Motif ID: Atf4

Z-value: 1.216


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.473.7e-03Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_148399901 10.723 ENSMUST00000048116.8
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr16_-_36367623 10.373 ENSMUST00000096089.2
BC100530
cDNA sequence BC100530
chr2_+_148798785 9.393 ENSMUST00000028931.3
ENSMUST00000109947.1
Cst8

cystatin 8 (cystatin-related epididymal spermatogenic)

chr14_-_56102458 9.360 ENSMUST00000015583.1
Ctsg
cathepsin G
chr7_-_3502465 8.073 ENSMUST00000065703.7
Tarm1
T cell-interacting, activating receptor on myeloid cells 1
chr16_-_36334330 7.428 ENSMUST00000114850.2
BC117090
cDNA sequence BC1179090
chr7_+_78913436 7.329 ENSMUST00000121645.1
Isg20
interferon-stimulated protein
chr7_+_78914216 7.306 ENSMUST00000120331.2
Isg20
interferon-stimulated protein
chr7_+_78913401 6.914 ENSMUST00000118867.1
Isg20
interferon-stimulated protein
chr7_+_78913765 6.823 ENSMUST00000038142.8
Isg20
interferon-stimulated protein
chr15_+_89322969 6.335 ENSMUST00000066991.5
Adm2
adrenomedullin 2
chr19_-_15924928 6.258 ENSMUST00000025542.3
Psat1
phosphoserine aminotransferase 1
chr14_-_69284982 5.690 ENSMUST00000183882.1
ENSMUST00000037064.4
Slc25a37

solute carrier family 25, member 37

chr4_+_43957678 5.384 ENSMUST00000107855.1
Glipr2
GLI pathogenesis-related 2
chr11_-_120643643 4.569 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
Pycr1




pyrroline-5-carboxylate reductase 1




chr11_+_9191934 4.516 ENSMUST00000042740.6
Abca13
ATP-binding cassette, sub-family A (ABC1), member 13
chr9_-_44344159 4.400 ENSMUST00000077353.7
Hmbs
hydroxymethylbilane synthase
chr14_+_55540266 4.155 ENSMUST00000048781.3
Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr6_-_129507107 4.036 ENSMUST00000183258.1
ENSMUST00000182784.1
ENSMUST00000032265.6
ENSMUST00000162815.1
Olr1



oxidized low density lipoprotein (lectin-like) receptor 1



chr4_+_46450892 4.004 ENSMUST00000102926.4
Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr19_-_40588453 3.987 ENSMUST00000025979.6
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr19_-_40588374 3.958 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
Aldh18a1


aldehyde dehydrogenase 18 family, member A1


chr2_+_172393900 3.929 ENSMUST00000109136.2
Cass4
Cas scaffolding protein family member 4
chr2_+_119047116 3.838 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chr19_-_40588338 3.770 ENSMUST00000176939.1
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr3_-_96263311 3.626 ENSMUST00000171473.1
Hist2h4
histone cluster 2, H4
chr6_-_83317589 3.418 ENSMUST00000005810.6
Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr11_-_87826023 3.329 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr3_-_105932664 3.193 ENSMUST00000098758.2
I830077J02Rik
RIKEN cDNA I830077J02 gene
chr17_+_48462355 3.158 ENSMUST00000162132.1
Unc5cl
unc-5 homolog C (C. elegans)-like
chr2_+_119047129 3.143 ENSMUST00000153300.1
ENSMUST00000028799.5
Casc5

cancer susceptibility candidate 5

chr7_+_44468020 3.078 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
Josd2


Josephin domain containing 2


chr7_+_44468051 2.851 ENSMUST00000118493.1
Josd2
Josephin domain containing 2
chr7_+_44467980 2.841 ENSMUST00000035844.4
Josd2
Josephin domain containing 2
chr12_+_85599047 2.733 ENSMUST00000177587.1
Jdp2
Jun dimerization protein 2
chr3_+_88616133 2.601 ENSMUST00000176500.1
ENSMUST00000177498.1
Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chr4_+_117835387 2.570 ENSMUST00000169885.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr8_-_92356103 2.505 ENSMUST00000034183.3
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr12_+_85599388 2.430 ENSMUST00000050687.6
Jdp2
Jun dimerization protein 2
chrX_+_164438039 2.215 ENSMUST00000033755.5
Asb11
ankyrin repeat and SOCS box-containing 11
chr1_+_134455524 2.091 ENSMUST00000112232.1
ENSMUST00000027725.4
ENSMUST00000116528.1
Klhl12


kelch-like 12


chr3_-_127409014 1.988 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
Ank2


ankyrin 2, brain


chr8_+_75093591 1.939 ENSMUST00000005548.6
Hmox1
heme oxygenase (decycling) 1
chr3_-_127409044 1.927 ENSMUST00000182704.1
Ank2
ankyrin 2, brain
chr6_-_16898441 1.920 ENSMUST00000031533.7
Tfec
transcription factor EC
chr7_+_125603420 1.912 ENSMUST00000033000.6
Il21r
interleukin 21 receptor
chr6_-_129533267 1.911 ENSMUST00000181594.1
1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr3_-_127408986 1.887 ENSMUST00000182588.1
ENSMUST00000182959.1
ENSMUST00000182452.1
Ank2


ankyrin 2, brain


chr15_-_98953541 1.699 ENSMUST00000097014.5
Tuba1a
tubulin, alpha 1A
chr11_-_20332689 1.662 ENSMUST00000109594.1
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr15_-_50889691 1.637 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr19_+_53140430 1.626 ENSMUST00000111741.2
Add3
adducin 3 (gamma)
chr19_-_50678642 1.623 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1

VPS10 domain receptor protein SORCS 1

chr14_-_32685246 1.595 ENSMUST00000096038.3
3425401B19Rik
RIKEN cDNA 3425401B19 gene
chr11_-_20332654 1.578 ENSMUST00000004634.6
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr3_+_89715016 1.518 ENSMUST00000098924.2
Adar
adenosine deaminase, RNA-specific
chr11_+_67171027 1.432 ENSMUST00000170159.1
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr6_+_55037988 1.417 ENSMUST00000003572.8
Gars
glycyl-tRNA synthetase
chr11_+_67171095 1.394 ENSMUST00000018641.7
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr4_+_127021311 1.370 ENSMUST00000030623.7
Sfpq
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr10_+_127290774 1.332 ENSMUST00000026475.8
ENSMUST00000139091.1
Ddit3

DNA-damage inducible transcript 3

chr4_+_129189760 1.221 ENSMUST00000106054.2
ENSMUST00000001365.2
Yars

tyrosyl-tRNA synthetase

chr13_+_49682191 1.189 ENSMUST00000172254.1
Iars
isoleucine-tRNA synthetase
chr5_-_36695969 1.170 ENSMUST00000031091.9
ENSMUST00000140063.1
D5Ertd579e

DNA segment, Chr 5, ERATO Doi 579, expressed

chr10_-_83533383 1.119 ENSMUST00000146640.1
Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr2_+_172393794 1.056 ENSMUST00000099061.2
ENSMUST00000103073.2
Cass4

Cas scaffolding protein family member 4

chr11_+_100320596 0.894 ENSMUST00000152521.1
Eif1
eukaryotic translation initiation factor 1
chr11_-_118290188 0.865 ENSMUST00000106296.2
ENSMUST00000092382.3
Usp36

ubiquitin specific peptidase 36

chr7_-_126502094 0.857 ENSMUST00000179818.1
Atxn2l
ataxin 2-like
chr3_-_127408937 0.842 ENSMUST00000183095.1
ENSMUST00000182610.1
Ank2

ankyrin 2, brain

chr5_-_31179901 0.841 ENSMUST00000101411.2
ENSMUST00000140793.1
Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chr11_-_118290167 0.796 ENSMUST00000144153.1
Usp36
ubiquitin specific peptidase 36
chr18_-_42262053 0.788 ENSMUST00000097590.3
Lars
leucyl-tRNA synthetase
chr8_-_122476036 0.786 ENSMUST00000014614.3
Rnf166
ring finger protein 166
chr7_+_144896523 0.764 ENSMUST00000033389.5
Fgf15
fibroblast growth factor 15
chr11_-_98400453 0.760 ENSMUST00000090827.5
Pgap3
post-GPI attachment to proteins 3
chr7_-_126502312 0.753 ENSMUST00000166682.2
Atxn2l
ataxin 2-like
chr17_+_35108279 0.751 ENSMUST00000037849.2
Ly6g5c
lymphocyte antigen 6 complex, locus G5C
chr11_-_98400393 0.722 ENSMUST00000128897.1
Pgap3
post-GPI attachment to proteins 3
chr4_+_124741844 0.676 ENSMUST00000094782.3
ENSMUST00000153837.1
ENSMUST00000154229.1
Inpp5b


inositol polyphosphate-5-phosphatase B


chr7_-_126502380 0.640 ENSMUST00000167759.1
Atxn2l
ataxin 2-like
chr3_-_59130610 0.639 ENSMUST00000065220.6
ENSMUST00000091112.4
P2ry14

purinergic receptor P2Y, G-protein coupled, 14

chr1_-_191183244 0.627 ENSMUST00000027941.8
Atf3
activating transcription factor 3
chr1_+_71653339 0.580 ENSMUST00000125934.1
Apol7d
apolipoprotein L 7d
chr13_+_49682100 0.570 ENSMUST00000165316.1
ENSMUST00000047363.7
Iars

isoleucine-tRNA synthetase

chr10_-_127311740 0.557 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars

methionine-tRNA synthetase

chrX_+_103422010 0.542 ENSMUST00000182089.1
Gm26992
predicted gene, 26992
chr1_-_78488846 0.520 ENSMUST00000068333.7
ENSMUST00000170217.1
Farsb

phenylalanyl-tRNA synthetase, beta subunit

chr7_-_126625676 0.484 ENSMUST00000032961.3
Nupr1
nuclear protein transcription regulator 1
chr3_+_138143799 0.467 ENSMUST00000159622.1
Trmt10a
tRNA methyltransferase 10A
chr5_-_31180110 0.450 ENSMUST00000043161.6
ENSMUST00000088010.5
Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chr14_-_54870913 0.449 ENSMUST00000146642.1
Homez
homeodomain leucine zipper-encoding gene
chr2_-_3512746 0.408 ENSMUST00000027961.5
ENSMUST00000056700.7
Hspa14
Hspa14
heat shock protein 14
heat shock protein 14
chr1_-_53187596 0.391 ENSMUST00000072235.3
1700019A02Rik
RIKEN cDNA 1700019A02 gene
chr8_-_105701077 0.381 ENSMUST00000042608.6
Acd
adrenocortical dysplasia
chr9_-_15112100 0.374 ENSMUST00000159985.1
Hephl1
hephaestin-like 1
chr18_-_64516547 0.319 ENSMUST00000025483.9
Nars
asparaginyl-tRNA synthetase
chr16_-_29544852 0.301 ENSMUST00000039090.8
Atp13a4
ATPase type 13A4
chr15_-_83510861 0.256 ENSMUST00000109479.1
ENSMUST00000109480.1
ENSMUST00000016897.4
Ttll1


tubulin tyrosine ligase-like 1


chr15_+_82147238 0.250 ENSMUST00000023100.6
Srebf2
sterol regulatory element binding factor 2
chr17_-_29078953 0.222 ENSMUST00000133221.1
Trp53cor1
tumor protein p53 pathway corepressor 1
chr7_-_61311679 0.210 ENSMUST00000107533.3
ENSMUST00000154958.1
A230006K03Rik

RIKEN cDNA A230006K03 gene

chr11_+_96271453 0.183 ENSMUST00000000010.8
ENSMUST00000174042.1
Hoxb9

homeobox B9

chr7_+_126565919 0.168 ENSMUST00000180459.1
G730046D07Rik
RIKEN cDNA G730046D07 gene
chr4_-_118179628 0.131 ENSMUST00000097911.2
Kdm4a
lysine (K)-specific demethylase 4A
chr1_+_156838915 0.123 ENSMUST00000111720.1
Angptl1
angiopoietin-like 1
chr10_+_102158858 0.120 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr2_+_163995503 0.117 ENSMUST00000131288.1
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr15_-_83510793 0.113 ENSMUST00000154401.1
Ttll1
tubulin tyrosine ligase-like 1
chr8_+_117157972 0.101 ENSMUST00000064488.4
ENSMUST00000162997.1
Gan

giant axonal neuropathy

chrX_+_106187100 0.095 ENSMUST00000081593.6
Pgk1
phosphoglycerate kinase 1
chr5_+_145140362 0.073 ENSMUST00000162594.1
ENSMUST00000162308.1
ENSMUST00000159018.1
ENSMUST00000160075.1
Bud31



BUD31 homolog (yeast)



chrX_-_75578188 0.069 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chr14_+_63436394 0.039 ENSMUST00000121288.1
Fam167a
family with sequence similarity 167, member A
chr13_-_118387224 0.033 ENSMUST00000022245.8
Mrps30
mitochondrial ribosomal protein S30
chr12_-_108893197 0.027 ENSMUST00000161154.1
ENSMUST00000161410.1
Wars

tryptophanyl-tRNA synthetase

chr3_+_93319740 0.021 ENSMUST00000090856.3
ENSMUST00000093774.3
Hrnr

hornerin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 28.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
3.9 11.7 GO:0006592 ornithine biosynthetic process(GO:0006592)
1.3 10.7 GO:1903826 arginine transmembrane transport(GO:1903826)
1.2 6.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
1.1 4.6 GO:0006561 proline biosynthetic process(GO:0006561)
1.0 9.4 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.9 2.6 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.7 6.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.7 4.2 GO:0006116 NADH oxidation(GO:0006116)
0.6 1.9 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.6 1.8 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.5 1.5 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.4 1.3 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.4 1.1 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.4 4.4 GO:0018065 protein-cofactor linkage(GO:0018065)
0.3 2.6 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.3 3.2 GO:0015808 L-alanine transport(GO:0015808)
0.3 5.7 GO:0015684 ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.3 1.4 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.2 0.2 GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368)
0.2 2.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2 0.8 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.2 1.4 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.2 2.8 GO:0001778 plasma membrane repair(GO:0001778)
0.2 3.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 5.2 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.2 3.4 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.2 4.0 GO:0043486 histone exchange(GO:0043486)
0.2 3.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 0.6 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 0.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.8 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1 2.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 0.4 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 6.3 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.1 5.4 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 0.3 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 10.4 GO:0016579 protein deubiquitination(GO:0016579)
0.1 1.6 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 0.6 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.1 0.9 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 5.7 GO:2000117 negative regulation of cysteine-type endopeptidase activity(GO:2000117)
0.0 0.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.5 GO:2000194 regulation of female gonad development(GO:2000194)
0.0 1.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.3 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 3.2 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 0.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.4 GO:0006825 copper ion transport(GO:0006825)
0.0 4.0 GO:0006898 receptor-mediated endocytosis(GO:0006898)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 28.3 GO:0015030 Cajal body(GO:0015030)
0.4 1.3 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.4 2.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.3 1.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 3.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 0.5 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.2 1.4 GO:0042382 paraspeckles(GO:0042382)
0.2 1.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 10.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 6.6 GO:0031430 M band(GO:0031430)
0.1 3.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.4 GO:0070187 shelterin complex(GO:0070187)
0.1 2.6 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 6.0 GO:0000793 condensed chromosome(GO:0000793)
0.0 3.2 GO:0005882 intermediate filament(GO:0005882)
0.0 1.9 GO:0042629 mast cell granule(GO:0042629)
0.0 1.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 9.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 4.0 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 5.4 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 28.4 GO:0008859 exoribonuclease II activity(GO:0008859)
3.9 11.7 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
1.3 10.7 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
1.1 3.4 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.7 4.4 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.7 4.6 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.5 1.5 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.5 1.9 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.5 5.7 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.4 1.1 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.4 1.8 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.3 3.2 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.3 0.6 GO:0004825 methionine-tRNA ligase activity(GO:0004825)
0.3 0.8 GO:0004823 leucine-tRNA ligase activity(GO:0004823)
0.3 2.6 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.2 0.7 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.2 4.0 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 1.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.3 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.1 0.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 6.6 GO:0030507 spectrin binding(GO:0030507)
0.1 0.4 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 10.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 3.3 GO:0004601 peroxidase activity(GO:0004601)
0.1 4.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 9.0 GO:0008201 heparin binding(GO:0008201)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 4.9 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 6.6 GO:0008301 DNA binding, bending(GO:0008301)
0.0 6.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.4 GO:0043047 single-stranded telomeric DNA binding(GO:0043047)
0.0 1.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.9 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 2.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0050815 phosphoserine residue binding(GO:0050815)
0.0 0.6 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 7.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 2.1 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 2.8 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.0 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 4.2 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.8 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.7 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 29.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.5 13.2 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 9.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 14.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 6.3 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 2.6 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 3.7 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 7.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.7 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 4.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 6.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.3 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 3.0 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK