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GSE58827: Dynamics of the Mouse Liver

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Results for Foxo4

Z-value: 0.62

Motif logo

Transcription factors associated with Foxo4

Gene Symbol Gene ID Gene Info
ENSMUSG00000042903.7 forkhead box O4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_101254574-0.163.6e-01Click!

Activity profile of Foxo4 motif

Sorted Z-values of Foxo4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_102107822 1.62 ENSMUST00000177304.1
ENSMUST00000017455.8
peptide YY
chr10_-_109010955 1.57 ENSMUST00000105276.1
ENSMUST00000064054.7
synaptotagmin I
chr18_-_38918642 1.30 ENSMUST00000040647.4
fibroblast growth factor 1
chr13_-_106547060 1.12 ENSMUST00000076359.2
DPH3B, KTI11 homolog B (S. cerevisiae), pseudogene
chr19_-_5796924 1.02 ENSMUST00000174808.1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr2_-_175931051 1.00 ENSMUST00000108949.2
ENSMUST00000109018.2
predicted gene 8898
chr7_-_4524229 0.99 ENSMUST00000154913.1
troponin I, cardiac 3
chr4_-_61835185 0.97 ENSMUST00000082287.2
major urinary protein 5
chr6_+_56714891 0.93 ENSMUST00000031805.8
AVL9 homolog (S. cerevisiase)
chr10_-_83337440 0.92 ENSMUST00000126617.1
solute carrier family 41, member 2
chr8_-_45410539 0.89 ENSMUST00000034056.4
ENSMUST00000167106.1
toll-like receptor 3
chr2_-_177840318 0.83 ENSMUST00000108939.2
ENSMUST00000150650.1
predicted gene 14325
chr2_-_175141999 0.76 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
predicted gene 14399
chr2_+_177000956 0.74 ENSMUST00000108975.2
ENSMUST00000156844.1
predicted gene 14419
chr4_-_59960659 0.71 ENSMUST00000075973.2
major urinary protein 4
chr2_+_175372436 0.68 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
predicted gene 4723
chr17_+_26202946 0.68 ENSMUST00000122058.1
ENSMUST00000025020.5
regulator of G-protein signaling 11
chr11_-_77078404 0.67 ENSMUST00000102494.1
coiled-coil domain containing 55
chr2_+_178023284 0.63 ENSMUST00000108925.3
ENSMUST00000108926.2
ethanol induced 1
chr8_+_26119361 0.63 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
ring finger protein 170
chr2_+_175869219 0.63 ENSMUST00000109011.1
predicted gene 6710
chr2_+_176798612 0.62 ENSMUST00000118012.2
predicted gene 14295
chr2_+_175469985 0.61 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
predicted gene 8923
chr9_+_37539255 0.60 ENSMUST00000002008.5
V-set and immunoglobulin domain containing 2
chr2_-_176486773 0.59 ENSMUST00000120959.1
ENSMUST00000120521.1
predicted gene 14434
chr2_+_176708328 0.58 ENSMUST00000108981.2
ENSMUST00000108980.2
predicted gene 14305
chr9_+_45319072 0.58 ENSMUST00000034597.7
transmembrane protease, serine 13
chr7_-_4778141 0.56 ENSMUST00000094892.5
interleukin 11
chr5_+_92392585 0.56 ENSMUST00000126281.1
ADP-ribosyltransferase 3
chr8_+_79639618 0.55 ENSMUST00000173078.1
ENSMUST00000173286.1
OTU domain containing 4
chr2_-_176636318 0.55 ENSMUST00000108990.2
ENSMUST00000119149.1
ENSMUST00000117267.1
predicted gene 14308
chr2_-_175206899 0.55 ENSMUST00000109055.1
ENSMUST00000099028.3
ENSMUST00000109056.1
ENSMUST00000109058.2
predicted gene 14391
chr2_+_176670522 0.54 ENSMUST00000121956.1
ENSMUST00000108985.2
predicted gene 14306
chr2_-_175435782 0.52 ENSMUST00000152941.1
ENSMUST00000109045.2
predicted gene 4724
chr2_-_175338197 0.52 ENSMUST00000121393.2
predicted gene 4631
chr2_-_178078425 0.52 ENSMUST00000108924.2
ENSMUST00000131702.1
ENSMUST00000108923.1
zinc finger protein 931
chr2_+_176521056 0.51 ENSMUST00000108997.2
ENSMUST00000178443.1
predicted gene 14431
chr10_+_79973737 0.48 ENSMUST00000149148.1
glutamate receptor, ionotropic, NMDA3B
chrX_+_134601271 0.48 ENSMUST00000050331.6
ENSMUST00000059297.5
heterogeneous nuclear ribonucleoprotein H2
chr2_+_176226569 0.47 ENSMUST00000099009.2
ENSMUST00000136719.1
RIKEN cDNA 2210418O10 gene
chr2_-_75938407 0.46 ENSMUST00000099996.3
tetratricopeptide repeat domain 30B
chr6_+_95117740 0.46 ENSMUST00000032107.7
ENSMUST00000119582.1
kelch repeat and BTB (POZ) domain containing 8
chr2_-_175703646 0.44 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
predicted gene 4245
chr2_-_176927809 0.44 ENSMUST00000099007.2
predicted gene 14296
chr8_+_26119611 0.44 ENSMUST00000140819.1
ring finger protein 170
chr2_-_177206421 0.43 ENSMUST00000108964.1
predicted gene 14410
chr10_-_127263346 0.42 ENSMUST00000099172.3
kinesin family member 5A
chr15_-_35938009 0.42 ENSMUST00000156915.1
cytochrome c oxidase subunit VIc
chr15_-_78204228 0.42 ENSMUST00000005860.9
parvalbumin
chr14_+_32028989 0.41 ENSMUST00000022460.4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr7_-_89517576 0.40 ENSMUST00000041761.5
protease, serine, 23
chrX_+_134601179 0.39 ENSMUST00000074950.4
ENSMUST00000113203.1
ENSMUST00000113202.1
heterogeneous nuclear ribonucleoprotein H2
chr14_+_53469756 0.38 ENSMUST00000103643.2
T cell receptor alpha variable 8-1
chr2_-_177957239 0.35 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
predicted gene 14326
chr2_-_45110336 0.35 ENSMUST00000028229.6
ENSMUST00000152232.1
zinc finger E-box binding homeobox 2
chr2_+_175965331 0.35 ENSMUST00000109007.1
ENSMUST00000174416.1
predicted gene 2026
chr6_+_42286676 0.34 ENSMUST00000031894.6
chloride channel 1
chr6_-_31218421 0.33 ENSMUST00000115107.1
cDNA sequence AB041803
chr6_+_42286709 0.33 ENSMUST00000163936.1
chloride channel 1
chr17_+_78508063 0.32 ENSMUST00000024880.9
vitrin
chr1_+_171214013 0.32 ENSMUST00000111328.1
nuclear receptor subfamily 1, group I, member 3
chr1_+_171213969 0.32 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
nuclear receptor subfamily 1, group I, member 3
chr14_-_18331855 0.28 ENSMUST00000022296.6
ubiquitin-conjugating enzyme E2E 1
chr8_+_121544378 0.28 ENSMUST00000181133.1
ENSMUST00000181679.1
RIKEN cDNA 1700030M09 gene
chr2_+_130012336 0.27 ENSMUST00000110299.2
transglutaminase 3, E polypeptide
chr5_+_139543889 0.27 ENSMUST00000174792.1
ENSMUST00000031523.8
UNC homeobox
chr14_+_52778447 0.26 ENSMUST00000103580.2
T cell receptor alpha variable 8D-1
chr16_-_64771146 0.25 ENSMUST00000076991.6
RIKEN cDNA 4930453N24 gene
chr15_-_35938186 0.25 ENSMUST00000014457.8
cytochrome c oxidase subunit VIc
chr11_-_85139939 0.24 ENSMUST00000108075.2
ubiquitin specific peptidase 32
chr5_+_37185897 0.24 ENSMUST00000094840.3
predicted gene 1043
chr1_-_171437288 0.21 ENSMUST00000181499.1
predicted gene, 26641
chr9_-_119322421 0.21 ENSMUST00000040853.4
oxidative-stress responsive 1
chr15_-_77596110 0.20 ENSMUST00000089465.4
apolipoprotein L 10B
chr13_-_91223955 0.18 ENSMUST00000022119.4
autophagy related 10
chr10_-_40257648 0.18 ENSMUST00000019982.7
general transcription factor IIIC, polypeptide 6, alpha
chr13_+_40704005 0.16 ENSMUST00000069457.1
predicted gene 9979
chr4_-_97778042 0.16 ENSMUST00000146447.1
RIKEN cDNA E130114P18 gene
chr5_-_149636164 0.15 ENSMUST00000076410.4
heat shock 105kDa/110kDa protein 1
chr12_+_75308308 0.14 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
ras homolog gene family, member J
chr7_-_19280032 0.13 ENSMUST00000032560.4
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr11_-_102579461 0.13 ENSMUST00000107081.1
predicted gene 11627
chr4_+_45972233 0.12 ENSMUST00000102929.1
tudor domain containing 7
chr14_+_32085804 0.12 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
oxidoreductase NAD-binding domain containing 1
chr12_-_69892989 0.12 ENSMUST00000110567.1
ENSMUST00000171211.1
mitogen-activated protein kinase kinase kinase kinase 5
chr17_-_23745829 0.12 ENSMUST00000046525.8
kringle containing transmembrane protein 2
chr17_+_87078255 0.10 ENSMUST00000090731.5
predicted pseudogene 5499
chr9_+_57076343 0.09 ENSMUST00000168678.1
transcriptional regulator, SIN3A (yeast)
chr9_+_57076395 0.08 ENSMUST00000168177.1
transcriptional regulator, SIN3A (yeast)
chr11_+_105589970 0.08 ENSMUST00000168598.1
ENSMUST00000100330.3
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr17_+_80944611 0.07 ENSMUST00000025092.4
transmembrane protein 178
chrX_-_73037103 0.07 ENSMUST00000114540.3
ENSMUST00000051569.6
paraneoplastic antigen family 5
chr4_+_136284658 0.06 ENSMUST00000144217.1
zinc finger protein 46
chr7_+_15882617 0.06 ENSMUST00000125993.1
ENSMUST00000130566.1
Crx opposite strand transcript 1
chr9_+_8900459 0.06 ENSMUST00000098986.3
ENSMUST00000070463.3
progesterone receptor
chr12_+_69893105 0.05 ENSMUST00000021466.8
atlastin GTPase 1
chr8_-_94012120 0.05 ENSMUST00000143265.1
autocrine motility factor receptor
chr15_-_102625061 0.04 ENSMUST00000184077.1
ENSMUST00000184906.1
ENSMUST00000169033.1
Cyclic AMP-dependent transcription factor ATF-7
chr8_-_121544315 0.04 ENSMUST00000182460.1
RIKEN cDNA 1700018B08 gene
chr8_-_47352348 0.03 ENSMUST00000110367.2
storkhead box 2
chr8_-_105943382 0.02 ENSMUST00000038896.7
lecithin cholesterol acyltransferase
chr1_+_6487231 0.01 ENSMUST00000140079.1
ENSMUST00000131494.1
suppression of tumorigenicity 18
chr2_-_26864943 0.01 ENSMUST00000102900.1
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase)
chr12_-_17329348 0.01 ENSMUST00000153090.1
ENSMUST00000143131.1
ATPase, H+ transporting, lysosomal V1 subunit C2
chr14_-_70153811 0.00 ENSMUST00000035612.5
cell cycle activator and apoptosis regulator 2
chr6_+_87009836 0.00 ENSMUST00000032060.8
ENSMUST00000117583.1
ENSMUST00000144776.1
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.2 1.0 GO:0035063 nuclear speck organization(GO:0035063)
0.2 0.9 GO:0002282 microglial cell activation involved in immune response(GO:0002282) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.2 1.0 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 1.6 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.4 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 1.6 GO:0032096 negative regulation of response to food(GO:0032096)
0.1 0.2 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 0.7 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.5 GO:0014029 neural crest formation(GO:0014029)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.6 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.1 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0 0.1 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.5 GO:0051205 protein insertion into membrane(GO:0051205)
0.0 0.2 GO:0006983 ER overload response(GO:0006983)
0.0 0.6 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.1 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 1.6 GO:0031045 dense core granule(GO:0031045)
0.0 0.7 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 1.0 GO:0030172 troponin C binding(GO:0030172)
0.1 1.3 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.6 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 1.7 GO:0005550 pheromone binding(GO:0005550)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0016594 glycine binding(GO:0016594)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.3 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 0.9 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 2.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events