Motif ID: Foxa2_Foxa1

Z-value: 2.032

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa2mm10_v2_chr2_-_148046896_1480469910.684.1e-06Click!
Foxa1mm10_v2_chr12_-_57546121_575461410.335.2e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_113258837 55.125 ENSMUST00000098673.3
Amy2a5
amylase 2a5
chr3_-_113532288 39.001 ENSMUST00000132353.1
Amy2a1
amylase 2a1
chr6_+_30541582 28.174 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr3_-_20275659 27.115 ENSMUST00000011607.5
Cpb1
carboxypeptidase B1 (tissue)
chr17_-_31144271 25.503 ENSMUST00000024826.7
Tff2
trefoil factor 2 (spasmolytic protein 1)
chr2_-_62483637 20.026 ENSMUST00000136686.1
ENSMUST00000102733.3
Gcg

glucagon

chr7_+_131032061 17.422 ENSMUST00000084509.3
Dmbt1
deleted in malignant brain tumors 1
chr6_+_142298419 16.685 ENSMUST00000041993.2
Iapp
islet amyloid polypeptide
chr3_+_107230608 13.085 ENSMUST00000179399.1
A630076J17Rik
RIKEN cDNA A630076J17 gene
chr9_+_46268601 12.352 ENSMUST00000121598.1
Apoa5
apolipoprotein A-V
chr6_-_136922169 11.189 ENSMUST00000032343.6
Erp27
endoplasmic reticulum protein 27
chr5_-_108795352 8.899 ENSMUST00000004943.1
Tmed11
transmembrane emp24 protein transport domain containing
chr6_-_41446062 8.880 ENSMUST00000095999.5
Gm10334
predicted gene 10334
chr3_-_113324052 8.364 ENSMUST00000179314.1
Amy2a3
amylase 2a3
chr3_-_113291449 8.284 ENSMUST00000179568.1
Amy2a4
amylase 2a4
chr4_-_57916283 8.182 ENSMUST00000063816.5
D630039A03Rik
RIKEN cDNA D630039A03 gene
chr7_+_140763739 7.701 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr15_+_10223974 7.111 ENSMUST00000128450.1
ENSMUST00000148257.1
ENSMUST00000128921.1
Prlr


prolactin receptor


chr1_+_130865669 6.824 ENSMUST00000038829.5
Faim3
Fas apoptotic inhibitory molecule 3
chr3_-_145032765 6.275 ENSMUST00000029919.5
Clca3
chloride channel calcium activated 3
chr2_+_164403194 6.179 ENSMUST00000017151.1
Rbpjl
recombination signal binding protein for immunoglobulin kappa J region-like
chr4_-_6275629 6.165 ENSMUST00000029905.1
Cyp7a1
cytochrome P450, family 7, subfamily a, polypeptide 1
chr19_+_23141183 4.798 ENSMUST00000036884.1
Klf9
Kruppel-like factor 9
chr6_-_87388878 4.755 ENSMUST00000032127.4
Gkn3
gastrokine 3
chr2_+_58755177 4.728 ENSMUST00000102755.3
Upp2
uridine phosphorylase 2
chr4_+_34893772 4.640 ENSMUST00000029975.3
ENSMUST00000135871.1
ENSMUST00000108130.1
Cga


glycoprotein hormones, alpha subunit


chr17_-_12675833 4.638 ENSMUST00000024596.8
Slc22a1
solute carrier family 22 (organic cation transporter), member 1
chr2_-_134554348 4.381 ENSMUST00000028704.2
Hao1
hydroxyacid oxidase 1, liver
chr2_+_58754910 4.130 ENSMUST00000059102.6
Upp2
uridine phosphorylase 2
chr16_+_22892035 4.012 ENSMUST00000023583.5
Ahsg
alpha-2-HS-glycoprotein
chr12_-_80968075 3.989 ENSMUST00000095572.4
Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr1_-_130661584 3.944 ENSMUST00000137276.2
C4bp
complement component 4 binding protein
chr9_+_37539255 3.720 ENSMUST00000002008.5
Vsig2
V-set and immunoglobulin domain containing 2
chr10_-_41611319 3.669 ENSMUST00000179614.1
Ccdc162
coiled-coil domain containing 162
chr17_+_47726834 3.528 ENSMUST00000024782.5
ENSMUST00000144955.1
Pgc

progastricsin (pepsinogen C)

chr5_-_89457763 3.488 ENSMUST00000049209.8
Gc
group specific component
chr17_-_31165045 3.464 ENSMUST00000024831.6
Tff1
trefoil factor 1
chr4_+_150853919 3.439 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr3_+_19957240 3.352 ENSMUST00000108325.2
Cp
ceruloplasmin
chr16_-_29378667 3.263 ENSMUST00000143373.1
ENSMUST00000075806.4
Atp13a5

ATPase type 13A5

chr2_-_148040196 3.251 ENSMUST00000136555.1
9030622O22Rik
RIKEN cDNA 9030622O22 gene
chr2_+_69219971 3.237 ENSMUST00000005364.5
ENSMUST00000112317.2
G6pc2

glucose-6-phosphatase, catalytic, 2

chr4_-_127354074 3.211 ENSMUST00000106090.1
ENSMUST00000060419.1
Gjb4

gap junction protein, beta 4

chr1_-_130661613 3.182 ENSMUST00000027657.7
C4bp
complement component 4 binding protein
chr17_+_12378603 3.050 ENSMUST00000014578.5
Plg
plasminogen
chr12_-_103773592 3.017 ENSMUST00000078869.5
Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr13_+_112467504 3.013 ENSMUST00000183868.1
Il6st
interleukin 6 signal transducer
chr10_+_111506286 2.979 ENSMUST00000164773.1
Phlda1
pleckstrin homology-like domain, family A, member 1
chr1_-_157256682 2.924 ENSMUST00000134543.1
Rasal2
RAS protein activator like 2
chr4_+_102570065 2.910 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr17_+_12584183 2.853 ENSMUST00000046959.7
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
chr14_+_41131777 2.851 ENSMUST00000022314.3
ENSMUST00000170719.1
Sftpa1

surfactant associated protein A1

chr13_+_4049001 2.661 ENSMUST00000118717.2
Akr1c14
aldo-keto reductase family 1, member C14
chr15_-_3303521 2.656 ENSMUST00000165386.1
Ccdc152
coiled-coil domain containing 152
chr2_-_160859601 2.625 ENSMUST00000103112.1
Zhx3
zinc fingers and homeoboxes 3
chr7_-_142661858 2.542 ENSMUST00000145896.2
Igf2
insulin-like growth factor 2
chr10_+_60106452 2.457 ENSMUST00000165024.2
Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr15_-_97020322 2.442 ENSMUST00000166223.1
Slc38a4
solute carrier family 38, member 4
chr13_+_23807027 2.437 ENSMUST00000006786.4
ENSMUST00000099697.2
Slc17a2

solute carrier family 17 (sodium phosphate), member 2

chr11_+_94565039 2.433 ENSMUST00000040418.8
Chad
chondroadherin
chr12_-_103738158 2.428 ENSMUST00000095450.4
Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr12_-_103904887 2.359 ENSMUST00000074051.5
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr2_-_102400863 2.349 ENSMUST00000102573.1
Trim44
tripartite motif-containing 44
chr16_+_33518528 2.314 ENSMUST00000119173.1
Slc12a8
solute carrier family 12 (potassium/chloride transporters), member 8
chr11_-_68386821 2.312 ENSMUST00000021284.3
Ntn1
netrin 1
chr7_-_105600103 2.311 ENSMUST00000033185.8
Hpx
hemopexin
chr1_-_97977233 2.302 ENSMUST00000161567.1
Pam
peptidylglycine alpha-amidating monooxygenase
chr9_-_71163224 2.258 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr16_+_91269759 2.232 ENSMUST00000056882.5
Olig1
oligodendrocyte transcription factor 1
chr8_-_65129317 2.230 ENSMUST00000098713.3
BC030870
cDNA sequence BC030870
chr3_+_98222148 2.217 ENSMUST00000029469.4
Reg4
regenerating islet-derived family, member 4
chr11_-_60036917 2.208 ENSMUST00000102692.3
Pemt
phosphatidylethanolamine N-methyltransferase
chr3_+_19957088 2.192 ENSMUST00000108328.1
Cp
ceruloplasmin
chr18_-_38918642 2.175 ENSMUST00000040647.4
Fgf1
fibroblast growth factor 1
chr5_+_90561102 2.054 ENSMUST00000094615.4
5830473C10Rik
RIKEN cDNA 5830473C10 gene
chr8_+_45628176 2.042 ENSMUST00000130850.1
Sorbs2
sorbin and SH3 domain containing 2
chr13_+_40859768 2.016 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr15_-_5108469 1.950 ENSMUST00000141020.1
Card6
caspase recruitment domain family, member 6
chr11_+_78499087 1.898 ENSMUST00000017488.4
Vtn
vitronectin
chr11_-_68386974 1.883 ENSMUST00000135141.1
Ntn1
netrin 1
chr3_+_19957037 1.825 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
Cp


ceruloplasmin


chr1_-_139858684 1.820 ENSMUST00000094489.3
Cfhr2
complement factor H-related 2
chr10_-_61979073 1.794 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
Col13a1


collagen, type XIII, alpha 1


chr19_-_58455903 1.786 ENSMUST00000131877.1
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr1_+_67123015 1.783 ENSMUST00000027144.7
Cps1
carbamoyl-phosphate synthetase 1
chr2_-_147186389 1.731 ENSMUST00000109970.3
ENSMUST00000067075.5
Nkx2-2

NK2 homeobox 2

chr14_-_41185188 1.719 ENSMUST00000077136.3
Sftpd
surfactant associated protein D
chr1_+_34121250 1.706 ENSMUST00000183006.1
Dst
dystonin
chr6_-_3494587 1.706 ENSMUST00000049985.8
Hepacam2
HEPACAM family member 2
chr8_-_45294854 1.706 ENSMUST00000116473.2
Klkb1
kallikrein B, plasma 1
chr9_-_107668967 1.704 ENSMUST00000177567.1
Slc38a3
solute carrier family 38, member 3
chr19_-_58455161 1.632 ENSMUST00000135730.1
ENSMUST00000152507.1
Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr17_-_56121946 1.622 ENSMUST00000041357.7
Lrg1
leucine-rich alpha-2-glycoprotein 1
chr16_-_38294774 1.610 ENSMUST00000023504.4
Nr1i2
nuclear receptor subfamily 1, group I, member 2
chrX_+_57212110 1.600 ENSMUST00000033466.1
Cd40lg
CD40 ligand
chr16_+_33518278 1.591 ENSMUST00000122427.1
ENSMUST00000059056.8
Slc12a8

solute carrier family 12 (potassium/chloride transporters), member 8

chr6_-_83656082 1.584 ENSMUST00000014686.2
Clec4f
C-type lectin domain family 4, member f
chr9_+_74848437 1.562 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chr7_+_113765998 1.547 ENSMUST00000046687.9
Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr14_-_30943275 1.546 ENSMUST00000006704.8
ENSMUST00000163118.1
Itih1

inter-alpha trypsin inhibitor, heavy chain 1

chr2_+_176236860 1.531 ENSMUST00000166464.1
2210418O10Rik
RIKEN cDNA 2210418O10 gene
chr6_+_129533183 1.487 ENSMUST00000032264.6
Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr17_+_28858411 1.480 ENSMUST00000114737.1
ENSMUST00000056866.5
Pnpla1

patatin-like phospholipase domain containing 1

chrX_-_108664891 1.471 ENSMUST00000178160.1
Gm379
predicted gene 379
chr1_-_179546261 1.453 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr11_+_32000452 1.420 ENSMUST00000020537.2
ENSMUST00000109409.1
Nsg2

neuron specific gene family member 2

chr14_+_73237891 1.420 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr1_+_87574016 1.416 ENSMUST00000166259.1
ENSMUST00000172222.1
ENSMUST00000163606.1
Neu2


neuraminidase 2


chr5_-_51567717 1.416 ENSMUST00000127135.1
ENSMUST00000151104.1
Ppargc1a

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

chr4_-_63154130 1.377 ENSMUST00000030041.4
Ambp
alpha 1 microglobulin/bikunin
chr6_+_34709610 1.370 ENSMUST00000031775.6
Cald1
caldesmon 1
chr2_+_158306493 1.362 ENSMUST00000016168.2
ENSMUST00000109491.1
Lbp

lipopolysaccharide binding protein

chr6_+_83743010 1.341 ENSMUST00000006431.6
Atp6v1b1
ATPase, H+ transporting, lysosomal V1 subunit B1
chr5_+_43515513 1.320 ENSMUST00000167522.1
ENSMUST00000144558.1
ENSMUST00000076939.6
C1qtnf7


C1q and tumor necrosis factor related protein 7


chrX_+_101376359 1.315 ENSMUST00000119080.1
Gjb1
gap junction protein, beta 1
chr10_+_128909866 1.264 ENSMUST00000026407.7
Cd63
CD63 antigen
chr8_-_84773381 1.254 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr9_+_55326913 1.254 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr19_+_26623419 1.248 ENSMUST00000176584.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr12_-_56613270 1.236 ENSMUST00000072631.5
Nkx2-9
NK2 homeobox 9
chr15_+_25940846 1.200 ENSMUST00000110438.1
Fam134b
family with sequence similarity 134, member B
chr2_+_27676440 1.184 ENSMUST00000129514.1
Rxra
retinoid X receptor alpha
chr10_+_87861309 1.184 ENSMUST00000122100.1
Igf1
insulin-like growth factor 1
chr16_-_63864114 1.179 ENSMUST00000064405.6
Epha3
Eph receptor A3
chr3_+_5218516 1.177 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr19_-_58455398 1.175 ENSMUST00000026076.7
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr2_+_50066429 1.171 ENSMUST00000112712.3
ENSMUST00000128451.1
ENSMUST00000053208.7
Lypd6


LY6/PLAUR domain containing 6


chrX_+_150594420 1.160 ENSMUST00000112713.2
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr18_-_62756275 1.148 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr6_+_134830216 1.119 ENSMUST00000111937.1
Crebl2
cAMP responsive element binding protein-like 2
chrX_-_94123087 1.108 ENSMUST00000113925.1
Zfx
zinc finger protein X-linked
chrX_-_139782353 1.104 ENSMUST00000101217.3
Ripply1
ripply1 homolog (zebrafish)
chr12_-_103863551 1.072 ENSMUST00000085056.6
ENSMUST00000072876.5
ENSMUST00000124717.1
Serpina1a


serine (or cysteine) peptidase inhibitor, clade A, member 1A


chr4_+_43669610 1.068 ENSMUST00000107866.1
Tmem8b
transmembrane protein 8B
chr1_+_132298606 1.051 ENSMUST00000046071.4
Klhdc8a
kelch domain containing 8A
chr2_+_4718145 1.047 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr15_-_5108492 1.040 ENSMUST00000118365.2
Card6
caspase recruitment domain family, member 6
chr16_-_95586585 1.036 ENSMUST00000077773.6
Erg
avian erythroblastosis virus E-26 (v-ets) oncogene related
chr18_-_84086379 1.035 ENSMUST00000060303.8
Tshz1
teashirt zinc finger family member 1
chr19_+_56461629 1.023 ENSMUST00000178590.1
ENSMUST00000039666.6
Plekhs1

pleckstrin homology domain containing, family S member 1

chr6_-_136781718 1.020 ENSMUST00000078095.6
ENSMUST00000032338.7
Gucy2c

guanylate cyclase 2c

chr2_-_176917518 1.017 ENSMUST00000108931.2
Gm14296
predicted gene 14296
chr13_-_66227573 0.992 ENSMUST00000167981.2
Gm10772
predicted gene 10772
chr11_+_114851142 0.983 ENSMUST00000133245.1
ENSMUST00000122967.2
Gprc5c

G protein-coupled receptor, family C, group 5, member C

chr9_+_53850243 0.969 ENSMUST00000048485.5
Sln
sarcolipin
chr9_+_46228580 0.963 ENSMUST00000034588.8
Apoa1
apolipoprotein A-I
chr15_+_59648644 0.959 ENSMUST00000118228.1
Trib1
tribbles homolog 1 (Drosophila)
chr11_+_70092705 0.938 ENSMUST00000124721.1
Asgr2
asialoglycoprotein receptor 2
chr4_+_98546710 0.926 ENSMUST00000102792.3
Inadl
InaD-like (Drosophila)
chr5_-_86906937 0.919 ENSMUST00000031181.9
ENSMUST00000113333.1
Ugt2b34

UDP glucuronosyltransferase 2 family, polypeptide B34

chr10_+_128908907 0.919 ENSMUST00000105229.1
Cd63
CD63 antigen
chr4_+_102254993 0.910 ENSMUST00000106908.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr7_+_101317073 0.906 ENSMUST00000163799.2
ENSMUST00000164479.2
Stard10

START domain containing 10

chr15_+_59648350 0.904 ENSMUST00000067543.6
Trib1
tribbles homolog 1 (Drosophila)
chr11_+_70092634 0.895 ENSMUST00000102572.1
Asgr2
asialoglycoprotein receptor 2
chr2_+_72054598 0.886 ENSMUST00000028525.5
Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
chr12_+_38781093 0.876 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr13_-_12464925 0.853 ENSMUST00000124888.1
Lgals8
lectin, galactose binding, soluble 8
chr19_+_26749726 0.852 ENSMUST00000175842.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr18_+_69925466 0.852 ENSMUST00000043929.4
Ccdc68
coiled-coil domain containing 68
chr4_+_98546919 0.852 ENSMUST00000030290.7
Inadl
InaD-like (Drosophila)
chr11_+_70092653 0.851 ENSMUST00000143772.1
Asgr2
asialoglycoprotein receptor 2
chr12_+_119443410 0.843 ENSMUST00000048880.6
Macc1
metastasis associated in colon cancer 1
chr3_+_53041517 0.835 ENSMUST00000059562.7
ENSMUST00000147139.1
Lhfp

lipoma HMGIC fusion partner

chr18_+_69925542 0.829 ENSMUST00000080050.5
Ccdc68
coiled-coil domain containing 68
chr7_+_67655414 0.828 ENSMUST00000107470.1
Ttc23
tetratricopeptide repeat domain 23
chr8_-_45262012 0.815 ENSMUST00000034064.3
F11
coagulation factor XI
chr10_+_96616998 0.814 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr5_+_16553488 0.806 ENSMUST00000030683.3
Hgf
hepatocyte growth factor
chr1_+_161494649 0.790 ENSMUST00000086084.1
Tnfsf18
tumor necrosis factor (ligand) superfamily, member 18
chr6_+_134830145 0.778 ENSMUST00000046303.5
Crebl2
cAMP responsive element binding protein-like 2
chr11_+_115334731 0.769 ENSMUST00000106543.1
ENSMUST00000019006.4
Otop3

otopetrin 3

chr19_+_7056731 0.762 ENSMUST00000040261.5
Macrod1
MACRO domain containing 1
chr9_+_32224246 0.756 ENSMUST00000168954.2
Arhgap32
Rho GTPase activating protein 32
chr18_+_36528145 0.755 ENSMUST00000074298.6
ENSMUST00000115694.2
Slc4a9

solute carrier family 4, sodium bicarbonate cotransporter, member 9

chr16_-_38433145 0.748 ENSMUST00000002926.6
Pla1a
phospholipase A1 member A
chr13_+_31558157 0.747 ENSMUST00000042118.8
Foxq1
forkhead box Q1
chr4_+_97777606 0.746 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr9_-_44802951 0.744 ENSMUST00000044694.6
Ttc36
tetratricopeptide repeat domain 36
chr3_-_69859875 0.744 ENSMUST00000051239.7
ENSMUST00000171529.1
Sptssb

serine palmitoyltransferase, small subunit B

chr18_-_60648290 0.740 ENSMUST00000143275.2
Synpo
synaptopodin
chr8_-_121083085 0.736 ENSMUST00000182264.1
Fendrr
Foxf1 adjacent non-coding developmental regulatory RNA
chr7_-_65371210 0.735 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr1_+_156838915 0.732 ENSMUST00000111720.1
Angptl1
angiopoietin-like 1
chr7_+_28825202 0.730 ENSMUST00000066264.6
Ech1
enoyl coenzyme A hydratase 1, peroxisomal
chr3_+_27154020 0.722 ENSMUST00000181124.1
1700125G22Rik
RIKEN cDNA 1700125G22 gene
chr9_+_44398176 0.722 ENSMUST00000165839.1
Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr2_-_60722636 0.721 ENSMUST00000028348.2
ENSMUST00000112517.1
Itgb6

integrin beta 6

chr18_-_3281036 0.715 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
Crem


cAMP responsive element modulator


chr19_+_42090422 0.712 ENSMUST00000066778.4
Pi4k2a
phosphatidylinositol 4-kinase type 2 alpha
chr11_-_100146120 0.699 ENSMUST00000007317.7
Krt19
keratin 19
chr3_+_5218546 0.694 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr5_+_102481374 0.692 ENSMUST00000094559.2
ENSMUST00000073302.5
Arhgap24

Rho GTPase activating protein 24

chr4_+_11123950 0.687 ENSMUST00000142297.1
Gm11827
predicted gene 11827
chr3_-_82903963 0.682 ENSMUST00000029632.6
Lrat
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
chr17_+_29090969 0.682 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr9_-_48835932 0.680 ENSMUST00000093852.3
Zbtb16
zinc finger and BTB domain containing 16
chr5_-_35679416 0.677 ENSMUST00000114233.2
Htra3
HtrA serine peptidase 3
chr5_-_66080971 0.671 ENSMUST00000127275.1
ENSMUST00000113724.1
Rbm47

RNA binding motif protein 47

chr5_+_92809372 0.655 ENSMUST00000113054.2
Shroom3
shroom family member 3

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 25.5 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
3.3 13.3 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
2.9 20.0 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
2.1 16.7 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
1.2 6.2 GO:0070859 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
1.2 7.1 GO:0038161 prolactin signaling pathway(GO:0038161)
1.1 5.6 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
1.1 4.4 GO:0009441 glycolate metabolic process(GO:0009441)
1.0 3.0 GO:0070104 negative regulation of interleukin-6-mediated signaling pathway(GO:0070104) interleukin-27-mediated signaling pathway(GO:0070106)
0.9 17.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.8 7.5 GO:1901374 acetate ester transport(GO:1901374)
0.8 4.8 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.7 3.5 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.7 3.4 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.6 1.9 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.6 1.7 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.6 1.7 GO:0006867 asparagine transport(GO:0006867) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) regulation of glutamine transport(GO:2000485)
0.5 1.6 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.5 4.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.5 2.6 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.5 4.6 GO:0008228 opsonization(GO:0008228)
0.5 2.4 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.5 1.4 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.5 2.3 GO:0015855 purine nucleobase transport(GO:0006863) nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.4 1.2 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.4 2.2 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.4 1.8 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.4 1.4 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.3 2.0 GO:0036438 maintenance of lens transparency(GO:0036438)
0.3 4.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 9.3 GO:0017144 drug metabolic process(GO:0017144)
0.3 4.6 GO:0032275 luteinizing hormone secretion(GO:0032275)
0.3 2.3 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) heme transport(GO:0015886)
0.3 2.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 1.2 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.3 0.9 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.3 2.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 7.9 GO:0046688 response to copper ion(GO:0046688)
0.3 0.8 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.3 2.3 GO:0031179 peptide modification(GO:0031179)
0.2 0.5 GO:0038091 VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.2 0.7 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.2 0.6 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.2 2.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 0.6 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.2 0.6 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) regulation of response to gamma radiation(GO:2001228)
0.2 3.2 GO:0042048 olfactory behavior(GO:0042048)
0.2 1.2 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.2 0.7 GO:1905355 spine apparatus assembly(GO:1905355)
0.2 0.7 GO:1990401 embryonic lung development(GO:1990401)
0.2 3.5 GO:0042359 vitamin D metabolic process(GO:0042359)
0.2 1.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.2 1.4 GO:0006689 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.2 0.5 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.2 2.4 GO:0060346 bone trabecula formation(GO:0060346)
0.2 1.0 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.2 1.0 GO:0060023 soft palate development(GO:0060023)
0.2 4.0 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.2 1.0 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.2 0.5 GO:0010159 specification of animal organ position(GO:0010159)
0.1 4.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.4 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.1 1.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 3.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 0.9 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 0.7 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 0.8 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 0.4 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.1 1.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 1.6 GO:0051132 NK T cell activation(GO:0051132)
0.1 1.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 8.9 GO:0009166 nucleotide catabolic process(GO:0009166)
0.1 0.4 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.1 1.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 1.5 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.1 0.5 GO:1903445 protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 0.3 GO:1990709 presynaptic active zone organization(GO:1990709)
0.1 0.7 GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system(GO:0071630)
0.1 0.8 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 0.4 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.1 0.8 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.1 1.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.7 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.1 0.2 GO:0072106 regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107) positive regulation of epithelial tube formation(GO:1905278)
0.1 0.8 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.7 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.1 0.3 GO:0009182 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066) nucleoside monophosphate phosphorylation(GO:0046940)
0.1 1.7 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 0.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 1.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.2 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.1 0.6 GO:0006642 triglyceride mobilization(GO:0006642)
0.1 0.2 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.1 0.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 0.7 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 0.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.3 GO:0090472 dibasic protein processing(GO:0090472)
0.1 1.1 GO:0060746 parental behavior(GO:0060746)
0.1 1.1 GO:0072189 ureter development(GO:0072189)
0.1 1.3 GO:0015865 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.1 0.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.6 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 3.2 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.1 0.5 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) positive regulation of artery morphogenesis(GO:1905653)
0.1 3.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 6.9 GO:0007586 digestion(GO:0007586)
0.1 1.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.6 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.1 0.4 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 1.6 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 0.5 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.1 1.5 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 2.9 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.3 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.6 GO:0033572 transferrin transport(GO:0033572)
0.0 0.2 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
0.0 0.6 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0 0.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 3.5 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 4.2 GO:0055088 lipid homeostasis(GO:0055088)
0.0 1.1 GO:0045851 pH reduction(GO:0045851)
0.0 0.3 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.4 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 2.8 GO:0099132 ATP hydrolysis coupled cation transmembrane transport(GO:0099132)
0.0 0.7 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.0 0.5 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 1.6 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.0 0.6 GO:0045109 intermediate filament organization(GO:0045109)
0.0 1.7 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.3 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.8 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
0.0 0.4 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.4 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.0 2.8 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.0 1.0 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.7 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.0 0.8 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 1.1 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.0 0.8 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.7 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.1 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.0 30.6 GO:0006508 proteolysis(GO:0006508)
0.0 0.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.1 GO:0003383 apical constriction(GO:0003383)
0.0 0.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:1904355 positive regulation of telomere capping(GO:1904355)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 17.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
1.1 8.9 GO:0045098 type III intermediate filament(GO:0045098)
1.0 3.0 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.9 3.8 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.6 13.9 GO:0042627 chylomicron(GO:0042627)
0.5 2.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.4 1.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.3 1.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 1.7 GO:0031673 H zone(GO:0031673)
0.2 0.7 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.2 0.7 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 1.6 GO:0030478 actin cap(GO:0030478)
0.2 0.9 GO:0044316 cone cell pedicle(GO:0044316)
0.2 4.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 2.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 3.6 GO:0005922 connexin complex(GO:0005922)
0.2 5.3 GO:0005771 multivesicular body(GO:0005771)
0.1 1.2 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1 20.7 GO:0072562 blood microparticle(GO:0072562)
0.1 2.5 GO:0071564 npBAF complex(GO:0071564)
0.1 0.7 GO:0097444 spine apparatus(GO:0097444)
0.1 0.7 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 3.3 GO:0005604 basement membrane(GO:0005604)
0.1 0.7 GO:1990357 terminal web(GO:1990357)
0.1 0.2 GO:0016939 kinesin II complex(GO:0016939)
0.1 0.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 1.5 GO:0000421 autophagosome membrane(GO:0000421)
0.1 0.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 3.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 4.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 1.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1 2.2 GO:0031526 brush border membrane(GO:0031526)
0.1 1.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 13.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 161.7 GO:0005615 extracellular space(GO:0005615)
0.0 5.5 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 0.2 GO:0001652 granular component(GO:0001652)
0.0 3.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 1.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 3.7 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0043219 lateral loop(GO:0043219)
0.0 0.9 GO:0005811 lipid droplet(GO:0005811)
0.0 1.6 GO:0009986 cell surface(GO:0009986)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 8.4 GO:0005576 extracellular region(GO:0005576)
0.0 0.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.5 GO:0005938 cell cortex(GO:0005938)
0.0 0.3 GO:0045178 basal part of cell(GO:0045178)
0.0 0.6 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.7 GO:0005902 microvillus(GO:0005902)
0.0 0.6 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
10.3 71.8 GO:0004556 alpha-amylase activity(GO:0004556)
2.5 7.5 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
1.9 24.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
1.8 8.9 GO:0004850 uridine phosphorylase activity(GO:0004850)
1.8 12.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
1.7 54.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.4 7.1 GO:0004925 prolactin receptor activity(GO:0004925)
1.1 4.4 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
1.1 3.2 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.0 3.0 GO:0019981 interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981)
0.9 3.5 GO:1902271 D3 vitamins binding(GO:1902271)
0.8 4.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.7 7.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.6 1.8 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.6 2.3 GO:0015232 heme transporter activity(GO:0015232)
0.6 2.3 GO:0016842 amidine-lyase activity(GO:0016842)
0.6 4.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.6 1.7 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.5 2.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.5 3.9 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.5 2.3 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.4 2.7 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.4 19.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.4 1.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.3 1.0 GO:0005118 sevenless binding(GO:0005118)
0.3 1.0 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.3 38.1 GO:0005179 hormone activity(GO:0005179)
0.3 1.4 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.2 0.7 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.2 3.1 GO:1990405 protein antigen binding(GO:1990405)
0.2 0.7 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 1.4 GO:0071723 lipopeptide binding(GO:0071723)
0.2 7.7 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.2 1.6 GO:0005534 galactose binding(GO:0005534)
0.2 0.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.6 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.2 2.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.2 1.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.2 2.4 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.2 0.7 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.2 1.4 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 6.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.2 2.2 GO:0044548 S100 protein binding(GO:0044548)
0.1 2.2 GO:0030247 polysaccharide binding(GO:0030247)
0.1 1.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 3.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 0.7 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.6 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 4.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.4 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.1 0.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.1 0.3 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.1 1.5 GO:0030957 Tat protein binding(GO:0030957)
0.1 3.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 1.3 GO:0005243 gap junction channel activity(GO:0005243)
0.1 1.4 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 1.7 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.6 GO:0035473 lipase binding(GO:0035473)
0.1 1.9 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.8 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 2.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 1.0 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.5 GO:0071253 connexin binding(GO:0071253)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.4 GO:0031404 chloride ion binding(GO:0031404)
0.1 1.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 2.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.7 GO:0019841 retinol binding(GO:0019841)
0.0 0.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.5 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.0 13.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.5 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 2.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 2.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 1.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.9 GO:0030552 cAMP binding(GO:0030552)
0.0 1.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.0 1.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 4.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229) intracellular chloride channel activity(GO:0061778)
0.0 0.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 30.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.0 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 1.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 23.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.9 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.1 7.4 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.1 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 0.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 1.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 4.6 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 4.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 3.0 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.0 1.9 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.5 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.6 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.2 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.7 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
1.1 19.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.6 4.6 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.6 7.5 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.5 13.9 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.5 8.9 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.5 17.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.5 6.2 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.4 4.0 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.4 7.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.3 4.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.3 3.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.3 5.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 4.5 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.2 2.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 8.5 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.2 2.8 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 3.8 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.1 2.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 0.7 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 4.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 4.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 4.0 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 0.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 2.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 0.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 0.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 2.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 2.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.4 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.6 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 5.4 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated