Motif ID: Hnf1a

Z-value: 1.688


Transcription factors associated with Hnf1a:

Gene SymbolEntrez IDGene Name
Hnf1a ENSMUSG00000029556.6 Hnf1a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hnf1amm10_v2_chr5_-_114971056_1149710790.473.5e-03Click!


Activity profile for motif Hnf1a.

activity profile for motif Hnf1a


Sorted Z-values histogram for motif Hnf1a

Sorted Z-values for motif Hnf1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf1a

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_10215955 15.572 ENSMUST00000130720.1
Prlr
prolactin receptor
chr11_+_101367542 13.923 ENSMUST00000019469.2
G6pc
glucose-6-phosphatase, catalytic
chr7_+_140763739 13.680 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr1_-_130661584 13.380 ENSMUST00000137276.2
C4bp
complement component 4 binding protein
chr1_-_130661613 12.986 ENSMUST00000027657.7
C4bp
complement component 4 binding protein
chr5_+_90518932 12.664 ENSMUST00000113179.2
ENSMUST00000128740.1
Afm

afamin

chr11_-_84167466 11.621 ENSMUST00000050771.7
Gm11437
predicted gene 11437
chr5_-_89457763 11.409 ENSMUST00000049209.8
Gc
group specific component
chr5_-_87337165 10.705 ENSMUST00000031195.2
Ugt2a3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_+_88211956 10.613 ENSMUST00000073049.6
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr6_+_141629499 10.482 ENSMUST00000042812.6
Slco1b2
solute carrier organic anion transporter family, member 1b2
chr12_-_103773592 9.259 ENSMUST00000078869.5
Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr4_+_138967112 9.044 ENSMUST00000116094.2
Rnf186
ring finger protein 186
chr12_-_103904887 9.005 ENSMUST00000074051.5
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr10_+_87859255 8.596 ENSMUST00000105300.2
Igf1
insulin-like growth factor 1
chr5_-_87092546 8.589 ENSMUST00000132667.1
ENSMUST00000145617.1
ENSMUST00000094649.4
Ugt2b36


UDP glucuronosyltransferase 2 family, polypeptide B36


chr10_+_87859062 8.369 ENSMUST00000095360.4
Igf1
insulin-like growth factor 1
chr2_-_35100677 8.194 ENSMUST00000045776.4
ENSMUST00000113050.3
AI182371

expressed sequence AI182371

chr17_+_12584183 7.936 ENSMUST00000046959.7
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
chr3_+_129836729 7.783 ENSMUST00000077918.5
Cfi
complement component factor i
chr2_-_91636394 7.771 ENSMUST00000111335.1
ENSMUST00000028681.8
F2

coagulation factor II

chr1_+_88138364 7.514 ENSMUST00000014263.4
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr17_+_12378603 7.117 ENSMUST00000014578.5
Plg
plasminogen
chr12_-_103863551 6.931 ENSMUST00000085056.6
ENSMUST00000072876.5
ENSMUST00000124717.1
Serpina1a


serine (or cysteine) peptidase inhibitor, clade A, member 1A


chr9_-_71163224 6.902 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr5_+_33104219 6.868 ENSMUST00000011178.2
Slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr5_+_90460889 6.650 ENSMUST00000031314.8
Alb
albumin
chr12_-_103738158 6.229 ENSMUST00000095450.4
Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr19_+_42045792 6.179 ENSMUST00000172244.1
ENSMUST00000081714.4
Hoga1

4-hydroxy-2-oxoglutarate aldolase 1

chr8_-_121944886 5.956 ENSMUST00000057653.7
Car5a
carbonic anhydrase 5a, mitochondrial
chr2_-_62412219 5.885 ENSMUST00000047812.7
Dpp4
dipeptidylpeptidase 4
chr11_-_78422217 5.828 ENSMUST00000001122.5
Slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr18_+_33464163 5.728 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr2_-_35061431 5.562 ENSMUST00000028233.3
Hc
hemolytic complement
chr4_-_140617062 5.539 ENSMUST00000154979.1
Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like
chr12_-_103657159 5.505 ENSMUST00000044159.6
Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr1_+_88070765 5.393 ENSMUST00000073772.4
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr11_-_11898092 5.071 ENSMUST00000178704.1
Ddc
dopa decarboxylase
chr11_-_11898044 5.027 ENSMUST00000066237.3
Ddc
dopa decarboxylase
chr3_+_94398517 4.856 ENSMUST00000050975.3
Lingo4
leucine rich repeat and Ig domain containing 4
chr2_+_163547148 4.675 ENSMUST00000109411.1
ENSMUST00000018094.6
Hnf4a

hepatic nuclear factor 4, alpha

chr1_-_20617992 4.629 ENSMUST00000088448.5
Pkhd1
polycystic kidney and hepatic disease 1
chr5_+_31297551 4.485 ENSMUST00000072228.5
Gckr
glucokinase regulatory protein
chr5_+_24428208 4.383 ENSMUST00000115049.2
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr2_-_134554348 4.356 ENSMUST00000028704.2
Hao1
hydroxyacid oxidase 1, liver
chr4_+_150853919 4.264 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr11_+_70519619 4.247 ENSMUST00000179000.1
Gltpd2
glycolipid transfer protein domain containing 2
chr5_+_35041539 4.156 ENSMUST00000030985.6
Hgfac
hepatocyte growth factor activator
chr12_-_103657095 3.980 ENSMUST00000152517.1
Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr19_+_56287943 3.947 ENSMUST00000166049.1
Habp2
hyaluronic acid binding protein 2
chr5_+_102845007 3.925 ENSMUST00000070000.4
Arhgap24
Rho GTPase activating protein 24
chr2_-_32424005 3.921 ENSMUST00000113307.2
Slc25a25
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr1_+_172698046 3.682 ENSMUST00000038495.3
Crp
C-reactive protein, pentraxin-related
chr19_+_56287911 3.658 ENSMUST00000095948.4
Habp2
hyaluronic acid binding protein 2
chr13_+_55152640 3.580 ENSMUST00000005452.5
Fgfr4
fibroblast growth factor receptor 4
chr2_-_86347764 3.573 ENSMUST00000099894.2
Olfr1055
olfactory receptor 1055
chrX_+_101377267 3.466 ENSMUST00000052130.7
Gjb1
gap junction protein, beta 1
chr7_-_79842287 3.384 ENSMUST00000049004.6
Anpep
alanyl (membrane) aminopeptidase
chr6_+_21986887 3.266 ENSMUST00000151315.1
Cped1
cadherin-like and PC-esterase domain containing 1
chr10_+_63061582 3.156 ENSMUST00000020266.8
ENSMUST00000178684.1
Pbld1

phenazine biosynthesis-like protein domain containing 1

chr2_+_163506808 2.946 ENSMUST00000143911.1
Hnf4a
hepatic nuclear factor 4, alpha
chr9_+_21835506 2.896 ENSMUST00000058777.6
Gm6484
predicted gene 6484
chr2_+_162987330 2.882 ENSMUST00000018012.7
Sgk2
serum/glucocorticoid regulated kinase 2
chr8_-_95142477 2.873 ENSMUST00000034240.7
ENSMUST00000169748.1
Kifc3

kinesin family member C3

chr2_+_162987502 2.841 ENSMUST00000117123.1
Sgk2
serum/glucocorticoid regulated kinase 2
chr11_+_118428203 2.834 ENSMUST00000124861.1
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr16_+_24448082 2.634 ENSMUST00000078988.2
Lpp
LIM domain containing preferred translocation partner in lipoma
chr12_-_103956891 2.600 ENSMUST00000085054.4
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
chr11_+_70519183 2.569 ENSMUST00000057685.2
Gltpd2
glycolipid transfer protein domain containing 2
chrX_+_101376359 2.539 ENSMUST00000119080.1
Gjb1
gap junction protein, beta 1
chr12_+_76533540 2.412 ENSMUST00000075249.4
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr15_+_54952939 2.365 ENSMUST00000181704.1
Gm26684
predicted gene, 26684
chr14_-_36919314 2.291 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr10_+_34483400 2.202 ENSMUST00000019913.7
ENSMUST00000170771.1
Frk

fyn-related kinase

chr7_-_119895446 2.174 ENSMUST00000098080.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr4_-_139968026 2.163 ENSMUST00000105031.2
Klhdc7a
kelch domain containing 7A
chr3_-_75270073 2.150 ENSMUST00000039047.4
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr14_-_36919513 2.125 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chr1_+_133309778 2.120 ENSMUST00000094557.4
ENSMUST00000183457.1
ENSMUST00000183738.1
ENSMUST00000185157.1
ENSMUST00000184603.1
Golt1a

Kiss1

GOLT1A
golgi transport 1 homolog A (S. cerevisiae)

KiSS-1 metastasis-suppressor

KISS1 isoform e
chr12_+_59095653 2.070 ENSMUST00000021384.4
Mia2
melanoma inhibitory activity 2
chr9_+_109096659 1.969 ENSMUST00000130366.1
Plxnb1
plexin B1
chr9_-_70934808 1.883 ENSMUST00000034731.8
Lipc
lipase, hepatic
chr7_+_141216626 1.855 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr7_-_45062393 1.768 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr16_-_38433145 1.711 ENSMUST00000002926.6
Pla1a
phospholipase A1 member A
chr12_-_103631404 1.692 ENSMUST00000121625.1
ENSMUST00000044231.5
Serpina10

serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

chrX_-_43167817 1.458 ENSMUST00000115058.1
ENSMUST00000115059.1
Tenm1

teneurin transmembrane protein 1

chr3_+_90537242 1.452 ENSMUST00000098911.3
S100a16
S100 calcium binding protein A16
chr7_-_144751968 1.303 ENSMUST00000155175.1
Ano1
anoctamin 1, calcium activated chloride channel
chr5_-_114444036 1.283 ENSMUST00000031560.7
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chrX_-_139085230 1.251 ENSMUST00000152457.1
Serpina7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr9_-_106158109 1.229 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk



glycerate kinase



chr2_+_91265252 1.216 ENSMUST00000028691.6
Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr5_-_114443993 1.150 ENSMUST00000112245.1
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr18_-_33464007 1.146 ENSMUST00000168890.1
Nrep
neuronal regeneration related protein
chr3_+_83026147 1.032 ENSMUST00000166581.1
ENSMUST00000029630.9
Fga

fibrinogen alpha chain

chr11_+_83852135 1.022 ENSMUST00000146786.1
Hnf1b
HNF1 homeobox B
chr18_-_33463747 1.005 ENSMUST00000171533.1
Nrep
neuronal regeneration related protein
chr17_-_35132050 0.990 ENSMUST00000025249.6
Apom
apolipoprotein M
chr3_+_90537306 0.987 ENSMUST00000107335.1
S100a16
S100 calcium binding protein A16
chr6_-_52183828 0.962 ENSMUST00000134831.1
Hoxa3
homeobox A3
chr5_+_7304128 0.925 ENSMUST00000160634.1
ENSMUST00000159546.1
4921511H03Rik

RIKEN cDNA 4921511H03 gene

chr3_-_83049797 0.921 ENSMUST00000048246.3
Fgb
fibrinogen beta chain
chr14_+_43957069 0.920 ENSMUST00000066719.4
Ang5
angiogenin, ribonuclease A family, member 5
chr7_+_141215852 0.895 ENSMUST00000046890.5
ENSMUST00000133763.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr2_+_74727074 0.888 ENSMUST00000111980.2
Hoxd3
homeobox D3
chrX_-_139085211 0.800 ENSMUST00000033626.8
ENSMUST00000060824.3
Serpina7

serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

chr3_-_122984404 0.773 ENSMUST00000090379.2
Usp53
ubiquitin specific peptidase 53
chr3_+_14480692 0.676 ENSMUST00000037321.7
ENSMUST00000120484.1
ENSMUST00000120801.1
Slc7a12


solute carrier family 7 (cationic amino acid transporter, y+ system), member 12


chr16_-_52296924 0.652 ENSMUST00000167115.1
Alcam
activated leukocyte cell adhesion molecule
chr11_+_115912001 0.536 ENSMUST00000132961.1
Smim6
small integral membrane protein 6
chr4_-_97778042 0.524 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_94650134 0.446 ENSMUST00000053419.2
Lrrc19
leucine rich repeat containing 19
chr11_+_43035746 0.431 ENSMUST00000069051.1
Gm9972
predicted gene 9972
chr3_-_69859875 0.421 ENSMUST00000051239.7
ENSMUST00000171529.1
Sptssb

serine palmitoyltransferase, small subunit B

chr8_+_64947177 0.240 ENSMUST00000079896.7
ENSMUST00000026595.5
Tmem192

transmembrane protein 192

chr2_+_110597298 0.237 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr5_-_114658414 0.227 ENSMUST00000112225.1
ENSMUST00000071968.2
Trpv4

transient receptor potential cation channel, subfamily V, member 4

chr2_-_68472138 0.206 ENSMUST00000102715.3
Stk39
serine/threonine kinase 39
chr5_+_88487982 0.199 ENSMUST00000031222.8
Enam
enamelin
chr5_+_122391878 0.192 ENSMUST00000102525.4
Arpc3
actin related protein 2/3 complex, subunit 3
chr13_-_84064772 0.182 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr6_+_29859374 0.145 ENSMUST00000115238.3
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr8_-_93535707 0.104 ENSMUST00000077816.6
Ces5a
carboxylesterase 5A
chr7_+_45062429 0.042 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
Nosip



nitric oxide synthase interacting protein



chr11_+_78178105 0.000 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.6 GO:0018879 biphenyl metabolic process(GO:0018879)
2.8 17.0 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
2.6 15.6 GO:0038161 prolactin signaling pathway(GO:0038161)
2.5 7.6 GO:1902569 negative regulation of activation of Janus kinase activity(GO:1902569)
2.3 13.9 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
2.2 6.7 GO:0051659 maintenance of mitochondrion location(GO:0051659)
2.0 5.9 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
1.9 7.8 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
1.6 23.6 GO:0052695 cellular glucuronidation(GO:0052695)
1.5 6.2 GO:0009436 glyoxylate catabolic process(GO:0009436)
1.4 10.1 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
1.4 7.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
1.4 6.9 GO:0015855 purine nucleobase transport(GO:0006863) nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
1.4 6.9 GO:0106001 intestinal D-glucose absorption(GO:0001951) intestinal hexose absorption(GO:0106001)
1.2 3.6 GO:0061144 alveolar secondary septum development(GO:0061144)
1.1 4.5 GO:0009750 response to fructose(GO:0009750)
1.1 5.6 GO:1905522 negative regulation of macrophage chemotaxis(GO:0010760) negative regulation of macrophage migration(GO:1905522)
1.1 4.4 GO:0009441 glycolate metabolic process(GO:0009441)
1.1 3.2 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.9 7.9 GO:1901374 acetate ester transport(GO:1901374)
0.9 4.3 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.8 37.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.8 6.8 GO:0120009 intermembrane lipid transfer(GO:0120009)
0.7 2.1 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.7 2.1 GO:0033189 response to vitamin A(GO:0033189)
0.6 11.4 GO:0042359 vitamin D metabolic process(GO:0042359)
0.5 13.7 GO:0017144 drug metabolic process(GO:0017144)
0.5 2.0 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.5 2.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.5 2.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.5 9.9 GO:0015865 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.4 3.9 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.4 5.9 GO:0006857 oligopeptide transport(GO:0006857)
0.3 2.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 1.0 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
0.3 9.5 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.3 2.8 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.3 1.8 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.3 1.0 GO:0061296 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.2 5.5 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.2 3.4 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.2 1.9 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.2 9.4 GO:0051180 vitamin transport(GO:0051180)
0.1 13.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 2.2 GO:0010225 response to UV-C(GO:0010225)
0.1 1.3 GO:0015705 iodide transport(GO:0015705)
0.1 4.4 GO:0015701 bicarbonate transport(GO:0015701)
0.1 4.9 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 4.6 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.1 24.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 2.1 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.1 0.2 GO:0071651 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.1 0.2 GO:1903789 regulation of amino acid transmembrane transport(GO:1903789) regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 0.4 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.0 0.2 GO:0070173 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) regulation of enamel mineralization(GO:0070173)
0.0 5.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 4.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.8 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 2.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 3.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 2.2 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015)
0.0 4.2 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 2.8 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 17.0 GO:0042567 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567)
1.8 7.1 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
1.0 1.0 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.8 10.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.7 5.9 GO:0071438 invadopodium membrane(GO:0071438)
0.6 5.6 GO:0005579 membrane attack complex(GO:0005579)
0.3 3.4 GO:0031983 vesicle lumen(GO:0031983)
0.3 2.9 GO:0005915 zonula adherens(GO:0005915)
0.3 40.4 GO:0072562 blood microparticle(GO:0072562)
0.3 6.0 GO:0005922 connexin complex(GO:0005922)
0.2 27.5 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 1.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 2.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.7 GO:0002080 acrosomal membrane(GO:0002080)
0.1 0.2 GO:0090725 peripheral region of growth cone(GO:0090725)
0.1 20.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 0.4 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 4.6 GO:0072686 mitotic spindle(GO:0072686)
0.0 10.1 GO:0008021 synaptic vesicle(GO:0008021)
0.0 4.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.9 GO:0030175 filopodium(GO:0030175)
0.0 6.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.6 GO:0030133 transport vesicle(GO:0030133)
0.0 10.7 GO:0009986 cell surface(GO:0009986)
0.0 2.8 GO:0005581 collagen trimer(GO:0005581)
0.0 2.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.0 4.4 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 9.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 24.7 GO:0005794 Golgi apparatus(GO:0005794)
0.0 2.0 GO:0043235 receptor complex(GO:0043235)
0.0 5.7 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.9 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
4.2 12.7 GO:0008431 vitamin E binding(GO:0008431)
3.1 15.6 GO:0004925 prolactin receptor activity(GO:0004925)
2.9 11.4 GO:1902271 D3 vitamins binding(GO:1902271)
2.6 7.9 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
2.5 7.6 GO:0070540 stearic acid binding(GO:0070540)
1.5 6.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.4 10.1 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
1.4 6.9 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
1.3 7.8 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.1 42.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
1.1 4.4 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
1.0 6.8 GO:0120013 intermembrane lipid transfer activity(GO:0120013)
0.7 5.9 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.6 3.6 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.6 4.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.5 7.1 GO:1990405 protein antigen binding(GO:1990405)
0.5 5.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.5 3.7 GO:0001849 complement component C1q binding(GO:0001849)
0.4 17.0 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.4 6.7 GO:0015643 toxic substance binding(GO:0015643)
0.4 13.7 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.4 3.6 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.4 6.0 GO:0005243 gap junction channel activity(GO:0005243)
0.4 49.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 6.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 3.9 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.2 5.7 GO:0017081 chloride channel regulator activity(GO:0017081)
0.2 4.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 1.3 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 7.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 3.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 2.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 4.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 2.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 2.2 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.2 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 13.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 5.6 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 7.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.6 GO:0005549 odorant binding(GO:0005549)
0.0 0.2 GO:0005308 creatine transmembrane transporter activity(GO:0005308) rubidium ion transmembrane transporter activity(GO:0035827)
0.0 0.4 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 2.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 2.8 GO:0005518 collagen binding(GO:0005518)
0.0 2.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 1.0 GO:0071837 HMG box domain binding(GO:0071837)
0.0 4.0 GO:0015293 symporter activity(GO:0015293)
0.0 4.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.0 GO:0016209 antioxidant activity(GO:0016209)
0.0 2.0 GO:0030674 protein binding, bridging(GO:0030674)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.8 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.4 22.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 13.9 PID_FOXO_PATHWAY FoxO family signaling
0.2 9.1 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 15.6 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.2 7.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 22.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.7 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 3.6 PID_FGF_PATHWAY FGF signaling pathway
0.1 7.6 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 2.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.5 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
1.2 16.0 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.8 15.6 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.7 6.7 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.6 9.7 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.6 7.9 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.6 7.8 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.6 6.9 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.5 10.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.5 3.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.4 5.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.4 18.4 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.3 11.4 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.3 6.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.3 5.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 7.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 6.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.2 3.6 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.9 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 6.9 REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.1 1.0 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 2.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.0 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 4.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 4.0 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 3.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases