Motif ID: E2f7

Z-value: 1.400


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.835.3e-10Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_108579445 15.058 ENSMUST00000102744.3
Orc1
origin recognition complex, subunit 1
chr7_-_142578139 11.193 ENSMUST00000136359.1
H19
H19 fetal liver mRNA
chr15_+_102296256 10.134 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr13_-_100775844 9.679 ENSMUST00000075550.3
Cenph
centromere protein H
chr12_+_24708984 8.706 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr10_+_3973086 8.655 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr13_-_21833575 8.134 ENSMUST00000081342.5
Hist1h2ap
histone cluster 1, H2ap
chr11_+_102248842 8.075 ENSMUST00000100392.4
BC030867
cDNA sequence BC030867
chr13_-_21753851 7.680 ENSMUST00000074752.2
Hist1h2ak
histone cluster 1, H2ak
chr12_+_24708241 7.501 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr4_+_136172367 7.391 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr10_-_69352886 7.123 ENSMUST00000119827.1
ENSMUST00000020099.5
Cdk1

cyclin-dependent kinase 1

chr3_+_108383829 6.104 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
Psrc1


proline/serine-rich coiled-coil 1


chr9_-_58741543 6.076 ENSMUST00000098674.4
2410076I21Rik
RIKEN cDNA 2410076I21 gene
chr14_-_54641347 5.790 ENSMUST00000067784.6
Cdh24
cadherin-like 24
chr4_+_126556994 5.746 ENSMUST00000147675.1
Clspn
claspin
chr8_+_75109528 5.710 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr4_+_126556935 5.671 ENSMUST00000048391.8
Clspn
claspin
chr2_+_72476159 5.393 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr6_-_88898664 5.106 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr13_-_22042949 4.727 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr13_+_21810428 4.721 ENSMUST00000091745.5
Hist1h2ao
histone cluster 1, H2ao
chr2_+_72476225 4.630 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr13_+_22043189 4.616 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr18_+_56707725 4.405 ENSMUST00000025486.8
Lmnb1
lamin B1
chr10_+_11281304 4.343 ENSMUST00000129456.1
Fbxo30
F-box protein 30
chr10_+_11281583 4.328 ENSMUST00000070300.4
Fbxo30
F-box protein 30
chr7_-_44548733 3.961 ENSMUST00000145956.1
ENSMUST00000049343.8
Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr12_+_73286868 3.935 ENSMUST00000153941.1
ENSMUST00000122920.1
ENSMUST00000101313.3
Slc38a6


solute carrier family 38, member 6


chr13_-_21783391 3.784 ENSMUST00000099704.3
Hist1h3i
histone cluster 1, H3i
chr11_-_69560186 3.704 ENSMUST00000004036.5
Efnb3
ephrin B3
chr14_-_20388822 3.700 ENSMUST00000022345.6
Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr12_-_11265768 3.585 ENSMUST00000166117.1
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr9_+_3017408 3.474 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr6_-_67037399 3.433 ENSMUST00000043098.6
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr13_-_55329723 3.392 ENSMUST00000021941.7
Mxd3
Max dimerization protein 3
chr1_-_128359610 3.256 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr17_-_35516780 3.113 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19


transcription factor 19


chr7_+_66109474 3.037 ENSMUST00000036372.6
Chsy1
chondroitin sulfate synthase 1
chr13_+_23581563 2.887 ENSMUST00000102968.1
Hist1h4d
histone cluster 1, H4d
chr3_+_88532314 2.807 ENSMUST00000172699.1
Mex3a
mex3 homolog A (C. elegans)
chr4_+_132768325 2.790 ENSMUST00000102561.4
Rpa2
replication protein A2
chr1_-_180813591 2.756 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3f3a


H3 histone, family 3A


chr11_-_87404380 2.694 ENSMUST00000067692.6
Rad51c
RAD51 homolog C
chr9_+_64281575 2.606 ENSMUST00000034964.6
Tipin
timeless interacting protein
chr9_+_3015654 2.600 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr13_+_21716385 2.535 ENSMUST00000070124.3
Hist1h2ai
histone cluster 1, H2ai
chr13_+_23555023 2.481 ENSMUST00000045301.6
Hist1h1d
histone cluster 1, H1d
chr1_-_156474249 2.460 ENSMUST00000051396.6
Soat1
sterol O-acyltransferase 1
chr13_-_22035589 2.427 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr9_+_3013140 2.426 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr11_-_70410010 2.389 ENSMUST00000019065.3
ENSMUST00000135148.1
Pelp1

proline, glutamic acid and leucine rich protein 1

chr10_-_35711891 2.220 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chrX_+_153006461 2.202 ENSMUST00000095755.3
Usp51
ubiquitin specific protease 51
chr14_+_79451791 2.170 ENSMUST00000100359.1
Zbtbd6
kelch repeat and BTB (POZ) domain containing 6
chr7_+_35802593 2.138 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr9_+_3025417 2.101 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr13_+_23574381 2.090 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr13_+_109685994 2.045 ENSMUST00000074103.5
Pde4d
phosphodiesterase 4D, cAMP specific
chrX_-_37085402 1.995 ENSMUST00000115231.3
Rpl39
ribosomal protein L39
chr16_+_38346986 1.992 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
Cox17

Gm21987
cytochrome c oxidase assembly protein 17

predicted gene 21987
chr18_+_44104407 1.979 ENSMUST00000081271.5
Spink12
serine peptidase inhibitor, Kazal type 11
chr1_+_172521044 1.973 ENSMUST00000085894.5
ENSMUST00000161140.1
ENSMUST00000162988.1
Ccdc19


coiled-coil domain containing 19


chr7_+_110122299 1.956 ENSMUST00000033326.8
Wee1
WEE 1 homolog 1 (S. pombe)
chr15_+_82298943 1.813 ENSMUST00000023089.3
Wbp2nl
WBP2 N-terminal like
chr1_+_74506044 1.787 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr1_+_136683375 1.760 ENSMUST00000181524.1
Gm19705
predicted gene, 19705
chr9_+_3037111 1.737 ENSMUST00000177969.1
Gm10715
predicted gene 10715
chr5_+_129020069 1.730 ENSMUST00000031383.7
ENSMUST00000111343.1
Ran

RAN, member RAS oncogene family

chr4_+_124714776 1.714 ENSMUST00000030734.4
Sf3a3
splicing factor 3a, subunit 3
chr10_-_117376922 1.554 ENSMUST00000177145.1
ENSMUST00000176670.1
Cpsf6

cleavage and polyadenylation specific factor 6

chr13_+_21754067 1.430 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr5_+_135187251 1.425 ENSMUST00000002825.5
Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr9_+_44334685 1.412 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chr15_+_84720052 1.382 ENSMUST00000006029.4
ENSMUST00000172307.2
Arhgap8

Rho GTPase activating protein 8

chr19_+_8723478 1.381 ENSMUST00000180819.1
ENSMUST00000181422.1
Snhg1

small nucleolar RNA host gene (non-protein coding) 1

chrX_+_68678541 1.336 ENSMUST00000088546.5
Fmr1
fragile X mental retardation syndrome 1
chr3_+_14533817 1.295 ENSMUST00000169079.1
ENSMUST00000091325.3
Lrrcc1

leucine rich repeat and coiled-coil domain containing 1

chr12_-_12941827 1.286 ENSMUST00000043396.7
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr7_-_28598140 1.270 ENSMUST00000108283.1
ENSMUST00000040531.8
Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chr7_-_45896656 1.257 ENSMUST00000120299.1
Syngr4
synaptogyrin 4
chr17_+_34850373 1.245 ENSMUST00000097343.4
ENSMUST00000173357.1
ENSMUST00000173065.1
ENSMUST00000165953.2
Nelfe



negative elongation factor complex member E, Rdbp



chr2_-_157204483 1.141 ENSMUST00000029170.7
Rbl1
retinoblastoma-like 1 (p107)
chr11_-_106301801 1.132 ENSMUST00000103071.3
Gh
growth hormone
chr1_+_118389058 1.104 ENSMUST00000049404.6
ENSMUST00000070989.7
ENSMUST00000165223.1
ENSMUST00000178710.1
Clasp1



CLIP associating protein 1



chr7_+_28169744 1.076 ENSMUST00000042405.6
Fbl
fibrillarin
chr10_-_117376955 1.055 ENSMUST00000069168.6
ENSMUST00000176686.1
Cpsf6

cleavage and polyadenylation specific factor 6

chr11_+_43681998 1.040 ENSMUST00000061070.5
Pwwp2a
PWWP domain containing 2A
chr4_-_108579330 1.038 ENSMUST00000079213.5
Prpf38a
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
chr11_+_43682038 1.033 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr3_+_14533788 0.997 ENSMUST00000108370.2
Lrrcc1
leucine rich repeat and coiled-coil domain containing 1
chr11_+_87127267 0.889 ENSMUST00000139532.1
Trim37
tripartite motif-containing 37
chr15_-_81871883 0.882 ENSMUST00000023117.8
Phf5a
PHD finger protein 5A
chr7_+_44816088 0.872 ENSMUST00000057195.9
ENSMUST00000107891.1
Nup62

nucleoporin 62

chrX_-_73966329 0.867 ENSMUST00000114372.2
ENSMUST00000033761.6
Hcfc1

host cell factor C1

chr1_-_191183244 0.865 ENSMUST00000027941.8
Atf3
activating transcription factor 3
chr13_+_22035821 0.858 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr2_+_179442427 0.848 ENSMUST00000000314.6
Cdh4
cadherin 4
chr17_-_35046726 0.837 ENSMUST00000097338.4
Msh5
mutS homolog 5 (E. coli)
chr3_-_57847478 0.785 ENSMUST00000120289.1
ENSMUST00000066882.8
Pfn2

profilin 2

chr12_+_55836365 0.779 ENSMUST00000059250.6
Brms1l
breast cancer metastasis-suppressor 1-like
chr3_+_14533867 0.767 ENSMUST00000163660.1
Lrrcc1
leucine rich repeat and coiled-coil domain containing 1
chr4_+_136286061 0.746 ENSMUST00000069195.4
ENSMUST00000130658.1
Zfp46

zinc finger protein 46

chr11_-_77513335 0.729 ENSMUST00000060417.4
Trp53i13
transformation related protein 53 inducible protein 13
chr5_-_137533170 0.703 ENSMUST00000168746.1
ENSMUST00000170293.1
Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr7_-_45694369 0.688 ENSMUST00000040636.6
Sec1
secretory blood group 1
chr4_+_94739276 0.624 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek

endothelial-specific receptor tyrosine kinase

chr9_-_121277160 0.587 ENSMUST00000051479.6
ENSMUST00000171923.1
Ulk4

unc-51-like kinase 4

chr17_+_12916329 0.497 ENSMUST00000089024.6
ENSMUST00000151287.1
ENSMUST00000143961.1
Tcp1


t-complex protein 1


chr13_-_21810190 0.486 ENSMUST00000110469.1
ENSMUST00000091749.2
Hist1h2bq

histone cluster 1, H2bq

chr12_+_112146187 0.477 ENSMUST00000128402.2
Kif26a
kinesin family member 26A
chrX_+_162760388 0.469 ENSMUST00000033720.5
ENSMUST00000112327.1
Rbbp7

retinoblastoma binding protein 7

chr11_+_85311232 0.446 ENSMUST00000020835.9
Ppm1d
protein phosphatase 1D magnesium-dependent, delta isoform
chrX_+_68678624 0.427 ENSMUST00000114656.1
Fmr1
fragile X mental retardation syndrome 1
chr2_+_147364989 0.421 ENSMUST00000109968.2
Pax1
paired box gene 1
chr19_+_34550664 0.383 ENSMUST00000149829.1
ENSMUST00000102826.3
Ifit2

interferon-induced protein with tetratricopeptide repeats 2

chr17_-_34850162 0.366 ENSMUST00000046022.9
Skiv2l
superkiller viralicidic activity 2-like (S. cerevisiae)
chr11_+_88047693 0.340 ENSMUST00000079866.4
Srsf1
serine/arginine-rich splicing factor 1
chr1_+_180568913 0.336 ENSMUST00000027777.6
Parp1
poly (ADP-ribose) polymerase family, member 1
chr13_-_21716143 0.297 ENSMUST00000091756.1
Hist1h2bl
histone cluster 1, H2bl
chrX_+_71981522 0.295 ENSMUST00000114569.1
Fate1
fetal and adult testis expressed 1
chr6_-_52183828 0.285 ENSMUST00000134831.1
Hoxa3
homeobox A3
chr6_-_30509706 0.241 ENSMUST00000064330.6
ENSMUST00000102991.2
ENSMUST00000115157.1
ENSMUST00000148638.1
Tmem209



transmembrane protein 209



chr15_-_98093245 0.225 ENSMUST00000180657.1
Senp1
SUMO1/sentrin specific peptidase 1
chr13_-_97198351 0.170 ENSMUST00000022169.7
Hexb
hexosaminidase B
chr3_+_60501252 0.162 ENSMUST00000099087.2
Mbnl1
muscleblind-like 1 (Drosophila)
chr17_+_35517100 0.133 ENSMUST00000164242.2
ENSMUST00000045956.7
Cchcr1

coiled-coil alpha-helical rod protein 1

chr5_-_92348871 0.102 ENSMUST00000038816.6
ENSMUST00000118006.1
Cxcl10

chemokine (C-X-C motif) ligand 10

chr17_+_33524170 0.093 ENSMUST00000087623.6
Adamts10
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
chr6_+_113077631 0.086 ENSMUST00000113157.1
Setd5
SET domain containing 5
chr9_+_111271832 0.081 ENSMUST00000060711.5
Epm2aip1
EPM2A (laforin) interacting protein 1
chr2_+_11172080 0.022 ENSMUST00000114853.1
Prkcq
protein kinase C, theta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 15.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
1.5 4.4 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
1.4 8.7 GO:0046654 10-formyltetrahydrofolate metabolic process(GO:0009256) tetrahydrofolate biosynthetic process(GO:0046654)
1.4 7.1 GO:1905448 positive regulation of mitochondrial ATP synthesis coupled electron transport(GO:1905448)
1.3 4.0 GO:0045004 DNA replication proofreading(GO:0045004)
1.1 7.4 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
1.0 11.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.9 16.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.9 11.2 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.8 8.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.7 2.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.7 2.8 GO:1902340 negative regulation of chromosome condensation(GO:1902340)
0.7 2.7 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.7 2.0 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.6 10.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.6 1.8 GO:0099578 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.5 2.6 GO:0000076 DNA replication checkpoint(GO:0000076)
0.4 3.7 GO:0016198 axon choice point recognition(GO:0016198)
0.4 3.6 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.3 5.3 GO:0051382 kinetochore assembly(GO:0051382)
0.3 2.5 GO:0016584 nucleosome positioning(GO:0016584)
0.3 3.0 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.3 0.9 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.3 0.9 GO:0019045 latent virus replication(GO:0019045) release from viral latency(GO:0019046)
0.2 2.5 GO:0042984 very-low-density lipoprotein particle assembly(GO:0034379) amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2 24.7 GO:0006342 chromatin silencing(GO:0006342)
0.2 1.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 0.9 GO:1903984 regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.2 6.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 1.1 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.2 1.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 6.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 0.9 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353) negative regulation of centriole replication(GO:0046600)
0.2 2.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 2.0 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 3.4 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 5.7 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.4 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.1 1.8 GO:0007343 egg activation(GO:0007343)
0.1 1.2 GO:1900364 negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA polyadenylation(GO:1900364)
0.1 2.4 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 2.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.5 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.1 0.5 GO:0010286 heat acclimation(GO:0010286)
0.1 0.3 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.1 1.3 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1 3.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 0.5 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.1 0.4 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1 0.8 GO:0051026 chiasma assembly(GO:0051026)
0.1 2.2 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.4 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.4 GO:0061056 sclerotome development(GO:0061056)
0.1 0.8 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 6.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.6 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 1.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.3 GO:0010159 specification of animal organ position(GO:0010159)
0.0 1.1 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.0 3.7 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 2.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.7 GO:0036065 fucosylation(GO:0036065)
0.0 0.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.4 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.1 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.0 0.2 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.6 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 1.1 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.1 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 1.7 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 2.0 GO:0030010 establishment of cell polarity(GO:0030010)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 16.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.5 20.2 GO:0005664 nuclear origin of replication recognition complex(GO:0005664)
1.3 4.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.6 4.4 GO:0005638 lamin filament(GO:0005638)
0.6 1.7 GO:0031074 nucleocytoplasmic transport complex(GO:0031074)
0.5 2.7 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.4 1.8 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.4 2.8 GO:0001740 Barr body(GO:0001740)
0.4 2.6 GO:0031298 replication fork protection complex(GO:0031298)
0.4 0.4 GO:0055087 Ski complex(GO:0055087)
0.3 2.6 GO:0042382 paraspeckles(GO:0042382)
0.3 1.2 GO:0032021 NELF complex(GO:0032021)
0.3 20.6 GO:0000786 nucleosome(GO:0000786)
0.3 1.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.2 13.2 GO:0005876 spindle microtubule(GO:0005876)
0.2 1.1 GO:0001651 dense fibrillar component(GO:0001651)
0.2 9.6 GO:0042555 MCM complex(GO:0042555) MCM core complex(GO:0097373)
0.2 3.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 10.5 GO:0005844 polysome(GO:0005844)
0.1 11.0 GO:0072686 mitotic spindle(GO:0072686)
0.1 2.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 1.9 GO:0071011 precatalytic spliceosome(GO:0071011)
0.1 0.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 1.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 10.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.8 GO:0070822 Sin3-type complex(GO:0070822)
0.0 5.3 GO:0000776 kinetochore(GO:0000776)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 2.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.5 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 16.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.2 8.7 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
2.2 10.8 GO:0043515 kinetochore binding(GO:0043515)
1.9 11.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.0 3.0 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.8 6.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.7 10.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 1.4 GO:0008434 calcitriol receptor activity(GO:0008434) calcitriol binding(GO:1902098)
0.4 5.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.3 7.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.3 2.2 GO:0019808 polyamine binding(GO:0019808)
0.3 1.7 GO:0070883 pre-miRNA binding(GO:0070883)
0.3 4.0 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.3 1.8 GO:0033592 RNA strand annealing activity(GO:0033592)
0.2 2.0 GO:0016531 copper chaperone activity(GO:0016531)
0.2 0.7 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.2 4.4 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.9 GO:0051425 PTB domain binding(GO:0051425)
0.1 1.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 6.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.3 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 0.9 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 3.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.4 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.2 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 1.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.0 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.1 2.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 3.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 6.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 8.1 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 2.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 10.1 GO:0001047 core promoter binding(GO:0001047)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 1.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 9.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.7 GO:0031072 heat shock protein binding(GO:0031072)
0.0 3.1 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 6.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.8 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 1.7 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 6.7 GO:0003682 chromatin binding(GO:0003682)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.1 GO:0005179 hormone activity(GO:0005179)
0.0 5.9 GO:0046982 protein heterodimerization activity(GO:0046982)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 9.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5 7.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5 21.9 PID_ATR_PATHWAY ATR signaling pathway
0.4 32.4 PID_E2F_PATHWAY E2F transcription factor network
0.2 2.5 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.1 5.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.4 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.1 8.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 3.7 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 1.4 PID_ATM_PATHWAY ATM pathway
0.1 2.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 22.2 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
1.5 7.4 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.2 16.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.1 14.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.8 6.8 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.4 21.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 6.5 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 2.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 6.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 2.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 3.0 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 3.5 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 4.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.6 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 1.1 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 1.9 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 2.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.2 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 2.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.9 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.2 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.5 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 2.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.7 REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.0 0.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity