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GSE58827: Dynamics of the Mouse Liver

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Results for Bhlhe40

Z-value: 0.53

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Transcription factors associated with Bhlhe40

Gene Symbol Gene ID Gene Info
Bhlhe40
ENSMUSG00000030103.5 basic helix-loop-helix family, member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660772_1086608740.591.4e-04Click!

Activity profile of Bhlhe40 motif

Sorted Z-values of Bhlhe40 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_136068236 4.33 ENSMUST00000049130.7
Bex2
brain expressed X-linked 2
chrX_-_136203637 3.93 ENSMUST00000151592.1
ENSMUST00000131510.1
ENSMUST00000066819.4
Tceal5
transcription elongation factor A (SII)-like 5
chrX_+_136138996 3.54 ENSMUST00000116527.1
Bex4
brain expressed gene 4
chrX_+_136270253 3.50 ENSMUST00000178632.1
ENSMUST00000053540.4
Ngfrap1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr4_+_148039097 2.90 ENSMUST00000141283.1
Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_+_148039035 2.89 ENSMUST00000097788.4
Mthfr
5,10-methylenetetrahydrofolate reductase
chrX_+_136270302 2.53 ENSMUST00000113112.1
Ngfrap1
nerve growth factor receptor (TNFRSF16) associated protein 1
chrX_-_135210672 2.31 ENSMUST00000033783.1
Tceal6
transcription elongation factor A (SII)-like 6
chr2_+_30286383 1.92 ENSMUST00000064447.5
Nup188
nucleoporin 188
chr9_-_97111117 1.64 ENSMUST00000085206.4
Slc25a36
solute carrier family 25, member 36
chr2_-_160619971 1.28 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr2_+_30286406 1.26 ENSMUST00000138666.1
ENSMUST00000113634.2
Nup188
nucleoporin 188
chr2_+_84839395 1.25 ENSMUST00000146816.1
ENSMUST00000028469.7
Slc43a1
solute carrier family 43, member 1
chr2_+_156840966 1.21 ENSMUST00000109564.1
Tgif2
TGFB-induced factor homeobox 2
chr11_-_117780630 1.19 ENSMUST00000026659.3
ENSMUST00000127227.1
Tmc6
transmembrane channel-like gene family 6
chr11_-_94653964 1.05 ENSMUST00000039949.4
Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chrX_+_68678712 0.93 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
Fmr1
fragile X mental retardation syndrome 1
chr1_-_152766323 0.91 ENSMUST00000111857.1
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr6_+_72097561 0.84 ENSMUST00000069994.4
ENSMUST00000114112.1
St3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chrX_-_7188713 0.80 ENSMUST00000004428.7
Clcn5
chloride channel 5
chrX_+_68678541 0.77 ENSMUST00000088546.5
Fmr1
fragile X mental retardation syndrome 1
chr11_-_75348261 0.75 ENSMUST00000000767.5
ENSMUST00000092907.5
Rpa1
replication protein A1
chr16_-_44139003 0.72 ENSMUST00000124102.1
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr4_+_119422806 0.69 ENSMUST00000094819.4
Zmynd12
zinc finger, MYND domain containing 12
chr1_-_152766281 0.68 ENSMUST00000111859.1
ENSMUST00000148865.1
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr9_+_108002501 0.68 ENSMUST00000035214.4
ENSMUST00000175874.1
Ip6k1
inositol hexaphosphate kinase 1
chr18_+_53176345 0.67 ENSMUST00000037850.5
Snx2
sorting nexin 2
chr8_+_85036906 0.64 ENSMUST00000093360.4
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr19_-_7241216 0.63 ENSMUST00000025675.9
Naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr3_-_90052463 0.63 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
Ubap2l
ubiquitin associated protein 2-like
chr12_-_3426700 0.63 ENSMUST00000180149.1
1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr4_-_137048695 0.63 ENSMUST00000049583.7
Zbtb40
zinc finger and BTB domain containing 40
chr8_+_41239718 0.62 ENSMUST00000045218.7
Pcm1
pericentriolar material 1
chr16_+_5050012 0.62 ENSMUST00000052449.5
Ubn1
ubinuclein 1
chr16_-_44139630 0.55 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr8_+_85037151 0.53 ENSMUST00000166592.1
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr4_+_134468320 0.53 ENSMUST00000030636.4
ENSMUST00000127279.1
ENSMUST00000105867.1
Stmn1
stathmin 1
chr11_+_49203465 0.52 ENSMUST00000150284.1
ENSMUST00000109197.1
ENSMUST00000151228.1
Zfp62
zinc finger protein 62
chr10_-_80139347 0.50 ENSMUST00000105369.1
Dos
downstream of Stk11
chr11_+_75348433 0.49 ENSMUST00000044530.2
Smyd4
SET and MYND domain containing 4
chrX_+_68678624 0.47 ENSMUST00000114656.1
Fmr1
fragile X mental retardation syndrome 1
chr7_+_128744870 0.44 ENSMUST00000042942.8
Sec23ip
Sec23 interacting protein
chr2_-_37703845 0.44 ENSMUST00000155237.1
Strbp
spermatid perinuclear RNA binding protein
chr11_+_97450136 0.43 ENSMUST00000107601.1
Arhgap23
Rho GTPase activating protein 23
chr19_-_60790692 0.40 ENSMUST00000025955.6
Eif3a
eukaryotic translation initiation factor 3, subunit A
chr4_-_48473403 0.40 ENSMUST00000164866.1
ENSMUST00000030030.8
Tex10
testis expressed gene 10
chr17_-_12769605 0.39 ENSMUST00000024599.7
Igf2r
insulin-like growth factor 2 receptor
chr11_+_49203285 0.37 ENSMUST00000109198.1
ENSMUST00000137061.2
Zfp62
zinc finger protein 62
chr19_-_4201591 0.29 ENSMUST00000025740.6
Rad9a
RAD9 homolog A
chr12_+_3426857 0.28 ENSMUST00000111215.3
ENSMUST00000092003.5
ENSMUST00000144247.2
ENSMUST00000153102.2
Asxl2
additional sex combs like 2 (Drosophila)
chr9_-_13826946 0.27 ENSMUST00000147115.1
Cep57
centrosomal protein 57
chr6_-_35133731 0.23 ENSMUST00000114993.2
ENSMUST00000114989.2
ENSMUST00000044163.6
Cnot4
CCR4-NOT transcription complex, subunit 4
chr5_-_137533170 0.23 ENSMUST00000168746.1
ENSMUST00000170293.1
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr8_+_84689308 0.22 ENSMUST00000125370.3
ENSMUST00000175784.1
Trmt1
tRNA methyltransferase 1
chr5_-_137533212 0.20 ENSMUST00000143495.1
ENSMUST00000111038.1
Gnb2
Epo
guanine nucleotide binding protein (G protein), beta 2
erythropoietin
chr10_+_79854618 0.19 ENSMUST00000165704.1
Ptbp1
polypyrimidine tract binding protein 1
chr17_-_33824346 0.19 ENSMUST00000173879.1
ENSMUST00000166693.2
ENSMUST00000173019.1
ENSMUST00000087342.6
ENSMUST00000173844.1
Rps28
ribosomal protein S28
chrX_+_153832225 0.19 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
Spin2c
spindlin family, member 2C
chr14_-_50924626 0.18 ENSMUST00000160375.1
ENSMUST00000162177.1
ENSMUST00000159292.1
Osgep
O-sialoglycoprotein endopeptidase
chr7_+_82648595 0.15 ENSMUST00000141726.1
ENSMUST00000179489.1
ENSMUST00000039881.3
Eftud1
elongation factor Tu GTP binding domain containing 1
chr18_+_31609512 0.14 ENSMUST00000164667.1
B930094E09Rik
RIKEN cDNA B930094E09 gene
chr5_-_72168142 0.13 ENSMUST00000013693.6
Commd8
COMM domain containing 8
chr19_+_29522263 0.12 ENSMUST00000043610.6
ENSMUST00000162184.1
C030046E11Rik
RIKEN cDNA C030046E11 gene
chr5_-_135078224 0.12 ENSMUST00000067935.4
ENSMUST00000076203.2
Vps37d
vacuolar protein sorting 37D (yeast)
chr3_-_95106907 0.12 ENSMUST00000107233.2
Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr5_-_123572976 0.11 ENSMUST00000031388.8
Vps33a
vacuolar protein sorting 33A (yeast)
chr8_+_84689247 0.08 ENSMUST00000109767.2
ENSMUST00000177084.1
ENSMUST00000109768.2
ENSMUST00000152301.2
ENSMUST00000177423.1
Trmt1
tRNA methyltransferase 1
chrX_+_134601271 0.08 ENSMUST00000050331.6
ENSMUST00000059297.5
Hnrnph2
heterogeneous nuclear ribonucleoprotein H2
chrX_+_134601179 0.08 ENSMUST00000074950.4
ENSMUST00000113203.1
ENSMUST00000113202.1
Hnrnph2
heterogeneous nuclear ribonucleoprotein H2
chr16_+_44139821 0.06 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr10_+_79854658 0.06 ENSMUST00000171599.1
ENSMUST00000095457.4
Ptbp1
polypyrimidine tract binding protein 1
chr7_-_35802968 0.06 ENSMUST00000061586.4
Zfp507
zinc finger protein 507
chr12_-_79296266 0.05 ENSMUST00000021547.6
Zfyve26
zinc finger, FYVE domain containing 26
chr11_+_3649494 0.05 ENSMUST00000093389.2
Morc2a
microrchidia 2A
chrX_-_152327430 0.03 ENSMUST00000181635.1
ENSMUST00000141922.1
ENSMUST00000154085.1
ENSMUST00000148326.1
ENSMUST00000135115.1
ENSMUST00000149098.1
2900056M20Rik
RIKEN cDNA 2900056M20 gene
chr19_-_33392255 0.02 ENSMUST00000096114.5
ENSMUST00000163093.1
Rnls
renalase, FAD-dependent amine oxidase
chr9_-_13827029 0.01 ENSMUST00000148086.1
ENSMUST00000034398.5
Cep57
centrosomal protein 57
chr1_+_155158703 0.01 ENSMUST00000027743.7
Stx6
syntaxin 6
chr6_+_116338013 0.01 ENSMUST00000079012.6
ENSMUST00000101032.3
March8
membrane-associated ring finger (C3HC4) 8
chr5_+_104046980 0.00 ENSMUST00000134313.1
Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9

Network of associatons between targets according to the STRING database.

First level regulatory network of Bhlhe40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.8 GO:0070829 heterochromatin maintenance(GO:0070829)
0.7 2.2 GO:0099578 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.6 3.2 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.3 1.6 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.2 1.1 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.1 1.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.3 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 0.4 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.3 GO:1900157 regulation of bone mineralization involved in bone maturation(GO:1900157)
0.1 0.6 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.5 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.6 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 0.7 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 1.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.2 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.9 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.7 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 1.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.8 GO:0006298 mismatch repair(GO:0006298)
0.0 0.3 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.4 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.6 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 4.3 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.0 GO:0071873 response to norepinephrine(GO:0071873)
0.0 0.3 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.4 GO:0007638 mechanosensory behavior(GO:0007638)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.5 2.2 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.2 0.7 GO:0030905 retromer, tubulation complex(GO:0030905)
0.2 1.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.8 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.4 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.6 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.4 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.2 GO:0030014 CCR4-NOT complex(GO:0030014)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.3 2.2 GO:0033592 RNA strand annealing activity(GO:0033592)
0.3 1.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 0.7 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.7 GO:0052724 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 1.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 6.2 GO:0050699 WW domain binding(GO:0050699)
0.1 3.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.6 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.1 0.2 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.1 0.3 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.3 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.2 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.1 0.3 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.8 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 1.6 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 4.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.8 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 1.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.0 PID ATR PATHWAY ATR signaling pathway
0.0 0.7 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.4 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 0.8 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 5.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 6.0 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 1.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex