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GSE58827: Dynamics of the Mouse Liver

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Results for Glis2

Z-value: 0.75

Motif logo

Transcription factors associated with Glis2

Gene Symbol Gene ID Gene Info
ENSMUSG00000014303.7 GLIS family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_45947350.572.7e-04Click!

Activity profile of Glis2 motif

Sorted Z-values of Glis2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_20269162 7.38 ENSMUST00000024155.7
potassium channel, subfamily K, member 16
chr7_-_103843154 6.30 ENSMUST00000063957.4
hemoglobin Z, beta-like embryonic chain
chr11_+_87793722 5.57 ENSMUST00000143021.2
myeloperoxidase
chr12_+_109544498 5.16 ENSMUST00000126289.1
maternally expressed 3
chr2_-_170427828 5.06 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
breast carcinoma amplified sequence 1
chr19_+_7268296 4.67 ENSMUST00000066646.4
REST corepressor 2
chr11_+_87793470 4.62 ENSMUST00000020779.4
myeloperoxidase
chr4_-_118620763 3.87 ENSMUST00000071972.4
WD repeat domain 65
chr4_+_115059507 3.85 ENSMUST00000162489.1
T cell acute lymphocytic leukemia 1
chr8_+_72761868 3.75 ENSMUST00000058099.8
coagulation factor II (thrombin) receptor-like 3
chr17_-_56830916 3.67 ENSMUST00000002444.7
ENSMUST00000086801.5
regulatory factor X, 2 (influences HLA class II expression)
chr2_+_118111876 3.55 ENSMUST00000039559.8
thrombospondin 1
chr10_-_128401218 3.55 ENSMUST00000042666.5
solute carrier family 39 (metal ion transporter), member 5
chr8_+_105690906 2.99 ENSMUST00000062574.6
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr7_-_126704736 2.67 ENSMUST00000131415.1
coronin, actin binding protein 1A
chr7_+_44572370 2.64 ENSMUST00000002274.8
napsin A aspartic peptidase
chr9_+_59680144 2.56 ENSMUST00000123914.1
GRAM domain containing 2
chr12_+_109545390 2.42 ENSMUST00000146701.1
maternally expressed 3
chr2_+_71117923 2.37 ENSMUST00000028403.2
cytochrome b reductase 1
chr7_-_126414855 2.21 ENSMUST00000032968.5
CD19 antigen
chr7_+_43440782 2.16 ENSMUST00000040227.1
claudin domain containing 2
chr7_-_126704816 2.09 ENSMUST00000032949.7
coronin, actin binding protein 1A
chr4_-_49593875 2.04 ENSMUST00000151542.1
transmembrane protein 246
chr17_-_46629420 1.91 ENSMUST00000044442.8
PTK7 protein tyrosine kinase 7
chr14_+_55854115 1.91 ENSMUST00000168479.1
NYN domain and retroviral integrase containing
chr1_+_86303221 1.89 ENSMUST00000113306.2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr2_-_152830615 1.78 ENSMUST00000146380.1
ENSMUST00000134902.1
ENSMUST00000134357.1
ENSMUST00000109820.3
BCL2-like 1
chr11_+_72042455 1.77 ENSMUST00000021164.3
family with sequence similarity 64, member A
chr10_-_127341583 1.72 ENSMUST00000026474.3
GLI-Kruppel family member GLI1
chr3_+_130180882 1.71 ENSMUST00000106353.1
ENSMUST00000080335.4
collagen, type XXV, alpha 1
chr9_+_107975529 1.57 ENSMUST00000035216.4
ubiquitin-like modifier activating enzyme 7
chr10_-_127189981 1.57 ENSMUST00000019611.7
Rho guanine nucleotide exchange factor (GEF) 25
chr2_-_164743182 1.57 ENSMUST00000103096.3
WAP four-disulfide core domain 3
chr8_+_70501116 1.48 ENSMUST00000127983.1
cytokine receptor-like factor 1
chr7_+_127746775 1.47 ENSMUST00000033081.7
F-box and leucine-rich repeat protein 19
chr3_+_105870858 1.46 ENSMUST00000164730.1
adenosine A3 receptor
chr5_-_137212389 1.41 ENSMUST00000179412.1
RIKEN cDNA A630081J09 gene
chr2_-_152831112 1.38 ENSMUST00000128172.1
BCL2-like 1
chr4_+_104367549 1.33 ENSMUST00000106830.2
disabled 1
chr17_-_45549655 1.31 ENSMUST00000180252.1
transmembrane protein 151B
chr4_-_133498538 1.30 ENSMUST00000125541.1
TMF1-regulated nuclear protein 1
chr10_-_127195709 1.29 ENSMUST00000038217.7
ENSMUST00000130855.1
ENSMUST00000116229.1
ENSMUST00000144322.1
deltex 3 homolog (Drosophila)
chr9_-_18512885 1.26 ENSMUST00000034653.6
mucin 16
chr7_-_126799134 1.25 ENSMUST00000087566.4
aldolase A, fructose-bisphosphate
chr2_+_91096744 1.23 ENSMUST00000132741.2
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_+_60469339 1.16 ENSMUST00000071880.2
ENSMUST00000081823.5
ENSMUST00000094135.2
myosin XV
chr7_-_126799163 1.15 ENSMUST00000032934.5
aldolase A, fructose-bisphosphate
chr4_-_58499398 1.11 ENSMUST00000107570.1
lysophosphatidic acid receptor 1
chr2_+_90677208 1.09 ENSMUST00000057481.6
nucleoporin 160
chr11_-_84819450 1.07 ENSMUST00000018549.7
mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
chr19_-_24901309 1.07 ENSMUST00000058600.2
forkhead box D4
chr3_+_105870898 1.05 ENSMUST00000010279.5
adenosine A3 receptor
chr16_+_44765732 1.04 ENSMUST00000057488.8
CD200 receptor 1
chrX_+_35888808 1.04 ENSMUST00000033419.6
dedicator of cytokinesis 11
chr15_+_39198244 1.03 ENSMUST00000082054.5
ENSMUST00000042917.9
regulating synaptic membrane exocytosis 2
chr4_+_148804420 1.01 ENSMUST00000094464.3
ENSMUST00000122222.1
castor zinc finger 1
chr19_+_6401675 0.99 ENSMUST00000113471.1
ENSMUST00000113469.2
RAS, guanyl releasing protein 2
chr11_-_106160708 0.98 ENSMUST00000106875.1
LIM domain containing 2
chr5_-_137533297 0.96 ENSMUST00000111020.1
ENSMUST00000111023.1
guanine nucleotide binding protein (G protein), beta 2
chr7_+_90130227 0.96 ENSMUST00000049537.7
phosphatidylinositol binding clathrin assembly protein
chr19_+_11404735 0.95 ENSMUST00000153546.1
membrane-spanning 4-domains, subfamily A, member 4C
chr5_-_134614953 0.92 ENSMUST00000036362.6
ENSMUST00000077636.4
linker for activation of T cells family, member 2
chr2_-_54085542 0.92 ENSMUST00000100089.2
reprimo, TP53 dependent G2 arrest mediator candidate
chr3_+_87948666 0.91 ENSMUST00000005019.5
cellular retinoic acid binding protein II
chr11_-_103356324 0.90 ENSMUST00000136491.2
ENSMUST00000107023.2
Rho GTPase activating protein 27
chr11_+_69098937 0.89 ENSMUST00000021271.7
period circadian clock 1
chr8_-_40634750 0.88 ENSMUST00000173957.1
myotubularin related protein 7
chr10_+_80016901 0.87 ENSMUST00000105373.1
histocompatibility (minor) HA-1
chr7_-_92874196 0.87 ENSMUST00000032877.9
RIKEN cDNA 4632434I11 gene
chr5_-_110839757 0.86 ENSMUST00000056937.5
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr2_+_24186469 0.86 ENSMUST00000057567.2
interleukin 1 family, member 9
chr3_-_95307132 0.84 ENSMUST00000015846.2
annexin A9
chr5_-_131538687 0.84 ENSMUST00000161374.1
autism susceptibility candidate 2
chr1_+_135836380 0.81 ENSMUST00000178204.1
troponin T2, cardiac
chr8_-_27413937 0.80 ENSMUST00000033882.8
cholinergic receptor, nicotinic, alpha polypeptide 6
chr4_-_139092958 0.80 ENSMUST00000042844.6
neuroblastoma, suppression of tumorigenicity 1
chr5_-_110839575 0.79 ENSMUST00000145318.1
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr5_+_136083916 0.76 ENSMUST00000042135.7
RAS p21 protein activator 4
chr19_+_55741810 0.76 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
transcription factor 7 like 2, T cell specific, HMG box
chr5_+_120589003 0.75 ENSMUST00000069259.2
IQ motif containing D
chr9_-_32542861 0.75 ENSMUST00000183767.1
Friend leukemia integration 1
chr2_-_154569720 0.71 ENSMUST00000000894.5
E2F transcription factor 1
chr5_+_120589020 0.70 ENSMUST00000094391.4
IQ motif containing D
chr7_-_142061021 0.69 ENSMUST00000084418.2
MOB kinase activator 2
chr5_-_122989086 0.66 ENSMUST00000046073.9
lysine (K)-specific demethylase 2B
chr5_-_137533212 0.65 ENSMUST00000143495.1
ENSMUST00000111038.1
guanine nucleotide binding protein (G protein), beta 2
erythropoietin
chr5_+_37338455 0.64 ENSMUST00000056365.8
Ellis van Creveld syndrome 2
chr11_+_70018421 0.63 ENSMUST00000108588.1
discs, large homolog 4 (Drosophila)
chr17_-_31512253 0.63 ENSMUST00000166626.1
WD repeat domain 4
chr7_+_3289012 0.62 ENSMUST00000164553.1
myeloid-associated differentiation marker
chr9_-_108083330 0.61 ENSMUST00000159372.1
ENSMUST00000160249.1
ring finger protein 123
chr5_-_122989260 0.60 ENSMUST00000118027.1
lysine (K)-specific demethylase 2B
chr14_+_61138445 0.59 ENSMUST00000089394.3
ENSMUST00000119509.1
sacsin
chr7_+_101361250 0.58 ENSMUST00000137384.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr5_+_115327125 0.57 ENSMUST00000031513.7
serine/arginine-rich splicing factor 9
chr10_-_25200110 0.57 ENSMUST00000100012.2
A kinase (PRKA) anchor protein 7
chr8_+_3631109 0.56 ENSMUST00000004745.8
syntaxin binding protein 2
chr17_+_17831004 0.55 ENSMUST00000172097.2
RIKEN cDNA 4930546H06 gene
chr5_+_136084022 0.55 ENSMUST00000100570.3
RAS p21 protein activator 4
chr4_+_109978004 0.54 ENSMUST00000061187.3
doublesex and mab-3 related transcription factor like family A2
chrX_-_10216918 0.53 ENSMUST00000072393.2
ENSMUST00000044598.6
ENSMUST00000073392.4
ENSMUST00000115533.1
ENSMUST00000115532.1
retinitis pigmentosa GTPase regulator
chr12_+_53248677 0.53 ENSMUST00000101432.2
neuronal PAS domain protein 3
chr16_+_57353093 0.51 ENSMUST00000159816.1
filamin A interacting protein 1-like
chr16_+_30008657 0.51 ENSMUST00000181485.1
RIKEN cDNA 4632428C04 gene
chr11_-_59029509 0.51 ENSMUST00000127937.1
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chrX_+_166344692 0.47 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
glycoprotein m6b
chr7_-_29518566 0.46 ENSMUST00000181975.1
signal-induced proliferation-associated 1 like 3
chrX_-_10216437 0.45 ENSMUST00000115534.1
retinitis pigmentosa GTPase regulator
chr7_-_45016224 0.45 ENSMUST00000085383.2
SR-related CTD-associated factor 1
chr1_-_93801840 0.45 ENSMUST00000112890.2
ENSMUST00000027503.7
deoxythymidylate kinase
chr2_-_164071124 0.44 ENSMUST00000109384.3
translocase of outer mitochondrial membrane 34
chr13_+_22327911 0.43 ENSMUST00000091734.1
vomeronasal 1 receptor 197
chr15_-_98778150 0.43 ENSMUST00000023732.5
wingless related MMTV integration site 10b
chr5_-_137533170 0.42 ENSMUST00000168746.1
ENSMUST00000170293.1
guanine nucleotide binding protein (G protein), beta 2
chr3_+_87971071 0.39 ENSMUST00000090973.5
nestin
chr2_-_57124003 0.38 ENSMUST00000112629.1
nuclear receptor subfamily 4, group A, member 2
chr3_-_66981279 0.38 ENSMUST00000162098.2
short stature homeobox 2
chr15_-_85581809 0.38 ENSMUST00000023015.7
wingless-related MMTV integration site 7B
chr7_-_19715395 0.37 ENSMUST00000032555.9
ENSMUST00000093552.5
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr10_+_36974536 0.37 ENSMUST00000019911.7
histone deacetylase 2
chr13_+_23738804 0.37 ENSMUST00000040914.1
histone cluster 1, H1c
chr3_+_87971129 0.36 ENSMUST00000160694.1
nestin
chr2_-_26294550 0.35 ENSMUST00000057224.3
RIKEN cDNA 4932418E24 gene
chr10_+_36974558 0.35 ENSMUST00000105510.1
histone deacetylase 2
chr5_+_140419248 0.34 ENSMUST00000100507.3
eukaryotic translation initiation factor 3, subunit B
chr11_+_77493408 0.33 ENSMUST00000037285.3
ENSMUST00000100812.3
G protein-coupled receptor kinase-interactor 1
chr16_+_17561885 0.32 ENSMUST00000171002.1
ENSMUST00000023441.4
purinergic receptor P2X, ligand-gated ion channel, 6
chr1_+_170232749 0.32 ENSMUST00000162752.1
SH2 domain protein 1B2
chr7_+_25282784 0.31 ENSMUST00000165239.1
capicua homolog (Drosophila)
chr2_+_164656043 0.31 ENSMUST00000094344.5
WAP four-disulfide core domain 10
chr19_+_29410919 0.31 ENSMUST00000112576.2
programmed cell death 1 ligand 2
chr2_+_172979827 0.29 ENSMUST00000109125.1
ENSMUST00000050442.9
ENSMUST00000109126.3
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
chr4_-_117914968 0.29 ENSMUST00000036156.5
importin 13
chr5_+_30105161 0.28 ENSMUST00000058045.4
GRB2 associated, regulator of MAPK1-like
chr17_+_29679247 0.28 ENSMUST00000129864.1
cap methyltransferase 1
chr1_-_152766281 0.28 ENSMUST00000111859.1
ENSMUST00000148865.1
ral guanine nucleotide dissociation stimulator,-like 1
chr12_-_80643799 0.28 ENSMUST00000166931.1
enhancer of rudimentary homolog (Drosophila)
chr14_-_76520850 0.26 ENSMUST00000181972.1
RIKEN cDNA 4930444M15 gene
chr2_-_3512746 0.25 ENSMUST00000056700.7
ENSMUST00000027961.5
heat shock protein 14
heat shock protein 14
chr13_+_109632760 0.25 ENSMUST00000135275.1
phosphodiesterase 4D, cAMP specific
chr9_-_106465940 0.25 ENSMUST00000164834.1
G protein-coupled receptor 62
chr5_+_77004055 0.24 ENSMUST00000071199.2
ADP-ribosylation factor-like 9
chr2_+_70039114 0.23 ENSMUST00000060208.4
myosin IIIB
chr7_-_35647441 0.23 ENSMUST00000118501.1
programmed cell death 5
chr1_-_192092540 0.23 ENSMUST00000085573.6
TNF receptor-associated factor 5
chr9_-_20336094 0.23 ENSMUST00000086473.3
olfactory receptor 18
chr8_-_120101473 0.21 ENSMUST00000034280.7
zinc finger, DHHC domain containing 7
chr6_-_116716888 0.21 ENSMUST00000056623.6
transmembrane protein 72
chr1_+_39900883 0.20 ENSMUST00000163854.2
ENSMUST00000168431.1
mitogen-activated protein kinase kinase kinase kinase 4
chr14_+_34086008 0.20 ENSMUST00000120077.1
annexin A8
chrX_-_148615153 0.19 ENSMUST00000112755.2
predicted gene 8334
chr16_+_57353271 0.18 ENSMUST00000099667.2
filamin A interacting protein 1-like
chr4_-_62360436 0.17 ENSMUST00000084527.3
ENSMUST00000098033.3
FK506 binding protein 15
chr7_+_5020561 0.17 ENSMUST00000085427.3
zinc finger protein 865
chr14_+_60378242 0.17 ENSMUST00000022561.6
APC membrane recruitment 2
chr4_+_152158867 0.16 ENSMUST00000030782.1
hairy and enhancer of split 2 (Drosophila)
chr16_-_32099697 0.16 ENSMUST00000155966.1
ENSMUST00000096109.4
phosphatidylinositol glycan anchor biosynthesis, class X
chr7_-_114636299 0.16 ENSMUST00000032906.4
ENSMUST00000032907.7
calcitonin/calcitonin-related polypeptide, alpha
chr6_+_120666388 0.15 ENSMUST00000112686.1
cat eye syndrome chromosome region, candidate 2
chr3_-_90509450 0.15 ENSMUST00000107343.1
ENSMUST00000001043.7
ENSMUST00000107344.1
ENSMUST00000076639.4
ENSMUST00000107346.1
ENSMUST00000146740.1
ENSMUST00000107342.1
ENSMUST00000049937.6
chromatin target of PRMT1
chr7_-_30193098 0.14 ENSMUST00000108196.1
calpain, small subunit 1
chr7_+_5020376 0.14 ENSMUST00000076251.4
zinc finger protein 865
chr4_+_41569775 0.13 ENSMUST00000102963.3
dynein, axonemal, intermediate chain 1
chr6_-_4747019 0.13 ENSMUST00000126151.1
ENSMUST00000133306.1
ENSMUST00000123907.1
sarcoglycan, epsilon
chr9_-_54647199 0.13 ENSMUST00000128163.1
acyl-CoA synthetase bubblegum family member 1
chr7_+_28881656 0.12 ENSMUST00000066880.4
calpain 12
chr1_-_153487639 0.12 ENSMUST00000042141.5
DEAH (Asp-Glu-Ala-His) box polypeptide 9
chr2_+_4976113 0.12 ENSMUST00000167607.1
ENSMUST00000115010.2
upper zone of growth plate and cartilage matrix associated
chr10_+_127078886 0.11 ENSMUST00000039259.6
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr12_-_11150305 0.10 ENSMUST00000055673.1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr12_+_73123709 0.10 ENSMUST00000021523.6
menage a trois 1
chr17_+_35016576 0.09 ENSMUST00000007245.1
ENSMUST00000172499.1
von Willebrand factor A domain containing 7
chr5_-_123524124 0.09 ENSMUST00000111586.1
ENSMUST00000031385.6
ENSMUST00000111587.3
diablo homolog (Drosophila)
chr2_+_83644435 0.09 ENSMUST00000081591.6
zinc finger CCCH-type containing 15
chr8_-_24596960 0.08 ENSMUST00000033956.6
indoleamine 2,3-dioxygenase 1
chr2_+_174330006 0.08 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr1_-_74284636 0.07 ENSMUST00000178235.1
ENSMUST00000006462.7
angio-associated migratory protein
chr6_-_51469869 0.06 ENSMUST00000114459.1
ENSMUST00000069949.6
heterogeneous nuclear ribonucleoprotein A2/B1
chr9_+_89909775 0.06 ENSMUST00000034912.4
ENSMUST00000034909.4
RAS protein-specific guanine nucleotide-releasing factor 1
chr7_+_5057161 0.06 ENSMUST00000045543.5
coiled-coil domain containing 106
chr7_-_35647127 0.05 ENSMUST00000120714.1
programmed cell death 5
chr16_+_16983382 0.05 ENSMUST00000069107.7
ENSMUST00000023462.6
mitogen-activated protein kinase 1
chr2_-_57113053 0.04 ENSMUST00000112627.1
nuclear receptor subfamily 4, group A, member 2
chr7_+_30459713 0.02 ENSMUST00000006825.8
nephrosis 1, nephrin
chr5_+_115279666 0.01 ENSMUST00000040421.4
coenzyme Q5 homolog, methyltransferase (yeast)
chr2_+_4976176 0.01 ENSMUST00000027978.1
upper zone of growth plate and cartilage matrix associated
chr11_+_46436925 0.01 ENSMUST00000152119.1
ENSMUST00000140027.1
ENSMUST00000020665.6
ENSMUST00000170928.1
ENSMUST00000109231.1
ENSMUST00000109232.3
ENSMUST00000128940.1
mediator complex subunit 7
chr5_+_94873797 0.01 ENSMUST00000180076.1
predicted gene 3183

Network of associatons between targets according to the STRING database.

First level regulatory network of Glis2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.2 GO:0002148 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
1.3 3.9 GO:0060217 hemangioblast cell differentiation(GO:0060217)
1.2 3.6 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752)
1.2 3.5 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.8 4.8 GO:0032796 uropod organization(GO:0032796)
0.8 3.2 GO:0046898 response to cycloheximide(GO:0046898)
0.8 6.3 GO:0015671 oxygen transport(GO:0015671)
0.4 1.3 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.4 6.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.4 1.7 GO:0060032 notochord regression(GO:0060032)
0.3 1.0 GO:1902870 camera-type eye photoreceptor cell fate commitment(GO:0060220) negative regulation of neural retina development(GO:0061076) negative regulation of retina development in camera-type eye(GO:1902867) negative regulation of amacrine cell differentiation(GO:1902870)
0.3 0.8 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.3 1.1 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.3 0.8 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.3 7.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.3 2.5 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.3 1.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.2 1.2 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.2 1.7 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.2 1.9 GO:0015074 DNA integration(GO:0015074)
0.2 1.6 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.2 3.7 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.2 0.4 GO:0046075 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.2 0.9 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.2 0.4 GO:0051885 positive regulation of anagen(GO:0051885)
0.2 1.5 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 1.3 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.2 0.8 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.2 1.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.2 1.0 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.2 3.7 GO:0001675 acrosome assembly(GO:0001675)
0.2 0.7 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.2 0.9 GO:0097167 circadian regulation of translation(GO:0097167)
0.2 2.6 GO:0043129 surfactant homeostasis(GO:0043129)
0.2 1.9 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.2 2.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 0.6 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.7 GO:0035983 response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.1 0.4 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 2.2 GO:0006968 cellular defense response(GO:0006968)
0.1 0.4 GO:0061642 chemoattraction of axon(GO:0061642)
0.1 0.6 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 1.0 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 2.4 GO:0010039 response to iron ion(GO:0010039)
0.1 0.3 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.1 0.3 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.3 GO:0097309 cap1 mRNA methylation(GO:0097309)
0.1 0.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.6 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.1 0.8 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.1 0.5 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.1 1.1 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.3 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 0.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 0.4 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 0.8 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.1 0.6 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 0.2 GO:0001983 baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.9 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.0 1.9 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 1.3 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.6 GO:0043306 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.7 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.9 GO:0043303 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.6 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0001771 immunological synapse formation(GO:0001771)
0.0 1.1 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 1.0 GO:0042073 intraciliary transport(GO:0042073)
0.0 0.5 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.5 GO:0001964 startle response(GO:0001964)
0.0 0.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.4 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:0001842 neural fold formation(GO:0001842)
0.0 0.2 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.3 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity(GO:0045953)
0.0 0.3 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
0.0 0.1 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0033193 Lsd1/2 complex(GO:0033193)
0.8 6.3 GO:0005833 hemoglobin complex(GO:0005833)
0.7 10.7 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.4 3.6 GO:0005577 fibrinogen complex(GO:0005577)
0.4 1.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.3 1.0 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.3 3.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 2.6 GO:0097208 alveolar lamellar body(GO:0097208)
0.2 5.0 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.7 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 0.8 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 2.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.6 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 1.7 GO:0097542 ciliary tip(GO:0097542)
0.1 1.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.5 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.1 0.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.5 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.4 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 1.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 4.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 2.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.3 GO:0034709 methylosome(GO:0034709)
0.0 1.0 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.2 GO:0032420 stereocilium(GO:0032420)
0.0 0.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.7 GO:0005581 collagen trimer(GO:0005581)
0.0 1.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 1.5 GO:0031526 brush border membrane(GO:0031526)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 3.5 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 2.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.1 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.9 3.7 GO:0015057 thrombin receptor activity(GO:0015057)
0.9 3.6 GO:0070052 collagen V binding(GO:0070052)
0.6 1.9 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.4 6.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.3 3.2 GO:0051434 BH3 domain binding(GO:0051434)
0.3 1.6 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.3 2.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 2.4 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.3 0.8 GO:0016015 morphogen activity(GO:0016015)
0.2 2.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.2 4.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 0.6 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.2 0.6 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.2 1.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.2 0.7 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.2 10.2 GO:0004601 peroxidase activity(GO:0004601)
0.2 1.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.4 GO:0009041 uridylate kinase activity(GO:0009041) nucleoside phosphate kinase activity(GO:0050145)
0.1 0.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.8 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 1.2 GO:0051525 NFAT protein binding(GO:0051525)
0.1 3.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.3 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 2.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 0.4 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.1 4.7 GO:0070888 E-box binding(GO:0070888)
0.1 1.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.6 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.8 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 0.6 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.1 0.3 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1 1.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 1.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.9 GO:0019841 retinol binding(GO:0019841)
0.1 0.3 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.4 GO:0015288 porin activity(GO:0015288)
0.1 1.3 GO:0015464 acetylcholine receptor activity(GO:0015464)
0.0 0.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 1.9 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 2.2 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.1 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
0.0 0.6 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 1.1 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.5 GO:0031432 titin binding(GO:0031432)
0.0 0.1 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.0 0.6 GO:0016208 AMP binding(GO:0016208)
0.0 0.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.6 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.4 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 1.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.6 GO:0051087 chaperone binding(GO:0051087)
0.0 3.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.1 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 3.1 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.2 PID IL23 PATHWAY IL23-mediated signaling events
0.2 3.7 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 3.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.6 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 2.4 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 2.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.1 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 2.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 3.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.7 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.6 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 2.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.6 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 3.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 3.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 2.5 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 5.6 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 1.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.9 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 3.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.7 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 0.8 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.1 2.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 2.4 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 2.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 3.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 1.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.6 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.9 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.6 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 1.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1