Motif ID: E2f8

Z-value: 1.494


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.774.3e-08Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_90695706 18.194 ENSMUST00000069960.5
ENSMUST00000117167.1
S100a9

S100 calcium binding protein A9 (calgranulin B)

chr10_-_21160925 14.616 ENSMUST00000020158.6
Myb
myeloblastosis oncogene
chr12_+_109540979 12.592 ENSMUST00000129245.1
ENSMUST00000143836.1
ENSMUST00000124106.1
Meg3


maternally expressed 3


chr11_+_98907801 11.591 ENSMUST00000092706.6
Cdc6
cell division cycle 6
chr17_+_56303321 11.402 ENSMUST00000001258.8
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr2_+_163054682 11.389 ENSMUST00000018005.3
Mybl2
myeloblastosis oncogene-like 2
chr5_+_123749696 10.866 ENSMUST00000031366.7
Kntc1
kinetochore associated 1
chr17_+_56303396 10.527 ENSMUST00000113038.1
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr8_+_75109528 10.178 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr12_+_24708984 9.210 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr17_+_56040350 9.115 ENSMUST00000002914.8
Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr6_-_88898664 8.409 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr16_-_18811615 8.227 ENSMUST00000096990.3
Cdc45
cell division cycle 45
chr12_+_24708241 7.703 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr1_-_128359610 7.279 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr9_-_36726374 7.084 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
Chek1


checkpoint kinase 1


chr10_+_128015157 6.218 ENSMUST00000178041.1
ENSMUST00000026461.7
Prim1

DNA primase, p49 subunit

chr2_-_34913976 5.862 ENSMUST00000028232.3
Phf19
PHD finger protein 19
chr8_-_107065632 5.348 ENSMUST00000034393.5
Tmed6
transmembrane emp24 protein transport domain containing 6
chr16_-_15637277 5.250 ENSMUST00000023353.3
Mcm4
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr19_+_38931008 4.885 ENSMUST00000145051.1
Hells
helicase, lymphoid specific
chr13_+_19623163 4.846 ENSMUST00000002883.5
Sfrp4
secreted frizzled-related protein 4
chr15_+_61985540 4.435 ENSMUST00000159327.1
ENSMUST00000167731.1
Myc

myelocytomatosis oncogene

chr11_-_101785252 4.411 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr15_+_61985377 4.323 ENSMUST00000161976.1
ENSMUST00000022971.7
Myc

myelocytomatosis oncogene

chr7_-_44548733 4.283 ENSMUST00000145956.1
ENSMUST00000049343.8
Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr12_+_110279228 3.921 ENSMUST00000097228.4
Dio3
deiodinase, iodothyronine type III
chr6_+_35177610 3.840 ENSMUST00000170234.1
Nup205
nucleoporin 205
chr17_+_8525369 3.826 ENSMUST00000115715.1
Pde10a
phosphodiesterase 10A
chr19_+_38930909 3.807 ENSMUST00000025965.5
Hells
helicase, lymphoid specific
chr6_+_35177386 3.449 ENSMUST00000043815.9
Nup205
nucleoporin 205
chr7_-_115824699 3.234 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr7_+_102065713 3.214 ENSMUST00000094129.2
ENSMUST00000094130.2
ENSMUST00000084843.3
Trpc2


transient receptor potential cation channel, subfamily C, member 2


chr3_-_126998408 3.192 ENSMUST00000182764.1
ENSMUST00000044443.8
Ank2

ankyrin 2, brain

chr2_-_45113255 3.127 ENSMUST00000068415.4
ENSMUST00000127520.1
Zeb2

zinc finger E-box binding homeobox 2

chr7_+_110122299 3.119 ENSMUST00000033326.8
Wee1
WEE 1 homolog 1 (S. pombe)
chr4_+_132768325 3.043 ENSMUST00000102561.4
Rpa2
replication protein A2
chr9_+_103305156 2.991 ENSMUST00000035164.3
Topbp1
topoisomerase (DNA) II binding protein 1
chr10_+_42860348 2.919 ENSMUST00000063063.7
Scml4
sex comb on midleg-like 4 (Drosophila)
chr5_-_33652296 2.863 ENSMUST00000151081.1
ENSMUST00000101354.3
Slbp

stem-loop binding protein

chr2_-_154569845 2.784 ENSMUST00000103145.4
E2f1
E2F transcription factor 1
chr7_+_102065485 2.720 ENSMUST00000106950.1
ENSMUST00000146450.1
Trpc2

transient receptor potential cation channel, subfamily C, member 2

chr16_+_10835046 2.297 ENSMUST00000037913.8
Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chrX_+_49470450 2.240 ENSMUST00000114904.3
Arhgap36
Rho GTPase activating protein 36
chrX_+_49470555 2.228 ENSMUST00000042444.6
Arhgap36
Rho GTPase activating protein 36
chr5_-_33652339 2.222 ENSMUST00000075670.6
Slbp
stem-loop binding protein
chr2_-_45112890 2.084 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr15_+_78926720 2.056 ENSMUST00000089377.5
Lgals1
lectin, galactose binding, soluble 1
chr2_-_154569720 2.032 ENSMUST00000000894.5
E2f1
E2F transcription factor 1
chr10_-_128525859 1.880 ENSMUST00000026427.6
Esyt1
extended synaptotagmin-like protein 1
chr13_+_44731265 1.818 ENSMUST00000173246.1
Jarid2
jumonji, AT rich interactive domain 2
chr7_-_48881596 1.701 ENSMUST00000119223.1
E2f8
E2F transcription factor 8
chr17_+_34377124 1.579 ENSMUST00000080254.5
Btnl1
butyrophilin-like 1
chr2_-_45113216 1.538 ENSMUST00000124942.1
Zeb2
zinc finger E-box binding homeobox 2
chr13_-_66851513 1.450 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr5_+_129020069 1.447 ENSMUST00000031383.7
ENSMUST00000111343.1
Ran

RAN, member RAS oncogene family

chr13_+_44731281 1.253 ENSMUST00000174086.1
Jarid2
jumonji, AT rich interactive domain 2
chr5_+_135187251 1.214 ENSMUST00000002825.5
Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr5_-_65335564 1.208 ENSMUST00000172780.1
Rfc1
replication factor C (activator 1) 1
chr2_-_157204483 1.179 ENSMUST00000029170.7
Rbl1
retinoblastoma-like 1 (p107)
chr15_+_101174096 1.179 ENSMUST00000000544.9
Acvr1b
activin A receptor, type 1B
chr6_-_125286015 1.067 ENSMUST00000088246.5
Tuba3a
tubulin, alpha 3A
chr16_+_15637844 0.977 ENSMUST00000023352.8
Prkdc
protein kinase, DNA activated, catalytic polypeptide
chr17_+_33909481 0.952 ENSMUST00000173626.1
ENSMUST00000174541.1
Daxx

Fas death domain-associated protein

chr5_+_111581422 0.922 ENSMUST00000064930.3
C130026L21Rik
RIKEN cDNA C130026L21 gene
chr15_+_55557575 0.875 ENSMUST00000170046.1
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr5_+_150673739 0.858 ENSMUST00000016569.4
ENSMUST00000038900.8
Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chrX_+_153832225 0.846 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
Spin2c


spindlin family, member 2C


chr11_+_88047693 0.806 ENSMUST00000079866.4
Srsf1
serine/arginine-rich splicing factor 1
chr11_+_26387194 0.801 ENSMUST00000109509.1
ENSMUST00000136830.1
Fancl

Fanconi anemia, complementation group L

chr15_+_55557399 0.712 ENSMUST00000022998.7
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr12_-_12941827 0.712 ENSMUST00000043396.7
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr7_-_48881032 0.700 ENSMUST00000058745.8
E2f8
E2F transcription factor 8
chr17_+_33909577 0.698 ENSMUST00000170075.2
Daxx
Fas death domain-associated protein
chr12_+_55836365 0.671 ENSMUST00000059250.6
Brms1l
breast cancer metastasis-suppressor 1-like
chr15_-_98093245 0.659 ENSMUST00000180657.1
Senp1
SUMO1/sentrin specific peptidase 1
chr6_+_38551786 0.553 ENSMUST00000161227.1
Luc7l2
LUC7-like 2 (S. cerevisiae)
chr14_+_55222005 0.467 ENSMUST00000022820.5
Dhrs2
dehydrogenase/reductase member 2
chr4_+_129189760 0.431 ENSMUST00000106054.2
ENSMUST00000001365.2
Yars

tyrosyl-tRNA synthetase

chr11_+_79993062 0.369 ENSMUST00000017692.8
ENSMUST00000163272.1
Suz12

suppressor of zeste 12 homolog (Drosophila)

chr1_-_168431896 0.340 ENSMUST00000176540.1
Pbx1
pre B cell leukemia homeobox 1
chr3_-_127553233 0.267 ENSMUST00000029588.5
Larp7
La ribonucleoprotein domain family, member 7
chr13_-_66852017 0.251 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chrX_-_41911877 0.249 ENSMUST00000047037.8
Thoc2
THO complex 2
chr5_-_65335597 0.165 ENSMUST00000172660.1
ENSMUST00000172732.1
ENSMUST00000031092.8
Rfc1


replication factor C (activator 1) 1


chr1_+_131910458 0.141 ENSMUST00000062264.6
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr8_+_40926220 0.130 ENSMUST00000034004.9
Pdgfrl
platelet-derived growth factor receptor-like
chr13_+_94875600 0.110 ENSMUST00000022195.10
Otp
orthopedia homolog (Drosophila)
chr4_-_129189600 0.092 ENSMUST00000117497.1
ENSMUST00000117350.1
S100pbp

S100P binding protein

chr17_+_33909409 0.079 ENSMUST00000173028.1
ENSMUST00000079421.7
Daxx

Fas death domain-associated protein

chr10_+_19356558 0.060 ENSMUST00000053225.5
Olig3
oligodendrocyte transcription factor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.2 GO:0070488 neutrophil aggregation(GO:0070488)
2.7 8.2 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
2.4 7.1 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
2.2 8.8 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
2.1 20.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
2.0 30.6 GO:0010216 maintenance of DNA methylation(GO:0010216)
1.6 4.8 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of sodium-dependent phosphate transport(GO:2000118)
1.4 4.3 GO:0045004 DNA replication proofreading(GO:0045004)
1.2 4.8 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
1.2 2.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.2 5.9 GO:0002121 inter-male aggressive behavior(GO:0002121)
1.2 17.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
1.1 6.7 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
1.0 1.0 GO:2001228 regulation of response to gamma radiation(GO:2001228)
0.9 16.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.8 5.9 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.6 21.8 GO:0006270 DNA replication initiation(GO:0006270)
0.6 4.4 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.5 1.6 GO:0045062 extrathymic T cell selection(GO:0045062)
0.5 7.3 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.5 5.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.4 1.7 GO:0072737 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.4 12.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.4 3.9 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.4 6.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.4 3.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 2.1 GO:0002317 plasma cell differentiation(GO:0002317)
0.3 1.6 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.3 3.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.3 9.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 1.2 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.2 1.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 11.4 GO:0090307 mitotic spindle assembly(GO:0090307)
0.2 3.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 3.0 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.2 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.1 0.7 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 10.9 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.1 0.9 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 0.7 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1 2.3 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.0 0.2 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.1 GO:0019045 latent virus replication(GO:0019045) release from viral latency(GO:0019046) modulation by host of viral molecular function(GO:0044868) regulation of DNA strand elongation(GO:0060382)
0.0 0.4 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.3 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 1.2 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.1 GO:0097476 spinal cord motor neuron migration(GO:0097476)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.9 GO:1990423 RZZ complex(GO:1990423)
3.4 16.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
3.0 9.1 GO:0033186 CAF-1 complex(GO:0033186)
2.3 11.4 GO:0031523 Myb complex(GO:0031523)
1.5 7.3 GO:0044611 nuclear pore inner ring(GO:0044611)
1.4 4.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.2 6.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.2 8.2 GO:0031298 replication fork protection complex(GO:0031298)
1.1 8.4 GO:0005664 nuclear origin of replication recognition complex(GO:0005664)
1.0 4.8 GO:0035189 Rb-E2F complex(GO:0035189)
0.8 30.4 GO:0005657 replication fork(GO:0005657)
0.7 5.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.6 24.0 GO:0042555 MCM complex(GO:0042555) MCM core complex(GO:0097373)
0.5 1.4 GO:0031074 nucleocytoplasmic transport complex(GO:0031074)
0.4 1.2 GO:0048179 activin receptor complex(GO:0048179)
0.4 9.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 10.5 GO:0051233 spindle midzone(GO:0051233)
0.3 8.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 8.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 3.0 GO:0001673 male germ cell nucleus(GO:0001673)
0.2 1.0 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1 5.9 GO:0032590 dendrite membrane(GO:0032590)
0.1 1.9 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 0.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.7 GO:0001741 XY body(GO:0001741)
0.1 3.2 GO:0031430 M band(GO:0031430)
0.0 0.7 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 14.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 3.1 GO:0043204 perikaryon(GO:0043204)
0.0 17.2 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 21.9 GO:0031493 nucleosomal histone binding(GO:0031493)
3.7 14.6 GO:0071987 WD40-repeat domain binding(GO:0071987)
3.4 16.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.4 7.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
2.3 18.2 GO:0050786 Toll-like receptor 4 binding(GO:0035662) RAGE receptor binding(GO:0050786)
1.7 5.1 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
1.7 26.8 GO:0003688 DNA replication origin binding(GO:0003688)
1.3 3.9 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
1.3 11.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.1 9.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.7 2.1 GO:0048030 disaccharide binding(GO:0048030)
0.5 5.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.4 3.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.4 1.2 GO:0008434 calcitriol receptor activity(GO:0008434) calcitriol binding(GO:1902098)
0.3 1.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.3 12.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 4.3 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.3 7.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 1.4 GO:0070883 pre-miRNA binding(GO:0070883)
0.2 3.0 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.2 0.7 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.2 4.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.2 GO:0016361 activin receptor activity, type I(GO:0016361)
0.2 6.7 GO:0070412 R-SMAD binding(GO:0070412)
0.2 8.8 GO:0070888 E-box binding(GO:0070888)
0.1 6.2 GO:0003899 DNA-directed 5'-3' RNA polymerase activity(GO:0003899)
0.1 1.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 6.0 GO:0140034 methylated histone binding(GO:0035064) methylation-dependent protein binding(GO:0140034)
0.1 3.1 GO:0032452 histone demethylase activity(GO:0032452)
0.1 1.7 GO:0008432 JUN kinase binding(GO:0008432)
0.1 8.7 GO:0004386 helicase activity(GO:0004386)
0.0 3.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 3.2 GO:0030507 spectrin binding(GO:0030507)
0.0 4.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 7.2 GO:0001047 core promoter binding(GO:0001047)
0.0 3.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.7 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 4.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 10.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.6 57.3 PID_E2F_PATHWAY E2F transcription factor network
0.5 18.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.3 11.5 PID_ATR_PATHWAY ATR signaling pathway
0.3 14.6 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.2 8.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 1.8 PID_BARD1_PATHWAY BARD1 signaling events
0.1 2.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 5.2 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.7 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 4.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.4 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 2.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 39.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.9 33.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.1 10.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.0 13.5 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.7 11.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.4 5.1 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3 8.7 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.3 8.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 3.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 14.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.2 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.8 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.0 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.0 4.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation