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GSE58827: Dynamics of the Mouse Liver

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Results for Cxxc1

Z-value: 0.33

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Transcription factors associated with Cxxc1

Gene Symbol Gene ID Gene Info
Cxxc1
ENSMUSG00000024560.6 CXXC finger 1 (PHD domain)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cxxc1mm10_v2_chr18_+_74216118_74216145-0.625.3e-05Click!

Activity profile of Cxxc1 motif

Sorted Z-values of Cxxc1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_87246649 1.05 ENSMUST00000068829.5
ENSMUST00000032781.7
Nox4
NADPH oxidase 4
chr2_+_25054355 0.61 ENSMUST00000100334.4
ENSMUST00000152122.1
ENSMUST00000116574.3
ENSMUST00000006646.8
Nsmf
NMDA receptor synaptonuclear signaling and neuronal migration factor
chr2_+_25054396 0.61 ENSMUST00000102931.4
ENSMUST00000074422.7
ENSMUST00000132172.1
ENSMUST00000114388.1
ENSMUST00000114386.1
Nsmf
NMDA receptor synaptonuclear signaling and neuronal migration factor
chr19_-_19111181 0.54 ENSMUST00000112832.1
Rorb
RAR-related orphan receptor beta
chr11_-_69920581 0.50 ENSMUST00000108610.1
Eif5a
eukaryotic translation initiation factor 5A
chr19_-_4439388 0.47 ENSMUST00000117462.1
ENSMUST00000048197.3
Rhod
ras homolog gene family, member D
chr1_+_59256906 0.44 ENSMUST00000160662.1
ENSMUST00000114248.2
Cdk15
cyclin-dependent kinase 15
chr10_+_128058974 0.43 ENSMUST00000084771.2
Ptges3
prostaglandin E synthase 3 (cytosolic)
chr5_+_125389284 0.43 ENSMUST00000100700.2
Gm10382
predicted gene 10382
chr10_+_128058947 0.39 ENSMUST00000052798.7
Ptges3
prostaglandin E synthase 3 (cytosolic)
chr5_+_30588078 0.39 ENSMUST00000066295.2
Kcnk3
potassium channel, subfamily K, member 3
chr10_+_80249441 0.35 ENSMUST00000020361.6
Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr4_+_42170845 0.35 ENSMUST00000179965.1
1700045I11Rik
RIKEN cDNA 1700045I11 gene
chr5_-_125389177 0.33 ENSMUST00000108707.2
Ubc
ubiquitin C
chr11_-_68386974 0.32 ENSMUST00000135141.1
Ntn1
netrin 1
chrX_-_155623325 0.31 ENSMUST00000038665.5
Ptchd1
patched domain containing 1
chrX_-_106011874 0.29 ENSMUST00000033583.7
ENSMUST00000151689.1
Magt1
magnesium transporter 1
chr5_+_125441546 0.28 ENSMUST00000049040.9
Bri3bp
Bri3 binding protein
chr16_-_4420416 0.28 ENSMUST00000120080.1
Adcy9
adenylate cyclase 9
chr2_+_151911204 0.25 ENSMUST00000028955.5
Angpt4
angiopoietin 4
chr8_-_122443404 0.25 ENSMUST00000006692.4
Mvd
mevalonate (diphospho) decarboxylase
chr9_+_46012810 0.25 ENSMUST00000126865.1
Sik3
SIK family kinase 3
chr17_-_14203695 0.25 ENSMUST00000053218.5
Dact2
dapper homolog 2, antagonist of beta-catenin (xenopus)
chr7_-_49636847 0.24 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr5_+_65391497 0.23 ENSMUST00000031101.3
ENSMUST00000122026.1
Lias
lipoic acid synthetase
chr11_+_88068242 0.23 ENSMUST00000018521.4
Vezf1
vascular endothelial zinc finger 1
chr5_-_125389915 0.22 ENSMUST00000136312.1
Ubc
ubiquitin C
chr1_-_124045523 0.22 ENSMUST00000112606.1
Dpp10
dipeptidylpeptidase 10
chrX_-_106011766 0.22 ENSMUST00000139421.1
ENSMUST00000113566.2
Magt1
magnesium transporter 1
chr11_+_96464649 0.21 ENSMUST00000107663.3
Skap1
src family associated phosphoprotein 1
chr5_+_143403819 0.21 ENSMUST00000110731.2
Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chrX_+_48623737 0.20 ENSMUST00000114936.1
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr7_-_45896677 0.20 ENSMUST00000039049.7
Syngr4
synaptogyrin 4
chr10_+_85928491 0.19 ENSMUST00000170396.1
Ascl4
achaete-scute complex homolog 4 (Drosophila)
chr15_+_82147238 0.18 ENSMUST00000023100.6
Srebf2
sterol regulatory element binding factor 2
chr5_-_45857473 0.18 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
Lcorl
ligand dependent nuclear receptor corepressor-like
chr1_-_124045247 0.17 ENSMUST00000112603.2
Dpp10
dipeptidylpeptidase 10
chr9_+_78109188 0.17 ENSMUST00000118869.1
ENSMUST00000125615.1
Ick
intestinal cell kinase
chr12_-_54656496 0.16 ENSMUST00000056228.6
Sptssa
serine palmitoyltransferase, small subunit A
chr2_+_147012996 0.16 ENSMUST00000028921.5
Xrn2
5'-3' exoribonuclease 2
chr11_+_71019593 0.15 ENSMUST00000133413.1
ENSMUST00000164220.1
ENSMUST00000048807.5
Mis12
MIS12 homolog (yeast)
chr7_-_45896656 0.14 ENSMUST00000120299.1
Syngr4
synaptogyrin 4
chr15_+_54952939 0.13 ENSMUST00000181704.1
Gm26684
predicted gene, 26684
chr8_+_92357787 0.12 ENSMUST00000034184.10
Irx5
Iroquois related homeobox 5 (Drosophila)
chr10_+_7681197 0.11 ENSMUST00000165952.1
Lats1
large tumor suppressor
chr11_-_77489666 0.11 ENSMUST00000037593.7
ENSMUST00000092892.3
Ankrd13b
ankyrin repeat domain 13b
chr1_-_14918862 0.11 ENSMUST00000041447.4
Trpa1
transient receptor potential cation channel, subfamily A, member 1
chr7_+_45896941 0.11 ENSMUST00000069772.7
ENSMUST00000107716.1
Tmem143
transmembrane protein 143
chr5_-_145201829 0.11 ENSMUST00000162220.1
ENSMUST00000031632.8
Zkscan14
zinc finger with KRAB and SCAN domains 14
chrX_-_7375830 0.10 ENSMUST00000115744.1
Usp27x
ubiquitin specific peptidase 27, X chromosome
chr10_+_50895651 0.09 ENSMUST00000020071.3
Sim1
single-minded homolog 1 (Drosophila)
chr6_-_135310347 0.09 ENSMUST00000050471.2
Pbp2
phosphatidylethanolamine binding protein 2
chr11_-_69920892 0.08 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
Eif5a
eukaryotic translation initiation factor 5A
chr11_-_69921057 0.08 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
Eif5a
eukaryotic translation initiation factor 5A
chr1_-_5917398 0.08 ENSMUST00000044180.4
Npbwr1
neuropeptides B/W receptor 1
chrX_-_158043266 0.07 ENSMUST00000026750.8
ENSMUST00000112513.1
Cnksr2
connector enhancer of kinase suppressor of Ras 2
chr11_+_60537978 0.07 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr7_-_4501636 0.06 ENSMUST00000013886.8
Ppp1r12c
protein phosphatase 1, regulatory (inhibitor) subunit 12C
chr12_-_82496537 0.05 ENSMUST00000179295.1
Gm5435
predicted gene 5435
chr18_-_43477764 0.05 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr15_-_77153772 0.04 ENSMUST00000166610.1
ENSMUST00000111581.2
Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr9_-_78108617 0.03 ENSMUST00000085311.6
Fbxo9
f-box protein 9
chr11_-_89302545 0.03 ENSMUST00000061728.3
Nog
noggin
chrX_+_53607918 0.03 ENSMUST00000114827.1
Cxx1c
CAAX box 1C
chr9_-_78109020 0.02 ENSMUST00000001402.7
Fbxo9
f-box protein 9
chr3_-_8964037 0.02 ENSMUST00000091354.5
ENSMUST00000094381.4
Tpd52
tumor protein D52
chr5_+_25516061 0.01 ENSMUST00000045016.7
Cct8l1
chaperonin containing TCP1, subunit 8 (theta)-like 1
chr9_-_106789130 0.01 ENSMUST00000046502.5
Rad54l2
RAD54 like 2 (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of Cxxc1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.1 0.7 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 0.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.3 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.2 GO:0072061 inner medullary collecting duct development(GO:0072061) negative regulation of nodal signaling pathway(GO:1900108)
0.1 1.1 GO:0050667 homocysteine metabolic process(GO:0050667)
0.1 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.2 GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368)
0.0 0.2 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.5 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.1 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.5 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.1 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.3 GO:0021794 thalamus development(GO:0021794)
0.0 0.3 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.2 GO:0060573 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.2 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0 0.5 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.7 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.2 GO:0097440 apical dendrite(GO:0097440)
0.0 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 1.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.2 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.1 0.3 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 0.2 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.5 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.4 GO:0044548 potassium ion leak channel activity(GO:0022841) S100 protein binding(GO:0044548)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.4 GO:0048038 quinone binding(GO:0048038)
0.0 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 1.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.1 GO:1990380 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.1 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.7 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis