Motif ID: E2f3

Z-value: 1.304


Transcription factors associated with E2f3:

Gene SymbolEntrez IDGene Name
E2f3 ENSMUSG00000016477.11 E2f3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f3mm10_v2_chr13_-_29984219_299843530.798.1e-09Click!


Activity profile for motif E2f3.

activity profile for motif E2f3


Sorted Z-values histogram for motif E2f3

Sorted Z-values for motif E2f3



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_6730412 7.634 ENSMUST00000051209.4
Peg3
paternally expressed 3
chr11_+_11685909 7.355 ENSMUST00000065433.5
Ikzf1
IKAROS family zinc finger 1
chr4_+_46450892 6.224 ENSMUST00000102926.4
Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr2_+_118111876 6.151 ENSMUST00000039559.8
Thbs1
thrombospondin 1
chr12_-_4874341 5.811 ENSMUST00000137337.1
ENSMUST00000045921.7
Mfsd2b

major facilitator superfamily domain containing 2B

chr3_-_84480419 5.460 ENSMUST00000107689.1
Fhdc1
FH2 domain containing 1
chr10_+_20347788 4.767 ENSMUST00000169712.1
Mtfr2
mitochondrial fission regulator 2
chrX_+_135993820 4.742 ENSMUST00000058119.7
Arxes2
adipocyte-related X-chromosome expressed sequence 2
chr2_+_109280738 4.682 ENSMUST00000028527.7
Kif18a
kinesin family member 18A
chr7_-_100863373 4.527 ENSMUST00000142885.1
ENSMUST00000008462.3
Relt

RELT tumor necrosis factor receptor

chr2_-_127133909 4.217 ENSMUST00000110387.3
Ncaph
non-SMC condensin I complex, subunit H
chrX_-_51205773 4.159 ENSMUST00000114875.1
Mbnl3
muscleblind-like 3 (Drosophila)
chr13_+_117220584 4.152 ENSMUST00000022242.7
Emb
embigin
chr15_+_102296256 4.062 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr12_-_69228167 4.020 ENSMUST00000021359.5
Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr17_+_35841668 3.861 ENSMUST00000174124.1
Mdc1
mediator of DNA damage checkpoint 1
chr15_-_79605084 3.690 ENSMUST00000023065.6
Dmc1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
chr7_+_113513854 3.642 ENSMUST00000067929.8
ENSMUST00000129087.1
ENSMUST00000164745.1
ENSMUST00000136158.1
Far1



fatty acyl CoA reductase 1



chr3_+_69004969 3.614 ENSMUST00000136502.1
ENSMUST00000107803.1
Smc4

structural maintenance of chromosomes 4

chrX_-_51205990 3.595 ENSMUST00000114876.2
Mbnl3
muscleblind-like 3 (Drosophila)
chr7_+_13278778 3.441 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
Lig1


ligase I, DNA, ATP-dependent


chr3_+_69004711 3.254 ENSMUST00000042901.8
Smc4
structural maintenance of chromosomes 4
chr4_+_115000174 3.210 ENSMUST00000129957.1
Stil
Scl/Tal1 interrupting locus
chrX_-_73659724 3.100 ENSMUST00000114473.1
ENSMUST00000002087.7
Pnck

pregnancy upregulated non-ubiquitously expressed CaM kinase

chr9_-_39603635 3.081 ENSMUST00000119722.1
AW551984
expressed sequence AW551984
chr18_-_52529692 3.065 ENSMUST00000025409.7
Lox
lysyl oxidase
chr2_+_103969528 3.043 ENSMUST00000123437.1
ENSMUST00000163256.1
Lmo2

LIM domain only 2

chr18_+_11657349 3.000 ENSMUST00000047322.6
Rbbp8
retinoblastoma binding protein 8
chr11_-_101551837 2.982 ENSMUST00000017290.4
Brca1
breast cancer 1
chr5_-_148399901 2.816 ENSMUST00000048116.8
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chrX_+_20703906 2.758 ENSMUST00000033383.2
Usp11
ubiquitin specific peptidase 11
chr12_+_24708241 2.700 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chrX_-_73660047 2.631 ENSMUST00000114472.1
Pnck
pregnancy upregulated non-ubiquitously expressed CaM kinase
chr4_+_115000156 2.584 ENSMUST00000030490.6
Stil
Scl/Tal1 interrupting locus
chr13_-_51793650 2.498 ENSMUST00000110040.2
ENSMUST00000021900.7
Sema4d

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

chr12_-_11265768 2.475 ENSMUST00000166117.1
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr4_-_43046196 2.468 ENSMUST00000036462.5
Fam214b
family with sequence similarity 214, member B
chr17_+_26917091 2.421 ENSMUST00000078961.4
Kifc5b
kinesin family member C5B
chr1_-_95667555 2.410 ENSMUST00000043336.4
St8sia4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr3_-_69004475 2.404 ENSMUST00000154741.1
ENSMUST00000148031.1
Ift80

intraflagellar transport 80

chrX_-_150814265 2.385 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
Maged2


melanoma antigen, family D, 2


chr15_+_84232030 2.373 ENSMUST00000023072.6
Parvb
parvin, beta
chr18_-_12941777 2.364 ENSMUST00000122175.1
Osbpl1a
oxysterol binding protein-like 1A
chr5_+_108132885 2.348 ENSMUST00000047677.7
Ccdc18
coiled-coil domain containing 18
chr9_+_64281575 2.345 ENSMUST00000034964.6
Tipin
timeless interacting protein
chr5_+_34573664 2.344 ENSMUST00000114338.2
Add1
adducin 1 (alpha)
chr12_+_86678685 2.259 ENSMUST00000021681.3
Vash1
vasohibin 1
chr4_-_133967235 2.221 ENSMUST00000123234.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr8_+_117498272 2.163 ENSMUST00000081232.7
Plcg2
phospholipase C, gamma 2
chr3_+_33799791 2.120 ENSMUST00000099153.3
Ttc14
tetratricopeptide repeat domain 14
chr7_+_113513829 2.113 ENSMUST00000033018.8
Far1
fatty acyl CoA reductase 1
chr1_-_191575534 2.100 ENSMUST00000027933.5
Dtl
denticleless homolog (Drosophila)
chr5_+_34573808 2.074 ENSMUST00000001108.4
ENSMUST00000114340.2
Add1

adducin 1 (alpha)

chr6_+_29694204 2.069 ENSMUST00000046750.7
ENSMUST00000115250.3
Tspan33

tetraspanin 33

chr12_+_4917376 2.061 ENSMUST00000045664.5
Atad2b
ATPase family, AAA domain containing 2B
chr8_-_94876269 2.037 ENSMUST00000046461.7
Dok4
docking protein 4
chr2_-_37703845 2.034 ENSMUST00000155237.1
Strbp
spermatid perinuclear RNA binding protein
chr4_+_43957678 2.008 ENSMUST00000107855.1
Glipr2
GLI pathogenesis-related 2
chr19_+_53600377 1.984 ENSMUST00000025930.9
Smc3
structural maintenance of chromosomes 3
chr3_+_33800158 1.958 ENSMUST00000139880.1
ENSMUST00000076916.6
ENSMUST00000142280.1
ENSMUST00000117915.1
ENSMUST00000108210.2
Ttc14




tetratricopeptide repeat domain 14




chr5_+_5573952 1.957 ENSMUST00000101627.2
Gm8773
predicted gene 8773
chrX_+_101274023 1.883 ENSMUST00000117706.1
Med12
mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
chr3_-_41742471 1.858 ENSMUST00000026866.8
Sclt1
sodium channel and clathrin linker 1
chr3_+_88607742 1.823 ENSMUST00000175903.1
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chrX_+_101274198 1.819 ENSMUST00000117203.1
ENSMUST00000087948.4
ENSMUST00000087956.5
Med12


mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)


chr4_-_129440800 1.769 ENSMUST00000053042.5
ENSMUST00000106046.1
Zbtb8b

zinc finger and BTB domain containing 8b

chr1_-_134079114 1.768 ENSMUST00000020692.6
Btg2
B cell translocation gene 2, anti-proliferative
chr10_-_93589621 1.756 ENSMUST00000020203.6
Snrpf
small nuclear ribonucleoprotein polypeptide F
chr14_-_60251473 1.730 ENSMUST00000041905.6
Nupl1
nucleoporin like 1
chr17_+_34398802 1.683 ENSMUST00000114175.1
ENSMUST00000078615.5
ENSMUST00000139063.1
ENSMUST00000097348.2
BC051142



cDNA sequence BC051142



chr9_+_57072024 1.682 ENSMUST00000169879.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr13_+_37826904 1.678 ENSMUST00000149745.1
Rreb1
ras responsive element binding protein 1
chr11_+_32347800 1.634 ENSMUST00000038753.5
Sh3pxd2b
SH3 and PX domains 2B
chr4_+_32615473 1.626 ENSMUST00000178925.1
ENSMUST00000029950.3
Casp8ap2

caspase 8 associated protein 2

chr3_+_103576081 1.584 ENSMUST00000183637.1
ENSMUST00000117221.2
ENSMUST00000118117.1
ENSMUST00000118563.2
Syt6



synaptotagmin VI



chr10_+_14523062 1.583 ENSMUST00000096020.5
Gm10335
predicted gene 10335
chr17_+_47593444 1.566 ENSMUST00000182209.1
Ccnd3
cyclin D3
chr9_+_109875541 1.559 ENSMUST00000094324.3
Cdc25a
cell division cycle 25A
chr16_+_34690548 1.518 ENSMUST00000023532.6
Ccdc14
coiled-coil domain containing 14
chr2_+_180598219 1.516 ENSMUST00000103059.1
Col9a3
collagen, type IX, alpha 3
chr3_-_95217690 1.515 ENSMUST00000107209.1
Gabpb2
GA repeat binding protein, beta 2
chr10_-_80918212 1.507 ENSMUST00000057623.7
ENSMUST00000179022.1
Lmnb2

lamin B2

chr17_-_24658425 1.497 ENSMUST00000095544.4
Npw
neuropeptide W
chr3_+_59006978 1.490 ENSMUST00000040325.7
ENSMUST00000164225.1
ENSMUST00000040846.8
ENSMUST00000029393.8
Med12l



mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)-like



chrX_-_105929397 1.485 ENSMUST00000113573.1
ENSMUST00000130980.1
Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr16_+_91485295 1.484 ENSMUST00000129878.1
Ifnar1
interferon (alpha and beta) receptor 1
chr13_-_21531084 1.473 ENSMUST00000045228.5
Zkscan8
zinc finger with KRAB and SCAN domains 8
chr16_-_43889669 1.471 ENSMUST00000023387.7
Qtrtd1
queuine tRNA-ribosyltransferase domain containing 1
chr2_-_180225812 1.451 ENSMUST00000015791.5
Lama5
laminin, alpha 5
chrX_-_105929333 1.447 ENSMUST00000134507.1
ENSMUST00000137453.1
ENSMUST00000150914.1
Atrx


alpha thalassemia/mental retardation syndrome X-linked homolog (human)


chr16_-_78376758 1.428 ENSMUST00000023570.7
Btg3
B cell translocation gene 3
chr19_+_40894692 1.377 ENSMUST00000050092.6
Zfp518a
zinc finger protein 518A
chr16_-_4719148 1.349 ENSMUST00000115851.3
Nmral1
NmrA-like family domain containing 1
chr3_-_95217741 1.327 ENSMUST00000107204.1
Gabpb2
GA repeat binding protein, beta 2
chr19_+_21778325 1.293 ENSMUST00000096194.2
ENSMUST00000025663.6
Tmem2

transmembrane protein 2

chrX_-_105929206 1.282 ENSMUST00000134381.1
ENSMUST00000154866.1
Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chrX_-_102189371 1.269 ENSMUST00000033683.7
Rps4x
ribosomal protein S4, X-linked
chr3_+_41742615 1.266 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr3_-_95217877 1.261 ENSMUST00000136139.1
Gabpb2
GA repeat binding protein, beta 2
chr2_+_150786735 1.253 ENSMUST00000045441.7
Pygb
brain glycogen phosphorylase
chr1_-_97661668 1.233 ENSMUST00000153115.1
ENSMUST00000142234.1
D1Ertd622e

DNA segment, Chr 1, ERATO Doi 622, expressed

chr3_-_69004565 1.208 ENSMUST00000169064.1
Ift80
intraflagellar transport 80
chr4_+_140701466 1.178 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr7_+_90130227 1.164 ENSMUST00000049537.7
Picalm
phosphatidylinositol binding clathrin assembly protein
chr8_-_34965631 1.140 ENSMUST00000033929.4
Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chrX_-_53269786 1.134 ENSMUST00000114841.1
ENSMUST00000071023.5
Fam122b

family with sequence similarity 122, member B

chr8_+_57488053 1.119 ENSMUST00000180690.1
2500002B13Rik
RIKEN cDNA 2500002B13 gene
chr1_-_97661950 1.106 ENSMUST00000053033.7
ENSMUST00000149927.1
D1Ertd622e

DNA segment, Chr 1, ERATO Doi 622, expressed

chrX_-_48454152 1.106 ENSMUST00000114958.1
Elf4
E74-like factor 4 (ets domain transcription factor)
chr3_-_69004503 1.098 ENSMUST00000107812.1
Ift80
intraflagellar transport 80
chr11_-_69900886 1.096 ENSMUST00000108621.2
ENSMUST00000100969.2
2810408A11Rik

RIKEN cDNA 2810408A11 gene

chr2_-_168590191 1.066 ENSMUST00000029057.6
ENSMUST00000074618.3
Nfatc2

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2

chr1_+_156558759 1.063 ENSMUST00000173929.1
Abl2
v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
chr7_+_100372224 1.027 ENSMUST00000051777.8
ENSMUST00000098259.4
C2cd3

C2 calcium-dependent domain containing 3

chr1_+_127774164 1.008 ENSMUST00000027587.8
ENSMUST00000112570.1
Ccnt2

cyclin T2

chr16_-_4719078 0.989 ENSMUST00000120056.1
ENSMUST00000074970.7
Nmral1

NmrA-like family domain containing 1

chr12_+_11265867 0.982 ENSMUST00000020931.5
Smc6
structural maintenance of chromosomes 6
chr6_+_4903350 0.979 ENSMUST00000175962.1
Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr11_+_55213783 0.962 ENSMUST00000108867.1
Slc36a1
solute carrier family 36 (proton/amino acid symporter), member 1
chr17_+_35841491 0.955 ENSMUST00000082337.6
Mdc1
mediator of DNA damage checkpoint 1
chr10_-_61784014 0.955 ENSMUST00000020283.4
H2afy2
H2A histone family, member Y2
chr19_+_8723478 0.923 ENSMUST00000180819.1
ENSMUST00000181422.1
Snhg1

small nucleolar RNA host gene (non-protein coding) 1

chr11_+_101552188 0.899 ENSMUST00000147239.1
Nbr1
neighbor of Brca1 gene 1
chr16_-_31081363 0.891 ENSMUST00000055389.7
Xxylt1
xyloside xylosyltransferase 1
chr8_-_119605199 0.884 ENSMUST00000093099.6
Taf1c
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C
chr15_-_80083374 0.872 ENSMUST00000081650.7
Rpl3
ribosomal protein L3
chr8_-_57487801 0.865 ENSMUST00000034022.3
Sap30
sin3 associated polypeptide
chr12_+_111538819 0.853 ENSMUST00000050993.9
Eif5
eukaryotic translation initiation factor 5
chr11_+_69655314 0.845 ENSMUST00000047373.5
Sox15
SRY-box containing gene 15
chr17_+_29032664 0.830 ENSMUST00000130216.1
Srsf3
serine/arginine-rich splicing factor 3
chr13_-_21531032 0.826 ENSMUST00000156674.2
ENSMUST00000110481.2
Zkscan8

zinc finger with KRAB and SCAN domains 8

chr5_-_65697856 0.805 ENSMUST00000031104.6
Pds5a
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr19_+_32485751 0.800 ENSMUST00000025827.8
Minpp1
multiple inositol polyphosphate histidine phosphatase 1
chr11_+_115564434 0.796 ENSMUST00000021085.4
Nup85
nucleoporin 85
chr12_+_112146187 0.794 ENSMUST00000128402.2
Kif26a
kinesin family member 26A
chr5_-_122900267 0.779 ENSMUST00000031435.7
Kdm2b
lysine (K)-specific demethylase 2B
chr13_+_55445301 0.769 ENSMUST00000001115.8
ENSMUST00000099482.3
Grk6

G protein-coupled receptor kinase 6

chr12_-_69681795 0.764 ENSMUST00000183277.1
ENSMUST00000035773.7
Sos2

son of sevenless homolog 2 (Drosophila)

chr6_-_51469869 0.752 ENSMUST00000114459.1
ENSMUST00000069949.6
Hnrnpa2b1

heterogeneous nuclear ribonucleoprotein A2/B1

chr5_+_32611171 0.739 ENSMUST00000072311.6
ENSMUST00000168707.2
Yes1

Yamaguchi sarcoma viral (v-yes) oncogene homolog 1

chr17_+_69417441 0.735 ENSMUST00000097289.2
C030034I22Rik
RIKEN cDNA C030034I22 gene
chr6_-_51469836 0.715 ENSMUST00000090002.7
Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr11_+_73240310 0.705 ENSMUST00000138853.1
Trpv1
transient receptor potential cation channel, subfamily V, member 1
chr11_-_97500340 0.702 ENSMUST00000056955.1
4933428G20Rik
RIKEN cDNA 4933428G20 gene
chr19_+_10525244 0.701 ENSMUST00000038379.3
Cpsf7
cleavage and polyadenylation specific factor 7
chr2_+_150909565 0.694 ENSMUST00000028948.4
Gins1
GINS complex subunit 1 (Psf1 homolog)
chr16_+_20696175 0.656 ENSMUST00000128273.1
Fam131a
family with sequence similarity 131, member A
chr2_+_113327756 0.650 ENSMUST00000102547.3
Fmn1
formin 1
chr11_-_100759942 0.645 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr12_+_80945520 0.643 ENSMUST00000110354.1
ENSMUST00000110352.3
ENSMUST00000110351.1
ENSMUST00000110356.2
Srsf5



serine/arginine-rich splicing factor 5



chr19_+_41482632 0.621 ENSMUST00000067795.5
Lcor
ligand dependent nuclear receptor corepressor
chr10_-_30600662 0.605 ENSMUST00000019927.6
Trmt11
tRNA methyltransferase 11
chr13_-_55329723 0.605 ENSMUST00000021941.7
Mxd3
Max dimerization protein 3
chr3_+_66985680 0.599 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr18_+_31789120 0.590 ENSMUST00000025106.3
Polr2d
polymerase (RNA) II (DNA directed) polypeptide D
chr5_+_74535535 0.588 ENSMUST00000121950.1
Fip1l1
FIP1 like 1 (S. cerevisiae)
chr12_+_84100654 0.588 ENSMUST00000056822.3
Acot6
acyl-CoA thioesterase 6
chr9_-_96631487 0.586 ENSMUST00000128346.1
ENSMUST00000034984.6
Rasa2

RAS p21 protein activator 2

chr3_-_127553233 0.561 ENSMUST00000029588.5
Larp7
La ribonucleoprotein domain family, member 7
chr13_-_9764865 0.555 ENSMUST00000128658.1
Zmynd11
zinc finger, MYND domain containing 11
chr11_-_94549165 0.553 ENSMUST00000040487.3
Rsad1
radical S-adenosyl methionine domain containing 1
chr9_+_57076343 0.549 ENSMUST00000168678.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr10_+_112928501 0.549 ENSMUST00000180464.1
Gm26596
predicted gene, 26596
chr10_+_93589413 0.539 ENSMUST00000181835.1
4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr12_-_21373606 0.538 ENSMUST00000064536.6
Adam17
a disintegrin and metallopeptidase domain 17
chr8_+_105860634 0.527 ENSMUST00000008594.7
Nutf2
nuclear transport factor 2
chr3_-_51340628 0.524 ENSMUST00000062009.7
Elf2
E74-like factor 2
chr4_-_34614886 0.518 ENSMUST00000140334.1
ENSMUST00000108142.1
ENSMUST00000048706.3
Orc3


origin recognition complex, subunit 3


chr5_-_33936301 0.515 ENSMUST00000030993.6
Nelfa
negative elongation factor complex member A, Whsc2
chr12_-_21373550 0.515 ENSMUST00000101551.3
Adam17
a disintegrin and metallopeptidase domain 17
chr5_-_39644597 0.513 ENSMUST00000152057.1
Hs3st1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr7_-_142372210 0.513 ENSMUST00000084412.5
Ifitm10
interferon induced transmembrane protein 10
chr6_-_72345144 0.499 ENSMUST00000070345.3
Usp39
ubiquitin specific peptidase 39
chr2_-_25224653 0.498 ENSMUST00000043584.4
Tubb4b
tubulin, beta 4B class IVB
chr4_-_148287927 0.496 ENSMUST00000047720.8
Ptchd2
patched domain containing 2
chr17_-_74294834 0.495 ENSMUST00000078459.6
Memo1
mediator of cell motility 1
chr11_+_68901538 0.492 ENSMUST00000073471.6
ENSMUST00000101014.2
ENSMUST00000128952.1
ENSMUST00000167436.1
Rpl26



ribosomal protein L26



chr6_+_71831441 0.486 ENSMUST00000171057.1
Immt
inner membrane protein, mitochondrial
chr16_+_43889896 0.486 ENSMUST00000122014.1
ENSMUST00000178400.1
2610015P09Rik

RIKEN cDNA 2610015P09 gene

chr17_+_47688992 0.475 ENSMUST00000156118.1
Frs3
fibroblast growth factor receptor substrate 3
chr8_+_121950492 0.474 ENSMUST00000093078.6
ENSMUST00000170857.1
ENSMUST00000026354.8
ENSMUST00000174753.1
ENSMUST00000172511.1
Banp




BTG3 associated nuclear protein




chr2_+_16356744 0.462 ENSMUST00000114703.3
Plxdc2
plexin domain containing 2
chr5_+_74535449 0.461 ENSMUST00000080164.5
ENSMUST00000113536.1
ENSMUST00000122245.1
ENSMUST00000120618.1
ENSMUST00000113535.2
ENSMUST00000113534.2
Fip1l1





FIP1 like 1 (S. cerevisiae)





chr6_+_57580992 0.454 ENSMUST00000031817.8
Herc6
hect domain and RLD 6
chr9_-_62980874 0.454 ENSMUST00000098651.4
Pias1
protein inhibitor of activated STAT 1
chr16_+_43889936 0.454 ENSMUST00000151183.1
2610015P09Rik
RIKEN cDNA 2610015P09 gene
chr3_-_51340555 0.450 ENSMUST00000091144.4
Elf2
E74-like factor 2
chr7_-_25816616 0.441 ENSMUST00000043314.3
Cyp2s1
cytochrome P450, family 2, subfamily s, polypeptide 1
chr12_+_24651346 0.436 ENSMUST00000020982.5
Klf11
Kruppel-like factor 11
chr1_+_139422196 0.435 ENSMUST00000039867.7
Zbtb41
zinc finger and BTB domain containing 41 homolog
chr14_-_30626196 0.434 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
Prkcd


protein kinase C, delta


chr5_+_150952607 0.432 ENSMUST00000078856.6
Kl
klotho
chr18_+_44380479 0.424 ENSMUST00000025350.8
Dcp2
DCP2 decapping enzyme homolog (S. cerevisiae)
chr17_-_67354459 0.418 ENSMUST00000037974.8
Ptprm
protein tyrosine phosphatase, receptor type, M
chr10_+_81233147 0.414 ENSMUST00000144087.1
ENSMUST00000117798.1
Zfr2

zinc finger RNA binding protein 2

chr16_+_91647859 0.411 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
Son



Son DNA binding protein



chr12_-_100899436 0.405 ENSMUST00000053668.3
Gpr68
G protein-coupled receptor 68
chr14_+_30716377 0.404 ENSMUST00000112177.1
Sfmbt1
Scm-like with four mbt domains 1
chr11_-_86544754 0.403 ENSMUST00000138810.1
ENSMUST00000058286.2
ENSMUST00000154617.1
Rps6kb1


ribosomal protein S6 kinase, polypeptide 1


chr4_+_132768325 0.394 ENSMUST00000102561.4
Rpa2
replication protein A2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:0045660 positive regulation of neutrophil differentiation(GO:0045660)
2.1 6.2 GO:0010752 negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752)
1.4 4.2 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
1.1 5.4 GO:1904908 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
1.0 3.0 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.0 6.9 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.0 5.8 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.8 2.4 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.7 2.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.7 4.0 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.6 2.5 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.6 3.0 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.6 0.6 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
0.6 4.1 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.6 2.3 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.5 3.7 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.5 4.7 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.5 3.4 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.5 1.5 GO:1905663 regulation of telomerase RNA reverse transcriptase activity(GO:1905661) positive regulation of telomerase RNA reverse transcriptase activity(GO:1905663)
0.5 3.7 GO:0042148 strand invasion(GO:0042148)
0.4 2.2 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.4 5.8 GO:0033504 floor plate development(GO:0033504)
0.4 4.2 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.4 2.8 GO:1903826 arginine transmembrane transport(GO:1903826)
0.3 1.0 GO:0019085 early viral transcription(GO:0019085)
0.3 2.3 GO:0048478 replication fork protection(GO:0048478)
0.3 1.0 GO:0015828 tyrosine transport(GO:0015828)
0.3 4.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.3 2.5 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.3 2.1 GO:0019985 translesion synthesis(GO:0019985)
0.3 2.4 GO:0070294 renal sodium ion absorption(GO:0070294)
0.3 0.8 GO:0048627 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) myoblast development(GO:0048627)
0.3 3.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.3 1.6 GO:1904179 positive regulation of adipose tissue development(GO:1904179)
0.3 1.1 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.3 1.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.2 6.2 GO:0043486 histone exchange(GO:0043486)
0.2 2.0 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.2 1.0 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.2 1.7 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.2 3.1 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.2 1.2 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) negative regulation of metalloendopeptidase activity(GO:1904684) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.2 1.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 1.6 GO:0036337 Fas signaling pathway(GO:0036337)
0.2 2.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 1.8 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.2 7.8 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.2 4.7 GO:0072520 seminiferous tubule development(GO:0072520)
0.2 2.3 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.2 1.0 GO:0061511 centriole elongation(GO:0061511)
0.2 3.0 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 1.6 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.2 0.8 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.2 1.2 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.2 0.8 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.2 1.1 GO:0001866 NK T cell proliferation(GO:0001866)
0.2 0.7 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.2 0.5 GO:0090204 protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.2 0.5 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2 2.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.2 0.5 GO:1902162 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162)
0.2 1.0 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.2 0.8 GO:0021993 initiation of neural tube closure(GO:0021993)
0.2 2.7 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 1.3 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.8 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.1 0.9 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.7 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 1.8 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.1 0.4 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.7 GO:1902969 mitotic DNA replication(GO:1902969)
0.1 2.2 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.1 1.0 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.4 GO:0006680 glucosylceramide catabolic process(GO:0006680) aspartate transport(GO:0015810) positive regulation of phospholipid catabolic process(GO:0060697)
0.1 0.4 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1 0.3 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.1 4.8 GO:0000266 mitochondrial fission(GO:0000266)
0.1 1.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 0.3 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 0.9 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 0.4 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 1.7 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 1.0 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.1 0.6 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.1 0.8 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 1.6 GO:1905508 protein localization to centrosome(GO:0071539) protein localization to microtubule organizing center(GO:1905508)
0.1 2.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 0.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.7 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0 0.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.5 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 1.3 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 1.8 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 4.5 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.3 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 1.1 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 1.1 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 1.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.5 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543) cellular response to fibroblast growth factor stimulus(GO:0044344) response to fibroblast growth factor(GO:0071774)
0.0 0.2 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.3 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 1.5 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.8 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 1.0 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.0 0.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 2.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 1.3 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 0.3 GO:0032274 gonadotropin secretion(GO:0032274)
0.0 0.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 1.8 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.4 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.0 0.3 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.1 GO:0045955 negative regulation of calcium ion-dependent exocytosis(GO:0045955)
0.0 0.9 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.6 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.7 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0 3.3 GO:0045444 fat cell differentiation(GO:0045444)
0.0 0.4 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.6 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.0 0.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 1.5 GO:0007631 feeding behavior(GO:0007631)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0000799 nuclear condensin complex(GO:0000799)
1.1 4.2 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
1.0 6.9 GO:0000796 condensin complex(GO:0000796)
0.8 4.0 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.7 6.2 GO:0005577 fibrinogen complex(GO:0005577)
0.7 4.7 GO:0005828 kinetochore microtubule(GO:0005828)
0.7 7.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.5 2.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.5 3.0 GO:0070531 BRCA1-A complex(GO:0070531)
0.4 4.4 GO:0008290 F-actin capping protein complex(GO:0008290)
0.4 1.2 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.4 1.5 GO:0005594 collagen type IX trimer(GO:0005594)
0.4 1.5 GO:0043259 laminin-5 complex(GO:0005610) laminin-10 complex(GO:0043259)
0.4 1.8 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.3 2.3 GO:0031298 replication fork protection complex(GO:0031298)
0.3 2.0 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.3 1.0 GO:0035061 interchromatin granule(GO:0035061)
0.3 2.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 1.5 GO:0005638 lamin filament(GO:0005638)
0.2 1.0 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 2.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 0.9 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.2 1.9 GO:0071439 clathrin complex(GO:0071439)
0.1 3.1 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.0 GO:0001740 Barr body(GO:0001740)
0.1 0.5 GO:0032021 NELF complex(GO:0032021)
0.1 4.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 5.2 GO:0016592 mediator complex(GO:0016592) core mediator complex(GO:0070847)
0.1 1.5 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 1.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 1.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 1.0 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 2.5 GO:0034451 centriolar satellite(GO:0034451)
0.1 3.5 GO:0002102 podosome(GO:0002102)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.5 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.5 GO:0005664 nuclear origin of replication recognition complex(GO:0005664)
0.1 1.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.3 GO:0001891 phagocytic cup(GO:0001891)
0.1 4.1 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.5 GO:0045298 tubulin complex(GO:0045298)
0.0 4.2 GO:0005776 autophagosome(GO:0005776)
0.0 1.4 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 2.1 GO:0005871 kinesin complex(GO:0005871)
0.0 3.6 GO:0016605 PML body(GO:0016605)
0.0 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.4 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 3.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.7 GO:0000811 GINS complex(GO:0000811)
0.0 1.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.7 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 2.3 GO:0005581 collagen trimer(GO:0005581)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.2 GO:0042555 MCM complex(GO:0042555) MCM core complex(GO:0097373)
0.0 1.4 GO:0035869 ciliary transition zone(GO:0035869)
0.0 6.2 GO:0005925 focal adhesion(GO:0005925)
0.0 0.8 GO:0031519 PcG protein complex(GO:0031519)
0.0 5.7 GO:0005813 centrosome(GO:0005813)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)
0.0 0.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.2 GO:0070052 collagen V binding(GO:0070052)
1.2 5.8 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.7 4.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.6 3.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.6 4.2 GO:0015616 DNA translocase activity(GO:0015616)
0.6 1.7 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637)
0.5 2.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 3.7 GO:0000150 recombinase activity(GO:0000150)
0.5 2.0 GO:0036033 mediator complex binding(GO:0036033)
0.4 2.5 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.4 2.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.4 3.4 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.4 1.5 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
0.4 2.8 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.3 1.0 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
0.3 1.3 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.2 4.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 1.6 GO:0032184 SUMO polymer binding(GO:0032184)
0.2 7.4 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.2 4.4 GO:0042608 T cell receptor binding(GO:0042608)
0.2 0.8 GO:0052743 inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.2 0.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.2 1.2 GO:1902944 aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902944)
0.2 0.8 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.2 2.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 1.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 1.1 GO:0050733 RS domain binding(GO:0050733)
0.1 1.3 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 0.9 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.4 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 4.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.4 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 0.9 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1 1.0 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 2.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.6 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.7 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.1 1.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 4.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.4 GO:0070976 TIR domain binding(GO:0070976)
0.1 0.4 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.1 2.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 3.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 2.1 GO:0070577 lysine-acetylated histone binding(GO:0070577) acetylation-dependent protein binding(GO:0140033)
0.1 1.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.9 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.1 0.5 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.3 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.1 14.0 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.9 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.3 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.5 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 2.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.3 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.1 4.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 7.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 1.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.7 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.7 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 1.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 2.5 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 2.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.8 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 3.4 GO:0030276 clathrin binding(GO:0030276)
0.0 1.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 2.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 3.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 1.3 GO:0019843 rRNA binding(GO:0019843)
0.0 0.3 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.5 GO:0030332 cyclin binding(GO:0030332)
0.0 1.4 GO:0015485 cholesterol binding(GO:0015485)
0.0 2.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.1 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.0 1.0 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.4 GO:0070330 aromatase activity(GO:0070330)
0.0 3.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.4 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.6 PID_ATM_PATHWAY ATM pathway
0.2 11.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 1.6 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 5.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 5.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 1.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 7.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.6 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.0 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.7 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.2 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.1 2.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.3 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.2 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.7 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 2.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.5 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.0 2.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.1 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.5 PID_SHP2_PATHWAY SHP2 signaling
0.0 3.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID_CXCR4_PATHWAY CXCR4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.6 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.3 4.0 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2 0.2 REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.2 4.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 5.5 REACTOME_KINESINS Genes involved in Kinesins
0.2 5.8 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.2 4.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.8 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 7.0 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.7 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 1.6 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 2.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.1 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 7.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.5 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 0.5 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 1.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 3.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.2 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.1 0.9 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 0.5 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 2.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.3 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.6 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.1 2.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 5.3 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 2.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.9 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.4 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 2.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.5 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.9 REACTOME_FRS2_MEDIATED_CASCADE Genes involved in FRS2-mediated cascade
0.0 1.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 0.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.9 REACTOME_TRANSLATION Genes involved in Translation