Motif ID: Hes5_Hes7

Z-value: 2.231

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes5mm10_v2_chr4_+_154960915_1549609300.772.9e-08Click!
Hes7mm10_v2_chr11_+_69120404_691204040.582.0e-04Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_12026237 88.252 ENSMUST00000150972.1
Grb10
growth factor receptor bound protein 10
chr11_-_12026732 78.463 ENSMUST00000143915.1
Grb10
growth factor receptor bound protein 10
chr17_-_26199008 43.226 ENSMUST00000142410.1
ENSMUST00000120333.1
ENSMUST00000039113.7
Pdia2


protein disulfide isomerase associated 2


chrX_+_8271381 33.242 ENSMUST00000033512.4
Slc38a5
solute carrier family 38, member 5
chrX_+_8271133 33.156 ENSMUST00000127103.1
ENSMUST00000115591.1
Slc38a5

solute carrier family 38, member 5

chr12_+_109549157 26.659 ENSMUST00000128458.1
ENSMUST00000150851.1
Meg3

maternally expressed 3

chrX_+_8271642 24.551 ENSMUST00000115590.1
Slc38a5
solute carrier family 38, member 5
chr8_+_122269569 18.813 ENSMUST00000055537.2
Gm22
predicted gene 22
chr12_+_109459843 15.844 ENSMUST00000173812.1
Dlk1
delta-like 1 homolog (Drosophila)
chr1_-_193035651 13.108 ENSMUST00000016344.7
Syt14
synaptotagmin XIV
chr6_+_4755327 11.768 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr13_+_108316395 10.659 ENSMUST00000171178.1
Depdc1b
DEP domain containing 1B
chr8_-_24948771 10.497 ENSMUST00000119720.1
ENSMUST00000121438.2
Adam32

a disintegrin and metallopeptidase domain 32

chr13_+_108316332 10.483 ENSMUST00000051594.5
Depdc1b
DEP domain containing 1B
chrX_-_9256899 10.145 ENSMUST00000115553.2
Gm14862
predicted gene 14862
chr6_-_52226165 10.109 ENSMUST00000114425.2
Hoxa9
homeobox A9
chr11_+_11684967 9.762 ENSMUST00000126058.1
ENSMUST00000141436.1
Ikzf1

IKAROS family zinc finger 1

chr4_-_138757578 9.697 ENSMUST00000030526.6
Pla2g2f
phospholipase A2, group IIF
chr19_-_5394385 8.948 ENSMUST00000044527.4
Tsga10ip
testis specific 10 interacting protein
chr3_-_95241598 7.516 ENSMUST00000090815.5
ENSMUST00000107197.1
Gm128

predicted gene 128

chr2_+_150570409 7.191 ENSMUST00000089200.2
Cst7
cystatin F (leukocystatin)
chr4_+_134468320 6.581 ENSMUST00000030636.4
ENSMUST00000127279.1
ENSMUST00000105867.1
Stmn1


stathmin 1


chr4_+_154869585 6.348 ENSMUST00000079269.7
ENSMUST00000163732.1
ENSMUST00000080559.6
Mmel1


membrane metallo-endopeptidase-like 1


chr5_+_31251678 5.742 ENSMUST00000054829.7
ENSMUST00000114570.1
ENSMUST00000075611.7
Krtcap3


keratinocyte associated protein 3


chr2_-_92370999 5.298 ENSMUST00000176810.1
ENSMUST00000090582.4
Gyltl1b

glycosyltransferase-like 1B

chr9_-_121641526 5.219 ENSMUST00000125075.1
ENSMUST00000077706.3
Lyzl4

lysozyme-like 4

chr15_+_39076885 5.173 ENSMUST00000067072.3
Cthrc1
collagen triple helix repeat containing 1
chr2_-_92371039 4.806 ENSMUST00000068586.6
Gyltl1b
glycosyltransferase-like 1B
chr9_-_36726374 4.762 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
Chek1


checkpoint kinase 1


chr4_+_11191354 4.668 ENSMUST00000170901.1
Ccne2
cyclin E2
chr6_-_145076106 4.579 ENSMUST00000111742.1
ENSMUST00000048252.4
Bcat1

branched chain aminotransferase 1, cytosolic

chr2_-_92370968 4.148 ENSMUST00000176774.1
Gyltl1b
glycosyltransferase-like 1B
chr9_+_64121501 4.114 ENSMUST00000118215.1
Lctl
lactase-like
chr2_+_24345282 3.965 ENSMUST00000114485.2
Il1rn
interleukin 1 receptor antagonist
chr19_+_47178820 3.730 ENSMUST00000111808.3
Neurl1a
neuralized homolog 1A (Drosophila)
chr6_+_71707561 3.701 ENSMUST00000121469.1
Reep1
receptor accessory protein 1
chr11_-_120348513 3.698 ENSMUST00000071555.6
Actg1
actin, gamma, cytoplasmic 1
chr9_+_107587711 3.656 ENSMUST00000010192.5
Ifrd2
interferon-related developmental regulator 2
chr9_-_78443204 3.529 ENSMUST00000070742.7
ENSMUST00000034898.7
Mb21d1

Mab-21 domain containing 1

chr4_-_149126688 3.168 ENSMUST00000030815.2
Cort
cortistatin
chr10_-_87493651 3.155 ENSMUST00000020243.7
Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr3_-_95855860 3.115 ENSMUST00000015892.7
Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr3_-_95855753 3.069 ENSMUST00000161476.1
Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr6_+_35177610 2.856 ENSMUST00000170234.1
Nup205
nucleoporin 205
chr8_+_60632856 2.827 ENSMUST00000160719.1
Mfap3l
microfibrillar-associated protein 3-like
chr3_-_95315086 2.734 ENSMUST00000098867.3
Gm10691
predicted gene 10691
chr8_+_60632818 2.625 ENSMUST00000161421.1
Mfap3l
microfibrillar-associated protein 3-like
chr17_+_35861318 2.535 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr1_+_63176818 2.468 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr10_+_36974536 2.422 ENSMUST00000019911.7
Hdac2
histone deacetylase 2
chr17_-_25273861 2.385 ENSMUST00000172868.1
ENSMUST00000172618.1
Ube2i

ubiquitin-conjugating enzyme E2I

chr11_-_120348091 2.376 ENSMUST00000106215.4
Actg1
actin, gamma, cytoplasmic 1
chr15_+_32244801 2.087 ENSMUST00000067458.6
Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr13_+_35741313 2.079 ENSMUST00000163595.2
Cdyl
chromodomain protein, Y chromosome-like
chr6_+_72097561 1.943 ENSMUST00000069994.4
ENSMUST00000114112.1
St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr2_+_91526756 1.926 ENSMUST00000111338.3
Ckap5
cytoskeleton associated protein 5
chr8_-_87804411 1.918 ENSMUST00000165770.2
Zfp423
zinc finger protein 423
chr7_-_131362687 1.890 ENSMUST00000059438.9
2310057M21Rik
RIKEN cDNA 2310057M21 gene
chr11_+_80477015 1.886 ENSMUST00000053413.10
ENSMUST00000147694.1
Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chr16_+_45224315 1.764 ENSMUST00000102802.3
ENSMUST00000063654.4
Btla

B and T lymphocyte associated

chr17_-_28080567 1.738 ENSMUST00000114836.1
ENSMUST00000042692.5
Tcp11

t-complex protein 11

chr14_+_31019183 1.722 ENSMUST00000052239.5
Pbrm1
polybromo 1
chr6_+_49319274 1.717 ENSMUST00000055559.7
ENSMUST00000114491.1
Ccdc126

coiled-coil domain containing 126

chr4_-_43562397 1.684 ENSMUST00000030187.7
Tln1
talin 1
chr10_+_79822617 1.618 ENSMUST00000046833.4
Misp
mitotic spindle positioning
chr3_-_90052463 1.528 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
Ubap2l


ubiquitin associated protein 2-like


chr12_+_77239036 1.486 ENSMUST00000062804.7
Fut8
fucosyltransferase 8
chr11_+_3963970 1.434 ENSMUST00000020705.4
ENSMUST00000109985.1
Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr15_-_32244632 1.362 ENSMUST00000181536.1
0610007N19Rik
RIKEN cDNA 0610007N19
chr4_-_117251879 1.275 ENSMUST00000165128.1
ENSMUST00000077500.4
Gm1661

predicted gene 1661

chr1_-_161876656 1.268 ENSMUST00000048377.5
Suco
SUN domain containing ossification factor
chr6_+_83165920 1.188 ENSMUST00000077407.5
ENSMUST00000113913.1
ENSMUST00000130212.1
Dctn1


dynactin 1


chr10_+_36974558 1.098 ENSMUST00000105510.1
Hdac2
histone deacetylase 2
chr3_+_104638658 0.844 ENSMUST00000046212.1
Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr9_+_20652107 0.775 ENSMUST00000034689.6
Pin1
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
chr4_-_133756769 0.773 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr18_-_46280820 0.730 ENSMUST00000025354.3
Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chrX_-_112406779 0.723 ENSMUST00000026601.2
Satl1
spermidine/spermine N1-acetyl transferase-like 1
chr2_+_163203072 0.722 ENSMUST00000109428.2
Tox2
TOX high mobility group box family member 2
chr18_+_37320374 0.642 ENSMUST00000078271.2
Pcdhb5
protocadherin beta 5
chr18_-_35722330 0.619 ENSMUST00000133064.1
Ecscr
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr17_-_25274299 0.610 ENSMUST00000172587.1
ENSMUST00000049911.9
ENSMUST00000173713.1
Ube2i


ubiquitin-conjugating enzyme E2I


chr8_+_124722139 0.590 ENSMUST00000034463.3
Arv1
ARV1 homolog (yeast)
chr14_+_31019159 0.490 ENSMUST00000112094.1
ENSMUST00000144009.1
Pbrm1

polybromo 1

chr5_+_141241490 0.458 ENSMUST00000085774.4
Sdk1
sidekick homolog 1 (chicken)
chr17_-_35979679 0.454 ENSMUST00000173724.1
ENSMUST00000172900.1
ENSMUST00000174849.1
Prr3


proline-rich polypeptide 3


chr3_+_10366903 0.452 ENSMUST00000029049.5
Chmp4c
charged multivesicular body protein 4C
chr2_-_65567465 0.349 ENSMUST00000066432.5
Scn3a
sodium channel, voltage-gated, type III, alpha
chr11_-_59787636 0.317 ENSMUST00000125307.1
Pld6
phospholipase D family, member 6
chr2_-_150255591 0.311 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr10_+_39369750 0.294 ENSMUST00000063091.6
ENSMUST00000099967.3
ENSMUST00000126486.1
Fyn


Fyn proto-oncogene


chrX_-_8175890 0.279 ENSMUST00000143984.1
Tbc1d25
TBC1 domain family, member 25
chr12_+_69372112 0.269 ENSMUST00000050063.7
Arf6
ADP-ribosylation factor 6
chr4_-_123904826 0.254 ENSMUST00000181292.1
Gm26606
predicted gene, 26606
chr5_+_43515513 0.239 ENSMUST00000167522.1
ENSMUST00000144558.1
ENSMUST00000076939.6
C1qtnf7


C1q and tumor necrosis factor related protein 7


chr5_+_128601106 0.207 ENSMUST00000117102.2
Fzd10
frizzled homolog 10 (Drosophila)
chr2_-_150179679 0.204 ENSMUST00000099418.2
Gm10770
predicted gene 10770
chrX_-_44368329 0.172 ENSMUST00000056834.3
ENSMUST00000115057.1
Dcaf12l2

DDB1 and CUL4 associated factor 12-like 2

chr2_+_29060239 0.163 ENSMUST00000100237.3
Ttf1
transcription termination factor, RNA polymerase I
chr11_+_97315716 0.128 ENSMUST00000019026.3
ENSMUST00000132168.1
Mrpl45

mitochondrial ribosomal protein L45


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
15.2 166.7 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
5.1 90.9 GO:0015816 glycine transport(GO:0015816)
3.3 43.2 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
3.3 9.8 GO:0045660 positive regulation of neutrophil differentiation(GO:0045660)
1.6 4.8 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
1.1 3.2 GO:0060166 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
0.9 6.6 GO:0070494 regulation of thrombin-activated receptor signaling pathway(GO:0070494) negative regulation of thrombin-activated receptor signaling pathway(GO:0070495)
0.9 26.7 GO:0008340 determination of adult lifespan(GO:0008340)
0.8 4.0 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.8 4.6 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.7 3.5 GO:0035984 response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.7 10.1 GO:0042118 endothelial cell activation(GO:0042118)
0.5 15.8 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.5 6.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.5 3.0 GO:1903755 regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755)
0.5 1.9 GO:0021586 pons maturation(GO:0021586)
0.4 1.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 5.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.4 1.5 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.4 2.9 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.3 5.2 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.3 3.7 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.3 1.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.3 9.7 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.3 2.1 GO:0090091 positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of extracellular matrix disassembly(GO:0090091)
0.2 1.2 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.2 1.7 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2 3.7 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.2 3.5 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.2 0.7 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.2 1.5 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.2 1.8 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.2 1.4 GO:0007000 nucleolus organization(GO:0007000)
0.2 0.8 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.2 0.5 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.1 0.7 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 20.8 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.1 8.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 3.2 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 0.3 GO:0008358 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
0.1 6.1 GO:0045214 sarcomere organization(GO:0045214)
0.1 0.8 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.1 4.5 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.7 GO:0060046 regulation of acrosome reaction(GO:0060046)
0.1 1.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.3 GO:1905664 regulation of calcium ion import across plasma membrane(GO:1905664)
0.1 1.9 GO:0097503 sialylation(GO:0097503)
0.1 0.6 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 1.3 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 2.5 GO:0045471 response to ethanol(GO:0045471)
0.0 0.2 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 0.6 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.2 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.0 1.7 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.3 GO:0097284 hepatocyte apoptotic process(GO:0097284)
0.0 2.9 GO:2000117 negative regulation of cysteine-type endopeptidase activity(GO:2000117)
0.0 3.8 GO:1901657 glycosyl compound metabolic process(GO:1901657)
0.0 0.3 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.5 GO:0048148 behavioral response to cocaine(GO:0048148)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.6 1.9 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.6 2.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.5 8.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.5 3.0 GO:1990356 sumoylated E2 ligase complex(GO:1990356)
0.4 2.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 3.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.2 6.2 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.2 4.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 2.5 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.4 GO:0070545 PeBoW complex(GO:0070545)
0.1 6.1 GO:0043034 costamere(GO:0043034)
0.1 1.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 3.7 GO:0097440 apical dendrite(GO:0097440)
0.1 1.2 GO:0005869 dynactin complex(GO:0005869)
0.1 1.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.7 GO:0097225 sperm midpiece(GO:0097225)
0.1 4.8 GO:0005657 replication fork(GO:0005657)
0.1 5.4 GO:0005581 collagen trimer(GO:0005581)
0.1 84.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.7 GO:0090543 Flemming body(GO:0090543)
0.1 1.9 GO:0090544 BAF-type complex(GO:0090544)
0.1 5.2 GO:0097540 sperm flagellum(GO:0036126) axonemal central pair(GO:0097540) axonemal outer doublet(GO:0097545) A axonemal microtubule(GO:0097649) B axonemal microtubule(GO:0097650) 9+2 motile cilium(GO:0097729) C1 axonemal microtubule(GO:1990719) C2 axonemal microtubule(GO:1990720)
0.0 4.1 GO:0005903 brush border(GO:0005903)
0.0 9.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 140.8 GO:0005829 cytosol(GO:0005829)
0.0 1.5 GO:0031519 PcG protein complex(GO:0031519)
0.0 9.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.7 GO:0001726 ruffle(GO:0001726)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 90.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
3.9 43.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
3.4 166.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.6 4.8 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.3 4.0 GO:0045352 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
0.9 3.7 GO:0031849 olfactory receptor binding(GO:0031849)
0.9 3.5 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.8 4.6 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.7 2.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.7 4.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.5 3.0 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.4 1.7 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.4 5.2 GO:0003796 lysozyme activity(GO:0003796)
0.3 9.8 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.2 0.7 GO:0019809 spermidine binding(GO:0019809)
0.2 9.7 GO:0004623 phospholipase A2 activity(GO:0004623)
0.2 0.8 GO:0050816 phosphothreonine residue binding(GO:0050816)
0.2 5.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.7 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.1 1.7 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.9 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907) G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.1 3.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 4.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.5 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 2.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 3.7 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.1 10.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 7.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 3.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 3.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.9 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 1.2 GO:0070840 dynein complex binding(GO:0070840)
0.0 15.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 4.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.1 GO:0140034 methylated histone binding(GO:0035064) methylation-dependent protein binding(GO:0140034)
0.0 6.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 3.5 GO:0016779 nucleotidyltransferase activity(GO:0016779)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 166.7 PID_IGF1_PATHWAY IGF1 pathway
0.5 4.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 41.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.4 6.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 4.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 12.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 3.0 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 5.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 16.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 9.2 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 6.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 15.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 0.8 PID_MYC_PATHWAY C-MYC pathway
0.1 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.5 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
7.9 166.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
1.9 90.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 9.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.5 4.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 15.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 4.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 4.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 1.9 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.0 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 21.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.9 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 4.0 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 0.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 3.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.8 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY Genes involved in Costimulation by the CD28 family
0.0 1.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.5 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.0 0.8 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)