_-_12592556 0.24 ENSMUST00000075317.5
Pdzd2
PDZ domain containing 2
chr10_-_19015347 0.22 ENSMUST00000019997.4
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr16_-_78376758 0.21 ENSMUST00000023570.7
Btg3
B cell translocation gene 3
chr3_-_9610074 0.21 ENSMUST00000041124.7
Zfp704
zinc finger protein 704
chr3_-_30969399 0.21 ENSMUST00000177992.1
ENSMUST00000129817.2
ENSMUST00000168645.1
ENSMUST00000108255.1
ENSMUST00000064718.5
ENSMUST00000099163.3
Phc3
polyhomeotic-like 3 (Drosophila)
chr6_+_52713729 0.21 ENSMUST00000080723.4
ENSMUST00000149588.1
Tax1bp1
Tax1 (human T cell leukemia virus type I) binding protein 1
chr1_+_74409376 0.21 ENSMUST00000027366.6
Vil1
villin 1
chr12_+_52516077 0.20 ENSMUST00000110725.1
Arhgap5
Rho GTPase activating protein 5
chr12_-_15816762 0.20 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr6_-_25690729 0.20 ENSMUST00000054867.6
Gpr37
G protein-coupled receptor 37
chr9_+_121760000 0.19 ENSMUST00000093772.3
Zfp651
zinc finger protein 651
chr3_+_60501252 0.19 ENSMUST00000099087.2
Mbnl1
muscleblind-like 1 (Drosophila)
chr19_-_59943647 0.19 ENSMUST00000171986.1
Rab11fip2
RAB11 family interacting protein 2 (class I)
chr18_+_53472981 0.18 ENSMUST00000115399.1
Prdm6
PR domain containing 6
chr5_+_137518880 0.18 ENSMUST00000031727.7
Gigyf1
GRB10 interacting GYF protein 1
chr13_-_111808938 0.17 ENSMUST00000109267.2
Map3k1
mitogen-activated protein kinase kinase kinase 1
chr5_-_69592311 0.16 ENSMUST00000031117.6
Gnpda2
glucosamine-6-phosphate deaminase 2
chr13_+_60211933 0.16 ENSMUST00000060705.2
Gm5084
predicted gene 5084
chr8_-_84687839 0.15 ENSMUST00000001975.4
Nacc1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr13_+_41606216 0.15 ENSMUST00000129449.1
Tmem170b
transmembrane protein 170B
chr3_-_59344256 0.14 ENSMUST00000039419.6
Igsf10
immunoglobulin superfamily, member 10
chr16_+_94085226 0.14 ENSMUST00000072182.7
Sim2
single-minded homolog 2 (Drosophila)
chr5_+_23434435 0.13 ENSMUST00000094962.2
ENSMUST00000115128.1
Kmt2e
lysine (K)-specific methyltransferase 2E
chr13_-_93499803 0.13 ENSMUST00000065537.7
Jmy
junction-mediating and regulatory protein
chrX_-_108834303 0.13 ENSMUST00000101283.3
ENSMUST00000150434.1
Brwd3
bromodomain and WD repeat domain containing 3
chr4_-_119492563 0.12 ENSMUST00000049994.7
Rimkla
ribosomal modification protein rimK-like family member A
chr13_-_41487306 0.12 ENSMUST00000021794.6
Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr10_+_13552894 0.12 ENSMUST00000019944.8
Adat2
adenosine deaminase, tRNA-specific 2
chr1_-_170215380 0.12 ENSMUST00000027979.7
ENSMUST00000123399.1
Uhmk1
U2AF homology motif (UHM) kinase 1
chr11_+_77686155 0.12 ENSMUST00000100802.4
ENSMUST00000181023.1
Nufip2
nuclear fragile X mental retardation protein interacting protein 2
chr2_+_65845767 0.11 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr11_+_32455362 0.10 ENSMUST00000051053.4
Ubtd2
ubiquitin domain containing 2
chr9_-_53536728 0.10 ENSMUST00000118282.1
Atm
ataxia telangiectasia mutated homolog (human)
chr13_+_97241096 0.10 ENSMUST00000041623.7
Enc1
ectodermal-neural cortex 1
chr2_+_19445632 0.08 ENSMUST00000028068.2
Ptf1a
pancreas specific transcription factor, 1a
chr7_-_126502380 0.08 ENSMUST00000167759.1
Atxn2l
ataxin 2-like
chr16_+_44139821 0.08 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_+_72285637 0.07 ENSMUST00000090824.5
ENSMUST00000135469.1
Zak
sterile alpha motif and leucine zipper containing kinase AZK
chr1_-_166002591 0.07 ENSMUST00000111429.4
ENSMUST00000176800.1
Pou2f1
POU domain, class 2, transcription factor 1
chr11_-_116086929 0.07 ENSMUST00000074628.6
ENSMUST00000106444.3
Wbp2
WW domain binding protein 2
chr1_+_134560190 0.06 ENSMUST00000112198.1
ENSMUST00000112197.1
Kdm5b
lysine (K)-specific demethylase 5B
chr12_+_3426857 0.05 ENSMUST00000111215.3
ENSMUST00000092003.5
ENSMUST00000144247.2
ENSMUST00000153102.2
Asxl2
additional sex combs like 2 (Drosophila)
chr10_+_80494835 0.05 ENSMUST00000051773.8
Onecut3
one cut domain, family member 3
chr3_+_96697076 0.04 ENSMUST00000162778.2
ENSMUST00000064900.9
Pias3
protein inhibitor of activated STAT 3
chr13_-_64153194 0.04 ENSMUST00000059817.4
ENSMUST00000117241.1
Zfp367
zinc finger protein 367
chr3_-_27896360 0.04 ENSMUST00000058077.3
Tmem212
transmembrane protein 212
chr1_-_161131428 0.03 ENSMUST00000111611.1
Klhl20
kelch-like 20
chr12_+_84875769 0.03 ENSMUST00000171853.1
D030025P21Rik
RIKEN cDNA D030025P21 gene
chr11_-_100738153 0.03 ENSMUST00000155500.1
ENSMUST00000107364.1
ENSMUST00000019317.5
Rab5c
RAB5C, member RAS oncogene family
chr13_-_48870885 0.02 ENSMUST00000035540.7
Phf2
PHD finger protein 2
chr16_-_52454074 0.01 ENSMUST00000023312.7
Alcam
activated leukocyte cell adhesion molecule
chr12_-_91590009 0.01 ENSMUST00000021345.6
Gtf2a1
general transcription factor II A, 1
chr12_+_12262139 0.01 ENSMUST00000069066.6
ENSMUST00000069005.8
Fam49a
family with sequence similarity 49, member A
chr3_+_88142328 0.01 ENSMUST00000001455.6
ENSMUST00000119251.1
Mef2d
myocyte enhancer factor 2D
chr1_-_135585314 0.00 ENSMUST00000040599.8
ENSMUST00000067414.6
Nav1
neuron navigator 1
chr8_-_94601720 0.00 ENSMUST00000034226.6
Fam192a
family with sequence similarity 192, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of AAGGUGC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.3 1.0 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
0.2 0.7 GO:0010752 negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752)
0.1 0.5 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.7 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 0.4 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.1 0.6 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.2 GO:0002631 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.1 0.7 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 0.2 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.4 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.2 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.5 GO:0010764 negative regulation of fibroblast migration(GO:0010764) negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.0 0.4 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.4 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.1 GO:0072434 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.3 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.3 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.2 GO:0045915 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0 0.6 GO:0010714 positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.0 0.2 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.1 GO:0035938 estradiol secretion(GO:0035938) regulation of estradiol secretion(GO:2000864)
0.0 0.3 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0032444 activin responsive factor complex(GO:0032444)
0.1 0.4 GO:0000811 GINS complex(GO:0000811)
0.1 0.7 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.7 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.5 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070052 collagen V binding(GO:0070052)
0.1 0.4 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.1 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 1.9 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.5 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.2 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 0.2 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 1.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.1 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.2 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0071933 Arp2/3 complex binding(GO:0071933)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling