Motif ID: Fos

Z-value: 1.839


Transcription factors associated with Fos:

Gene SymbolEntrez IDGene Name
Fos ENSMUSG00000021250.7 Fos

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosmm10_v2_chr12_+_85473883_854738960.555.0e-04Click!


Activity profile for motif Fos.

activity profile for motif Fos


Sorted Z-values histogram for motif Fos

Sorted Z-values for motif Fos



Network of associatons between targets according to the STRING database.



First level regulatory network of Fos

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_102365111 20.640 ENSMUST00000006749.9
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr2_+_84734050 18.199 ENSMUST00000090729.2
Ypel4
yippee-like 4 (Drosophila)
chr1_-_132390301 18.097 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2
chr14_+_80000292 16.338 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr7_-_45920830 15.599 ENSMUST00000164119.1
Emp3
epithelial membrane protein 3
chr7_+_24370255 15.472 ENSMUST00000171904.1
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_+_174172738 15.454 ENSMUST00000027817.7
Spta1
spectrin alpha, erythrocytic 1
chr11_+_116533257 12.661 ENSMUST00000154034.1
Sphk1
sphingosine kinase 1
chr11_+_116531744 12.598 ENSMUST00000106387.2
ENSMUST00000100201.3
Sphk1

sphingosine kinase 1

chr7_+_110772604 11.820 ENSMUST00000005829.6
Ampd3
adenosine monophosphate deaminase 3
chr3_-_88503187 11.442 ENSMUST00000120377.1
Lmna
lamin A
chr13_+_95696851 10.555 ENSMUST00000022182.4
F2rl2
coagulation factor II (thrombin) receptor-like 2
chr11_-_53480178 10.497 ENSMUST00000104955.2
Sowaha
sosondowah ankyrin repeat domain family member A
chr4_-_140774196 10.445 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr7_-_143502515 10.006 ENSMUST00000010904.4
Phlda2
pleckstrin homology-like domain, family A, member 2
chr7_-_126369543 9.945 ENSMUST00000032997.6
Lat
linker for activation of T cells
chr7_+_78914216 9.676 ENSMUST00000120331.2
Isg20
interferon-stimulated protein
chr3_-_88503331 9.669 ENSMUST00000029699.6
Lmna
lamin A
chr19_-_34166037 9.330 ENSMUST00000025686.7
Ankrd22
ankyrin repeat domain 22
chr2_+_13573927 9.185 ENSMUST00000141365.1
ENSMUST00000028062.2
Vim

vimentin

chr17_-_57194170 9.127 ENSMUST00000005976.6
Tnfsf14
tumor necrosis factor (ligand) superfamily, member 14
chr3_-_123034943 9.108 ENSMUST00000029761.7
Myoz2
myozenin 2
chr7_+_78913765 9.004 ENSMUST00000038142.8
Isg20
interferon-stimulated protein
chr9_+_51213683 8.871 ENSMUST00000034554.7
Pou2af1
POU domain, class 2, associating factor 1
chr8_+_94984399 8.837 ENSMUST00000093271.6
Gpr56
G protein-coupled receptor 56
chr1_+_107511489 8.601 ENSMUST00000064916.2
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrX_-_104671048 8.529 ENSMUST00000042070.5
Zdhhc15
zinc finger, DHHC domain containing 15
chr13_-_21780616 8.487 ENSMUST00000080511.2
Hist1h1b
histone cluster 1, H1b
chr1_+_107511416 8.469 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrX_-_143827391 8.457 ENSMUST00000087316.5
Capn6
calpain 6
chr6_+_4755327 8.456 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr2_+_24336846 7.865 ENSMUST00000114487.2
Il1rn
interleukin 1 receptor antagonist
chr10_+_88091070 7.812 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr2_-_102451792 7.730 ENSMUST00000099678.3
Fjx1
four jointed box 1 (Drosophila)
chr7_-_126799134 7.621 ENSMUST00000087566.4
Aldoa
aldolase A, fructose-bisphosphate
chr1_+_40515362 7.364 ENSMUST00000027237.5
Il18rap
interleukin 18 receptor accessory protein
chr5_+_31116722 7.289 ENSMUST00000114637.1
Trim54
tripartite motif-containing 54
chr7_-_126799163 7.071 ENSMUST00000032934.5
Aldoa
aldolase A, fructose-bisphosphate
chr2_+_164948219 7.059 ENSMUST00000017881.2
Mmp9
matrix metallopeptidase 9
chr5_+_31116702 7.041 ENSMUST00000013771.8
Trim54
tripartite motif-containing 54
chr11_-_100207507 6.854 ENSMUST00000007272.7
Krt14
keratin 14
chr1_+_170277376 6.811 ENSMUST00000179976.1
Sh2d1b1
SH2 domain protein 1B1
chr3_+_103102604 6.590 ENSMUST00000173206.1
Dennd2c
DENN/MADD domain containing 2C
chr5_-_134946917 6.369 ENSMUST00000051401.2
Cldn4
claudin 4
chr11_+_69125896 6.338 ENSMUST00000021268.2
Aloxe3
arachidonate lipoxygenase 3
chr4_-_43040279 6.325 ENSMUST00000107958.1
ENSMUST00000107959.1
ENSMUST00000152846.1
Fam214b


family with sequence similarity 214, member B


chr8_+_88289028 6.254 ENSMUST00000171456.1
Adcy7
adenylate cyclase 7
chrX_-_134583114 6.238 ENSMUST00000113213.1
ENSMUST00000033617.6
Btk

Bruton agammaglobulinemia tyrosine kinase

chr8_-_25091341 6.075 ENSMUST00000125466.1
Plekha2
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
chr19_+_53460610 5.964 ENSMUST00000180442.1
4833407H14Rik
RIKEN cDNA 4833407H14 gene
chr7_+_30776394 5.957 ENSMUST00000041703.7
Dmkn
dermokine
chr5_-_65091584 5.935 ENSMUST00000043352.4
Tmem156
transmembrane protein 156
chr10_+_128909866 5.901 ENSMUST00000026407.7
Cd63
CD63 antigen
chr13_-_90905321 5.705 ENSMUST00000109541.3
Atp6ap1l
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr7_+_30787897 5.667 ENSMUST00000098559.1
Krtdap
keratinocyte differentiation associated protein
chr14_-_54712139 5.652 ENSMUST00000064290.6
Cebpe
CCAAT/enhancer binding protein (C/EBP), epsilon
chr18_+_82910863 5.305 ENSMUST00000171238.1
Zfp516
zinc finger protein 516
chr17_-_47834682 5.179 ENSMUST00000066368.6
Mdfi
MyoD family inhibitor
chr1_-_52190901 5.128 ENSMUST00000156887.1
ENSMUST00000129107.1
Gls

glutaminase

chr13_+_76579670 5.093 ENSMUST00000126960.1
ENSMUST00000109583.2
Mctp1

multiple C2 domains, transmembrane 1

chr6_+_49036518 5.060 ENSMUST00000031840.7
Gpnmb
glycoprotein (transmembrane) nmb
chr4_+_43506966 4.968 ENSMUST00000030183.3
Car9
carbonic anhydrase 9
chr11_-_100135928 4.909 ENSMUST00000107411.2
Krt15
keratin 15
chr6_-_129507107 4.778 ENSMUST00000183258.1
ENSMUST00000182784.1
ENSMUST00000032265.6
ENSMUST00000162815.1
Olr1



oxidized low density lipoprotein (lectin-like) receptor 1



chr12_+_80518990 4.745 ENSMUST00000021558.6
Galnt16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr9_+_78615501 4.716 ENSMUST00000093812.4
Cd109
CD109 antigen
chr5_+_34999111 4.701 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr7_-_109781538 4.645 ENSMUST00000033331.6
Nrip3
nuclear receptor interacting protein 3
chr3_+_109573907 4.618 ENSMUST00000106576.2
Vav3
vav 3 oncogene
chr3_+_95929325 4.614 ENSMUST00000171368.1
ENSMUST00000168106.1
Anp32e

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr16_+_78930940 4.592 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
Chodl


chondrolectin


chr11_+_50357759 4.563 ENSMUST00000052596.2
Cby3
chibby homolog 3 (Drosophila)
chr11_-_79059872 4.559 ENSMUST00000141409.1
Ksr1
kinase suppressor of ras 1
chr5_+_34999046 4.549 ENSMUST00000114281.1
Rgs12
regulator of G-protein signaling 12
chr2_+_156475844 4.540 ENSMUST00000103135.1
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr3_+_95929246 4.532 ENSMUST00000165307.1
ENSMUST00000015893.6
Anp32e

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr6_+_135362931 4.526 ENSMUST00000032330.9
Emp1
epithelial membrane protein 1
chr15_-_9529868 4.494 ENSMUST00000003981.4
Il7r
interleukin 7 receptor
chrX_-_7671341 4.467 ENSMUST00000033486.5
Plp2
proteolipid protein 2
chr17_+_35049966 4.465 ENSMUST00000007257.9
Clic1
chloride intracellular channel 1
chr15_-_64312636 4.413 ENSMUST00000177083.1
ENSMUST00000177371.1
Asap1

ArfGAP with SH3 domain, ankyrin repeat and PH domain1

chr2_+_156475803 4.409 ENSMUST00000029155.8
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr14_-_34588654 4.388 ENSMUST00000022328.6
ENSMUST00000064098.6
ENSMUST00000022327.5
ENSMUST00000022330.7
Ldb3



LIM domain binding 3



chrX_+_159840463 4.336 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1

SH3-domain kinase binding protein 1

chrX_-_48454152 4.310 ENSMUST00000114958.1
Elf4
E74-like factor 4 (ets domain transcription factor)
chr9_+_69453620 4.282 ENSMUST00000034756.8
ENSMUST00000123470.1
Anxa2

annexin A2

chr10_+_119992916 4.280 ENSMUST00000105261.2
Grip1
glutamate receptor interacting protein 1
chrX_+_96455359 4.273 ENSMUST00000033553.7
Heph
hephaestin
chr3_+_14641722 4.248 ENSMUST00000029071.8
Car13
carbonic anhydrase 13
chr17_+_46161021 4.235 ENSMUST00000024748.7
ENSMUST00000172170.1
Gtpbp2

GTP binding protein 2

chrX_-_160906998 4.215 ENSMUST00000069417.5
Gja6
gap junction protein, alpha 6
chr12_+_103388656 4.201 ENSMUST00000101094.2
ENSMUST00000021620.6
Otub2

OTU domain, ubiquitin aldehyde binding 2

chr14_-_33185489 4.189 ENSMUST00000159606.1
Wdfy4
WD repeat and FYVE domain containing 4
chr13_-_23991158 4.172 ENSMUST00000021770.7
Scgn
secretagogin, EF-hand calcium binding protein
chr16_-_92826004 4.145 ENSMUST00000023673.7
Runx1
runt related transcription factor 1
chr5_+_34999070 4.094 ENSMUST00000114280.1
Rgs12
regulator of G-protein signaling 12
chr10_+_80930071 4.031 ENSMUST00000015456.8
Gadd45b
growth arrest and DNA-damage-inducible 45 beta
chr5_-_24392012 4.026 ENSMUST00000059401.6
Atg9b
autophagy related 9B
chr1_-_58973421 3.973 ENSMUST00000173590.1
ENSMUST00000027186.5
Trak2

trafficking protein, kinesin binding 2

chr11_-_76509419 3.973 ENSMUST00000094012.4
Abr
active BCR-related gene
chr1_+_171559186 3.958 ENSMUST00000004829.7
Cd244
CD244 natural killer cell receptor 2B4
chrX_-_7740206 3.906 ENSMUST00000128289.1
Ccdc120
coiled-coil domain containing 120
chr11_-_109473598 3.878 ENSMUST00000070152.5
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr7_+_30763750 3.865 ENSMUST00000165887.1
ENSMUST00000085691.4
ENSMUST00000085688.4
ENSMUST00000054427.6
Dmkn



dermokine



chr1_+_135783065 3.810 ENSMUST00000132795.1
Tnni1
troponin I, skeletal, slow 1
chr4_-_43558386 3.787 ENSMUST00000130353.1
Tln1
talin 1
chr11_-_100261021 3.782 ENSMUST00000080893.6
Krt17
keratin 17
chr4_+_150927918 3.754 ENSMUST00000139826.1
ENSMUST00000116257.1
Tnfrsf9

tumor necrosis factor receptor superfamily, member 9

chr10_+_119992962 3.753 ENSMUST00000154238.1
Grip1
glutamate receptor interacting protein 1
chr3_-_92485886 3.737 ENSMUST00000054599.7
Sprr1a
small proline-rich protein 1A
chr2_-_166581969 3.695 ENSMUST00000109246.1
Prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr5_+_105415738 3.662 ENSMUST00000112707.1
Lrrc8b
leucine rich repeat containing 8 family, member B
chr14_-_33185066 3.640 ENSMUST00000061753.8
ENSMUST00000130509.2
Wdfy4

WD repeat and FYVE domain containing 4

chr4_+_109406623 3.606 ENSMUST00000124209.1
Ttc39a
tetratricopeptide repeat domain 39A
chr1_-_153186447 3.606 ENSMUST00000027753.6
Lamc2
laminin, gamma 2
chr8_+_21529031 3.595 ENSMUST00000084041.3
Gm15308
predicted gene 15308
chr8_+_21391811 3.543 ENSMUST00000120874.3
Gm21002
predicted gene, 21002
chr6_+_42350000 3.484 ENSMUST00000164375.1
Zyx
zyxin
chr8_+_69902178 3.477 ENSMUST00000050373.5
Tssk6
testis-specific serine kinase 6
chr11_+_61684419 3.452 ENSMUST00000093019.5
Fam83g
family with sequence similarity 83, member G
chr8_+_122282117 3.348 ENSMUST00000054052.8
Zfpm1
zinc finger protein, multitype 1
chr17_+_12119274 3.347 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr16_+_35770382 3.340 ENSMUST00000023555.4
Hspbap1
Hspb associated protein 1
chr6_-_129533267 3.316 ENSMUST00000181594.1
1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr17_+_28951950 3.288 ENSMUST00000153462.1
Kctd20
potassium channel tetramerisation domain containing 20
chr13_-_55528511 3.263 ENSMUST00000047877.4
Dok3
docking protein 3
chr16_-_44558864 3.260 ENSMUST00000023370.4
Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr8_+_21378560 3.126 ENSMUST00000170275.2
Defa2
defensin, alpha, 2
chr6_+_42349826 3.116 ENSMUST00000070635.6
Zyx
zyxin
chr15_-_90679307 3.081 ENSMUST00000014777.8
ENSMUST00000064391.5
Cpne8

copine VIII

chr7_+_27486910 3.026 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chr11_+_78188422 3.024 ENSMUST00000002128.7
ENSMUST00000150941.1
Rab34

RAB34, member of RAS oncogene family

chr7_+_92741603 2.963 ENSMUST00000032879.7
Rab30
RAB30, member RAS oncogene family
chr18_+_44071390 2.958 ENSMUST00000068473.2
Spink6
serine peptidase inhibitor, Kazal type 6
chr13_-_62858364 2.940 ENSMUST00000021907.7
Fbp2
fructose bisphosphatase 2
chr7_+_126776939 2.926 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
Ypel3






yippee-like 3 (Drosophila)






chr8_-_11008458 2.925 ENSMUST00000040514.6
Irs2
insulin receptor substrate 2
chr10_+_116143881 2.856 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr5_+_30013141 2.854 ENSMUST00000026845.7
Il6
interleukin 6
chr7_+_126766397 2.801 ENSMUST00000032944.7
Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
chr2_+_118663235 2.788 ENSMUST00000099557.3
Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chrX_+_71962971 2.781 ENSMUST00000048790.6
Prrg3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr7_+_126584937 2.778 ENSMUST00000039522.6
Apobr
apolipoprotein B receptor
chr2_+_30441831 2.776 ENSMUST00000131476.1
Ppp2r4
protein phosphatase 2A, regulatory subunit B (PR 53)
chr5_+_25247344 2.685 ENSMUST00000114950.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr1_+_135232045 2.680 ENSMUST00000110798.3
Gm4204
predicted gene 4204
chr14_+_79515618 2.676 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr2_+_131909951 2.661 ENSMUST00000124100.1
ENSMUST00000136783.1
PRND

prion protein gene complex (Prn), transcript variant 1, mRNA

chrX_-_167209149 2.658 ENSMUST00000112176.1
Tmsb4x
thymosin, beta 4, X chromosome
chr4_+_133130505 2.656 ENSMUST00000084241.5
ENSMUST00000138831.1
Wasf2

WAS protein family, member 2

chr7_-_142372210 2.567 ENSMUST00000084412.5
Ifitm10
interferon induced transmembrane protein 10
chr16_-_44558879 2.493 ENSMUST00000114634.1
Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr12_-_54999102 2.485 ENSMUST00000173529.1
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr8_+_69822429 2.480 ENSMUST00000164890.1
ENSMUST00000034325.4
Lpar2

lysophosphatidic acid receptor 2

chr17_+_35841668 2.475 ENSMUST00000174124.1
Mdc1
mediator of DNA damage checkpoint 1
chr1_+_165302625 2.453 ENSMUST00000111450.1
Gpr161
G protein-coupled receptor 161
chr7_+_30751471 2.450 ENSMUST00000182229.1
ENSMUST00000182227.1
ENSMUST00000080518.6
ENSMUST00000182721.1
Sbsn



suprabasin



chr3_+_95232287 2.429 ENSMUST00000107200.1
ENSMUST00000107199.1
Cdc42se1

CDC42 small effector 1

chr5_+_100846364 2.417 ENSMUST00000092990.3
ENSMUST00000145612.1
Agpat9

1-acylglycerol-3-phosphate O-acyltransferase 9

chr11_-_33843526 2.411 ENSMUST00000065970.5
ENSMUST00000109340.2
Kcnip1

Kv channel-interacting protein 1

chr9_-_112187766 2.381 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr1_-_165160773 2.380 ENSMUST00000027859.5
Tbx19
T-box 19
chr8_+_95703037 2.379 ENSMUST00000073139.7
ENSMUST00000080666.7
Ndrg4

N-myc downstream regulated gene 4

chr7_-_126594941 2.373 ENSMUST00000058429.5
Il27
interleukin 27
chr5_+_100846130 2.367 ENSMUST00000112887.1
ENSMUST00000031255.8
Agpat9

1-acylglycerol-3-phosphate O-acyltransferase 9

chr16_-_29946499 2.313 ENSMUST00000181968.1
Gm26569
predicted gene, 26569
chr11_+_67798269 2.301 ENSMUST00000168612.1
ENSMUST00000040574.4
Dhrs7c

dehydrogenase/reductase (SDR family) member 7C

chr3_-_107518001 2.296 ENSMUST00000169449.1
ENSMUST00000029499.8
Slc6a17

solute carrier family 6 (neurotransmitter transporter), member 17

chr13_+_15463837 2.217 ENSMUST00000110510.3
Gli3
GLI-Kruppel family member GLI3
chr3_+_103576081 2.207 ENSMUST00000183637.1
ENSMUST00000117221.2
ENSMUST00000118117.1
ENSMUST00000118563.2
Syt6



synaptotagmin VI



chr10_+_111473186 2.167 ENSMUST00000065917.8
Nap1l1
nucleosome assembly protein 1-like 1
chr19_-_56389877 2.150 ENSMUST00000166203.1
ENSMUST00000167239.1
ENSMUST00000040711.8
ENSMUST00000095947.4
ENSMUST00000073536.6
Nrap




nebulin-related anchoring protein




chr11_+_78188806 2.139 ENSMUST00000056241.5
Rab34
RAB34, member of RAS oncogene family
chr13_+_76579681 2.120 ENSMUST00000109589.2
Mctp1
multiple C2 domains, transmembrane 1
chr10_+_80264942 2.119 ENSMUST00000105362.1
ENSMUST00000105361.3
Dazap1

DAZ associated protein 1

chr17_+_75178797 2.115 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr14_+_103513328 2.096 ENSMUST00000095576.3
Scel
sciellin
chr1_+_74125535 2.083 ENSMUST00000080167.4
ENSMUST00000127134.1
Rufy4

RUN and FYVE domain containing 4

chr19_+_33822908 2.076 ENSMUST00000042061.6
Gm5519
predicted pseudogene 5519
chr1_-_171437288 2.048 ENSMUST00000181499.1
Gm26641
predicted gene, 26641
chr17_-_7385305 2.045 ENSMUST00000070059.3
Gm9992
predicted gene 9992
chr2_-_164404606 2.040 ENSMUST00000109359.1
ENSMUST00000109358.1
ENSMUST00000103103.3
Matn4


matrilin 4


chr7_-_105482197 2.029 ENSMUST00000047040.2
Prkcdbp
protein kinase C, delta binding protein
chr14_-_34588607 2.026 ENSMUST00000090040.4
Ldb3
LIM domain binding 3
chr2_-_45110336 2.017 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr3_+_116594959 2.000 ENSMUST00000029571.8
Sass6
spindle assembly 6 homolog (C. elegans)
chr14_-_70177668 1.989 ENSMUST00000022681.4
Pdlim2
PDZ and LIM domain 2
chr9_-_32541589 1.989 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr2_-_101797650 1.972 ENSMUST00000141814.1
ENSMUST00000171088.1
ENSMUST00000043845.7
Prr5l


proline rich 5 like


chr12_+_31265234 1.969 ENSMUST00000169088.1
Lamb1
laminin B1
chr11_+_20543307 1.954 ENSMUST00000093292.4
Sertad2
SERTA domain containing 2
chr3_-_92573715 1.922 ENSMUST00000053107.4
Ivl
involucrin
chr2_+_174760781 1.905 ENSMUST00000140908.1
Edn3
endothelin 3
chr17_+_75178911 1.903 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr10_+_94550852 1.875 ENSMUST00000148910.1
ENSMUST00000117460.1
Tmcc3

transmembrane and coiled coil domains 3

chr10_+_127290774 1.869 ENSMUST00000026475.8
ENSMUST00000139091.1
Ddit3

DNA-damage inducible transcript 3

chr1_+_130717320 1.858 ENSMUST00000049813.4
Yod1
YOD1 OTU deubiquitinating enzyme 1 homologue (S. cerevisiae)
chr15_-_58823530 1.857 ENSMUST00000072113.5
Tmem65
transmembrane protein 65
chr3_+_88621436 1.848 ENSMUST00000170653.2
ENSMUST00000177303.1
Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chr12_+_31265279 1.805 ENSMUST00000002979.8
ENSMUST00000170495.1
Lamb1

laminin B1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 21.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
4.2 25.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
3.7 18.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
3.0 9.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
3.0 9.1 GO:0060722 spongiotrophoblast cell proliferation(GO:0060720) cell proliferation involved in embryonic placenta development(GO:0060722)
2.7 13.3 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
2.6 7.8 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
2.4 7.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
2.1 10.7 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
2.1 10.4 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
2.1 6.2 GO:0002343 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
1.8 9.2 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
1.7 3.5 GO:0035092 sperm chromatin condensation(GO:0035092)
1.7 6.8 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
1.4 4.3 GO:1905602 regulation of low-density lipoprotein particle receptor binding(GO:1905595) positive regulation of receptor-mediated endocytosis involved in cholesterol transport(GO:1905602)
1.4 4.1 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
1.3 4.0 GO:0071613 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
1.3 11.8 GO:0032264 IMP salvage(GO:0032264)
1.3 6.3 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
1.3 17.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.2 6.2 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
1.2 16.0 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
1.2 9.8 GO:1903575 cornified envelope assembly(GO:1903575)
1.2 5.9 GO:2000680 regulation of rubidium ion transport(GO:2000680)
1.1 3.2 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
1.1 4.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
1.0 7.1 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.9 3.8 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.9 3.8 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.9 4.4 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.9 5.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.8 3.3 GO:0042097 interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402)
0.8 4.0 GO:0044805 late nucleophagy(GO:0044805)
0.8 4.0 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.8 4.7 GO:0072675 osteoclast fusion(GO:0072675)
0.7 2.2 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.7 20.6 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.7 7.8 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.6 1.9 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.6 1.7 GO:0036363 transforming growth factor beta activation(GO:0036363)
0.6 3.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.6 4.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.6 1.7 GO:2000642 negative regulation of cytoplasmic transport(GO:1903650) negative regulation of early endosome to late endosome transport(GO:2000642)
0.6 9.9 GO:0006968 cellular defense response(GO:0006968)
0.5 9.0 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.5 2.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.5 3.8 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.5 2.3 GO:0015820 leucine transport(GO:0015820)
0.4 2.9 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.4 6.2 GO:0071361 cellular response to ethanol(GO:0071361)
0.4 4.0 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.4 1.9 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826)
0.4 3.4 GO:0038203 TORC2 signaling(GO:0038203)
0.4 15.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.4 9.1 GO:0043486 histone exchange(GO:0043486)
0.4 16.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.3 20.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.3 11.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.3 2.7 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.3 2.9 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.3 1.1 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.3 3.6 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.3 3.0 GO:1900003 regulation of serine-type endopeptidase activity(GO:1900003) negative regulation of serine-type endopeptidase activity(GO:1900004) regulation of serine-type peptidase activity(GO:1902571) negative regulation of serine-type peptidase activity(GO:1902572)
0.3 1.8 GO:0001866 NK T cell proliferation(GO:0001866)
0.3 3.6 GO:0070831 basement membrane assembly(GO:0070831)
0.3 3.1 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.2 0.7 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.2 2.5 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.2 1.3 GO:1901525 negative regulation of mitophagy(GO:1901525)
0.2 2.7 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.2 7.7 GO:0010842 retina layer formation(GO:0010842)
0.2 0.6 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.2 1.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.2 9.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.2 0.6 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959) interleukin-12-mediated signaling pathway(GO:0035722) positive regulation of growth hormone receptor signaling pathway(GO:0060399) cellular response to interleukin-12(GO:0071349)
0.2 2.4 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.2 4.2 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.2 0.9 GO:0030578 PML body organization(GO:0030578) positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.2 4.6 GO:0035855 megakaryocyte development(GO:0035855)
0.2 1.9 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.2 4.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 3.5 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.1 5.8 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 2.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 4.0 GO:0010714 positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.1 4.3 GO:0006825 copper ion transport(GO:0006825)
0.1 1.4 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 1.0 GO:0007296 vitellogenesis(GO:0007296)
0.1 3.8 GO:0031424 keratinization(GO:0031424)
0.1 0.5 GO:0019062 virion attachment to host cell(GO:0019062)
0.1 3.7 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.1 0.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 1.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 6.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 8.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 2.8 GO:0007612 learning(GO:0007612)
0.1 1.0 GO:0042940 D-amino acid transport(GO:0042940)
0.1 5.1 GO:0032720 negative regulation of tumor necrosis factor production(GO:0032720)
0.1 2.0 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 8.4 GO:0030239 myofibril assembly(GO:0030239)
0.1 1.0 GO:0030049 muscle filament sliding(GO:0030049)
0.1 3.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 4.2 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.1 1.0 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.8 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.4 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 1.0 GO:0006020 inositol metabolic process(GO:0006020)
0.1 1.4 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 2.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 3.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 0.8 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 1.7 GO:0042481 regulation of odontogenesis(GO:0042481)
0.1 2.3 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.1 0.1 GO:2000851 positive regulation of glucocorticoid secretion(GO:2000851)
0.1 4.6 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 2.4 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 4.5 GO:0070527 platelet aggregation(GO:0070527)
0.1 2.0 GO:0007099 centriole replication(GO:0007099)
0.1 2.4 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.1 0.4 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.1 0.5 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.8 GO:0048484 enteric nervous system development(GO:0048484)
0.1 1.2 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.1 0.2 GO:1905355 spine apparatus assembly(GO:1905355)
0.0 2.4 GO:0021983 pituitary gland development(GO:0021983)
0.0 0.7 GO:0014029 neural crest formation(GO:0014029)
0.0 0.0 GO:1901534 positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 1.4 GO:0019236 response to pheromone(GO:0019236)
0.0 1.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 1.1 GO:0034389 lipid particle organization(GO:0034389)
0.0 4.8 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 3.1 GO:0042089 cytokine biosynthetic process(GO:0042089)
0.0 1.3 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.6 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.5 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.5 GO:0045109 intermediate filament organization(GO:0045109)
0.0 4.3 GO:0044070 regulation of anion transport(GO:0044070)
0.0 0.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 3.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.7 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0 1.0 GO:0010107 potassium ion import(GO:0010107)
0.0 3.2 GO:0030509 BMP signaling pathway(GO:0030509)
0.0 0.9 GO:1902373 negative regulation of mRNA catabolic process(GO:1902373)
0.0 0.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.4 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.3 GO:0016540 protein autoprocessing(GO:0016540)
0.0 2.6 GO:0007030 Golgi organization(GO:0007030)
0.0 0.4 GO:0040020 regulation of meiotic nuclear division(GO:0040020)
0.0 0.9 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
0.0 6.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.1 GO:0048570 notochord morphogenesis(GO:0048570)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 1.7 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 1.0 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 0.4 GO:0050798 activated T cell proliferation(GO:0050798)
0.0 0.3 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.0 0.3 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.2 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 21.1 GO:0005638 lamin filament(GO:0005638)
2.6 15.5 GO:0032437 cuticular plate(GO:0032437)
2.5 7.4 GO:0005607 laminin-2 complex(GO:0005607)
1.5 5.9 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.4 4.3 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
1.3 4.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.1 9.2 GO:0045098 type III intermediate filament(GO:0045098)
1.1 16.8 GO:0042581 specific granule(GO:0042581)
0.8 14.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.8 2.4 GO:1990047 spindle matrix(GO:1990047)
0.7 2.9 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.6 1.9 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.6 2.5 GO:0008623 CHRAC(GO:0008623)
0.4 1.7 GO:0061827 sperm head(GO:0061827)
0.4 18.7 GO:0015030 Cajal body(GO:0015030)
0.3 2.0 GO:0098536 deuterosome(GO:0098536)
0.3 5.7 GO:0042599 lamellar body(GO:0042599)
0.3 2.5 GO:0000138 Golgi trans cisterna(GO:0000138)
0.2 6.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 2.7 GO:0031209 SCAR complex(GO:0031209)
0.2 3.4 GO:0031932 TORC2 complex(GO:0031932)
0.2 3.8 GO:0005861 troponin complex(GO:0005861)
0.2 9.9 GO:0008180 COP9 signalosome(GO:0008180)
0.2 4.8 GO:0005922 connexin complex(GO:0005922)
0.2 5.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 0.9 GO:0005914 spot adherens junction(GO:0005914)
0.2 1.1 GO:0000235 astral microtubule(GO:0000235)
0.1 13.2 GO:0014704 intercalated disc(GO:0014704)
0.1 1.4 GO:0045298 tubulin complex(GO:0045298)
0.1 0.6 GO:0031523 Myb complex(GO:0031523)
0.1 2.8 GO:0034362 low-density lipoprotein particle(GO:0034362) chylomicron(GO:0042627)
0.1 6.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 10.4 GO:0005882 intermediate filament(GO:0005882)
0.1 2.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 1.0 GO:0016461 unconventional myosin complex(GO:0016461)
0.1 4.8 GO:0005876 spindle microtubule(GO:0005876)
0.1 7.4 GO:0000786 nucleosome(GO:0000786)
0.1 21.0 GO:0008021 synaptic vesicle(GO:0008021)
0.1 3.8 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 6.8 GO:0030139 endocytic vesicle(GO:0030139)
0.1 10.8 GO:0055037 recycling endosome(GO:0055037)
0.1 3.1 GO:0002102 podosome(GO:0002102)
0.1 6.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 4.0 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.7 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 2.7 GO:0016592 mediator complex(GO:0016592) core mediator complex(GO:0070847)
0.1 2.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 3.0 GO:0005801 cis-Golgi network(GO:0005801)
0.1 3.9 GO:0042629 mast cell granule(GO:0042629)
0.1 1.9 GO:0001533 cornified envelope(GO:0001533)
0.1 1.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 10.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.2 GO:0097444 spine apparatus(GO:0097444)
0.1 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 10.6 GO:0005875 microtubule associated complex(GO:0005875)
0.0 3.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 5.1 GO:0034702 ion channel complex(GO:0034702)
0.0 1.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.9 GO:0016605 PML body(GO:0016605)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.0 GO:0005844 polysome(GO:0005844)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 2.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.6 GO:0005901 caveola(GO:0005901)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 18.7 GO:0008859 exoribonuclease II activity(GO:0008859)
3.9 15.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
3.6 25.3 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
2.6 10.6 GO:0015057 thrombin-activated receptor activity(GO:0015057)
2.6 7.9 GO:0045352 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
2.3 11.6 GO:1990254 keratin filament binding(GO:1990254)
2.1 10.4 GO:0004668 protein-arginine deiminase activity(GO:0004668)
1.8 9.1 GO:0051373 FATZ binding(GO:0051373)
1.6 14.7 GO:0070061 fructose binding(GO:0070061)
1.3 11.8 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.0 20.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
1.0 4.0 GO:0050436 microfibril binding(GO:0050436)
1.0 2.9 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.9 4.3 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.9 5.1 GO:0004359 glutaminase activity(GO:0004359)
0.7 3.7 GO:0030280 structural constituent of epidermis(GO:0030280)
0.7 4.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.7 7.4 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.6 5.1 GO:0045545 syndecan binding(GO:0045545)
0.6 9.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.6 2.4 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.6 21.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.5 9.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.5 3.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.5 2.5 GO:0033188 ceramide phosphoethanolamine synthase activity(GO:0002950) sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.5 1.9 GO:0031708 endothelin B receptor binding(GO:0031708)
0.5 2.8 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.5 4.6 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.4 1.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.4 1.3 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.4 4.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 5.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.4 9.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.4 4.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.4 7.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 8.7 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.3 0.7 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.3 3.8 GO:0030274 LIM domain binding(GO:0030274)
0.3 3.8 GO:0043208 glycosphingolipid binding(GO:0043208)
0.3 8.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.3 7.6 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.3 2.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 1.7 GO:0002135 CTP binding(GO:0002135)
0.3 8.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 13.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 9.1 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.3 6.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.3 5.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 1.0 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.2 1.9 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.2 16.0 GO:0035591 signaling adaptor activity(GO:0035591)
0.2 4.0 GO:0050811 GABA receptor binding(GO:0050811)
0.2 0.7 GO:0004947 bradykinin receptor activity(GO:0004947)
0.2 4.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 1.0 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.2 4.0 GO:0042288 MHC class I protein binding(GO:0042288)
0.2 6.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 1.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 1.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 9.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 7.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 3.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 4.2 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 0.9 GO:0061649 ubiquitin modification-dependent histone binding(GO:0061649)
0.1 5.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 5.0 GO:0019956 chemokine binding(GO:0019956)
0.1 7.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 2.8 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 6.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 6.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 3.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) tumor necrosis factor binding(GO:0043120)
0.1 4.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 1.9 GO:0035497 cAMP response element binding(GO:0035497)
0.1 6.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 11.8 GO:0005179 hormone activity(GO:0005179)
0.1 3.7 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.5 GO:0046812 host cell surface binding(GO:0046812)
0.1 0.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 0.6 GO:0048039 ubiquinone binding(GO:0048039)
0.1 0.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 3.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 3.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 4.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 10.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 0.5 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931)
0.1 2.8 GO:0070412 R-SMAD binding(GO:0070412)
0.1 21.2 GO:0008017 microtubule binding(GO:0008017)
0.1 0.1 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.1 1.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 4.0 GO:0097110 scaffold protein binding(GO:0097110)
0.1 0.9 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.7 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 1.4 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 1.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 3.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 2.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 1.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 7.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 7.8 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.3 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.8 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 1.0 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 5.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.2 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 1.3 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.6 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 1.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)
0.0 6.2 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 25.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.7 10.6 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.6 9.9 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.6 7.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.4 28.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 6.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 11.7 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.2 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 3.4 ST_STAT3_PATHWAY STAT3 Pathway
0.2 7.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 6.2 ST_GA12_PATHWAY G alpha 12 Pathway
0.2 7.6 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.2 5.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 10.2 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.2 7.0 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.2 12.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.5 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 2.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 4.0 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 2.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 7.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 4.4 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 10.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.9 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 3.8 PID_ATM_PATHWAY ATM pathway
0.1 1.3 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.1 3.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 4.9 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 7.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.8 SIG_CHEMOTAXIS Genes related to chemotaxis
0.1 0.8 PID_ALK2_PATHWAY ALK2 signaling events
0.1 3.8 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 2.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.5 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 0.6 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.1 3.1 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.1 1.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 3.2 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 2.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 4.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID_IL1_PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.8 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.6 27.8 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.5 8.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.4 6.3 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.4 30.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.4 16.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 9.9 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.3 14.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 16.2 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 3.4 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.3 4.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.3 2.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.2 3.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 5.2 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 8.1 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 3.8 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 2.9 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 1.7 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.2 8.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 16.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 5.5 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.1 5.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 7.1 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 6.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.3 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 21.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 7.1 REACTOME_SIGNALING_BY_SCF_KIT Genes involved in Signaling by SCF-KIT
0.1 2.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 13.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 6.8 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.1 1.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 4.3 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 2.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.3 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 4.4 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 3.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 3.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 3.0 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.0 1.1 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 1.0 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.7 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.0 0.7 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 2.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.5 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF