Motif ID: Erg

Z-value: 2.804


Transcription factors associated with Erg:

Gene SymbolEntrez IDGene Name
Erg ENSMUSG00000040732.12 Erg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ergmm10_v2_chr16_-_95459245_954593840.849.5e-11Click!


Activity profile for motif Erg.

activity profile for motif Erg


Sorted Z-values histogram for motif Erg

Sorted Z-values for motif Erg



Network of associatons between targets according to the STRING database.



First level regulatory network of Erg

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_87793470 37.568 ENSMUST00000020779.4
Mpo
myeloperoxidase
chr11_+_87793722 35.325 ENSMUST00000143021.2
Mpo
myeloperoxidase
chr1_+_40515362 23.039 ENSMUST00000027237.5
Il18rap
interleukin 18 receptor accessory protein
chr3_-_90695706 20.509 ENSMUST00000069960.5
ENSMUST00000117167.1
S100a9

S100 calcium binding protein A9 (calgranulin B)

chr14_-_43819639 19.111 ENSMUST00000100691.3
Ear1
eosinophil-associated, ribonuclease A family, member 1
chr14_+_51853699 18.334 ENSMUST00000169070.1
ENSMUST00000074477.6
Ear6

eosinophil-associated, ribonuclease A family, member 6

chr10_-_75940633 17.664 ENSMUST00000059658.4
Gm867
predicted gene 867
chr14_-_43875517 17.181 ENSMUST00000179200.1
Ear1
eosinophil-associated, ribonuclease A family, member 1
chr17_+_48359891 16.256 ENSMUST00000024792.6
Treml1
triggering receptor expressed on myeloid cells-like 1
chr11_-_72550255 15.234 ENSMUST00000021154.6
Spns3
spinster homolog 3
chr8_-_85380964 14.181 ENSMUST00000122452.1
Mylk3
myosin light chain kinase 3
chr10_-_81500132 13.431 ENSMUST00000053646.5
S1pr4
sphingosine-1-phosphate receptor 4
chr14_-_33185489 13.058 ENSMUST00000159606.1
Wdfy4
WD repeat and FYVE domain containing 4
chr7_-_126369543 12.693 ENSMUST00000032997.6
Lat
linker for activation of T cells
chr4_-_118620763 11.920 ENSMUST00000071972.4
Wdr65
WD repeat domain 65
chr8_+_22974844 11.473 ENSMUST00000110688.2
ENSMUST00000121802.2
Ank1

ankyrin 1, erythroid

chr7_-_127137807 11.416 ENSMUST00000049931.5
Spn
sialophorin
chr13_-_37050237 11.377 ENSMUST00000164727.1
F13a1
coagulation factor XIII, A1 subunit
chr16_+_17980565 11.321 ENSMUST00000075371.3
Vpreb2
pre-B lymphocyte gene 2
chr3_-_20242173 11.130 ENSMUST00000001921.1
Cpa3
carboxypeptidase A3, mast cell
chr2_+_118598209 10.671 ENSMUST00000038341.7
Bub1b
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
chr2_-_156839790 10.575 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
Gm14230


predicted gene 14230


chr8_-_71723308 9.857 ENSMUST00000125092.1
Fcho1
FCH domain only 1
chr6_+_87778084 9.335 ENSMUST00000032133.3
Gp9
glycoprotein 9 (platelet)
chr9_-_123968683 9.269 ENSMUST00000026911.4
Ccr1
chemokine (C-C motif) receptor 1
chr3_+_84666192 8.798 ENSMUST00000107682.1
Tmem154
transmembrane protein 154
chrX_-_106840572 8.727 ENSMUST00000062010.9
Zcchc5
zinc finger, CCHC domain containing 5
chr1_+_170277376 8.605 ENSMUST00000179976.1
Sh2d1b1
SH2 domain protein 1B1
chr11_+_115887601 8.594 ENSMUST00000167507.2
Myo15b
myosin XVB
chr14_-_33185066 8.483 ENSMUST00000061753.8
ENSMUST00000130509.2
Wdfy4

WD repeat and FYVE domain containing 4

chr6_+_60944472 8.268 ENSMUST00000129603.1
Mmrn1
multimerin 1
chr16_+_33794345 8.182 ENSMUST00000023520.6
Muc13
mucin 13, epithelial transmembrane
chr16_+_33794008 8.144 ENSMUST00000115044.1
Muc13
mucin 13, epithelial transmembrane
chr10_-_6980376 8.137 ENSMUST00000105617.1
Ipcef1
interaction protein for cytohesin exchange factors 1
chr2_+_164948219 8.119 ENSMUST00000017881.2
Mmp9
matrix metallopeptidase 9
chr17_+_32403006 8.068 ENSMUST00000065921.5
A530088E08Rik
RIKEN cDNA A530088E08 gene
chr3_+_103832562 8.021 ENSMUST00000062945.5
Bcl2l15
BCLl2-like 15
chr16_-_19983005 7.939 ENSMUST00000058839.8
Klhl6
kelch-like 6
chr15_-_96642883 7.892 ENSMUST00000088452.4
Slc38a1
solute carrier family 38, member 1
chr7_+_24897381 7.878 ENSMUST00000003469.7
Cd79a
CD79A antigen (immunoglobulin-associated alpha)
chr13_-_110357136 7.808 ENSMUST00000058806.5
Gapt
Grb2-binding adaptor, transmembrane
chr17_-_14694223 7.674 ENSMUST00000170872.1
Thbs2
thrombospondin 2
chr9_+_56089962 7.571 ENSMUST00000059206.7
Pstpip1
proline-serine-threonine phosphatase-interacting protein 1
chr3_+_68869563 7.563 ENSMUST00000054551.2
1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr2_-_32083783 7.397 ENSMUST00000056406.6
Fam78a
family with sequence similarity 78, member A
chr5_-_123879992 7.395 ENSMUST00000164267.1
Gpr81
G protein-coupled receptor 81
chr5_+_65863563 7.316 ENSMUST00000031106.4
Rhoh
ras homolog gene family, member H
chr2_+_103970115 7.305 ENSMUST00000111143.1
ENSMUST00000138815.1
Lmo2

LIM domain only 2

chrX_+_159303266 7.230 ENSMUST00000112491.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr1_+_135133272 7.220 ENSMUST00000167080.1
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr6_-_123289862 7.183 ENSMUST00000032239.4
ENSMUST00000177367.1
Clec4e

C-type lectin domain family 4, member e

chr1_-_132367879 7.183 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr1_-_193201435 7.136 ENSMUST00000043550.4
Traf3ip3
TRAF3 interacting protein 3
chr1_+_135132693 6.891 ENSMUST00000049449.4
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr17_-_32403551 6.842 ENSMUST00000135618.1
ENSMUST00000063824.7
Rasal3

RAS protein activator like 3

chr19_-_11266122 6.640 ENSMUST00000169159.1
Ms4a1
membrane-spanning 4-domains, subfamily A, member 1
chr11_+_70639118 6.479 ENSMUST00000055184.6
ENSMUST00000108551.2
Gp1ba

glycoprotein 1b, alpha polypeptide

chr5_+_99979061 6.472 ENSMUST00000046721.1
4930524J08Rik
RIKEN cDNA 4930524J08 gene
chr17_-_32403526 6.469 ENSMUST00000137458.1
Rasal3
RAS protein activator like 3
chr17_+_33638056 6.462 ENSMUST00000052079.7
Pram1
PML-RAR alpha-regulated adaptor molecule 1
chr10_-_30655859 6.345 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr2_+_103970221 6.335 ENSMUST00000111140.2
ENSMUST00000111139.2
Lmo2

LIM domain only 2

chr12_-_32208470 6.205 ENSMUST00000085469.5
Pik3cg
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chrX_-_8090442 6.131 ENSMUST00000033505.6
Was
Wiskott-Aldrich syndrome homolog (human)
chr13_+_55369732 6.093 ENSMUST00000063771.7
Rgs14
regulator of G-protein signaling 14
chrX_+_48146436 6.078 ENSMUST00000033427.6
Sash3
SAM and SH3 domain containing 3
chr5_-_148392810 6.072 ENSMUST00000138257.1
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr4_-_63403330 6.044 ENSMUST00000035724.4
Akna
AT-hook transcription factor
chr7_-_25615874 6.028 ENSMUST00000098663.1
Gm7092
predicted gene 7092
chr13_-_19619820 5.988 ENSMUST00000002885.6
Epdr1
ependymin related protein 1 (zebrafish)
chr15_+_57985873 5.964 ENSMUST00000050374.2
Fam83a
family with sequence similarity 83, member A
chr1_+_171388954 5.958 ENSMUST00000056449.8
Arhgap30
Rho GTPase activating protein 30
chr3_-_137981523 5.958 ENSMUST00000136613.1
ENSMUST00000029806.6
Dapp1

dual adaptor for phosphotyrosine and 3-phosphoinositides 1

chr17_+_28207778 5.880 ENSMUST00000002327.5
Def6
differentially expressed in FDCP 6
chr2_-_73486456 5.860 ENSMUST00000141264.1
Wipf1
WAS/WASL interacting protein family, member 1
chr4_+_126556935 5.817 ENSMUST00000048391.8
Clspn
claspin
chr11_+_87755567 5.804 ENSMUST00000123700.1
A430104N18Rik
RIKEN cDNA A430104N18 gene
chr12_+_110279228 5.743 ENSMUST00000097228.4
Dio3
deiodinase, iodothyronine type III
chr11_+_104550663 5.709 ENSMUST00000018800.2
Myl4
myosin, light polypeptide 4
chr1_-_170927567 5.678 ENSMUST00000046322.7
ENSMUST00000159171.1
Fcrla

Fc receptor-like A

chr4_+_126556994 5.624 ENSMUST00000147675.1
Clspn
claspin
chrX_-_9469288 5.596 ENSMUST00000015484.3
Cybb
cytochrome b-245, beta polypeptide
chr2_+_156840077 5.584 ENSMUST00000081335.6
ENSMUST00000073352.3
Tgif2

TGFB-induced factor homeobox 2

chr12_-_32208609 5.575 ENSMUST00000053215.7
Pik3cg
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr8_-_68121527 5.525 ENSMUST00000178529.1
Gm21807
predicted gene, 21807
chr1_+_171767123 5.468 ENSMUST00000015460.4
Slamf1
signaling lymphocytic activation molecule family member 1
chr1_-_170927540 5.465 ENSMUST00000162136.1
ENSMUST00000162887.1
Fcrla

Fc receptor-like A

chr7_-_127218390 5.458 ENSMUST00000142356.1
ENSMUST00000106314.1
Sept1

septin 1

chr2_-_26021679 5.425 ENSMUST00000036509.7
Ubac1
ubiquitin associated domain containing 1
chr3_+_124321031 5.402 ENSMUST00000058994.4
Tram1l1
translocation associated membrane protein 1-like 1
chrX_-_164258186 5.341 ENSMUST00000112265.2
Bmx
BMX non-receptor tyrosine kinase
chr6_+_125071277 5.308 ENSMUST00000140346.2
ENSMUST00000171989.1
Lpar5

lysophosphatidic acid receptor 5

chr2_-_26021532 5.306 ENSMUST00000136750.1
Ubac1
ubiquitin associated domain containing 1
chr6_-_129917650 5.245 ENSMUST00000118060.1
Klra5
killer cell lectin-like receptor, subfamily A, member 5
chr8_-_88636117 5.233 ENSMUST00000034087.7
Snx20
sorting nexin 20
chr1_-_133690100 5.202 ENSMUST00000169295.1
Lax1
lymphocyte transmembrane adaptor 1
chr16_+_44765732 5.176 ENSMUST00000057488.8
Cd200r1
CD200 receptor 1
chr14_+_44102654 5.137 ENSMUST00000074839.6
Ear2
eosinophil-associated, ribonuclease A family, member 2
chr12_-_78906929 5.102 ENSMUST00000021544.7
Plek2
pleckstrin 2
chr3_+_88616133 5.086 ENSMUST00000176500.1
ENSMUST00000177498.1
Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chrX_+_93675088 5.072 ENSMUST00000045898.3
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr9_-_66919646 5.068 ENSMUST00000041139.7
Rab8b
RAB8B, member RAS oncogene family
chr4_-_129573637 5.009 ENSMUST00000102596.1
Lck
lymphocyte protein tyrosine kinase
chr7_+_29983948 5.000 ENSMUST00000148442.1
Zfp568
zinc finger protein 568
chr8_+_88289028 4.974 ENSMUST00000171456.1
Adcy7
adenylate cyclase 7
chr7_-_127218303 4.911 ENSMUST00000106313.1
Sept1
septin 1
chr3_+_28781305 4.884 ENSMUST00000060500.7
Eif5a2
eukaryotic translation initiation factor 5A2
chr9_+_122923050 4.870 ENSMUST00000051667.7
ENSMUST00000148851.1
Zfp105

zinc finger protein 105

chr11_-_101785252 4.816 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr3_-_14778452 4.776 ENSMUST00000094365.4
Car1
carbonic anhydrase 1
chr3_-_52104891 4.766 ENSMUST00000121440.1
Maml3
mastermind like 3 (Drosophila)
chr2_+_84840612 4.732 ENSMUST00000111625.1
Slc43a1
solute carrier family 43, member 1
chr5_-_137072254 4.653 ENSMUST00000077523.3
ENSMUST00000041388.4
Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

chr9_-_120068263 4.651 ENSMUST00000064165.3
ENSMUST00000177637.1
Cx3cr1

chemokine (C-X3-C) receptor 1

chr4_-_129558387 4.602 ENSMUST00000067240.4
Lck
lymphocyte protein tyrosine kinase
chr7_+_140218258 4.596 ENSMUST00000084460.6
Cd163l1
CD163 molecule-like 1
chr6_+_65778988 4.592 ENSMUST00000031976.7
ENSMUST00000081219.7
ENSMUST00000031973.6
ENSMUST00000172638.1
Prdm5



PR domain containing 5



chr10_+_127323700 4.584 ENSMUST00000069548.5
Arhgap9
Rho GTPase activating protein 9
chr11_-_102819663 4.553 ENSMUST00000092567.4
Gjc1
gap junction protein, gamma 1
chr9_-_20952838 4.533 ENSMUST00000004202.9
Dnmt1
DNA methyltransferase (cytosine-5) 1
chr12_-_109600328 4.529 ENSMUST00000149046.2
Rtl1
retrotransposon-like 1
chr11_-_103363431 4.525 ENSMUST00000092557.5
Arhgap27
Rho GTPase activating protein 27
chr6_-_16898441 4.503 ENSMUST00000031533.7
Tfec
transcription factor EC
chr4_-_129558355 4.454 ENSMUST00000167288.1
ENSMUST00000134336.1
Lck

lymphocyte protein tyrosine kinase

chr2_+_163602331 4.436 ENSMUST00000152135.1
Ttpal
tocopherol (alpha) transfer protein-like
chr11_-_102469839 4.414 ENSMUST00000103086.3
Itga2b
integrin alpha 2b
chr1_+_152807877 4.395 ENSMUST00000027754.6
Ncf2
neutrophil cytosolic factor 2
chr9_+_21526144 4.355 ENSMUST00000086361.5
ENSMUST00000179459.1
ENSMUST00000173769.2
AB124611


cDNA sequence AB124611


chr17_+_47594629 4.331 ENSMUST00000182846.1
Ccnd3
cyclin D3
chr2_-_118728345 4.310 ENSMUST00000159756.1
Plcb2
phospholipase C, beta 2
chr14_+_70774304 4.275 ENSMUST00000022698.7
Dok2
docking protein 2
chr16_-_21995478 4.258 ENSMUST00000074230.4
ENSMUST00000060673.6
Liph

lipase, member H

chr2_-_73453918 4.249 ENSMUST00000102679.1
Wipf1
WAS/WASL interacting protein family, member 1
chr2_-_164356507 4.242 ENSMUST00000109367.3
Slpi
secretory leukocyte peptidase inhibitor
chr16_-_75909272 4.240 ENSMUST00000114239.2
Samsn1
SAM domain, SH3 domain and nuclear localization signals, 1
chr2_+_164805082 4.203 ENSMUST00000052107.4
Zswim3
zinc finger SWIM-type containing 3
chr6_+_134981998 4.137 ENSMUST00000167323.1
Apold1
apolipoprotein L domain containing 1
chr10_+_79988584 4.104 ENSMUST00000004784.4
ENSMUST00000105374.1
Cnn2

calponin 2

chr4_-_43558386 4.072 ENSMUST00000130353.1
Tln1
talin 1
chr15_-_9529868 4.061 ENSMUST00000003981.4
Il7r
interleukin 7 receptor
chr1_+_75507077 4.040 ENSMUST00000037330.4
Inha
inhibin alpha
chr9_+_124102110 4.012 ENSMUST00000168841.1
ENSMUST00000055918.6
Ccr2

chemokine (C-C motif) receptor 2

chrX_-_136085206 3.979 ENSMUST00000138878.1
ENSMUST00000080929.6
Nxf3

nuclear RNA export factor 3

chr1_+_52630692 3.968 ENSMUST00000165859.1
Tmem194b
transmembrane protein 194B
chr2_+_91650116 3.963 ENSMUST00000111331.2
Arhgap1
Rho GTPase activating protein 1
chr14_+_52863299 3.958 ENSMUST00000103616.3
Trav15d-1-dv6d-1
T cell receptor alpha variable 15D-1-DV6D-1
chr16_-_3718105 3.948 ENSMUST00000023180.7
ENSMUST00000100222.2
Mefv

Mediterranean fever

chr8_+_69808672 3.948 ENSMUST00000036074.8
ENSMUST00000123453.1
Gmip

Gem-interacting protein

chr17_+_47505043 3.934 ENSMUST00000182129.1
ENSMUST00000171031.1
Ccnd3

cyclin D3

chr4_-_47010781 3.929 ENSMUST00000135777.1
Gm568
predicted gene 568
chrX_+_134686519 3.888 ENSMUST00000124226.2
Armcx4
armadillo repeat containing, X-linked 4
chr17_+_47505149 3.874 ENSMUST00000183177.1
ENSMUST00000182848.1
Ccnd3

cyclin D3

chr11_+_32533290 3.849 ENSMUST00000102821.3
Stk10
serine/threonine kinase 10
chr17_+_47505211 3.827 ENSMUST00000182935.1
ENSMUST00000182506.1
Ccnd3

cyclin D3

chr11_-_76509419 3.820 ENSMUST00000094012.4
Abr
active BCR-related gene
chr17_+_47505117 3.789 ENSMUST00000183044.1
ENSMUST00000037333.10
Ccnd3

cyclin D3

chrX_+_159627534 3.771 ENSMUST00000073094.3
Sh3kbp1
SH3-domain kinase binding protein 1
chr1_-_156474249 3.765 ENSMUST00000051396.6
Soat1
sterol O-acyltransferase 1
chr9_+_124101944 3.760 ENSMUST00000171719.1
Ccr2
chemokine (C-C motif) receptor 2
chr4_+_135152496 3.708 ENSMUST00000119564.1
Runx3
runt related transcription factor 3
chr11_+_61485431 3.699 ENSMUST00000064783.3
ENSMUST00000040522.6
Mfap4

microfibrillar-associated protein 4

chr16_-_36642742 3.696 ENSMUST00000135280.1
Cd86
CD86 antigen
chr17_-_51826562 3.635 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
Satb1




special AT-rich sequence binding protein 1




chr7_-_126463100 3.625 ENSMUST00000032974.6
Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr2_-_101883010 3.605 ENSMUST00000154525.1
Prr5l
proline rich 5 like
chr19_-_4191035 3.593 ENSMUST00000045864.2
Tbc1d10c
TBC1 domain family, member 10c
chr2_+_129592818 3.589 ENSMUST00000153491.1
ENSMUST00000161620.1
ENSMUST00000179001.1
Sirpa


signal-regulatory protein alpha


chr2_+_165055668 3.580 ENSMUST00000081310.4
ENSMUST00000140951.1
Cd40

CD40 antigen

chr7_+_75701965 3.576 ENSMUST00000094307.3
Akap13
A kinase (PRKA) anchor protein 13
chr7_+_131032061 3.525 ENSMUST00000084509.3
Dmbt1
deleted in malignant brain tumors 1
chr14_+_51129055 3.513 ENSMUST00000095923.3
Rnase6
ribonuclease, RNase A family, 6
chr3_+_98382438 3.484 ENSMUST00000056096.8
Zfp697
zinc finger protein 697
chr3_-_105932664 3.484 ENSMUST00000098758.2
I830077J02Rik
RIKEN cDNA I830077J02 gene
chr1_-_54926311 3.468 ENSMUST00000179030.1
ENSMUST00000044359.9
Ankrd44

ankyrin repeat domain 44

chr4_+_126024506 3.450 ENSMUST00000106162.1
Csf3r
colony stimulating factor 3 receptor (granulocyte)
chr5_+_34989473 3.434 ENSMUST00000114284.1
ENSMUST00000114285.1
Rgs12

regulator of G-protein signaling 12

chrX_+_164373363 3.432 ENSMUST00000033751.7
Figf
c-fos induced growth factor
chr11_-_79530569 3.399 ENSMUST00000103236.3
ENSMUST00000170799.1
ENSMUST00000170422.2
Evi2a

Evi2b
ecotropic viral integration site 2a

ecotropic viral integration site 2b
chr2_+_91650169 3.341 ENSMUST00000090614.4
Arhgap1
Rho GTPase activating protein 1
chr7_+_43437073 3.305 ENSMUST00000070518.2
Nkg7
natural killer cell group 7 sequence
chr19_+_27217011 3.282 ENSMUST00000164746.1
ENSMUST00000172302.1
Vldlr

very low density lipoprotein receptor

chr2_-_148443543 3.273 ENSMUST00000099269.3
Cd93
CD93 antigen
chr7_+_92819892 3.267 ENSMUST00000107180.1
ENSMUST00000107179.1
Rab30

RAB30, member RAS oncogene family

chr2_-_101797650 3.255 ENSMUST00000141814.1
ENSMUST00000171088.1
ENSMUST00000043845.7
Prr5l


proline rich 5 like


chr10_-_62508097 3.253 ENSMUST00000159020.1
Srgn
serglycin
chr2_-_118728430 3.233 ENSMUST00000102524.1
Plcb2
phospholipase C, beta 2
chr8_+_70501116 3.213 ENSMUST00000127983.1
Crlf1
cytokine receptor-like factor 1
chr9_-_60687459 3.207 ENSMUST00000114032.1
ENSMUST00000166168.1
ENSMUST00000132366.1
Lrrc49


leucine rich repeat containing 49


chr4_-_83021102 3.201 ENSMUST00000071708.5
Frem1
Fras1 related extracellular matrix protein 1
chr16_-_46120238 3.201 ENSMUST00000023336.9
Cd96
CD96 antigen
chr2_-_93046053 3.176 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
Prdm11


PR domain containing 11


chrX_+_159840463 3.176 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1

SH3-domain kinase binding protein 1

chr17_+_47140942 3.162 ENSMUST00000077951.7
Trerf1
transcriptional regulating factor 1
chr5_-_122900267 3.147 ENSMUST00000031435.7
Kdm2b
lysine (K)-specific demethylase 2B
chr3_+_88621274 3.146 ENSMUST00000107510.3
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr6_-_136941494 3.090 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr3_+_88621102 3.086 ENSMUST00000029694.7
ENSMUST00000176804.1
Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chr15_-_64382908 3.080 ENSMUST00000177374.1
ENSMUST00000023008.9
ENSMUST00000110115.2
ENSMUST00000110114.3
Asap1



ArfGAP with SH3 domain, ankyrin repeat and PH domain1



chr6_+_48904979 3.031 ENSMUST00000162948.1
ENSMUST00000167529.1
Aoc1

amine oxidase, copper-containing 1

chr11_+_101325063 3.017 ENSMUST00000041095.7
ENSMUST00000107264.1
Aoc2

amine oxidase, copper containing 2 (retina-specific)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
24.3 72.9 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
6.8 20.5 GO:0070488 neutrophil aggregation(GO:0070488)
3.8 11.4 GO:0002884 regulation of type IV hypersensitivity(GO:0001807) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) negative regulation of hypersensitivity(GO:0002884) T cell aggregation(GO:0070489)
3.6 10.7 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
2.7 8.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
2.7 13.3 GO:0051140 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
2.6 10.4 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
2.6 7.8 GO:1902567 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) astrocyte chemotaxis(GO:0035700) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) negative regulation of eosinophil activation(GO:1902567) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458)
2.6 2.6 GO:0042223 positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
2.4 14.2 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
2.2 8.6 GO:0002765 immune response-inhibiting signal transduction(GO:0002765) immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
2.0 8.1 GO:0035744 T-helper 1 cell cytokine production(GO:0035744)
2.0 3.9 GO:0071608 macrophage inflammatory protein-1 alpha production(GO:0071608)
1.9 3.8 GO:0071593 lymphocyte aggregation(GO:0071593)
1.7 11.8 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
1.7 13.3 GO:0071802 negative regulation of podosome assembly(GO:0071802)
1.7 28.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
1.4 5.7 GO:0033380 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
1.4 5.6 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
1.3 8.9 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
1.2 3.7 GO:0002644 negative regulation of tolerance induction(GO:0002644)
1.2 7.3 GO:0032439 endosome localization(GO:0032439)
1.2 3.6 GO:0090076 positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) maintenance of mitochondrion location(GO:0051659) relaxation of skeletal muscle(GO:0090076)
1.2 14.1 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
1.2 4.7 GO:2000097 leukotriene production involved in inflammatory response(GO:0002540) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
1.2 5.8 GO:0034436 glycoprotein transport(GO:0034436)
1.1 11.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.1 4.6 GO:0086053 AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
1.1 4.5 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
1.1 7.9 GO:0006868 glutamine transport(GO:0006868)
1.1 15.9 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
1.0 10.3 GO:0043313 regulation of neutrophil degranulation(GO:0043313) regulation of neutrophil activation(GO:1902563)
1.0 6.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
1.0 5.0 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.9 21.7 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.9 13.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.9 4.4 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.9 11.4 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.8 3.4 GO:0010286 heat acclimation(GO:0010286)
0.8 11.0 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.8 6.5 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.8 4.9 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.8 4.0 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.8 3.2 GO:0002370 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.8 4.0 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.8 12.7 GO:0006968 cellular defense response(GO:0006968)
0.8 7.9 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.8 6.9 GO:0038203 TORC2 signaling(GO:0038203)
0.8 6.1 GO:1903826 arginine transmembrane transport(GO:1903826)
0.8 5.3 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.8 2.3 GO:1905663 response to rapamycin(GO:1901355) regulation of telomerase RNA reverse transcriptase activity(GO:1905661) positive regulation of telomerase RNA reverse transcriptase activity(GO:1905663)
0.7 6.0 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.7 2.1 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.7 5.0 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.7 5.6 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.7 4.8 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.7 3.4 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.7 3.4 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.7 2.0 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685) negative regulation of interleukin-18 production(GO:0032701)
0.7 2.7 GO:0002283 neutrophil activation involved in immune response(GO:0002283)
0.6 1.9 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.6 5.1 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.6 3.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.6 1.8 GO:2000349 negative regulation of CD40 signaling pathway(GO:2000349)
0.6 3.6 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.6 2.3 GO:0032053 ciliary basal body organization(GO:0032053)
0.6 8.1 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.6 5.7 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.6 3.4 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.5 1.6 GO:0007493 endodermal cell fate determination(GO:0007493) regulation of cardiac cell fate specification(GO:2000043)
0.5 3.8 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.5 1.1 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.5 6.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.5 1.6 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.5 2.6 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.5 1.0 GO:0060137 maternal process involved in parturition(GO:0060137)
0.5 4.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.5 2.0 GO:0031296 B cell costimulation(GO:0031296)
0.5 1.5 GO:0030538 embryonic genitalia morphogenesis(GO:0030538) embryonic hindgut morphogenesis(GO:0048619)
0.5 2.9 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.5 1.9 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.5 1.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.5 3.8 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.5 5.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.5 1.8 GO:1902340 negative regulation of chromosome condensation(GO:1902340)
0.5 1.8 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.4 3.6 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.4 2.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.4 1.8 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.4 1.3 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.4 3.5 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.4 6.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.4 4.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.4 3.7 GO:0071493 elastic fiber assembly(GO:0048251) cellular response to UV-B(GO:0071493)
0.4 2.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.4 1.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.4 1.2 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.4 7.5 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.4 1.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.4 1.5 GO:0032847 regulation of nitrogen utilization(GO:0006808) regulation of cellular pH reduction(GO:0032847)
0.4 1.1 GO:0021553 olfactory nerve development(GO:0021553)
0.4 1.1 GO:0006742 NADP catabolic process(GO:0006742)
0.4 6.5 GO:0042730 fibrinolysis(GO:0042730)
0.3 1.0 GO:0070543 response to linoleic acid(GO:0070543)
0.3 64.7 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.3 1.7 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.3 1.0 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.3 1.0 GO:0099548 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.3 2.4 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.3 4.7 GO:0090037 positive regulation of protein kinase C signaling(GO:0090037)
0.3 1.3 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701) regulation of inositol trisphosphate biosynthetic process(GO:0032960) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.3 1.0 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.3 1.9 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.3 5.3 GO:0001865 NK T cell differentiation(GO:0001865)
0.3 0.9 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.3 0.9 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.3 3.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.3 1.8 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.3 1.5 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.3 1.2 GO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.3 10.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.3 8.9 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 2.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.3 4.6 GO:0006657 CDP-choline pathway(GO:0006657)
0.3 2.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.3 3.0 GO:0071280 cellular response to copper ion(GO:0071280)
0.3 0.8 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.3 2.9 GO:0070970 interleukin-2 secretion(GO:0070970)
0.3 5.6 GO:0038092 nodal signaling pathway(GO:0038092)
0.3 11.0 GO:0048821 erythrocyte development(GO:0048821)
0.3 5.4 GO:0002467 germinal center formation(GO:0002467)
0.3 1.0 GO:0010726 positive regulation of hydrogen peroxide metabolic process(GO:0010726)
0.2 1.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 1.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 3.1 GO:0048305 immunoglobulin secretion(GO:0048305)
0.2 5.6 GO:0043486 histone exchange(GO:0043486)
0.2 1.8 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.2 4.1 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.2 1.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 0.8 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.2 2.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 5.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 2.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.2 19.9 GO:0030168 platelet activation(GO:0030168)
0.2 15.7 GO:0042100 B cell proliferation(GO:0042100)
0.2 3.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 2.6 GO:0015747 urate transport(GO:0015747)
0.2 1.3 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.2 1.8 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.2 3.6 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 0.7 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.2 2.2 GO:2000738 positive regulation of stem cell differentiation(GO:2000738)
0.2 2.0 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.2 13.4 GO:0007596 blood coagulation(GO:0007596)
0.2 4.6 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2 5.7 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.2 5.3 GO:0048266 behavioral response to pain(GO:0048266)
0.2 4.2 GO:0019731 antibacterial humoral response(GO:0019731)
0.2 0.5 GO:0040010 positive regulation of growth rate(GO:0040010)
0.2 0.6 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.2 0.5 GO:0071639 positive regulation of monocyte chemotactic protein-1 production(GO:0071639)
0.1 2.9 GO:1903830 magnesium ion transport(GO:0015693) magnesium ion transmembrane transport(GO:1903830)
0.1 3.0 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 1.2 GO:0045759 negative regulation of action potential(GO:0045759)
0.1 2.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.3 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.1 1.8 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.1 2.0 GO:0001771 immunological synapse formation(GO:0001771)
0.1 1.0 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 1.3 GO:0023041 neuronal signal transduction(GO:0023041)
0.1 1.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.3 GO:0002946 tRNA C5-cytosine methylation(GO:0002946)
0.1 6.8 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 2.4 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.1 2.9 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 3.9 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.1 5.0 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 1.3 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.1 1.8 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.1 0.8 GO:0010669 epithelial structure maintenance(GO:0010669)
0.1 0.5 GO:0071352 interleukin-2-mediated signaling pathway(GO:0038110) cellular response to interleukin-2(GO:0071352)
0.1 0.7 GO:0031442 positive regulation of mRNA 3'-end processing(GO:0031442)
0.1 0.6 GO:0090383 phagosome acidification(GO:0090383)
0.1 1.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 4.2 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 0.6 GO:1903351 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)
0.1 0.5 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 2.2 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.1 1.6 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 7.5 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.1 0.6 GO:0097352 autophagosome maturation(GO:0097352)
0.1 1.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 0.5 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1 0.7 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 1.1 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694)
0.1 0.7 GO:0071236 cellular response to antibiotic(GO:0071236)
0.1 0.2 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.8 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 0.5 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 2.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.7 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.1 2.0 GO:0007099 centriole replication(GO:0007099)
0.1 0.4 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 0.9 GO:0031268 pseudopodium organization(GO:0031268)
0.1 1.2 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.1 2.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.3 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.1 2.5 GO:0051567 histone H3-K9 methylation(GO:0051567)
0.1 0.9 GO:0001946 lymphangiogenesis(GO:0001946)
0.1 0.2 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 2.1 GO:0007091 metaphase/anaphase transition of mitotic cell cycle(GO:0007091)
0.0 1.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.1 GO:0071544 diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.0 1.4 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 1.5 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 1.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 2.4 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 0.2 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 4.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.2 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.7 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 1.7 GO:0051028 mRNA transport(GO:0051028)
0.0 2.4 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 2.3 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.5 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
0.0 0.3 GO:0006664 glycolipid metabolic process(GO:0006664)
0.0 1.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 1.3 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 4.6 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 2.1 GO:0042113 B cell activation(GO:0042113)
0.0 1.9 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 0.7 GO:0003015 heart process(GO:0003015)
0.0 0.2 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.7 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.2 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 1.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 2.6 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.7 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.5 GO:0007229 integrin-mediated signaling pathway(GO:0007229)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 69.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
2.9 11.8 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
1.9 5.6 GO:0005607 laminin-2 complex(GO:0005607)
1.5 7.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
1.3 4.0 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
1.3 4.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
1.1 7.7 GO:0019815 B cell receptor complex(GO:0019815)
1.0 3.8 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
1.0 11.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.9 7.6 GO:0005826 actomyosin contractile ring(GO:0005826)
0.9 4.7 GO:0042583 chromaffin granule(GO:0042583)
0.9 3.7 GO:0071953 elastic fiber(GO:0071953)
0.9 10.4 GO:0072687 meiotic spindle(GO:0072687)
0.8 10.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.8 3.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.7 13.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.7 2.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.7 2.9 GO:0008623 CHRAC(GO:0008623)
0.7 0.7 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.6 3.8 GO:0097443 sorting endosome(GO:0097443)
0.6 3.8 GO:0031673 H zone(GO:0031673)
0.6 14.3 GO:0000242 pericentriolar material(GO:0000242)
0.5 3.5 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.5 11.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.5 1.5 GO:0005940 septin ring(GO:0005940)
0.4 6.9 GO:0031932 TORC2 complex(GO:0031932)
0.4 2.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.4 3.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.4 2.0 GO:0098536 deuterosome(GO:0098536)
0.4 2.0 GO:0005683 U7 snRNP(GO:0005683)
0.4 1.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.4 1.4 GO:0045160 myosin I complex(GO:0045160)
0.4 21.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 23.0 GO:0042629 mast cell granule(GO:0042629)
0.3 2.7 GO:0042382 paraspeckles(GO:0042382)
0.3 1.3 GO:0008537 proteasome activator complex(GO:0008537)
0.3 3.0 GO:0031080 nuclear pore outer ring(GO:0031080)
0.3 6.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.3 1.1 GO:1990696 USH2 complex(GO:1990696)
0.3 7.3 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich plasma lipoprotein particle(GO:0034385)
0.3 5.3 GO:0000346 transcription export complex(GO:0000346)
0.2 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 2.2 GO:0061574 ASAP complex(GO:0061574)
0.2 15.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 3.4 GO:0001891 phagocytic cup(GO:0001891)
0.2 5.7 GO:0043196 varicosity(GO:0043196)
0.2 10.8 GO:0002102 podosome(GO:0002102)
0.2 6.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 1.6 GO:0097208 alveolar lamellar body(GO:0097208)
0.2 3.6 GO:0035102 PRC1 complex(GO:0035102)
0.2 2.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 5.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 1.6 GO:0000801 central element(GO:0000801)
0.2 3.6 GO:0031527 filopodium membrane(GO:0031527)
0.2 2.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 6.2 GO:0030139 endocytic vesicle(GO:0030139)
0.2 2.1 GO:0071001 U4 snRNP(GO:0005687) U4/U6 snRNP(GO:0071001)
0.1 5.0 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.9 GO:0031011 Ino80 complex(GO:0031011)
0.1 1.0 GO:0090543 Flemming body(GO:0090543)
0.1 11.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 3.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.5 GO:0046930 pore complex(GO:0046930)
0.1 1.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 4.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 3.3 GO:0005876 spindle microtubule(GO:0005876)
0.1 3.1 GO:0031519 PcG protein complex(GO:0031519)
0.1 11.9 GO:0000922 spindle pole(GO:0000922)
0.1 5.2 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 5.7 GO:0031672 A band(GO:0031672)
0.1 4.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 3.4 GO:0097440 apical dendrite(GO:0097440)
0.1 10.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 2.5 GO:0008305 integrin complex(GO:0008305)
0.1 1.9 GO:0005922 connexin complex(GO:0005922)
0.1 1.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.7 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 1.6 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 1.4 GO:0016460 myosin II complex(GO:0016460)
0.1 3.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 5.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.2 GO:0044194 cytolytic granule(GO:0044194)
0.1 4.3 GO:0005643 nuclear pore(GO:0005643)
0.1 4.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.9 GO:0036038 MKS complex(GO:0036038)
0.1 3.6 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 5.7 GO:0000932 P-body(GO:0000932)
0.1 5.2 GO:0072562 blood microparticle(GO:0072562)
0.0 9.0 GO:0001726 ruffle(GO:0001726)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 1.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 14.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.4 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.3 GO:0002080 acrosomal membrane(GO:0002080)
0.0 4.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.8 GO:0000145 exocyst(GO:0000145)
0.0 1.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 2.0 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.2 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.4 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 2.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 5.5 GO:0012506 vesicle membrane(GO:0012506)
0.0 0.5 GO:0001527 microfibril(GO:0001527)
0.0 4.3 GO:0001650 fibrillar center(GO:0001650)
0.0 1.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.6 GO:0005604 basement membrane(GO:0005604)
0.0 0.5 GO:0035371 microtubule plus-end(GO:0035371)
0.0 5.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 4.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.5 GO:0014704 intercalated disc(GO:0014704)
0.0 1.8 GO:0005923 bicellular tight junction(GO:0005923)
0.0 9.3 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 3.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 4.4 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.0 GO:0035717 chemokine (C-C motif) ligand 7 binding(GO:0035717)
2.9 22.9 GO:0050786 RAGE receptor binding(GO:0050786)
2.8 14.1 GO:0042610 CD8 receptor binding(GO:0042610)
2.2 15.2 GO:0046624 sphingolipid transporter activity(GO:0046624)
2.1 23.0 GO:0004908 interleukin-1 receptor activity(GO:0004908)
1.9 5.8 GO:0034437 glycoprotein transporter activity(GO:0034437)
1.9 5.7 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
1.9 11.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.8 14.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
1.6 7.9 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
1.2 6.1 GO:0030621 U4 snRNA binding(GO:0030621)
1.1 11.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.1 4.6 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
1.1 72.9 GO:0004601 peroxidase activity(GO:0004601)
1.1 11.8 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
1.0 3.0 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
1.0 12.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
1.0 3.8 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.9 4.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.9 4.4 GO:0070051 fibrinogen binding(GO:0070051)
0.8 3.1 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.8 6.1 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.7 6.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.7 2.9 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.7 11.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.7 0.7 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.7 2.0 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.6 2.6 GO:0019767 IgE receptor activity(GO:0019767)
0.6 5.1 GO:0030911 TPR domain binding(GO:0030911)
0.6 7.4 GO:0030274 LIM domain binding(GO:0030274)
0.6 1.8 GO:0008434 calcitriol receptor activity(GO:0008434) calcitriol binding(GO:1902098)
0.6 4.8 GO:0004064 arylesterase activity(GO:0004064)
0.6 9.9 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.6 4.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.6 2.3 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
0.6 2.2 GO:1990460 leptin receptor binding(GO:1990460)
0.5 3.0 GO:0008131 primary amine oxidase activity(GO:0008131)
0.5 4.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.4 4.0 GO:0034711 inhibin binding(GO:0034711)
0.4 61.6 GO:0004540 ribonuclease activity(GO:0004540)
0.4 3.3 GO:0001849 complement component C1q binding(GO:0001849)
0.4 2.5 GO:0004359 glutaminase activity(GO:0004359)
0.4 3.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.4 4.7 GO:0043208 glycosphingolipid binding(GO:0043208)
0.4 13.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.4 6.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.4 1.5 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.4 8.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 1.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.3 11.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 11.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 6.6 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.3 4.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.3 3.6 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.3 1.5 GO:0043515 kinetochore binding(GO:0043515)
0.3 6.0 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.3 5.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.3 15.1 GO:0035591 signaling adaptor activity(GO:0035591)
0.3 7.6 GO:0001968 fibronectin binding(GO:0001968)
0.3 1.0 GO:0001847 opsonin receptor activity(GO:0001847)
0.2 2.9 GO:0050700 CARD domain binding(GO:0050700)
0.2 14.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 6.9 GO:0043274 phospholipase binding(GO:0043274)
0.2 2.9 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 1.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 1.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 1.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 4.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 8.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 2.4 GO:0051525 NFAT protein binding(GO:0051525)
0.2 2.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 1.5 GO:0051434 BH3 domain binding(GO:0051434)
0.2 5.2 GO:0042169 SH2 domain binding(GO:0042169)
0.2 1.7 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.2 0.7 GO:0019770 IgG receptor activity(GO:0019770)
0.2 7.0 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.2 33.7 GO:0017124 SH3 domain binding(GO:0017124)
0.2 0.5 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.2 1.0 GO:0019208 phosphatase regulator activity(GO:0019208)
0.2 7.0 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 3.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 1.3 GO:0016531 copper chaperone activity(GO:0016531) cuprous ion binding(GO:1903136)
0.2 3.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 0.5 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.2 1.5 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 4.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 5.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 18.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 0.9 GO:0004111 creatine kinase activity(GO:0004111)
0.1 1.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.9 GO:1990948 ubiquitin ligase inhibitor activity(GO:1990948)
0.1 5.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 4.2 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 5.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 4.1 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.4 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 3.2 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 1.2 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.1 0.8 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 3.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 4.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 3.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 2.6 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 1.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.2 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.7 GO:0051400 BH domain binding(GO:0051400)
0.1 2.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 1.3 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.0 GO:0045499 chemorepellent activity(GO:0045499)
0.1 8.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 4.3 GO:0009055 electron carrier activity(GO:0009055)
0.1 5.1 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 1.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 4.0 GO:0005518 collagen binding(GO:0005518)
0.1 0.2 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 1.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.2 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.1 1.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.2 GO:0019961 interferon binding(GO:0019961)
0.0 0.2 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 16.8 GO:0005525 GTP binding(GO:0005525)
0.0 1.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 9.1 GO:0003729 mRNA binding(GO:0003729)
0.0 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 1.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 4.7 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.8 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 1.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.3 GO:0001540 amyloid-beta binding(GO:0001540)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 3.3 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 4.2 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.2 GO:0046332 SMAD binding(GO:0046332)
0.0 0.1 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 3.2 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.4 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.2 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 1.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.3 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 1.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 2.4 GO:0008168 methyltransferase activity(GO:0008168)
0.0 0.2 GO:0022829 wide pore channel activity(GO:0022829)
0.0 0.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.7 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 88.0 PID_IL23_PATHWAY IL23-mediated signaling events
1.0 13.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
1.0 11.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.8 14.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.8 13.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.7 27.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.5 8.1 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.4 7.5 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.4 5.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.4 16.6 PID_REELIN_PATHWAY Reelin signaling pathway
0.4 19.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.4 8.0 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4 13.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.4 8.1 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4 12.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.4 10.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.4 22.1 PID_PLK1_PATHWAY PLK1 signaling events
0.3 12.9 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.3 3.8 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.3 8.9 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.3 7.5 PID_CD40_PATHWAY CD40/CD40L signaling
0.3 10.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.3 15.1 PID_BCR_5PATHWAY BCR signaling pathway
0.3 10.9 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.3 2.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 9.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 3.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.2 10.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 6.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 6.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 4.4 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 25.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 4.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 1.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 3.0 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.8 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.9 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 0.8 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 5.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 4.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 13.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.8 PID_CDC42_PATHWAY CDC42 signaling events
0.1 3.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.2 ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway
0.1 1.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.6 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.3 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.8 PID_P73PATHWAY p73 transcription factor network
0.0 1.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.2 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.6 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.2 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 3.0 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
1.3 7.8 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
1.1 14.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
1.0 17.2 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.9 10.9 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.9 11.5 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.8 11.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.7 15.3 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.7 7.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.6 12.8 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.6 24.5 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.5 7.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.5 11.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.5 0.5 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.4 4.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.4 13.5 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.4 18.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.4 18.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.4 4.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.3 5.0 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.3 5.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.3 7.0 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.3 4.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 9.0 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 11.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 3.1 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.3 3.6 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.3 2.0 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.2 2.7 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors
0.2 1.5 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.2 18.5 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 16.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 9.6 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 4.6 REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.2 2.9 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 6.3 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 8.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 4.2 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 4.6 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 5.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.4 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.8 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.5 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 1.8 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 2.0 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.1 10.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.9 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 6.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 2.1 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 15.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 0.8 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.1 4.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.3 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 0.9 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 7.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 3.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 5.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 0.5 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.0 2.9 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 1.1 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.5 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.0 1.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.1 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0 0.2 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage