Motif ID: Hmx1

Z-value: 1.481


Transcription factors associated with Hmx1:

Gene SymbolEntrez IDGene Name
Hmx1 ENSMUSG00000067438.3 Hmx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx1mm10_v2_chr5_+_35388844_353888820.326.0e-02Click!


Activity profile for motif Hmx1.

activity profile for motif Hmx1


Sorted Z-values histogram for motif Hmx1

Sorted Z-values for motif Hmx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_56102458 16.477 ENSMUST00000015583.1
Ctsg
cathepsin G
chr12_+_109459843 12.737 ENSMUST00000173812.1
Dlk1
delta-like 1 homolog (Drosophila)
chr14_-_79301623 10.438 ENSMUST00000022595.7
Rgcc
regulator of cell cycle
chr7_+_18884679 8.139 ENSMUST00000032573.6
Pglyrp1
peptidoglycan recognition protein 1
chr4_+_120666562 6.981 ENSMUST00000094814.4
Cited4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr17_-_33890539 6.737 ENSMUST00000173386.1
Kifc1
kinesin family member C1
chr6_+_30738044 6.677 ENSMUST00000128398.1
ENSMUST00000163949.2
ENSMUST00000124665.1
Mest


mesoderm specific transcript


chr13_+_91461050 6.612 ENSMUST00000004094.8
ENSMUST00000042122.8
Ssbp2

single-stranded DNA binding protein 2

chr17_-_33890584 6.461 ENSMUST00000114361.2
ENSMUST00000173492.1
Kifc1

kinesin family member C1

chr11_+_69965396 6.265 ENSMUST00000018713.6
Cldn7
claudin 7
chr8_-_122460666 5.650 ENSMUST00000006762.5
Snai3
snail homolog 3 (Drosophila)
chr1_-_75505641 5.537 ENSMUST00000155084.1
Obsl1
obscurin-like 1
chr1_-_75506331 5.237 ENSMUST00000113567.2
ENSMUST00000113565.2
Obsl1

obscurin-like 1

chr11_+_61956779 5.096 ENSMUST00000049836.7
Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chrX_+_50841434 5.081 ENSMUST00000114887.2
2610018G03Rik
RIKEN cDNA 2610018G03 gene
chr6_+_90619241 5.075 ENSMUST00000032177.8
Slc41a3
solute carrier family 41, member 3
chr4_-_152477433 5.019 ENSMUST00000159186.1
ENSMUST00000162017.1
ENSMUST00000030768.2
Kcnab2


potassium voltage-gated channel, shaker-related subfamily, beta member 2


chr17_-_71310952 4.940 ENSMUST00000024849.9
Emilin2
elastin microfibril interfacer 2
chr1_+_43730593 4.827 ENSMUST00000027217.8
1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr11_+_11686213 4.793 ENSMUST00000076700.4
ENSMUST00000048122.6
Ikzf1

IKAROS family zinc finger 1

chr6_+_29433248 4.776 ENSMUST00000101617.2
ENSMUST00000065090.5
Flnc

filamin C, gamma

chr17_+_26917091 4.761 ENSMUST00000078961.4
Kifc5b
kinesin family member C5B
chr14_-_56234650 4.509 ENSMUST00000015585.2
Gzmc
granzyme C
chr3_-_152166230 4.509 ENSMUST00000046614.9
Gipc2
GIPC PDZ domain containing family, member 2
chrX_-_7671341 4.421 ENSMUST00000033486.5
Plp2
proteolipid protein 2
chr6_-_67535783 4.412 ENSMUST00000058178.4
Tacstd2
tumor-associated calcium signal transducer 2
chr2_+_153492790 4.204 ENSMUST00000109783.1
4930404H24Rik
RIKEN cDNA 4930404H24 gene
chr12_+_35992900 4.185 ENSMUST00000020898.5
Agr2
anterior gradient 2
chr6_+_29433131 3.811 ENSMUST00000090474.4
Flnc
filamin C, gamma
chr3_+_28781305 3.754 ENSMUST00000060500.7
Eif5a2
eukaryotic translation initiation factor 5A2
chrX_-_134808984 3.739 ENSMUST00000035559.4
Armcx2
armadillo repeat containing, X-linked 2
chr9_-_42124276 3.672 ENSMUST00000060989.8
Sorl1
sortilin-related receptor, LDLR class A repeats-containing
chr9_+_108560422 3.639 ENSMUST00000081111.8
Impdh2
inosine 5'-phosphate dehydrogenase 2
chr2_-_92370999 3.557 ENSMUST00000176810.1
ENSMUST00000090582.4
Gyltl1b

glycosyltransferase-like 1B

chr14_+_54640952 3.519 ENSMUST00000169818.2
Gm17606
predicted gene, 17606
chr12_+_110279228 3.477 ENSMUST00000097228.4
Dio3
deiodinase, iodothyronine type III
chr2_-_92371039 3.471 ENSMUST00000068586.6
Gyltl1b
glycosyltransferase-like 1B
chr11_-_46312220 3.412 ENSMUST00000129474.1
ENSMUST00000093166.4
ENSMUST00000165599.2
Cyfip2


cytoplasmic FMR1 interacting protein 2


chr11_+_3290300 3.345 ENSMUST00000057089.6
ENSMUST00000093402.5
Patz1

POZ (BTB) and AT hook containing zinc finger 1

chrX_-_74246364 3.260 ENSMUST00000130007.1
Flna
filamin, alpha
chr2_+_129198757 3.227 ENSMUST00000028880.3
Slc20a1
solute carrier family 20, member 1
chr8_+_105297663 3.223 ENSMUST00000015003.8
E2f4
E2F transcription factor 4
chrX_-_74246534 3.215 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna

filamin, alpha

chr7_-_126369543 3.170 ENSMUST00000032997.6
Lat
linker for activation of T cells
chr10_-_61273242 3.125 ENSMUST00000120336.1
Adamts14
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
chr6_-_124733067 3.039 ENSMUST00000173647.1
Ptpn6
protein tyrosine phosphatase, non-receptor type 6
chr6_-_127151044 3.038 ENSMUST00000000188.8
Ccnd2
cyclin D2
chr2_+_92915080 3.011 ENSMUST00000028648.2
Syt13
synaptotagmin XIII
chr2_-_92370968 2.987 ENSMUST00000176774.1
Gyltl1b
glycosyltransferase-like 1B
chr17_-_23684019 2.924 ENSMUST00000085989.5
Cldn9
claudin 9
chr3_+_145292472 2.872 ENSMUST00000029848.4
ENSMUST00000139001.1
Col24a1

collagen, type XXIV, alpha 1

chr13_+_55369732 2.869 ENSMUST00000063771.7
Rgs14
regulator of G-protein signaling 14
chr15_-_79834261 2.802 ENSMUST00000148358.1
Cbx6
chromobox 6
chr15_-_78572754 2.768 ENSMUST00000043214.6
Rac2
RAS-related C3 botulinum substrate 2
chr15_-_79834224 2.715 ENSMUST00000109623.1
ENSMUST00000109625.1
ENSMUST00000023060.6
ENSMUST00000089299.5
Cbx6

Npcd

chromobox 6

neuronal pentraxin chromo domain

chr6_+_34476207 2.696 ENSMUST00000045372.5
ENSMUST00000138668.1
ENSMUST00000139067.1
Bpgm


2,3-bisphosphoglycerate mutase


chr1_+_52008210 2.687 ENSMUST00000027277.5
Stat4
signal transducer and activator of transcription 4
chr18_-_62179948 2.680 ENSMUST00000053640.3
Adrb2
adrenergic receptor, beta 2
chr17_+_48462355 2.677 ENSMUST00000162132.1
Unc5cl
unc-5 homolog C (C. elegans)-like
chr18_+_62180119 2.665 ENSMUST00000067743.1
Gm9949
predicted gene 9949
chr7_+_118712516 2.634 ENSMUST00000106557.1
Ccp110
centriolar coiled coil protein 110
chr5_+_121220191 2.606 ENSMUST00000119892.2
ENSMUST00000042614.6
Gm15800

predicted gene 15800

chr2_-_73453918 2.558 ENSMUST00000102679.1
Wipf1
WAS/WASL interacting protein family, member 1
chr3_-_127499095 2.541 ENSMUST00000182594.1
Ank2
ankyrin 2, brain
chr4_+_129985098 2.433 ENSMUST00000106017.1
ENSMUST00000121049.1
Bai2

brain-specific angiogenesis inhibitor 2

chr9_-_61976563 2.430 ENSMUST00000113990.1
Paqr5
progestin and adipoQ receptor family member V
chr19_-_4615453 2.374 ENSMUST00000053597.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr11_-_69858723 2.342 ENSMUST00000001626.3
ENSMUST00000108626.1
Tnk1

tyrosine kinase, non-receptor, 1

chr9_+_62838767 2.319 ENSMUST00000034776.6
Cln6
ceroid-lipofuscinosis, neuronal 6
chr8_+_88272403 2.280 ENSMUST00000169037.1
Adcy7
adenylate cyclase 7
chr4_+_94556546 2.254 ENSMUST00000094969.1
Gm10306
predicted gene 10306
chr8_+_70315759 2.239 ENSMUST00000165819.2
ENSMUST00000140239.1
Gdf1
Cers1
growth differentiation factor 1
ceramide synthase 1
chr10_-_61273409 2.238 ENSMUST00000092486.4
Adamts14
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
chr16_+_49699198 2.231 ENSMUST00000046777.4
ENSMUST00000142682.1
Ift57

intraflagellar transport 57

chr17_-_47833169 2.201 ENSMUST00000131971.1
ENSMUST00000129360.1
ENSMUST00000113280.1
ENSMUST00000132125.1
Mdfi



MyoD family inhibitor



chr11_+_44518959 2.189 ENSMUST00000019333.3
Rnf145
ring finger protein 145
chr11_+_68692070 2.176 ENSMUST00000108673.1
Myh10
myosin, heavy polypeptide 10, non-muscle
chr17_-_47833256 2.156 ENSMUST00000152455.1
ENSMUST00000035375.7
Mdfi

MyoD family inhibitor

chr16_+_11984581 2.120 ENSMUST00000170672.2
ENSMUST00000023138.7
Shisa9

shisa homolog 9 (Xenopus laevis)

chr3_-_92485886 2.114 ENSMUST00000054599.7
Sprr1a
small proline-rich protein 1A
chr2_+_165595009 2.110 ENSMUST00000088132.6
Eya2
eyes absent 2 homolog (Drosophila)
chr10_-_76961788 2.102 ENSMUST00000001148.4
ENSMUST00000105411.2
Pcbp3

poly(rC) binding protein 3

chr3_-_89418287 2.096 ENSMUST00000029679.3
Cks1b
CDC28 protein kinase 1b
chr13_+_20090538 2.087 ENSMUST00000072519.5
Elmo1
engulfment and cell motility 1
chr10_+_80264942 2.082 ENSMUST00000105362.1
ENSMUST00000105361.3
Dazap1

DAZ associated protein 1

chr8_+_120537423 2.075 ENSMUST00000118136.1
Gse1
genetic suppressor element 1
chrX_+_159255919 2.023 ENSMUST00000112492.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr9_-_21312255 1.974 ENSMUST00000115433.3
ENSMUST00000003397.7
Ap1m2

adaptor protein complex AP-1, mu 2 subunit

chr7_-_79715669 1.967 ENSMUST00000184137.1
ENSMUST00000183846.1
Kif7

kinesin family member 7

chr3_+_108085976 1.961 ENSMUST00000070502.1
Gm12500
predicted gene 12500
chr15_+_54745702 1.960 ENSMUST00000050027.8
Nov
nephroblastoma overexpressed gene
chr2_+_130274437 1.949 ENSMUST00000141872.1
Nop56
NOP56 ribonucleoprotein
chrY_+_90843934 1.906 ENSMUST00000178550.1
Gm21742
predicted gene, 21742
chr11_+_3289880 1.899 ENSMUST00000110043.1
ENSMUST00000094471.3
Patz1

POZ (BTB) and AT hook containing zinc finger 1

chr15_-_98778150 1.892 ENSMUST00000023732.5
Wnt10b
wingless related MMTV integration site 10b
chr5_-_140565060 1.889 ENSMUST00000042993.6
Grifin
galectin-related inter-fiber protein
chr11_+_68691906 1.884 ENSMUST00000102611.3
Myh10
myosin, heavy polypeptide 10, non-muscle
chr2_+_153108468 1.834 ENSMUST00000109799.1
ENSMUST00000003370.7
Hck

hemopoietic cell kinase

chr18_-_24603791 1.820 ENSMUST00000070726.3
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr13_+_20090500 1.800 ENSMUST00000165249.2
Elmo1
engulfment and cell motility 1
chr8_+_94152607 1.794 ENSMUST00000034211.8
Mt3
metallothionein 3
chr1_+_135729147 1.791 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr2_+_25242227 1.769 ENSMUST00000154498.1
Rnf208
ring finger protein 208
chr11_+_77982710 1.765 ENSMUST00000108360.1
ENSMUST00000049167.7
Phf12

PHD finger protein 12

chr13_-_32338565 1.763 ENSMUST00000041859.7
Gmds
GDP-mannose 4, 6-dehydratase
chr7_-_83735503 1.733 ENSMUST00000001792.4
Il16
interleukin 16
chr7_-_126160992 1.731 ENSMUST00000164741.1
Xpo6
exportin 6
chr18_+_65581704 1.711 ENSMUST00000182979.1
Zfp532
zinc finger protein 532
chr17_+_34592248 1.705 ENSMUST00000038149.6
Pbx2
pre B cell leukemia homeobox 2
chr5_-_134614953 1.703 ENSMUST00000036362.6
ENSMUST00000077636.4
Lat2

linker for activation of T cells family, member 2

chr15_-_102231920 1.694 ENSMUST00000001327.3
ENSMUST00000127014.1
Itgb7

integrin beta 7

chr19_-_4615647 1.681 ENSMUST00000113822.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chrX_-_166585679 1.675 ENSMUST00000000412.2
Egfl6
EGF-like-domain, multiple 6
chr15_+_102503722 1.670 ENSMUST00000096145.4
Gm10337
predicted gene 10337
chr15_-_74709535 1.645 ENSMUST00000050234.2
Jrk
jerky
chr6_-_137169678 1.640 ENSMUST00000119610.1
Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr2_+_32876114 1.637 ENSMUST00000028135.8
Fam129b
family with sequence similarity 129, member B
chr1_-_87156127 1.587 ENSMUST00000160810.1
Ecel1
endothelin converting enzyme-like 1
chr3_+_131112785 1.553 ENSMUST00000098611.3
Lef1
lymphoid enhancer binding factor 1
chr4_+_129984833 1.533 ENSMUST00000120204.1
Bai2
brain-specific angiogenesis inhibitor 2
chr14_-_54686926 1.525 ENSMUST00000022793.8
ENSMUST00000111484.2
Acin1

apoptotic chromatin condensation inducer 1

chr11_+_68692097 1.496 ENSMUST00000018887.8
Myh10
myosin, heavy polypeptide 10, non-muscle
chr6_-_91116785 1.482 ENSMUST00000113509.1
ENSMUST00000032179.7
Nup210

nucleoporin 210

chr2_-_38287174 1.467 ENSMUST00000130472.1
Dennd1a
DENN/MADD domain containing 1A
chr4_+_134468320 1.465 ENSMUST00000030636.4
ENSMUST00000127279.1
ENSMUST00000105867.1
Stmn1


stathmin 1


chr8_+_83389846 1.441 ENSMUST00000002259.6
Clgn
calmegin
chr6_+_86849488 1.429 ENSMUST00000089519.6
ENSMUST00000113668.1
Aak1

AP2 associated kinase 1

chr3_-_56183678 1.409 ENSMUST00000029374.6
Nbea
neurobeachin
chr2_+_130274424 1.398 ENSMUST00000103198.4
Nop56
NOP56 ribonucleoprotein
chr4_+_140986873 1.380 ENSMUST00000168047.1
ENSMUST00000037055.7
ENSMUST00000127833.2
Atp13a2


ATPase type 13A2


chr8_+_83389878 1.368 ENSMUST00000109831.2
Clgn
calmegin
chrX_+_9272756 1.361 ENSMUST00000015486.6
Xk
Kell blood group precursor (McLeod phenotype) homolog
chr17_-_36867187 1.361 ENSMUST00000025329.6
ENSMUST00000174195.1
Trim15

tripartite motif-containing 15

chr15_+_32244801 1.356 ENSMUST00000067458.6
Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr11_+_115974709 1.313 ENSMUST00000021107.7
ENSMUST00000106461.1
ENSMUST00000169928.1
Itgb4


integrin beta 4


chr9_+_32696005 1.293 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
Ets1


E26 avian leukemia oncogene 1, 5' domain


chr15_-_79141197 1.290 ENSMUST00000169604.1
1700088E04Rik
RIKEN cDNA 1700088E04 gene
chr14_-_54686605 1.284 ENSMUST00000147714.1
Acin1
apoptotic chromatin condensation inducer 1
chr11_-_69858687 1.282 ENSMUST00000125571.1
Tnk1
tyrosine kinase, non-receptor, 1
chr15_+_103503261 1.280 ENSMUST00000023132.3
Pde1b
phosphodiesterase 1B, Ca2+-calmodulin dependent
chr1_+_166130467 1.236 ENSMUST00000166860.1
Gpa33
glycoprotein A33 (transmembrane)
chr15_-_79834323 1.235 ENSMUST00000177316.2
ENSMUST00000175858.2
Nptxr

neuronal pentraxin receptor

chr11_+_62820469 1.232 ENSMUST00000108703.1
Trim16
tripartite motif-containing 16
chr10_+_80265035 1.218 ENSMUST00000092305.5
Dazap1
DAZ associated protein 1
chr8_+_83900706 1.177 ENSMUST00000045393.8
ENSMUST00000132500.1
ENSMUST00000152978.1
Lphn1


latrophilin 1


chr1_+_166130238 1.175 ENSMUST00000060833.7
ENSMUST00000166159.1
Gpa33

glycoprotein A33 (transmembrane)

chrX_+_159255782 1.156 ENSMUST00000126686.1
ENSMUST00000033671.6
Rps6ka3

ribosomal protein S6 kinase polypeptide 3

chr5_-_39644597 1.117 ENSMUST00000152057.1
Hs3st1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr7_-_46179929 1.088 ENSMUST00000033123.6
Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr2_-_162661075 1.079 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
Ptprt



protein tyrosine phosphatase, receptor type, T



chr9_+_106170918 1.067 ENSMUST00000020490.5
Wdr82
WD repeat domain containing 82
chr15_-_32244632 1.054 ENSMUST00000181536.1
0610007N19Rik
RIKEN cDNA 0610007N19
chr11_+_68432112 1.048 ENSMUST00000021283.7
Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5, p101
chr11_-_94242701 1.043 ENSMUST00000061469.3
Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr15_-_13173607 1.041 ENSMUST00000036439.4
Cdh6
cadherin 6
chr18_+_34220890 1.034 ENSMUST00000171187.1
Apc
adenomatosis polyposis coli
chr17_-_24073479 1.026 ENSMUST00000017090.5
Kctd5
potassium channel tetramerisation domain containing 5
chr2_-_164404606 1.018 ENSMUST00000109359.1
ENSMUST00000109358.1
ENSMUST00000103103.3
Matn4


matrilin 4


chr15_+_59374198 1.013 ENSMUST00000079703.3
ENSMUST00000168722.1
Nsmce2

non-SMC element 2 homolog (MMS21, S. cerevisiae)

chr6_-_137169710 0.999 ENSMUST00000117919.1
Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr1_-_153186447 0.976 ENSMUST00000027753.6
Lamc2
laminin, gamma 2
chr14_-_52237791 0.973 ENSMUST00000149975.1
Chd8
chromodomain helicase DNA binding protein 8
chr5_+_100518309 0.964 ENSMUST00000045993.8
ENSMUST00000151414.1
Cops4

COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)

chr15_-_79687776 0.963 ENSMUST00000023061.5
Josd1
Josephin domain containing 1
chr5_-_33274966 0.962 ENSMUST00000079746.6
Ctbp1
C-terminal binding protein 1
chr2_+_118926496 0.923 ENSMUST00000099546.4
ENSMUST00000110837.1
Chst14

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14

chr15_-_85578070 0.915 ENSMUST00000109424.2
Wnt7b
wingless-related MMTV integration site 7B
chr9_-_44735189 0.914 ENSMUST00000034611.8
Phldb1
pleckstrin homology-like domain, family B, member 1
chr2_+_28513105 0.901 ENSMUST00000135803.1
Ralgds
ral guanine nucleotide dissociation stimulator
chr11_+_115974930 0.899 ENSMUST00000106460.2
Itgb4
integrin beta 4
chr11_-_102319093 0.894 ENSMUST00000174302.1
ENSMUST00000178839.1
ENSMUST00000006754.7
Ubtf


upstream binding transcription factor, RNA polymerase I


chr5_-_139130159 0.884 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr17_+_86963279 0.868 ENSMUST00000139344.1
Rhoq
ras homolog gene family, member Q
chr4_+_116221689 0.862 ENSMUST00000106490.2
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr5_+_147430407 0.838 ENSMUST00000176600.1
Pan3
PAN3 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr9_-_110654161 0.836 ENSMUST00000133191.1
ENSMUST00000167320.1
Nbeal2

neurobeachin-like 2

chr17_-_12769605 0.814 ENSMUST00000024599.7
Igf2r
insulin-like growth factor 2 receptor
chr5_+_115429944 0.794 ENSMUST00000067168.5
Msi1
musashi RNA-binding protein 1
chr13_-_38658991 0.779 ENSMUST00000001757.7
Eef1e1
eukaryotic translation elongation factor 1 epsilon 1
chr15_+_60822947 0.777 ENSMUST00000180730.1
9930014A18Rik
RIKEN cDNA 9930014A18 gene
chrX_-_74373260 0.775 ENSMUST00000073067.4
ENSMUST00000037967.5
Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr1_-_143702832 0.769 ENSMUST00000018337.7
Cdc73
cell division cycle 73, Paf1/RNA polymerase II complex component
chr3_-_108085346 0.769 ENSMUST00000078912.5
Ampd2
adenosine monophosphate deaminase 2
chr5_-_39644634 0.762 ENSMUST00000053116.6
Hs3st1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr11_-_116110211 0.758 ENSMUST00000106441.1
ENSMUST00000021120.5
Trim47

tripartite motif-containing 47

chr17_-_35979679 0.756 ENSMUST00000173724.1
ENSMUST00000172900.1
ENSMUST00000174849.1
Prr3


proline-rich polypeptide 3


chr10_-_80844025 0.755 ENSMUST00000053986.7
Lingo3
leucine rich repeat and Ig domain containing 3
chr12_-_24493656 0.727 ENSMUST00000073088.2
Gm16372
predicted pseudogene 16372
chr2_+_28192971 0.716 ENSMUST00000113920.1
Olfm1
olfactomedin 1
chr4_+_156013835 0.702 ENSMUST00000030952.5
Tnfrsf4
tumor necrosis factor receptor superfamily, member 4
chr8_+_82863351 0.694 ENSMUST00000078525.5
Rnf150
ring finger protein 150
chr2_-_119271202 0.688 ENSMUST00000037360.7
Rhov
ras homolog gene family, member V
chr14_-_52237572 0.686 ENSMUST00000089752.4
Chd8
chromodomain helicase DNA binding protein 8
chr17_-_33824346 0.665 ENSMUST00000173879.1
ENSMUST00000166693.2
ENSMUST00000173019.1
ENSMUST00000087342.6
ENSMUST00000173844.1
Rps28




ribosomal protein S28




chr5_-_34288318 0.656 ENSMUST00000094868.3
Zfyve28
zinc finger, FYVE domain containing 28
chr15_-_79254737 0.648 ENSMUST00000039752.3
Slc16a8
solute carrier family 16 (monocarboxylic acid transporters), member 8
chr7_-_30914327 0.625 ENSMUST00000040548.7
Mag
myelin-associated glycoprotein
chr17_+_35194502 0.613 ENSMUST00000173600.1
Ltb
lymphotoxin B
chr1_-_9700209 0.610 ENSMUST00000088658.4
Mybl1
myeloblastosis oncogene-like 1
chr3_-_88548249 0.607 ENSMUST00000131775.1
ENSMUST00000008745.6
Rab25

RAB25, member RAS oncogene family


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.2 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
3.5 10.4 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
2.7 8.1 GO:0051714 regulation of cytolysis in other organism(GO:0051710) positive regulation of cytolysis in other organism(GO:0051714)
2.2 6.5 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
1.9 5.6 GO:0070650 actin filament bundle distribution(GO:0070650)
1.8 16.5 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
1.6 4.8 GO:0045660 positive regulation of neutrophil differentiation(GO:0045660)
1.0 4.2 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.9 3.7 GO:2001137 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953) positive regulation of endocytic recycling(GO:2001137)
0.9 4.5 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.9 1.8 GO:0097212 lysosomal membrane organization(GO:0097212)
0.7 2.2 GO:0072720 cellular response to UV-A(GO:0071492) response to dithiothreitol(GO:0072720)
0.7 3.6 GO:0006177 GMP biosynthetic process(GO:0006177)
0.7 3.4 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.7 10.8 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.7 2.7 GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure(GO:0002025)
0.7 2.6 GO:0032053 ciliary basal body organization(GO:0032053)
0.7 2.0 GO:1904057 negative regulation of SMAD protein import into nucleus(GO:0060392) endothelial cell-cell adhesion(GO:0071603) negative regulation of sensory perception of pain(GO:1904057) bone regeneration(GO:1990523)
0.6 3.8 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.6 2.8 GO:0071593 lymphocyte aggregation(GO:0071593)
0.5 2.7 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.5 4.8 GO:0070314 G1 to G0 transition(GO:0070314)
0.5 2.1 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.5 2.4 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.5 1.9 GO:0051885 positive regulation of timing of anagen(GO:0051885)
0.4 3.4 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.4 12.2 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.4 1.6 GO:0021943 formation of radial glial scaffolds(GO:0021943)
0.4 5.0 GO:0070995 NADPH oxidation(GO:0070995)
0.4 1.1 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.4 2.8 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.3 3.5 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.3 1.4 GO:0018197 peptidyl-aspartic acid modification(GO:0018197)
0.3 1.0 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.3 6.3 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.3 1.0 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.3 0.9 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.3 0.9 GO:0061642 chemoattraction of axon(GO:0061642)
0.3 2.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 1.4 GO:0075733 intracellular transport of virus(GO:0075733) regulation of intracellular transport of viral material(GO:1901252)
0.3 2.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.3 2.9 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.3 1.3 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.2 1.2 GO:0023041 neuronal signal transduction(GO:0023041)
0.2 3.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.2 3.9 GO:0006968 cellular defense response(GO:0006968)
0.2 1.4 GO:0031133 regulation of axon diameter(GO:0031133)
0.2 1.5 GO:0070494 regulation of thrombin-activated receptor signaling pathway(GO:0070494) negative regulation of thrombin-activated receptor signaling pathway(GO:0070495)
0.2 0.8 GO:0070889 platelet alpha granule organization(GO:0070889)
0.2 2.2 GO:0035878 nail development(GO:0035878)
0.2 1.8 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.2 2.9 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 1.4 GO:0090091 positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of extracellular matrix disassembly(GO:0090091)
0.2 4.2 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.2 1.3 GO:0036006 response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006)
0.2 0.8 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.2 0.3 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.2 2.3 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 1.8 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 1.7 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 7.0 GO:0010883 regulation of lipid storage(GO:0010883)
0.1 0.8 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 2.3 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 1.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 1.0 GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337) positive regulation of protein localization to centrosome(GO:1904781)
0.1 3.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.9 GO:0070831 basement membrane assembly(GO:0070831)
0.1 0.6 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 8.3 GO:0048747 muscle fiber development(GO:0048747)
0.1 5.1 GO:0030199 collagen fibril organization(GO:0030199)
0.1 1.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1 1.0 GO:0032264 IMP salvage(GO:0032264)
0.1 1.7 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.9 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.1 0.8 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.3 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.1 3.3 GO:0000154 rRNA modification(GO:0000154)
0.1 2.2 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.3 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.1 0.8 GO:0031442 positive regulation of mRNA 3'-end processing(GO:0031442)
0.1 0.6 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.1 1.6 GO:0032274 gonadotropin secretion(GO:0032274)
0.1 5.0 GO:0043627 response to estrogen(GO:0043627)
0.1 3.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 2.6 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 1.7 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 5.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.4 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.3 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 2.8 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 2.1 GO:0031424 keratinization(GO:0031424)
0.1 1.1 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.1 1.0 GO:0000338 protein deneddylation(GO:0000338)
0.1 2.0 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.1 0.9 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 3.4 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 0.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.6 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.1 1.7 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 1.4 GO:2000369 regulation of clathrin-dependent endocytosis(GO:2000369)
0.0 0.6 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.2 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
0.0 1.0 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 1.6 GO:0003016 respiratory system process(GO:0003016)
0.0 1.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.4 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 2.5 GO:0046718 viral entry into host cell(GO:0046718)
0.0 1.8 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.9 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077)
0.0 0.5 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:1905034 regulation of antifungal innate immune response(GO:1905034) negative regulation of antifungal innate immune response(GO:1905035)
0.0 3.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.9 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 2.4 GO:0048477 oogenesis(GO:0048477)
0.0 1.4 GO:0051028 mRNA transport(GO:0051028)
0.0 2.9 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.1 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 1.0 GO:0048678 response to axon injury(GO:0048678)
0.0 1.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0060536 cartilage morphogenesis(GO:0060536)
0.0 1.1 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 1.4 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 2.6 GO:0030217 T cell differentiation(GO:0030217)
0.0 0.4 GO:0051930 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.5 GO:0031523 Myb complex(GO:0031523)
0.9 5.6 GO:0097513 myosin II filament(GO:0097513)
0.8 3.0 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.6 12.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.5 3.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.4 10.8 GO:0005859 muscle myosin complex(GO:0005859)
0.4 3.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.3 1.4 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.3 1.0 GO:0005607 laminin-2 complex(GO:0005607)
0.3 2.8 GO:0061574 ASAP complex(GO:0061574)
0.3 4.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.3 4.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 0.8 GO:0031251 PAN complex(GO:0031251)
0.3 1.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.3 1.0 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.3 4.8 GO:0031045 dense core granule(GO:0031045)
0.3 5.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 3.9 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 2.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 14.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.0 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.2 1.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 1.0 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.4 GO:0044299 C-fiber(GO:0044299)
0.1 1.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 3.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.7 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 1.4 GO:0071439 clathrin complex(GO:0071439)
0.1 2.2 GO:0044292 dendrite terminus(GO:0044292)
0.1 7.1 GO:0005871 kinesin complex(GO:0005871)
0.1 7.6 GO:0042629 mast cell granule(GO:0042629)
0.1 2.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.8 GO:0016580 Sin3 complex(GO:0016580)
0.1 2.5 GO:0031430 M band(GO:0031430)
0.1 0.6 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 0.8 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 5.5 GO:0031519 PcG protein complex(GO:0031519)
0.1 5.1 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.9 GO:0045180 basal cortex(GO:0045180)
0.1 2.1 GO:0001533 cornified envelope(GO:0001533)
0.1 1.4 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.1 5.0 GO:0016528 sarcoplasm(GO:0016528)
0.1 3.5 GO:0005844 polysome(GO:0005844)
0.1 4.9 GO:0005643 nuclear pore(GO:0005643)
0.1 2.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.7 GO:0008305 integrin complex(GO:0008305)
0.0 1.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 3.6 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.8 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.6 GO:0031143 pseudopodium(GO:0031143)
0.0 0.8 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 3.8 GO:0005581 collagen trimer(GO:0005581)
0.0 4.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.9 GO:0000922 spindle pole(GO:0000922)
0.0 1.0 GO:0008180 COP9 signalosome(GO:0008180)
0.0 8.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.4 GO:0005903 brush border(GO:0005903)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0031901 early endosome membrane(GO:0031901)
0.0 3.5 GO:0030141 secretory granule(GO:0030141)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.3 GO:0072686 mitotic spindle(GO:0072686)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 8.1 GO:0016019 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
1.3 6.5 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
1.2 3.5 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
1.1 3.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.9 3.6 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.9 2.7 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.7 2.7 GO:0031711 beta-adrenergic receptor activity(GO:0004939) bradykinin receptor binding(GO:0031711)
0.6 3.7 GO:1902944 aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902944)
0.6 10.8 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.5 2.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.5 3.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.5 13.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.5 1.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.4 2.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.4 2.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.3 0.6 GO:1905576 ganglioside GT1b binding(GO:1905576)
0.3 1.2 GO:0001847 opsonin receptor activity(GO:0001847)
0.3 2.2 GO:0038132 neuregulin binding(GO:0038132)
0.3 1.4 GO:0004348 glucosylceramidase activity(GO:0004348)
0.3 1.9 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.3 5.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 4.2 GO:0002162 dystroglycan binding(GO:0002162)
0.2 0.9 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.2 10.0 GO:0070412 R-SMAD binding(GO:0070412)
0.2 2.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 8.0 GO:0030506 ankyrin binding(GO:0030506)
0.2 1.6 GO:0030284 estrogen receptor activity(GO:0030284)
0.2 1.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 3.3 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 5.0 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.2 0.9 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.2 1.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 0.9 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.2 5.6 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.2 2.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.2 1.0 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.2 1.7 GO:0042609 CD4 receptor binding(GO:0042609)
0.2 3.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 3.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 4.4 GO:0019956 chemokine binding(GO:0019956)
0.1 2.9 GO:0001618 virus receptor activity(GO:0001618)
0.1 2.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.9 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 1.0 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 7.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 2.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.3 GO:0034437 glycoprotein transporter activity(GO:0034437)
0.1 0.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 5.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 7.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 3.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 3.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.9 GO:0005522 profilin binding(GO:0005522)
0.1 0.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 2.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 2.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.4 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 1.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 5.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 2.1 GO:0098960 postsynaptic neurotransmitter receptor activity(GO:0098960)
0.1 3.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 11.8 GO:0008201 heparin binding(GO:0008201)
0.1 1.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 6.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 0.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.5 GO:0043426 MRF binding(GO:0043426)
0.1 3.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.7 GO:0042169 SH2 domain binding(GO:0042169)
0.0 2.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 1.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.9 GO:0005109 frizzled binding(GO:0005109)
0.0 1.0 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 1.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.7 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 1.5 GO:0030507 spectrin binding(GO:0030507)
0.0 0.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) tumor necrosis factor binding(GO:0043120)
0.0 2.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 2.5 GO:0017124 SH3 domain binding(GO:0017124)
0.0 5.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.6 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 2.8 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.1 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 3.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.8 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 3.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 15.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 3.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 3.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 13.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 8.5 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.2 2.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.6 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 1.5 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 2.9 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.3 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 3.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 3.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 2.4 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.2 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 2.8 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 3.3 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 4.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.0 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 4.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.4 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.0 0.7 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 3.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 16.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 13.2 REACTOME_KINESINS Genes involved in Kinesins
0.3 12.7 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 8.6 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 7.9 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 3.4 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.2 7.7 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.2 3.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 2.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 2.3 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 3.2 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.1 5.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 3.8 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 3.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 8.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 5.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.9 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 1.8 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.0 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.1 2.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.0 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 2.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.8 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 2.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.0 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 2.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.7 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 1.7 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.9 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 1.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.2 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.4 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.4 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.8 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.9 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.6 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 2.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex