Motif ID: Grhl1

Z-value: 1.220


Transcription factors associated with Grhl1:

Gene SymbolEntrez IDGene Name
Grhl1 ENSMUSG00000020656.9 Grhl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Grhl1mm10_v2_chr12_+_24572276_24572308-0.076.9e-01Click!


Activity profile for motif Grhl1.

activity profile for motif Grhl1


Sorted Z-values histogram for motif Grhl1

Sorted Z-values for motif Grhl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Grhl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_78347140 10.254 ENSMUST00000034902.5
Gsta2
glutathione S-transferase, alpha 2 (Yc2)
chr9_-_78347162 9.492 ENSMUST00000129247.1
Gsta2
glutathione S-transferase, alpha 2 (Yc2)
chr9_+_78289923 8.301 ENSMUST00000119823.1
ENSMUST00000121273.1
Gm10639

predicted gene 10639

chr11_+_72435565 7.397 ENSMUST00000100903.2
Ggt6
gamma-glutamyltransferase 6
chr5_-_86518578 6.317 ENSMUST00000134179.1
Tmprss11g
transmembrane protease, serine 11g
chr1_+_135818593 5.708 ENSMUST00000038760.8
Lad1
ladinin
chr8_-_93229517 5.618 ENSMUST00000176282.1
ENSMUST00000034173.7
Ces1e

carboxylesterase 1E

chr18_+_56432116 5.615 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chrX_-_38456407 5.553 ENSMUST00000074913.5
ENSMUST00000016678.7
ENSMUST00000061755.8
Lamp2


lysosomal-associated membrane protein 2


chr4_+_141242850 4.740 ENSMUST00000138096.1
ENSMUST00000006618.2
ENSMUST00000125392.1
Arhgef19


Rho guanine nucleotide exchange factor (GEF) 19


chr3_-_85722474 4.670 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr16_+_44173271 3.821 ENSMUST00000088356.4
ENSMUST00000169582.1
Gm608

predicted gene 608

chr15_-_76014318 3.720 ENSMUST00000060807.5
Fam83h
family with sequence similarity 83, member H
chr2_-_30205772 3.706 ENSMUST00000113662.1
Ccbl1
cysteine conjugate-beta lyase 1
chr2_-_30205794 3.704 ENSMUST00000113663.2
ENSMUST00000044038.3
Ccbl1

cysteine conjugate-beta lyase 1

chr19_+_18631927 3.691 ENSMUST00000159572.1
ENSMUST00000042392.7
Nmrk1

nicotinamide riboside kinase 1

chr13_+_8885501 3.504 ENSMUST00000169314.2
Idi1
isopentenyl-diphosphate delta isomerase
chr7_+_101321703 3.199 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
Stard10




START domain containing 10




chr17_+_56005672 3.181 ENSMUST00000133998.1
Mpnd
MPN domain containing
chr7_+_65693447 3.170 ENSMUST00000143508.1
Tm2d3
TM2 domain containing 3
chr17_-_56005566 3.145 ENSMUST00000043785.6
Stap2
signal transducing adaptor family member 2
chr14_-_73385225 3.082 ENSMUST00000022704.7
Itm2b
integral membrane protein 2B
chr16_+_44173239 2.906 ENSMUST00000119746.1
Gm608
predicted gene 608
chr7_+_65693417 2.622 ENSMUST00000032726.7
ENSMUST00000107495.3
Tm2d3

TM2 domain containing 3

chr4_+_108834601 2.202 ENSMUST00000030296.8
Txndc12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr7_+_12927410 1.987 ENSMUST00000045870.4
2310014L17Rik
RIKEN cDNA 2310014L17 gene
chr8_-_71381907 1.985 ENSMUST00000002466.8
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr4_+_134065897 1.921 ENSMUST00000137053.1
Aim1l
absent in melanoma 1-like
chr17_+_29268788 1.889 ENSMUST00000064709.5
ENSMUST00000120346.1
BC004004

cDNA sequence BC004004

chr12_+_90738201 1.858 ENSMUST00000181874.1
Gm26512
predicted gene, 26512
chr19_-_18631754 1.723 ENSMUST00000025631.6
Ostf1
osteoclast stimulating factor 1
chr7_+_141338963 1.687 ENSMUST00000143633.1
Eps8l2
EPS8-like 2
chr8_+_45628176 1.676 ENSMUST00000130850.1
Sorbs2
sorbin and SH3 domain containing 2
chr17_-_34628380 1.636 ENSMUST00000167097.2
Ppt2
palmitoyl-protein thioesterase 2
chr3_-_10335650 1.509 ENSMUST00000078748.3
Slc10a5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr11_+_53350783 1.421 ENSMUST00000060945.5
Aff4
AF4/FMR2 family, member 4
chr2_-_127541412 1.420 ENSMUST00000028855.7
Prom2
prominin 2
chr2_-_127541385 1.303 ENSMUST00000103214.2
Prom2
prominin 2
chr4_-_155086271 1.254 ENSMUST00000030914.3
Rer1
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
chr1_-_131279544 1.211 ENSMUST00000062108.3
Ikbke
inhibitor of kappaB kinase epsilon
chrX_-_112698642 1.209 ENSMUST00000039887.3
Pof1b
premature ovarian failure 1B
chr17_-_34628005 1.204 ENSMUST00000166040.2
Ppt2
palmitoyl-protein thioesterase 2
chr18_-_25753852 1.197 ENSMUST00000025117.6
ENSMUST00000115816.2
Celf4

CUGBP, Elav-like family member 4

chr18_-_64660981 1.160 ENSMUST00000025482.8
Atp8b1
ATPase, class I, type 8B, member 1
chr3_-_103732553 1.156 ENSMUST00000169286.1
BC027582
cDNA sequence BC027582
chr17_+_13760502 1.084 ENSMUST00000139347.1
ENSMUST00000156591.1
ENSMUST00000170827.2
ENSMUST00000139666.1
ENSMUST00000137784.1
ENSMUST00000137708.1
ENSMUST00000150848.1
Mllt4






myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4






chr2_+_172550761 1.036 ENSMUST00000099058.3
Tfap2c
transcription factor AP-2, gamma
chr5_-_86676346 0.987 ENSMUST00000038448.6
Tmprss11bnl
transmembrane protease, serine 11b N terminal like
chr4_-_19570073 0.949 ENSMUST00000029885.4
Cpne3
copine III
chr7_-_102065044 0.853 ENSMUST00000130074.1
ENSMUST00000131104.1
ENSMUST00000096639.5
Rnf121


ring finger protein 121


chr14_-_57133268 0.824 ENSMUST00000160703.1
Gjb6
gap junction protein, beta 6
chr3_+_92288566 0.823 ENSMUST00000090872.4
Sprr2a3
small proline-rich protein 2A3
chr17_+_7324646 0.818 ENSMUST00000095726.4
ENSMUST00000128533.1
ENSMUST00000129709.1
ENSMUST00000147803.1
ENSMUST00000140192.1
ENSMUST00000138222.1
ENSMUST00000144861.1
Tcp10a






t-complex protein 10a






chr6_-_113377510 0.787 ENSMUST00000099118.2
Tada3
transcriptional adaptor 3
chr9_-_107541816 0.785 ENSMUST00000041459.3
Cyb561d2
cytochrome b-561 domain containing 2
chr4_+_155086577 0.746 ENSMUST00000030915.4
ENSMUST00000155775.1
ENSMUST00000127457.1
Morn1


MORN repeat containing 1


chr11_-_22860467 0.736 ENSMUST00000055549.3
B3gnt2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
chr2_-_30967859 0.736 ENSMUST00000028200.8
Tor1a
torsin family 1, member A (torsin A)
chr5_+_136057138 0.696 ENSMUST00000111137.1
Upk3bl
uroplakin 3B-like
chr4_+_109676568 0.692 ENSMUST00000102724.4
Faf1
Fas-associated factor 1
chr8_+_123477859 0.671 ENSMUST00000001520.7
Afg3l1
AFG3(ATPase family gene 3)-like 1 (yeast)
chr5_-_86518562 0.652 ENSMUST00000140095.1
Tmprss11g
transmembrane protease, serine 11g
chr2_-_180289879 0.634 ENSMUST00000038529.1
Rbbp8nl
RBBP8 N-terminal like
chr9_-_44268156 0.625 ENSMUST00000169651.1
Nlrx1
NLR family member X1
chr3_-_88548249 0.621 ENSMUST00000131775.1
ENSMUST00000008745.6
Rab25

RAB25, member RAS oncogene family

chr5_-_137600650 0.585 ENSMUST00000111007.1
ENSMUST00000133705.1
Mospd3

motile sperm domain containing 3

chr8_-_95853501 0.575 ENSMUST00000040481.3
Slc38a7
solute carrier family 38, member 7
chr12_-_54656496 0.546 ENSMUST00000056228.6
Sptssa
serine palmitoyltransferase, small subunit A
chr2_+_24276909 0.532 ENSMUST00000028360.1
ENSMUST00000168941.1
ENSMUST00000123053.1
Il1f5


interleukin 1 family, member 5 (delta)


chr7_+_29519158 0.454 ENSMUST00000141713.1
4932431P20Rik
RIKEN cDNA 4932431P20 gene
chr17_+_43389436 0.412 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr17_+_13354572 0.366 ENSMUST00000097403.3
Tcp10c
t-complex protein 10c
chr19_+_3958803 0.352 ENSMUST00000179433.1
1700055N04Rik
RIKEN cDNA 1700055N04 gene
chr9_-_7873016 0.314 ENSMUST00000013949.8
Birc3
baculoviral IAP repeat-containing 3
chr16_-_55822128 0.297 ENSMUST00000114458.1
Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
chr17_+_36837123 0.289 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
Trim26





tripartite motif-containing 26





chr2_-_25546872 0.253 ENSMUST00000114234.1
ENSMUST00000028311.6
Traf2

TNF receptor-associated factor 2

chr4_+_135728116 0.244 ENSMUST00000102546.3
Il22ra1
interleukin 22 receptor, alpha 1
chr12_-_20900867 0.211 ENSMUST00000079237.5
Zfp125
zinc finger protein 125
chr9_-_7872983 0.197 ENSMUST00000115672.1
Birc3
baculoviral IAP repeat-containing 3
chr9_+_15239045 0.153 ENSMUST00000034413.6
Vstm5
V-set and transmembrane domain containing 5
chr15_-_63808747 0.137 ENSMUST00000110125.2
Gsdmc
gasdermin C
chr6_-_113377376 0.064 ENSMUST00000043333.2
Tada3
transcriptional adaptor 3
chr2_-_144332146 0.063 ENSMUST00000037423.3
Ovol2
ovo-like 2 (Drosophila)
chr4_+_88754868 0.030 ENSMUST00000094992.1
Gm13271
predicted gene 13271
chr2_+_149830894 0.027 ENSMUST00000137280.1
ENSMUST00000149705.1
Syndig1

synapse differentiation inducing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.8 23.2 GO:0035634 response to stilbenoid(GO:0035634)
0.7 2.7 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.5 7.4 GO:0006751 glutathione catabolic process(GO:0006751)
0.4 3.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.4 3.2 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.3 2.8 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.3 1.0 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 1.9 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.2 1.2 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.2 0.6 GO:0006867 asparagine transport(GO:0006867)
0.2 0.7 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.2 3.7 GO:0019363 pyridine nucleotide biosynthetic process(GO:0019363)
0.2 0.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 1.7 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.6 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 1.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 0.9 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.7 GO:0051584 regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940) positive regulation of synaptic vesicle endocytosis(GO:1900244)
0.1 1.3 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.1 0.5 GO:0019732 antifungal humoral response(GO:0019732)
0.1 0.7 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 2.0 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 2.2 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 3.7 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.1 1.5 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 1.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.7 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 0.6 GO:0031268 pseudopodium organization(GO:0031268)
0.0 1.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.4 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.0 4.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.2 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.9 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0031088 platelet dense granule membrane(GO:0031088) intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.7 2.7 GO:0044393 microspike(GO:0044393)
0.2 3.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 0.7 GO:0005745 m-AAA complex(GO:0005745)
0.1 3.7 GO:0045095 keratin filament(GO:0045095)
0.1 0.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.3 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 5.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.5 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.7 GO:0036501 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) UFD1-NPL4 complex(GO:0036501)
0.1 0.9 GO:0071819 SAGA complex(GO:0000124) DUBm complex(GO:0071819)
0.0 3.1 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 2.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.7 GO:0005604 basement membrane(GO:0005604)
0.0 1.2 GO:0030057 desmosome(GO:0030057)
0.0 0.6 GO:0031143 pseudopodium(GO:0031143)
0.0 0.8 GO:0005922 connexin complex(GO:0005922)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.2 GO:0032421 stereocilium(GO:0032420) stereocilium bundle(GO:0032421)
0.0 1.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.9 GO:0030496 midbody(GO:0030496)
0.0 0.3 GO:0001533 cornified envelope(GO:0001533)
0.0 1.2 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.7 3.7 GO:1990254 keratin filament binding(GO:1990254)
0.7 2.2 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.7 19.7 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.6 7.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.3 8.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 5.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.3 2.8 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 0.7 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.2 1.2 GO:0008384 IkappaB kinase activity(GO:0008384)
0.2 1.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 0.6 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.1 0.5 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 1.2 GO:1901612 cardiolipin binding(GO:1901612)
0.1 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.7 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 3.1 GO:0001540 amyloid-beta binding(GO:0001540)
0.0 4.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.5 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 2.7 GO:0015485 cholesterol binding(GO:0015485)
0.0 5.6 GO:0051087 chaperone binding(GO:0051087)
0.0 1.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 1.9 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 2.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 7.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 4.5 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 19.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.4 7.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.1 3.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.2 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 3.1 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 5.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.7 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway