Motif ID: E2f4

Z-value: 2.929


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.945.0e-17Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_72438519 29.368 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438534 27.707 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr2_+_163054682 27.198 ENSMUST00000018005.3
Mybl2
myeloblastosis oncogene-like 2
chr4_+_134510999 25.352 ENSMUST00000105866.2
Aunip
aurora kinase A and ninein interacting protein
chr18_-_34751502 24.227 ENSMUST00000060710.7
Cdc25c
cell division cycle 25C
chr8_-_53638945 23.666 ENSMUST00000047768.4
Neil3
nei like 3 (E. coli)
chr14_-_47418407 23.547 ENSMUST00000043296.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr4_-_132345715 23.171 ENSMUST00000084250.4
Rcc1
regulator of chromosome condensation 1
chr16_-_30310773 22.316 ENSMUST00000061190.6
Gp5
glycoprotein 5 (platelet)
chr4_-_132345686 22.173 ENSMUST00000030726.6
Rcc1
regulator of chromosome condensation 1
chr14_-_87141114 22.019 ENSMUST00000168889.1
Diap3
diaphanous homolog 3 (Drosophila)
chr19_+_6084983 21.239 ENSMUST00000025704.2
Cdca5
cell division cycle associated 5
chr6_+_124830217 20.981 ENSMUST00000131847.1
ENSMUST00000151674.1
Cdca3

cell division cycle associated 3

chr13_+_23535411 20.867 ENSMUST00000080859.5
Hist1h3g
histone cluster 1, H3g
chr14_-_87141206 20.407 ENSMUST00000022599.7
Diap3
diaphanous homolog 3 (Drosophila)
chr10_-_88146867 19.312 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
Parpbp



PARP1 binding protein



chr1_-_169531343 18.411 ENSMUST00000028000.7
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr3_-_54915867 17.962 ENSMUST00000070342.3
Sertm1
serine rich and transmembrane domain containing 1
chr1_-_189688074 17.675 ENSMUST00000171929.1
ENSMUST00000165962.1
Cenpf

centromere protein F

chr4_-_116123618 17.230 ENSMUST00000102704.3
ENSMUST00000102705.3
Rad54l

RAD54 like (S. cerevisiae)

chr17_-_25727364 15.970 ENSMUST00000170070.1
ENSMUST00000048054.7
Chtf18

CTF18, chromosome transmission fidelity factor 18

chr1_-_169531447 15.876 ENSMUST00000111368.1
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr11_+_98907801 15.218 ENSMUST00000092706.6
Cdc6
cell division cycle 6
chr13_-_23745511 15.117 ENSMUST00000091752.2
Hist1h3c
histone cluster 1, H3c
chrX_+_8271381 14.942 ENSMUST00000033512.4
Slc38a5
solute carrier family 38, member 5
chrX_+_8271133 14.820 ENSMUST00000127103.1
ENSMUST00000115591.1
Slc38a5

solute carrier family 38, member 5

chr7_-_38107490 13.796 ENSMUST00000108023.3
Ccne1
cyclin E1
chr18_-_58209926 13.777 ENSMUST00000025497.6
Fbn2
fibrillin 2
chrX_+_8271642 13.063 ENSMUST00000115590.1
Slc38a5
solute carrier family 38, member 5
chr9_-_123678782 13.051 ENSMUST00000170591.1
ENSMUST00000171647.1
Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr4_-_133967235 12.146 ENSMUST00000123234.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr4_-_133967296 11.496 ENSMUST00000105893.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr13_-_73937761 11.305 ENSMUST00000022053.8
Trip13
thyroid hormone receptor interactor 13
chr9_-_32344237 11.219 ENSMUST00000034533.5
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr9_+_107950952 10.952 ENSMUST00000049348.3
Traip
TRAF-interacting protein
chr6_+_113531675 10.887 ENSMUST00000036340.5
ENSMUST00000101051.2
Fancd2

Fanconi anemia, complementation group D2

chr9_+_119937606 10.733 ENSMUST00000035100.5
Ttc21a
tetratricopeptide repeat domain 21A
chr2_+_103970221 10.536 ENSMUST00000111140.2
ENSMUST00000111139.2
Lmo2

LIM domain only 2

chr15_-_76639840 10.367 ENSMUST00000166974.1
ENSMUST00000168185.1
Tonsl

tonsoku-like, DNA repair protein

chr11_-_101551837 10.232 ENSMUST00000017290.4
Brca1
breast cancer 1
chr12_+_117843873 10.062 ENSMUST00000176735.1
ENSMUST00000177339.1
Cdca7l

cell division cycle associated 7 like

chr1_-_33669745 9.823 ENSMUST00000027312.9
Prim2
DNA primase, p58 subunit
chr1_+_86303221 9.682 ENSMUST00000113306.2
B3gnt7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr17_-_29237759 9.101 ENSMUST00000137727.1
ENSMUST00000024805.7
Cpne5

copine V

chr4_-_133967893 9.030 ENSMUST00000100472.3
ENSMUST00000136327.1
Hmgn2

high mobility group nucleosomal binding domain 2

chr1_+_52630692 9.024 ENSMUST00000165859.1
Tmem194b
transmembrane protein 194B
chr7_-_92874196 8.618 ENSMUST00000032877.9
4632434I11Rik
RIKEN cDNA 4632434I11 gene
chr1_-_60043087 8.458 ENSMUST00000027172.6
Ica1l
islet cell autoantigen 1-like
chr11_+_16951371 8.349 ENSMUST00000109635.1
ENSMUST00000061327.1
Fbxo48

F-box protein 48

chr18_+_34751803 8.257 ENSMUST00000181453.1
ENSMUST00000181641.1
2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr11_-_6606053 8.238 ENSMUST00000045713.3
Nacad
NAC alpha domain containing
chr17_-_24251382 8.222 ENSMUST00000115390.3
Ccnf
cyclin F
chr18_+_56707725 8.143 ENSMUST00000025486.8
Lmnb1
lamin B1
chr16_-_90727329 7.966 ENSMUST00000099554.4
Mis18a
MIS18 kinetochore protein homolog A (S. pombe)
chr12_+_106010263 7.239 ENSMUST00000021539.8
ENSMUST00000085026.4
ENSMUST00000072040.5
Vrk1


vaccinia related kinase 1


chr8_+_18595131 7.204 ENSMUST00000039412.8
Mcph1
microcephaly, primary autosomal recessive 1
chr5_+_88764983 7.161 ENSMUST00000031311.9
Dck
deoxycytidine kinase
chr1_-_57377476 6.609 ENSMUST00000181949.1
4930558J18Rik
RIKEN cDNA 4930558J18 gene
chr2_+_106695594 6.484 ENSMUST00000016530.7
Mpped2
metallophosphoesterase domain containing 2
chr4_-_59783800 6.410 ENSMUST00000107526.1
ENSMUST00000095063.4
Inip

INTS3 and NABP interacting protein

chr4_-_133967953 6.244 ENSMUST00000102553.4
Hmgn2
high mobility group nucleosomal binding domain 2
chr18_-_60848911 6.226 ENSMUST00000177172.1
ENSMUST00000175934.1
ENSMUST00000176630.1
Tcof1


Treacher Collins Franceschetti syndrome 1, homolog


chr8_+_18595526 6.175 ENSMUST00000146819.1
Mcph1
microcephaly, primary autosomal recessive 1
chr7_+_126781483 5.585 ENSMUST00000172352.1
ENSMUST00000094037.4
Tbx6

T-box 6

chr10_+_79997463 5.573 ENSMUST00000171637.1
ENSMUST00000043866.7
Abca7

ATP-binding cassette, sub-family A (ABC1), member 7

chr10_-_117792663 5.541 ENSMUST00000167943.1
ENSMUST00000064848.5
Nup107

nucleoporin 107

chr4_+_11558914 5.533 ENSMUST00000178703.1
ENSMUST00000095145.5
ENSMUST00000108306.2
ENSMUST00000070755.6
Rad54b



RAD54 homolog B (S. cerevisiae)



chr5_-_138172383 5.518 ENSMUST00000000505.9
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chrX_+_164980592 5.436 ENSMUST00000101082.4
ENSMUST00000167446.1
ENSMUST00000057150.6
Fancb


Fanconi anemia, complementation group B


chr4_-_44704006 5.260 ENSMUST00000146335.1
Pax5
paired box gene 5
chr9_-_65580040 5.118 ENSMUST00000068944.7
Plekho2
pleckstrin homology domain containing, family O member 2
chr17_+_50698525 5.003 ENSMUST00000061681.7
Gm7334
predicted gene 7334
chrX_-_8074720 4.994 ENSMUST00000115636.3
ENSMUST00000115638.3
Suv39h1

suppressor of variegation 3-9 homolog 1 (Drosophila)

chr2_+_129593528 4.890 ENSMUST00000049262.7
ENSMUST00000163034.1
ENSMUST00000160276.1
Sirpa


signal-regulatory protein alpha


chr15_+_12824815 4.752 ENSMUST00000169061.1
Drosha
drosha, ribonuclease type III
chr15_+_12824841 4.718 ENSMUST00000090292.5
Drosha
drosha, ribonuclease type III
chr12_-_118198917 4.623 ENSMUST00000084806.6
Dnah11
dynein, axonemal, heavy chain 11
chr6_-_56704673 4.588 ENSMUST00000170382.2
Lsm5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr9_+_44334685 4.520 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chrX_+_162901226 4.506 ENSMUST00000101095.2
Ctps2
cytidine 5'-triphosphate synthase 2
chrX_+_105079735 4.419 ENSMUST00000033577.4
Pbdc1
polysaccharide biosynthesis domain containing 1
chr2_-_166713758 4.341 ENSMUST00000036719.5
Prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr1_-_77515048 4.340 ENSMUST00000027451.6
Epha4
Eph receptor A4
chr2_+_30286406 4.226 ENSMUST00000138666.1
ENSMUST00000113634.2
Nup188

nucleoporin 188

chrX_-_167209149 4.163 ENSMUST00000112176.1
Tmsb4x
thymosin, beta 4, X chromosome
chr12_+_99884498 4.151 ENSMUST00000153627.1
Tdp1
tyrosyl-DNA phosphodiesterase 1
chr2_+_129593195 4.031 ENSMUST00000099113.3
ENSMUST00000103202.3
Sirpa

signal-regulatory protein alpha

chr9_+_44134562 3.945 ENSMUST00000034650.8
ENSMUST00000098852.2
Mcam

melanoma cell adhesion molecule

chr5_-_138171813 3.934 ENSMUST00000155902.1
ENSMUST00000148879.1
Mcm7

minichromosome maintenance deficient 7 (S. cerevisiae)

chr5_-_25705791 3.809 ENSMUST00000030773.7
Xrcc2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr7_+_58658181 3.739 ENSMUST00000168747.1
Atp10a
ATPase, class V, type 10A
chr14_-_54517353 3.665 ENSMUST00000023873.5
Prmt5
protein arginine N-methyltransferase 5
chrX_+_162901567 3.647 ENSMUST00000112303.1
ENSMUST00000033727.7
Ctps2

cytidine 5'-triphosphate synthase 2

chr9_-_83441065 3.638 ENSMUST00000034791.8
ENSMUST00000034793.8
Lca5

Leber congenital amaurosis 5 (human)

chr5_-_33652296 3.611 ENSMUST00000151081.1
ENSMUST00000101354.3
Slbp

stem-loop binding protein

chr10_+_127677064 3.471 ENSMUST00000118612.1
ENSMUST00000048099.4
Tmem194

transmembrane protein 194

chr2_+_181319714 3.429 ENSMUST00000098971.4
ENSMUST00000054622.8
ENSMUST00000108814.1
ENSMUST00000048608.9
ENSMUST00000108815.1
Rtel1




regulator of telomere elongation helicase 1




chr7_-_127208423 3.407 ENSMUST00000120705.1
Tbc1d10b
TBC1 domain family, member 10b
chr17_+_87975044 3.356 ENSMUST00000005503.3
Msh6
mutS homolog 6 (E. coli)
chr5_-_33652339 3.280 ENSMUST00000075670.6
Slbp
stem-loop binding protein
chr2_+_181319806 3.232 ENSMUST00000153112.1
Rtel1
regulator of telomere elongation helicase 1
chr1_+_9798123 3.157 ENSMUST00000168907.1
ENSMUST00000166384.1
Sgk3

serum/glucocorticoid regulated kinase 3

chrX_-_78583882 3.142 ENSMUST00000114025.1
ENSMUST00000134602.1
ENSMUST00000114024.2
Prrg1


proline rich Gla (G-carboxyglutamic acid) 1


chr19_+_46075842 3.134 ENSMUST00000165017.1
Nolc1
nucleolar and coiled-body phosphoprotein 1
chr7_+_97371604 3.125 ENSMUST00000098300.4
Alg8
asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase)
chr10_+_88146992 3.100 ENSMUST00000052355.7
Nup37
nucleoporin 37
chr2_+_153649617 3.033 ENSMUST00000109771.1
Dnmt3b
DNA methyltransferase 3B
chr4_-_58553311 2.959 ENSMUST00000107571.1
ENSMUST00000055018.4
Lpar1

lysophosphatidic acid receptor 1

chrX_+_162901762 2.867 ENSMUST00000112302.1
ENSMUST00000112301.1
Ctps2

cytidine 5'-triphosphate synthase 2

chr4_-_58553553 2.862 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
Lpar1


lysophosphatidic acid receptor 1


chr9_+_57708534 2.795 ENSMUST00000043990.7
ENSMUST00000142807.1
Edc3

enhancer of mRNA decapping 3 homolog (S. cerevisiae)

chr14_+_76488436 2.766 ENSMUST00000101618.2
Tsc22d1
TSC22 domain family, member 1
chr5_+_30889326 2.766 ENSMUST00000124908.1
Agbl5
ATP/GTP binding protein-like 5
chr11_+_108425192 2.702 ENSMUST00000150863.2
ENSMUST00000061287.5
ENSMUST00000149683.2
Cep112


centrosomal protein 112


chr4_-_43562397 2.677 ENSMUST00000030187.7
Tln1
talin 1
chr10_+_88147061 2.654 ENSMUST00000169309.1
Nup37
nucleoporin 37
chr2_+_129592914 2.652 ENSMUST00000103203.1
Sirpa
signal-regulatory protein alpha
chr19_-_5366626 2.485 ENSMUST00000025762.8
Banf1
barrier to autointegration factor 1
chr5_+_141241490 2.453 ENSMUST00000085774.4
Sdk1
sidekick homolog 1 (chicken)
chr17_-_35046726 2.306 ENSMUST00000097338.4
Msh5
mutS homolog 5 (E. coli)
chr13_+_73937799 2.274 ENSMUST00000099384.2
Brd9
bromodomain containing 9
chr12_-_4233958 2.147 ENSMUST00000111169.3
ENSMUST00000020981.5
Cenpo

centromere protein O

chr1_+_134415414 2.042 ENSMUST00000112237.1
Adipor1
adiponectin receptor 1
chr15_-_98831498 2.034 ENSMUST00000168846.1
Prkag1
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr9_-_82975475 2.004 ENSMUST00000034787.5
Phip
pleckstrin homology domain interacting protein
chr7_+_6383310 1.871 ENSMUST00000081022.7
Zfp28
zinc finger protein 28
chr17_+_29490812 1.868 ENSMUST00000024811.6
Pim1
proviral integration site 1
chrX_-_78583782 1.761 ENSMUST00000177904.1
Prrg1
proline rich Gla (G-carboxyglutamic acid) 1
chr8_+_124023394 1.669 ENSMUST00000034457.8
Urb2
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr17_-_17624458 1.661 ENSMUST00000041047.2
Lnpep
leucyl/cystinyl aminopeptidase
chr9_-_60688118 1.516 ENSMUST00000114034.2
ENSMUST00000065603.5
Lrrc49

leucine rich repeat containing 49

chr4_-_3835595 1.487 ENSMUST00000138502.1
Rps20
ribosomal protein S20
chr2_-_3512746 1.451 ENSMUST00000027961.5
ENSMUST00000056700.7
Hspa14
Hspa14
heat shock protein 14
heat shock protein 14
chr4_+_84884418 1.439 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr5_+_21372642 1.346 ENSMUST00000035799.5
Fgl2
fibrinogen-like protein 2
chr7_+_24884651 1.334 ENSMUST00000153451.2
ENSMUST00000108429.1
Rps19

ribosomal protein S19

chr6_+_70726430 1.250 ENSMUST00000103410.1
Igkc
immunoglobulin kappa constant
chr14_+_55578123 1.243 ENSMUST00000174484.1
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chrX_-_37110257 1.147 ENSMUST00000076265.6
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr17_+_34982099 1.125 ENSMUST00000007266.7
Lsm2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr11_-_106999369 1.101 ENSMUST00000106768.1
ENSMUST00000144834.1
Kpna2

karyopherin (importin) alpha 2

chr4_+_44004438 1.085 ENSMUST00000107846.3
Clta
clathrin, light polypeptide (Lca)
chr4_-_132463873 1.076 ENSMUST00000102567.3
Med18
mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)
chr1_+_133351909 1.052 ENSMUST00000112287.1
Ren1
renin 1 structural
chr4_+_84884276 1.042 ENSMUST00000047023.6
Cntln
centlein, centrosomal protein
chr11_-_106999482 1.023 ENSMUST00000018506.6
Kpna2
karyopherin (importin) alpha 2
chr5_-_92348871 1.003 ENSMUST00000038816.6
ENSMUST00000118006.1
Cxcl10

chemokine (C-X-C motif) ligand 10

chr7_+_24884611 0.888 ENSMUST00000108428.1
Rps19
ribosomal protein S19
chr4_-_58553184 0.842 ENSMUST00000145361.1
Lpar1
lysophosphatidic acid receptor 1
chr7_-_16285454 0.828 ENSMUST00000174270.1
Ccdc9
coiled-coil domain containing 9
chr1_+_33669816 0.823 ENSMUST00000051203.5
1700001G17Rik
RIKEN cDNA 1700001G17 gene
chr7_-_16286010 0.798 ENSMUST00000145519.2
Ccdc9
coiled-coil domain containing 9
chr17_+_34982154 0.794 ENSMUST00000173004.1
Lsm2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_-_145935014 0.769 ENSMUST00000001818.4
Crnkl1
Crn, crooked neck-like 1 (Drosophila)
chr7_-_109865586 0.765 ENSMUST00000007423.5
ENSMUST00000106728.2
ENSMUST00000106729.1
Scube2


signal peptide, CUB domain, EGF-like 2


chrY_+_90784738 0.734 ENSMUST00000179483.1
Erdr1
erythroid differentiation regulator 1
chr1_+_179803376 0.685 ENSMUST00000097454.2
Gm10518
predicted gene 10518
chr3_-_142881942 0.684 ENSMUST00000043812.8
Pkn2
protein kinase N2
chr17_-_87025353 0.662 ENSMUST00000024957.6
Pigf
phosphatidylinositol glycan anchor biosynthesis, class F
chr11_+_26593241 0.631 ENSMUST00000089614.4
Gm6899
predicted gene 6899
chrX_+_170009892 0.491 ENSMUST00000180251.1
Gm21887
predicted gene, 21887
chrX_+_71981522 0.484 ENSMUST00000114569.1
Fate1
fetal and adult testis expressed 1
chr5_+_30888852 0.471 ENSMUST00000069705.4
ENSMUST00000031057.8
ENSMUST00000046182.5
ENSMUST00000114704.1
ENSMUST00000061213.6
ENSMUST00000114696.1
ENSMUST00000114700.2
Agbl5






ATP/GTP binding protein-like 5






chr13_-_69533839 0.450 ENSMUST00000044081.7
Papd7
PAP associated domain containing 7
chr2_+_174076296 0.445 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
Stx16


syntaxin 16


chr1_+_157412352 0.380 ENSMUST00000061537.5
2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr17_-_84187939 0.359 ENSMUST00000060366.6
Zfp36l2
zinc finger protein 36, C3H type-like 2
chr7_+_97579868 0.255 ENSMUST00000042399.7
ENSMUST00000107153.1
Rsf1

remodeling and spacing factor 1

chr2_+_71786923 0.233 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6

integrin alpha 6

chr9_+_92250039 0.216 ENSMUST00000093801.3
Plscr1
phospholipid scramblase 1
chr9_+_118926453 0.186 ENSMUST00000073109.5
Ctdspl
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr17_-_35046539 0.148 ENSMUST00000007250.7
Msh5
mutS homolog 5 (E. coli)
chr2_+_145934800 0.089 ENSMUST00000138774.1
ENSMUST00000152515.1
ENSMUST00000130168.1
ENSMUST00000133433.1
ENSMUST00000118002.1
4930529M08Rik




RIKEN cDNA 4930529M08 gene




chrX_+_105079761 0.014 ENSMUST00000119477.1
Pbdc1
polysaccharide biosynthesis domain containing 1
chr9_+_99456243 0.007 ENSMUST00000163199.2
1600029I14Rik
RIKEN cDNA 1600029I14 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 21.2 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) regulation of protein localization to chromatin(GO:1905634)
3.4 10.2 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
3.1 55.9 GO:0015816 glycine transport(GO:0015816)
2.9 54.7 GO:0070986 left/right axis specification(GO:0070986)
2.8 13.8 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
2.7 8.1 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
2.2 13.4 GO:0060623 regulation of chromosome condensation(GO:0060623)
1.9 5.6 GO:1901074 aminophospholipid transport(GO:0015917) regulation of engulfment of apoptotic cell(GO:1901074)
1.8 5.5 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
1.8 7.2 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
1.8 7.2 GO:0046125 pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
1.8 16.0 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.7 6.7 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.7 6.7 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990) negative regulation of t-circle formation(GO:1904430) regulation of telomeric loop disassembly(GO:1904533)
1.6 24.7 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
1.6 11.2 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) potassium ion import across plasma membrane(GO:1990573)
1.4 4.3 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
1.4 11.3 GO:0007144 female meiosis I(GO:0007144)
1.4 9.5 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
1.3 38.9 GO:0040034 regulation of development, heterochronic(GO:0040034)
1.3 8.0 GO:0061644 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) protein localization to CENP-A containing chromatin(GO:0061644)
1.2 17.2 GO:0000733 DNA strand renaturation(GO:0000733)
1.2 8.2 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
1.1 66.2 GO:0051290 protein heterotetramerization(GO:0051290)
1.1 10.9 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
1.0 15.2 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
1.0 3.0 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
1.0 3.8 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.9 9.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.9 3.7 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.9 32.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.9 22.3 GO:0010544 negative regulation of platelet activation(GO:0010544)
0.8 4.2 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.8 5.6 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.8 11.0 GO:0046036 CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.8 24.2 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.7 11.0 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.7 10.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.7 6.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.7 9.8 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.7 17.7 GO:0051310 metaphase plate congression(GO:0051310)
0.6 10.4 GO:0031297 replication fork processing(GO:0031297)
0.6 10.7 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.6 5.4 GO:0007000 nucleolus organization(GO:0007000)
0.6 23.7 GO:0006284 base-excision repair(GO:0006284)
0.6 3.4 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.5 27.2 GO:0090307 mitotic spindle assembly(GO:0090307)
0.5 4.6 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.5 5.0 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.4 6.2 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.4 2.5 GO:0044826 viral genome integration into host DNA(GO:0044826)
0.4 4.2 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.4 5.3 GO:0051573 negative regulation of histone H3-K9 methylation(GO:0051573)
0.4 9.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.3 2.8 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.3 4.2 GO:0000012 single strand break repair(GO:0000012)
0.3 13.8 GO:0006270 DNA replication initiation(GO:0006270)
0.3 2.7 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.3 12.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.3 3.2 GO:0035608 protein deglutamylation(GO:0035608)
0.3 1.9 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.3 1.0 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.2 23.2 GO:0007051 spindle organization(GO:0007051)
0.2 2.0 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.2 5.5 GO:0008340 determination of adult lifespan(GO:0008340)
0.2 1.1 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.2 2.5 GO:0051026 chiasma assembly(GO:0051026)
0.2 3.1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.2 2.1 GO:0034508 centromere complex assembly(GO:0034508)
0.2 0.8 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.2 4.5 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.2 15.4 GO:0006334 nucleosome assembly(GO:0006334)
0.2 1.8 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.2 1.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 2.0 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 1.3 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 2.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 2.5 GO:0048148 behavioral response to cocaine(GO:0048148)
0.1 3.2 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1 3.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 4.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.2 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.1 0.4 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 3.7 GO:0045332 phospholipid translocation(GO:0045332)
0.1 6.4 GO:0010212 response to ionizing radiation(GO:0010212)
0.1 3.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 5.7 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 2.7 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 3.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 1.7 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.3 GO:0019835 cytolysis(GO:0019835)
0.0 1.5 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 3.4 GO:0007286 spermatid development(GO:0007286)
0.0 0.2 GO:0035878 nail development(GO:0035878)
0.0 0.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 0.7 GO:0006506 GPI anchor biosynthetic process(GO:0006506)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 34.3 GO:0031262 Ndc80 complex(GO:0031262)
5.4 27.2 GO:0031523 Myb complex(GO:0031523)
3.5 10.4 GO:0035101 FACT complex(GO:0035101)
3.2 9.5 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
2.4 21.2 GO:0008278 cohesin complex(GO:0008278)
2.0 9.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.8 16.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.7 10.2 GO:0070531 BRCA1-A complex(GO:0070531)
1.5 17.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.3 6.4 GO:0070876 SOSS complex(GO:0070876)
1.2 10.7 GO:0030991 intraciliary transport particle A(GO:0030991)
1.2 8.1 GO:0005638 lamin filament(GO:0005638)
1.1 23.5 GO:0031616 spindle pole centrosome(GO:0031616)
1.1 11.1 GO:0031080 nuclear pore outer ring(GO:0031080)
1.0 5.0 GO:0033553 rDNA heterochromatin(GO:0033553)
1.0 6.9 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.9 15.8 GO:0001673 male germ cell nucleus(GO:0001673)
0.9 6.4 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.8 4.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.8 13.8 GO:0001527 microfibril(GO:0001527)
0.8 3.8 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.6 20.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.5 15.2 GO:0051233 spindle midzone(GO:0051233)
0.5 57.1 GO:0005882 intermediate filament(GO:0005882)
0.5 5.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.5 3.4 GO:0032300 mismatch repair complex(GO:0032300)
0.4 3.7 GO:0034709 methylosome(GO:0034709)
0.4 47.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.4 15.1 GO:0000786 nucleosome(GO:0000786)
0.4 1.1 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.3 1.2 GO:0008537 proteasome activator complex(GO:0008537)
0.3 25.4 GO:0000922 spindle pole(GO:0000922)
0.3 13.4 GO:0000793 condensed chromosome(GO:0000793)
0.2 13.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 9.5 GO:0042555 MCM complex(GO:0042555) MCM core complex(GO:0097373)
0.2 5.6 GO:0001891 phagocytic cup(GO:0001891)
0.1 14.7 GO:0043198 dendritic shaft(GO:0043198)
0.1 15.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 8.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 10.0 GO:0030315 T-tubule(GO:0030315)
0.1 0.8 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 7.7 GO:0005795 Golgi stack(GO:0005795)
0.1 2.7 GO:0060077 inhibitory synapse(GO:0060077)
0.1 2.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 3.1 GO:0015030 Cajal body(GO:0015030)
0.1 1.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 11.2 GO:0001650 fibrillar center(GO:0001650)
0.1 3.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 20.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 5.3 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 6.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 8.3 GO:0005930 axoneme(GO:0005930)
0.0 3.9 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 9.1 GO:0043025 neuronal cell body(GO:0043025)
0.0 12.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.7 GO:0016235 aggresome(GO:0016235)
0.0 2.1 GO:0005643 nuclear pore(GO:0005643)
0.0 2.8 GO:0000932 P-body(GO:0000932)
0.0 16.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 6.6 GO:0005925 focal adhesion(GO:0005925)
0.0 0.3 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.5 GO:0016592 mediator complex(GO:0016592) core mediator complex(GO:0070847)
0.0 1.1 GO:0045177 apical part of cell(GO:0045177)
0.0 14.8 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 45.3 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
4.7 23.7 GO:0000405 bubble DNA binding(GO:0000405)
3.7 11.2 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
3.1 42.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
2.8 11.0 GO:0003883 CTP synthase activity(GO:0003883)
2.5 27.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
2.3 6.9 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
2.1 6.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
1.9 9.5 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
1.9 13.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.9 5.6 GO:0030226 aminophospholipid transporter activity(GO:0015247) apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
1.8 7.2 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
1.7 17.2 GO:0036310 annealing helicase activity(GO:0036310)
1.5 16.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.2 7.2 GO:0031493 nucleosomal histone binding(GO:0031493) histone threonine kinase activity(GO:0035184)
1.1 3.4 GO:0032137 guanine/thymine mispair binding(GO:0032137) single guanine insertion binding(GO:0032142)
1.0 3.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.0 6.7 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.9 3.7 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.8 5.5 GO:0015616 DNA translocase activity(GO:0015616)
0.8 36.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.7 4.3 GO:1902944 PH domain binding(GO:0042731) aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902944)
0.6 3.8 GO:0000150 recombinase activity(GO:0000150)
0.6 17.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.6 5.0 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.5 2.0 GO:0097003 adipokinetic hormone receptor activity(GO:0097003) adipokinetic hormone binding(GO:0097004)
0.5 24.2 GO:0050699 WW domain binding(GO:0050699)
0.5 17.7 GO:0070840 dynein complex binding(GO:0070840)
0.5 2.5 GO:0030983 mismatched DNA binding(GO:0030983)
0.4 3.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.4 9.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 13.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.3 9.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 8.1 GO:0008432 JUN kinase binding(GO:0008432)
0.3 9.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 13.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 14.8 GO:0003684 damaged DNA binding(GO:0003684)
0.2 42.8 GO:0008301 DNA binding, bending(GO:0008301)
0.2 20.0 GO:0005518 collagen binding(GO:0005518)
0.2 2.7 GO:0030274 LIM domain binding(GO:0030274)
0.2 9.7 GO:0008378 galactosyltransferase activity(GO:0008378)
0.2 1.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 1.9 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.2 10.5 GO:0070888 E-box binding(GO:0070888)
0.2 4.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 15.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 0.8 GO:0097108 hedgehog family protein binding(GO:0097108)
0.1 1.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 3.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 3.2 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 4.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 11.6 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.1 2.8 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.1 3.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 4.2 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.0 GO:0016208 AMP binding(GO:0016208)
0.1 11.8 GO:0042393 histone binding(GO:0042393)
0.1 22.4 GO:0008017 microtubule binding(GO:0008017)
0.1 1.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 2.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 1.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 2.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.5 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 2.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.2 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 5.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.2 GO:0038132 neuregulin binding(GO:0038132)
0.0 8.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.7 GO:0004697 protein kinase C activity(GO:0004697)
0.0 7.7 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 2.5 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.7 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 2.1 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 59.8 PID_ATR_PATHWAY ATR signaling pathway
1.0 13.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.8 33.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.5 16.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 47.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 30.9 PID_E2F_PATHWAY E2F transcription factor network
0.3 10.0 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 10.4 ST_GAQ_PATHWAY G alpha q Pathway
0.3 11.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 8.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 4.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 6.7 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 5.0 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 0.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 9.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 15.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 4.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.1 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.0 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.5 PID_LKB1_PATHWAY LKB1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 24.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
2.2 56.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
1.5 22.3 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
1.4 9.5 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
1.2 10.9 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.1 15.7 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
1.1 9.8 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.9 42.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.8 40.5 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.6 9.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.6 11.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.6 6.9 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.6 1.7 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.5 60.9 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.5 9.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.4 10.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 11.0 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4 7.2 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.3 9.7 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.3 2.5 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.3 8.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 5.6 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 2.7 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2 17.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 11.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 3.7 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.2 4.2 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.1 2.5 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 2.0 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 3.1 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 3.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.1 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 4.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 7.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 4.3 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.0 1.1 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.4 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.7 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.2 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6