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GSE58827: Dynamics of the Mouse Liver

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Results for Evx2

Z-value: 0.43

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Transcription factors associated with Evx2

Gene Symbol Gene ID Gene Info
Evx2
ENSMUSG00000001815.9 even-skipped homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Evx2mm10_v2_chr2_-_74659861_746598610.076.9e-01Click!

Activity profile of Evx2 motif

Sorted Z-values of Evx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_172555932 1.82 ENSMUST00000061835.3
Vsig8
V-set and immunoglobulin domain containing 8
chr1_+_91801453 0.98 ENSMUST00000007949.3
Twist2
twist basic helix-loop-helix transcription factor 2
chr3_-_15575065 0.84 ENSMUST00000091319.4
Sirpb1b
signal-regulatory protein beta 1B
chr6_-_69400097 0.84 ENSMUST00000177795.1
Igkv4-62
immunoglobulin kappa variable 4-62
chr16_-_38800193 0.81 ENSMUST00000057767.4
Upk1b
uroplakin 1B
chr6_+_116650674 0.79 ENSMUST00000067354.5
ENSMUST00000178241.1
8430408G22Rik
RIKEN cDNA 8430408G22 gene
chr2_-_168767029 0.76 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr6_-_69284319 0.75 ENSMUST00000103349.1
Igkv4-69
immunoglobulin kappa variable 4-69
chr2_-_168767136 0.74 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4
sal-like 4 (Drosophila)
chr2_+_154548888 0.71 ENSMUST00000045116.4
ENSMUST00000109709.3
1700003F12Rik
RIKEN cDNA 1700003F12 gene
chr7_-_48843663 0.55 ENSMUST00000167786.2
Csrp3
cysteine and glycine-rich protein 3
chr17_-_47834682 0.44 ENSMUST00000066368.6
Mdfi
MyoD family inhibitor
chr6_-_124779686 0.44 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23
leucine rich repeat containing 23
chr14_-_59365410 0.37 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d
PHD finger protein 11D
chr19_+_5088534 0.36 ENSMUST00000025811.4
Yif1a
Yip1 interacting factor homolog A (S. cerevisiae)
chr1_+_36761847 0.35 ENSMUST00000027291.4
Zap70
zeta-chain (TCR) associated protein kinase
chr2_+_164613519 0.35 ENSMUST00000094346.2
Wfdc6b
WAP four-disulfide core domain 6B
chr14_-_59365465 0.35 ENSMUST00000095157.4
Phf11d
PHD finger protein 11D
chr10_-_80701811 0.31 ENSMUST00000003438.9
Mob3a
MOB kinase activator 3A
chr11_+_116843278 0.31 ENSMUST00000106370.3
Mettl23
methyltransferase like 23
chr4_+_109978004 0.28 ENSMUST00000061187.3
Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr9_-_107679592 0.28 ENSMUST00000010205.7
Gnat1
guanine nucleotide binding protein, alpha transducing 1
chrX_-_60893430 0.26 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr4_-_132345715 0.25 ENSMUST00000084250.4
Rcc1
regulator of chromosome condensation 1
chr1_-_184999549 0.24 ENSMUST00000027929.4
Mark1
MAP/microtubule affinity-regulating kinase 1
chr19_-_5560570 0.24 ENSMUST00000025861.1
Ovol1
OVO homolog-like 1 (Drosophila)
chr10_-_128525859 0.24 ENSMUST00000026427.6
Esyt1
extended synaptotagmin-like protein 1
chr11_-_113709520 0.23 ENSMUST00000173655.1
ENSMUST00000100248.4
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr4_-_132345686 0.23 ENSMUST00000030726.6
Rcc1
regulator of chromosome condensation 1
chr2_-_155074447 0.23 ENSMUST00000137242.1
ENSMUST00000054607.9
Ahcy
S-adenosylhomocysteine hydrolase
chr8_+_92855319 0.22 ENSMUST00000046290.1
Lpcat2
lysophosphatidylcholine acyltransferase 2
chr17_-_36032682 0.21 ENSMUST00000102678.4
H2-T23
histocompatibility 2, T region locus 23
chr15_+_34453285 0.21 ENSMUST00000060894.7
BC030476
cDNA sequence BC030476
chr7_-_126800354 0.21 ENSMUST00000106348.1
Aldoa
aldolase A, fructose-bisphosphate
chr18_+_77332394 0.20 ENSMUST00000148341.1
Loxhd1
lipoxygenase homology domains 1
chr3_-_151835967 0.20 ENSMUST00000106126.1
Ptgfr
prostaglandin F receptor
chr18_-_24603791 0.19 ENSMUST00000070726.3
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr6_+_122626410 0.19 ENSMUST00000049644.2
Dppa3
developmental pluripotency-associated 3
chr4_+_100478806 0.17 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
Ube2u
ubiquitin-conjugating enzyme E2U (putative)
chr3_-_130709419 0.17 ENSMUST00000043937.7
Ostc
oligosaccharyltransferase complex subunit
chrX_+_58030622 0.17 ENSMUST00000088627.4
Zic3
zinc finger protein of the cerebellum 3
chr19_-_55241236 0.16 ENSMUST00000069183.6
Gucy2g
guanylate cyclase 2g
chr18_-_24603464 0.16 ENSMUST00000154205.1
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr19_+_41933464 0.16 ENSMUST00000026154.7
Zdhhc16
zinc finger, DHHC domain containing 16
chr11_+_35121126 0.15 ENSMUST00000069837.3
Slit3
slit homolog 3 (Drosophila)
chr11_-_113710017 0.15 ENSMUST00000018871.1
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr10_+_80264942 0.15 ENSMUST00000105362.1
ENSMUST00000105361.3
Dazap1
DAZ associated protein 1
chr18_+_24603952 0.15 ENSMUST00000025120.6
Elp2
elongator acetyltransferase complex subunit 2
chr16_-_42340595 0.15 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr2_+_91256813 0.15 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chrX_-_20950597 0.15 ENSMUST00000009550.7
Elk1
ELK1, member of ETS oncogene family
chr2_+_91257323 0.14 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr3_-_15426427 0.14 ENSMUST00000099201.3
Sirpb1a
signal-regulatory protein beta 1A
chr13_+_51645232 0.13 ENSMUST00000075853.5
Cks2
CDC28 protein kinase regulatory subunit 2
chr2_-_150255591 0.13 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chrX_+_58030999 0.13 ENSMUST00000088631.4
ENSMUST00000088629.3
Zic3
zinc finger protein of the cerebellum 3
chr11_-_120378692 0.13 ENSMUST00000026448.9
2310003H01Rik
RIKEN cDNA 2310003H01 gene
chr17_-_49564262 0.12 ENSMUST00000057610.6
Daam2
dishevelled associated activator of morphogenesis 2
chr12_-_98577940 0.12 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr15_-_58034289 0.12 ENSMUST00000100655.3
9130401M01Rik
RIKEN cDNA 9130401M01 gene
chr9_-_66514567 0.12 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr10_+_39612934 0.11 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr12_+_52699297 0.11 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chrM_+_10167 0.11 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr4_+_140701466 0.11 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2
regulator of chromosome condensation 2
chr10_-_8886033 0.10 ENSMUST00000015449.5
Sash1
SAM and SH3 domain containing 1
chr15_-_9529868 0.10 ENSMUST00000003981.4
Il7r
interleukin 7 receptor
chr17_-_36462329 0.09 ENSMUST00000169950.1
ENSMUST00000057502.7
H2-M10.4
histocompatibility 2, M region locus 10.4
chrM_+_7759 0.09 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr5_-_106926245 0.08 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr2_-_132247747 0.08 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
Tmem230
transmembrane protein 230
chr4_-_129227883 0.08 ENSMUST00000106051.1
C77080
expressed sequence C77080
chr7_-_143460989 0.07 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c
cyclin-dependent kinase inhibitor 1C (P57)
chr16_-_45724600 0.07 ENSMUST00000096057.4
Tagln3
transgelin 3
chr9_-_120068263 0.07 ENSMUST00000064165.3
ENSMUST00000177637.1
Cx3cr1
chemokine (C-X3-C) receptor 1
chr7_+_6222278 0.06 ENSMUST00000072662.5
ENSMUST00000155314.1
Zscan5b
zinc finger and SCAN domain containing 5B
chr6_+_72097561 0.06 ENSMUST00000069994.4
ENSMUST00000114112.1
St3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr1_-_134955908 0.05 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr12_+_109545390 0.02 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr17_+_36837123 0.02 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
Trim26
tripartite motif-containing 26
chr11_+_116657106 0.02 ENSMUST00000116318.2
Gm11744
predicted gene 11744
chr8_+_14888022 0.02 ENSMUST00000123990.1
ENSMUST00000027554.7
Cln8
ceroid-lipofuscinosis, neuronal 8

Network of associatons between targets according to the STRING database.

First level regulatory network of Evx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1903919 regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919)
0.1 1.0 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.1 0.2 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 1.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.3 GO:0043366 beta selection(GO:0043366)
0.1 0.3 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342)
0.1 0.2 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.1 0.2 GO:2000566 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.2 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.2 GO:1901536 regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.0 0.2 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 0.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.4 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.2 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0 0.4 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.2 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.1 GO:2000481 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.4 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0001940 male pronucleus(GO:0001940)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.7 GO:0000792 heterochromatin(GO:0000792)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0031527 filopodium membrane(GO:0031527)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.5 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.2 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.2 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels